• 한국식품영양학회지
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• 제29권4호
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• pp.499-505
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• 2016

To improve the shelf-life of mushrooms, Lentinula edodes GNA01 mushrooms were treated with gel packs containing slow-released chlorine dioxide ($ClO_2$) gas at 5~10 ppm for 5 days at $20^{\circ}C$ and the weight loss rate as well as the changes in pH, color and texture properties of the treated samples were investigated. The weight of the control and $ClO_2$ gas treated samples were decreased slightly, and there were no differences during the storage period. However, the weight of the control changed faster than those of the $ClO_2$ gas treated samples during storage period. The pH in the control and in the $ClO_2$ gas treated samples were decreased during storage period, but the samples treated with 5 and 7 ppm $ClO_2$ gas were the least changed. On the other hand, the samples treated with 10 ppm $ClO_2$ gas showed no difference from the other treatments during 4 days, but the pH was lower than that of the control on the fifth day. The lightness of inside and outside in mushroom were decreased whereas redness and yellowness were increased during storage period. However, color changes in the $ClO_2$ gas treated samples were lower than those of the control. Especially, the samples treated with 5 and 7 ppm $ClO_2$ gas were the least changed. The texture of the mushroom were decreased consistently during storage period. The texture of the control changed faster than those of the $ClO_2$ gas treatments during 5 days. Especially, the samples treated 5 ppm $ClO_2$ gas were the least changed.

• Structural Engineering and Mechanics
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• 제53권6호
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• pp.1201-1214
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• 2015

This paper introduces the combined effect of electric field, magnetic field and thermal field on edge wave propagating in a homogeneous isotropic prestressed plate of finite thickness and infinite length. The dispersion relation of edge wave has been obtained by using classical dynamical theory of thermoelasticity. The phase velocity has been computed and shown graphically for various initial stress parameter, electro-magneto parameter, electric parameter and thermoelastic coupling parameter.

• Earthquakes and Structures
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• 제8권6호
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• pp.1299-1323
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• 2015

A model for reflection and refraction of magneto-thermoelastic SV-waves at the interface of two transversely isotropic and homogeneous solid half spaces under initial stress by applying classical dynamical theory of thermoelasticity is purposed. The reflection and refraction coefficients of SV-waves are obtained with ideal boundary conditions for SV-wave incident on the solid-solid interface. The effects of magnetic field, temperature and initial stress on the amplitude ratios after numerical computations are shown graphically with MATLAB software for the particular model.

• Earthquakes and Structures
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• 제9권2호
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• pp.305-320
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• 2015

The present paper is devoted to study SH-wave propagation in heterogeneous layer laying over an inhomogeneous isotropic elastic half-space. The dispersion relation for propagation of said waves is derived with Green's function method and Fourier transform. As a special case when the upper layer and lower half-space are homogeneous, our derived equation is in agreement with the general equation of Love wave. Numerically, it is observed that the velocity of SH-wave increases with the increase of inhomogeneity parameter.

• Earthquakes and Structures
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• 제9권1호
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• pp.111-126
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• 2015

In this study, the coupled effects of magnetic field, stress and thermal field on gravity waves propagating in a liquid layer over a solid surface are discussed. Due to change in temperature, initial hydrostatic stress and magnetic field, the gravity-sound Rayleigh waves can propagate in the liquid-solid interface. Dispersion properties of waves are derived by using classical dynamical theory of thermoelasticity. The phase velocity of gravity waves influenced quite remarkably in the presence of initial stress parameter, magneto-thermoelastic coupling parameter in the half space. Numerical solutions are also discussed for gravity-Rayleigh waves. In the absence of temperature, stress and magnetic field, the obtained results are in agreement with classical results.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2018년도 춘계 종합학술대회 논문집
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• pp.73-74
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• 2018

This paper presents the incorporation of still-alive access points (SAPs) and helper access points (HAPs) that can be utilized as anchor nodes for position estimation of a First Responders (FRs) for rapidly deployable Emergency Communication Systems (ECS) in disaster recovery. In addition, the localization environment has is formulated and initially examines the use of a distributed Gauss-Newton algorithm (GNA) as optimization technizue. A simulation has been conducted and compared with the commonly used trilateration approach in position estimation.

• 대한치과보철학회지
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• 제58권4호
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• pp.290-299
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• 2020

