• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2129-2132
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• 2012

Objective: To explore improved treatment by retrospectively comparing survival time of gemcitabine-based concurrent chemoradiotherapy (GemRT) versus chemotherapy (Gem) alone in patients with locally advanced pancreatic cancer (LAPC). Methods: From January 2005 to June 2010, 56 patients with LAPC from Subei People's Hospital were treated either with Gem (n=21) or GemRT (n=35). Gem consisted of 4-6 cycles gemcitabine alone (1000 mg/m2 on Days 1, 8, 15, 28-day a cycle). GemRT consisted of 50.4Gy/28F radiotherapy with concurrent 2 cycles of gemcitabine (1000 $mg/m^2$ on days of radiation 1, 8, 15, 21-day a cycle). Radiation was delivered to the gross tumor volume plus 1-1.5 cm by use of a three-dimensional conformal technique. The follow-up time was calculated from the time of diagnosis to the date of death or last contact. Kaplan-Meier methodology wes used to evaluate survival. Results: Patient characteristics were not significantly different between treatment groups. The disease control rate and the objective response rate of GemRT versus Gem was 97.1% vs 71.4%, 74.3% vs 38.1%. The overall survival (OS) was significantly better for GemRT compared to Gem (median 13 months versus 8 months; 51.4% versus 14.3% at 1 year, respectively). Conclusion: Radiation therapy at 50.4Gy with 2 concurrent cycles of gemcitabine results in favorable rates of OS. Concurrent chemoradiotherapy should be the first choice for patients with LAPC.

• Atmosphere
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• v.25 no.1
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• pp.85-97
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• 2015

This study is to investigate future changes in carbon cycle using the HadGEM2-Carbon Cycle simulations driven by $CO_2$ emissions. For experiment, global carbon budget is integrated from the two (8.5/2.6) representative concentration pathways (RCPs) for the period of 1860~2100 by Hadley Centre Global Environmental Model, version 2, Carbon Cycle (Had-GEM2-CC). From 1985 to 2005, total cumulative $CO_2$ amount of anthropogenic emission prescribed as 156 GtC. The amount matches to the observed estimates (CDIAC) over the same period (136 GtC). As $CO_2$ emissions into the atmosphere increase, the similar increasing tendency is found in the simulated atmospheric $CO_2$ concentration and temperature. Atmospheric $CO_2$ concentration in the simulation is projected to be 430 ppm for RCP 2.6 at the end of the twenty-first century and as high as 931 ppm for RCP 8.5. Simulated global mean temperature is expected to rise by $1.6^{\circ}C$ and $3.5^{\circ}C$ for RCP 2.6 and 8.5, respectively. Land and ocean carbon uptakes also increase in proportion to the $CO_2$ emissions of RCPs. The fractions of the amount of $CO_2$ stored in atmosphere, land, and ocean are different in RCP 8.5 and 2.6. Further study is needed for reducing the simulation uncertainty based on multiple model simulations.

• Atmosphere
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• v.23 no.4
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• pp.425-441
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• 2013

This study investigates the projections of water cycle, budget and river discharge over land in the world at the end of twenty-first century simulated by atmosphere-ocean climate model of Hadley Centre (HadGEM2-AO) and total runoff integrating pathways (TRIP) based on the RCP scenario. Firstly, to validate the HadGEM2-AO hydrology, the surface water states were evaluated for the present period using precipitation, evaporation, runoff and river discharge. Although this model underestimates the annual precipitation about 0.4 mm $mon^{-1}$, evaporation 3.7 mm $mon^{-1}$, total runoff 1.6 mm $mon^{-1}$ and river discharge 8.6% than observation and reanalysis data, it has good water balance in terms of inflow and outflow at surface. In other words, it indicates the -0.3 mm $mon^{-1}$ of water storage (P-E-R) compared with ERA40 showing -2.4 mm $mon^{-1}$ for the present hydrological climate. At the end of the twenty-first century, annual mean precipitation may decrease in heavy rainfall region, such as northern part of South America, central Africa and eastern of North America, but for increase over the Tropical Western Pacific and East Asian region. Also it can generally increase in high latitudes inland of the Northern Hemisphere. Spatial patterns of annual evaporation and runoff are similar to that of precipitation. And river discharge tends to increase over all continents except for South America including Amazon Basin, due to increased runoff. Overall, HadGEM2-AO prospects that water budget for the future will globally have negative signal (-8.0~-0.3% of change rate) in all RCP scenarios indicating drier phase than the present climate over land.

