• 제목/요약/키워드: GIST

검색결과 806건 처리시간 0.037초

3차 교차상관신호의 역상관을 통한 펨토초 및 처프된 피코초 펄스의 정확한 선행펄스 대비율 측정 (Accurate Contrast-ratio Measurement of Femtosecond and Chirped Picosecond Pulses from the Decorrelation of Third-order Correlation Trace)

  • Hong, Kyung-Han;Sung, Jae-Hee;Yu, Tae-Jun;Choi, Il-Woo;Kim, Hyung-Taek;Noh, Young-Chul;Ko, Do-Kyeong;Lee, Jong-Min
    • 한국광학회:학술대회논문집
    • /
    • 한국광학회 2007년도 동계학술발표회 논문집
    • /
    • pp.349-350
    • /
    • 2007

  • PDF

Coherent Absorption Spectroscopy with Supercontinuum for Semiconductor Quantum Well Structure

  • Byeon, Ciare C.;Oh, Myoung-Kyu;Kang, Hoon-Soo;Ko, Do-Kyeong;Lee, Jong-Min;Kim, Jong-Su;Choi, Hyoung-Gyu;Jeong, Mun-Seok;Kee, Chul-Sik
    • Journal of the Optical Society of Korea
    • /
    • 제11권3호
    • /
    • pp.138-141
    • /
    • 2007

  • We suggest that supercontinuum can be used for absorption spectroscopy to observe the exciton levels of a semiconductor nano-structure. Exciton absorption spectrum of a GaAs/AlGaAs quantum well was observed using supercontinuum generated by a microstructrured fiber pumped by a femtosecond (fs) pulsed laser. Significantly narrower peaks were observed in the absorption spectrum from 11 K up to room temperature than photoluminescence (PL) spectrum peaks. Because supercontinuum is coherent light and can readily provide high enough intensity, this method can provide a coherent ultra-broad band light source to identify exciton levels in semiconductors, and be applicable to coherent nonlinear spectroscopy such as electromagnetically induced transparency (EIT), lasing without inversion (LWI) and coherent photon control in semiconductor quantum structures.

  • https://doi.org/10.3807/JOSK.2007.11.3.138 인용 PDF KSCI

MiR-374b Promotes Proliferation and Inhibits Apoptosis of Human GIST Cells by Inhibiting PTEN through Activation of the PI3K/Akt Pathway

  • Long, Zi-Wen;Wu, Jiang-Hong;Hong, Cai;Wang, Ya-Nong;Zhou, Ye
    • Molecules and Cells
    • /
    • 제41권6호
    • /
    • pp.532-544
    • /
    • 2018

  • Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. In order to investigate a new treatment fot GIST, we hypothesized the effect of miR-374b targeting PTEN gene-mediated PI3K/Akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (GIST) cells. We obtained GIST tissues and adjacent normal tissues from 143 patients with GIST to measure the levels of miR-374b, PTEN, PI3K, Akt, caspase9, Bax, MMP2, MMP9, ki67, PCNA, P53 and cyclinD1. Finally, cell viability, cell cycle and apoptosis were detected. According to the KFGG analysis of DEGs, PTEN was involved in a variety of signaling pathways and miRs were associated with cancer development. The results showed that MiR-374b was highly expressed, while PTEN was downregulated in the GIST tissues. The levels of miR-374b, PI3K, AKT and PTEN were related to tumor diameter and pathological stage. Additionally, miR-374b increased the mRNA and protein levels of PI3K, Akt, MMP2, MMP9, P53 and cyclinD1, suggesting that miR-374b activates PI3K/Akt signaling pathway in GIST-T1 cells. Moreover, MiR374b promoted cell viability, migration, invasion, and cell cycle entry, and inhibited apoptosis in GIST cells. Taken together, the results indicated that miR-374b promotes viability and inhibits apoptosis of human GIST cells by targeting PTEN gene through the PI3K/Akt signaling pathway. Thus, this study provides a new potential target for GIST treatment.

  • https://doi.org/10.14348/molcells.2018.2211 인용 PDF KSCI