목적: 본 연구에서는 나노방출제어시스템을 이용하여 trichloroacetic acid (TCA) 및 epidermal growth factor (EGF)를 인간치은섬유아세포에 적용하였을 때, 나타나는 액틴 세포골격과 관련된 유전자 발현의 변화 양상을 확인하고자 하였다. 재료 및 방법: TCA와 EGF가 조절방출될 수 있도록 만들어진 나노방출제어시스템을 이용하였다. 인간치은섬유아세포에 TCA만 적용된 군(EXP1), TCA와 EGF가 적용된 군(EXP2), 대조군(CON)의 3가지 군으로 나누어 48시간 배양하였다. Real-time PCR을 이용하여 액틴 세포골격과 관련된 유전자 26개의 발현 양상을 분석하였다. 피어슨상관관계분석을 통해 유전자들의 상관관계와 영향요인을 확인하였다. 결과: 액틴 세포골격과 관련된 유전자 26개 중 23개가 EXP1과 EXP2에서 상향조절되었고, 이 중 14개는 EXP1에 비하여 EXP2에서 유의미한 발현량 증가를 보였다. LPAR1은 EXP1에서만 하향조절되었고, GNA13은 EXP2에서만 상향조절되었고, F2R은 EXP2에서만 하향조절되었다. 액틴 단백질의 유전자 발현에 대하여 Rac1관련 유전자 중 3개와 CDC42가 가장 큰 영향요인으로 확인되었다. 결론: 인간치은섬유아세포의 액틴 세포골격 관련 유전자들은 나노방출제어시스템을 통하여 조절 방출된 TCA와 EGF에 의해 대부분 상향조절되었다.

• BMB Reports
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• 제57권8호
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• pp.369-374
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• 2024

Antigen 43 (Ag43) proteins, found on the outer membrane of Escherichia coli, are β-sheets that fold into a unique cylindrical structure known as a β-barrel. There are several known structural similarities between bacterial Ag43 autotransporters and physical components; however, the factors that stabilize the barrel and the mechanism for Ag43 passenger domain-mediated translocation across the pore of the β-barrel remain unclear. In this study, we analyzed Ag43β-enhanced green fluorescent protein chimeric variants to provide new insights into the autotransporter Ag43β-barrel assembly, focusing on the impact of the α-helical linker domain. Among the chimeric variants, Ag43β700 showed the highest surface display, which was confirmed through extracellular protease digestion, flow cytometry, and an evaluation of outer membrane vesicles (OMVs). The Ag43β700 module offered reliable information on stable barrel folding and chimera expression at the exterior of the OMVs.

• Journal of Gastric Cancer
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• 제20권1호
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• pp.29-40
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• 2020

Purpose: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors. In this study, a targeted next-generation sequencing (NGS) assay with an Oncomine Focus Assay (OFA) panel was used for the genetic characterization of molecular targets in 30 Korean patients with GIST. Materials and Methods: Using the OFA that enables rapid and simultaneous detection of hotspots, single nucleotide variants (SNVs), insertion and deletions (Indels), copy number variants (CNVs), and gene fusions across 52 genes relevant to solid tumors, targeted NGS was performed using genomic DNA extracted from formalin-fixed and paraffin-embedded samples of 30 GISTs. Results: Forty-three hotspot/other likely pathogenic variants (33 SNVs, 8 Indels, and 2 amplifications) in 16 genes were identified in 26 of the 30 GISTs. KIT variants were most frequent (44%, 19/43), followed by 6 variants in PIK3CA, 3 in PDGFRA, 2 each in JAK1 and EGFR, and 1 each in AKT1, ALK, CCND1, CTNNB1, FGFR3, FGFR4, GNA11, GNAQ, JAK3, MET, and SMO. Based on the mutation types, majority of the variants carried missense mutations (60%, 26/43), followed by 8 frameshifts, 6 nonsense, 1 stop-loss, and 2 amplifications. Conclusions: Our study confirmed the advantage of using targeted NGS with a cancer gene panel to efficiently identify mutations associated with GISTs. These findings may provide a molecular genetic basis for developing new drugs targeting these gene mutations for GIST therapy.

• 한국융합학회논문지
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• 제12권10호
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• pp.9-17
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• 2021

최근 빅데이터 분석, 인공지능, 기계학습 등의 발전으로 인해서 데이터를 과학적으로 분석하는 기술이 발전하고 있으며 이는 의사결정 문제를 최적으로 해결해주고 있다. 그러나 특정 분야의 경우에는 데이터의 양이 부족해서 과학적 방식에 적용하는 것이 어렵다. 예컨대 부동산과 같은 데이터는 데이터 발표 시점이 최근이거나 비 유동성 자산이다 보니 발표 주기가 긴 경우가 많다. 따라서 본 연구에서는 이런 문제점을 극복하기 위해서 TimeGAN 모형을 통해 기존의 시계열의 확장 가능성에 대해서 연구하고자 한다. 이를 위해 부동산과 관련된 총 45개의 시계열을 데이터 셋에 맞게 2012년부터 2021년까지 주 단위로 데이터를 수집하고 시계열 간의 상관관계를 고려해서 총 15개의 최종 시계열을 선정한다. 15개의 시계열에 대해서 TimeGAN 모형을 통해 데이터 확장을한 결과, PCA 및 T-SNE 시각화 알고리즘을 통해 실제 데이터와 확장 데이터 간의 통계적 분포가 유사하다는 것을 확인할 수 있었다. 따라서 본 논문을 통해서 데이터의 과적합 또는 과소적합이라는 한계점을 극복할 수 있는 다양한 실험이 연구되기를 기대한다.