• Journal of the Korean Society of Systems Engineering
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• v.12 no.1
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• pp.7-23
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• 2016

Plant engineering industry is considered as a key industry which will drive the future of Korea. However, Korean plant engineering companies have recently made huge losses in overseas businesses and the lack of engineering capability is pointed out as a main cause of this situation. Unlike Korean plant engineering companies, world leading engineering companies such as Flour and Bechtel have their own systems Engineering Standards/Guides ensuring successful fulfillments of the concept and basic design processes. An engineering standard for an organization is an essential means to shorten the time for engineering design, to maintain the engineering quality and to secure the engineering efficiency in the development of the complex system. Korean plant engineering companies'lack of engineering capability comes from the absence of the engineering standard. In the paper, we have developed a steel-making plant engineering standard based on a systems engineering standard. We chose both ISO/IEC/IEEE 15288 and NASA SE Handbook as main reference standards. First, we have introduced a life-cycle definition and a physical hierarchy of a general steel-making plant. Then we have introduced detailed engineering processes of each life-cycle stage. The full scope of the study was from the feasibility study to the basic design but in the paper, we have only introduced detailed engineering processes and exit criteria for the feasibility study and the concept design.

• Journal of the Korean Society of Systems Engineering
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• v.10 no.2
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• pp.21-31
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• 2014

Recently, global market competition of iron and steel products is ever increasing due to over-supply from increased number of industries in rapidly growing countries, such as China, Brazil, and Indonesia. To occupy the big market, major industries are trying to develop high quality, high performance steel products via developing a new iron and steel making process. In other words, development of a new and innovative steel plant is a key to cope with the tough situation. Design and development for the life cycle of iron and steel making plant is very much complex and multi-disciplinary. In this paper, Plant Systems Engineering (PSE), a tailored SE process for industrial plant based on ISO/IEC 15288 is used for the design of Continuous Casting Process (CCP) Plant system. The CCP is a crucial process in steel making plant, whose design technology is occupied by the advanced foreign companies. For the sake of increasing engineering capability for the design of CCP, we applied PSE Process for the renovation of the existing CCP Process. Through the study, we were convinced that the applied method can be used for other plant systems, and SE is really the way of thinking, design, and development of modern complex and multi-disciplinary systems where high risk factors are present throughout the whole life cycle.

• Journal of The Korean Association For Science Education
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• v.36 no.3
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• pp.361-369
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• 2016

In this study, we investigated the characteristics of group discussion and classroom discussion in the scientific modeling of the particulate model of matter. 7th graders in Seoul participated in this study. We implemented science instructions based on the GEM cycle of scientific modeling. We analyzed the differences between group discussion and classroom discussion in three steps: exploring thoughts, comparing thoughts, and drawing conclusions. We also looked into the level of argumentations of the students in the modeling activities. The analysis of the results indicated that students generated a group model by extracting commonalities from each model of their group members, and then they evaluated and modified the group model by comparing the differences among the models in classroom discussion. The main step involved in group discussion was 'exploring thoughts', whereas in classroom discussion it was 'comparing thoughts'. Although the levels of argumentation among the students were generally low, most students participated with enthusiasm, as they expressed their interest and had positive perception in the modeling activities. As a result, the modeling activities were found to have positive influences on concept development. Some suggestions to implement the modeling activities in science teaching effectively were discussed.

• Korean Journal of Construction Engineering and Management
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• v.12 no.3
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• pp.31-41
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• 2011

The $LCCO_2$ evaluation programs previously developed in Korea involve limitations in establishing strategies of reducing environmental loads to optimal level in a way to put in materials directly after designing. Therefore, this study has the purpose to extract and propose elements required for the establishment of highly accurate system by counteracting swiftly in a method with high energy efficiency over cost at planning stage. To that end, existing $LCCO_2$ evaluation programs in Korea and abroad were compared and analyzed, and in the planning stage, GEM-21P and Carbon-navigator intended for the establishment of building energy performance improving strategy were selected as the evaluation program for survey. On such basis, after comparison and analysis between $LCCO_2$ calculating methods and system structures of the two programs, elements required for system establishment that can evaluate life-cycle environmental loads of building in planning stage were proposed.

• Atmosphere
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• v.24 no.3
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• pp.303-315
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• 2014

Terrestrial ecosystem plays the important role as carbon sink in the global carbon cycle. Understanding of interactions of terrestrial carbon cycle with climate is important for better prediction of future climate change. In this paper, terrestrial carbon cycle is investigated by Hadley Centre Global Environmental Model, version 2, Carbon Cycle (HadGEM2-CC) that considers vegetation dynamics and an interactive carbon cycle with climate. The simulation for future projection is based on the three (8.5/4.5/2.6) representative concentration pathways (RCPs) from 2006 to 2100 and compared with historical land carbon uptake from 1979 to 2005. Projected changes in ecological features such as production, respiration, net ecosystem exchange and climate condition show similar pattern in three RCPs, while the response amplitude in each RCPs are different. For all RCP scenarios, temperature and precipitation increase with rising of the atmospheric $CO_2$. Such climate conditions are favorable for vegetation growth and extension, causing future increase of terrestrial carbon uptakes in all RCPs. At the end of 21st century, the global average of gross and net primary productions and respiration increase in all RCPs and terrestrial ecosystem remains as carbon sink. This enhancement of land $CO_2$ uptake is attributed by the vegetated area expansion, increasing LAI, and early onset of growing season. After mid-21st century, temperature rising leads to excessive increase of soil respiration than net primary production and thus the terrestrial carbon uptake begins to fall since that time. Regionally the NEE average value of East-Asia ($90^{\circ}E-140^{\circ}E$, $20^{\circ}N{\sim}60^{\circ}N$) area is bigger than that of the same latitude band. In the end-$21^{st}$ the NEE mean values in East-Asia area are $-2.09PgC\;yr^{-1}$, $-1.12PgC\;yr^{-1}$, $-0.47PgC\;yr^{-1}$ and zonal mean NEEs of the same latitude region are $-1.12PgC\;yr^{-1}$, $-0.55PgC\;yr^{-1}$, $-0.17PgC\;yr^{-1}$ for RCP 8.5, 4.5, 2.6.

• Journal of Climate Change Research
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• v.7 no.4
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• pp.433-442
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• 2016

In this study, we examine future changes in surface radiation associated with cloud amount and aerosol emission over East Asia. Data in this study is HadGEM2-CC (Hadley Centre Global Environmental Model version 2, Carbon Cycle) simulations of the Representative Concentration Pathways (RCPs) 2.6/4.5/8.5. Results show that temperature and precipitation increase with rising of the atmosphere $CO_2$. At the end of $21^{st}$ century (2070~2099) relative to the end of $20^{st}$ century (1981~2005), changes in temperature and precipitation rate are expected to increase by $+1.85^{\circ}C/+6.6%$ for RCP2.6, $+3.09^{\circ}C/+8.5%$ for RCP4.5, $+5.49^{\circ}C/10%$ for RCP8.5. The warming results from increasing Net Down Surface Long Wave Radiation Flux (LW) and Net Down Surface Short Wave Radiation Flux (SW) as well. SW change increases mainly from reduced total Aerosol Optical Depth (AOD) and low-level cloud amount. LW change is associated with increasing of atmospheric $CO_2$ and total cloud amount, since increasing cloud amounts are related to absorb LW radiation and remit the energy toward the surface. The enhancement of precipitation is attributed by increasing of high-level cloud amount. Such climate conditions are favorable for vegetation growth and extension. Expansion of C3 grass and shrub is distinct over East Asia, inducing large latent heat flux increment.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.24 no.3
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• pp.99-105
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• 2014

$LiCoO_2$ thin film have received attention as cathodes of thin-film microbatteries. In this study, $LiCoO_2$ thin films were synthesized on Au substrates by sol-gel spin coating method and electrochemical properties were investigated under annealing temperature and time. The phycochemical properties of $LiCoO_2$ thin film were investigated by X-ray diffraction, scaning electron microscopy and atomic force microscopy. The electrochemical properties were characterized using galvanostatic charging/discharging cycling tests. From X-ray diffraction, as-grown films annealed at $550^{\circ}C$ and $750^{\circ}C$ are presumed to be spinel structure and a single phase of the layered-rock-salt, respectively. The RMS roughness and grain size of the films which annealed at $750^{\circ}C$ has similar values for annealing time 10 and 30 min, while for annealing time 120 min surface roughness, grain size increase and pore appearance were observed. The first discharge capacity of $LiCoO_2$ thin films annealed at $750^{\circ}C$ for 10, 30 and 120 min is about 54.5, 56.8 and $51.87{\mu}Ah/cm^2{\mu}m$, respectively. Corresponding capacity retention at 50th cycle is 97.25, 76.69, 77.19%.