• Journal of Veterinary Clinics
• /
• v.26 no.5
• /
• pp.486-489
• /
• 2009

An 8-year-old Thoroughbred mare showing anestrus for longer than 6 months with left ovarian mass was referred to Veterinary Medical Teaching Hospital of Seoul National University. For 6 months, the mare had received 2 times hormonal therapies with $PGF_2{\alpha}$ and progesterone. The mare had not responded to these therapies and not shown estrous behavior. On rectal palpation, the left ovary was enlarged and contralateral ovary was small and inactive. Transrectal ultrasonographic examination of the left ovary revealed a mass composed of multiple, irregularly shaped follicles. Granulosa cell tumor (GCT) was suspected according to her history. Ovariectomy was performed through the left flank laparotomy with a standing position in a simple chute located outside of horse farm. The mass was diagnosed as GCT on histopathology. The mare was recovered without any problem and became pregnant next spring.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.44 no.7 s.361
• /
• pp.54-61
• /
• 2007

A variable gain low noise amplifier (VG-LNA) implemented in TSMC 0.18 um process is presented. This VG-LNA is designed of two stage amplifier, and its gain is controlled by the shunt feedback loop composed of a gain control transistor (GCT) and a coupling capacitor in second stage. The channel resistance of GCT in the shunt feedback loop influences the input and output stages of a second stage by the Miller effect. Total gain of the proposed VG-LNA is changed by two factors, the load impedance reduction and the interstage mismatch by controlling the channel resistance of the GCT. Consequently, by adding a shunt feedback with a gain control transistor, this proposed VG-LNA achieves both wide gain tuning range of 37 dB and continuous gain control simultaneously.

• Journal of Ginseng Research
• /
• v.45 no.1
• /
• pp.149-155
• /
• 2021

Background: We have reported that internal deletions in the nef, gag, and pol genes in HIV-1-infected patients are induced in those treated with Korean Red Ginseng (KRG). KRG delays the development of resistance mutations to antiretroviral drugs. Methods: The vif-vpr genes over 26 years in 20 hemophiliacs infected with HIV-1 from a single source were sequenced to investigate whether vif-vpr genes were affected by KRG and KRG plus highly active antiretroviral therapy (ART) (hereafter called GCT) and compared the results with our previous data. Results: A significantly higher number of in-frame small deletions were found in the vif-vpr genes of KRG-treated patients than at the baseline, in control patients, and in ART-alone patients (p < 0.001). These were significantly reduced in GCT patients (p < 0.05). In contrast, sequences harboring a premature stop codon (SC) were more significant in GCT patients (10.1%) than in KRG-alone patients, control (p < 0.01), and ART-alone patients (p = 0.078 for peripheral blood mononuclear cells). The proportion of SC in Vpr was similar to that in Vif, whereas the proportion of sequences revealing SC in the env-nef genes was significantly lower than that in the pol-vif-vpr genes (p < 0.01). The genetic distance was 1.8 times higher in the sequences harboring SC than in the sequences without SC (p < 0.001). Q135P in the vif gene is significantly associated with rapid progression to AIDS (p < 0.01). Conclusion: Our data show that KRG might induce sD in the vif-vpr genes and that vif-vpr genes are similarly affected by lethal mutations.

• The Journal of the Korean bone and joint tumor society
• /
• v.9 no.1
• /
• pp.52-60
• /
• 2003

Purpose: To analyse their end results and also to differentiate the single or multiple giant cell tumor(GCT) of tendon sheath in hand. Materials & Methods: Total 21 cases with GCT of tendon sheath in hand were treated surgically and analyzed their end results with clinically, radiologically and pathologically to allowed for average 16 months after surgical excision. Results: The finger flexor tendons, especially on index and ring finger, involving distal interphalangeal joint and mid-phalanges in fourth decades (average age of 47 years old) were frequently involved, and the mass was not exceed than 2 cm in size, fixed on tendon sheath with rubbery hard tenderness but rare bony involvements except 4 cases of bony erosion and cortical perforation. The three cases with multiple GCT of hand was also combined with familial hypercholesterolemia, and are commonly involved the extensor tendons as well as achilles tendons bilaterally, treated with partial excision because of multiplicity. Average 16 months after surgical excision for single GCT cases was followed and showed the recurrence in 3 cases(3/18,16.7%), treated with wide excision. The single and multifocal GCT are similar in pathologic changes but different soft tissue tumors in their pathogenesis, treatment and prognosis. Conclusion: Incomplete excision of GCT of tendon sheath in hand are thought to be the cause of recurrence, especially in cases with incomplete lesional excision, in multilobular and bony involvement etc. So careful wide excision is necessary to prevent the recurrence.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.21 no.4
• /
• pp.408-416
• /
• 2010

A study on the calibration of an X-band HPS(Hongik Polarimetric Scatterometer) system for ground-based operation is presented in this paper. In order to calibrate the scatterometer system, the degree of its distortions are analyzed by comparison between theoretical- and measured-values using the theoretically well-known calibration targets such as a metal sphere, a trihedral corner reflector(CR) and a metal cylinder. The calibration works in the field conditions depend on the precise and stable measurements of those calibration target. we present a measurement technique, so-called, an automatic 2-D target-scanning technique, using the incidence-angle(${\xi}-$ and ${\phi}-$ directions) control of HPS system. Then, we used STCT(Single-Target Calibration Technique) and GCT(General Calibration Technique) to calibrate a distortion of the scatterometer system, and measured the polarimetric RCS(Radar Cross Section) and phase-difference of a trihedral-CR as a test-target to verify the accuracy of the calibration technique. Then, three different types(i.e., 10, 20, 30 cm) of trihedral-CR were used. we obtained the error ranges about ${\pm}1.0$dB, ${\pm}0.5$ dB in a polarimetric RCS and about $-20^{\circ}{\sim}0^{\circ}$ and ${\pm}5^{\circ}$ in the co-polarized phase-difference by using the GCT and STCT, respectively.

• The Plant Pathology Journal
• /
• v.22 no.4
• /
• pp.369-374
• /
• 2006

To characterize benzimidazole-resistant and -sensitive Monilinia fructicola populations, the fungal isolates were obtained from peach plants showing brown rot and bloosom blight. Benzimidazole-sensitive isolates did not grow on potato dextrose agar(PDA) amended with $\geq1.0{\mu}g$ active ingredient(a.i.)/ml of the fungicides. However, benzimidazole-resistant isolates grew on PDA regardless of the tested concentrations of fungicides. Benzimidazole-resistant isolates did not grow on diethofencarb-PDA, but sensitive isolates grew on the same PDA. In the nucleotide sequences of $\beta$-tubulin gene, only codon 198(GAG: glutamic acid), a target site for benzimidazole, was replaced with GCG(alanine) in all of the resistant isolates, and this substitution seems to play an important role in the development of resistance. Other interesting codons such as 165(GCT), 200(TTC), and 241(GCT) were not changed among the isolates. Benzimidazole-resistant and -sensitive isolates were clustered clearly in random amplified polymerphic DNA analyses and the results revealed that low levels of genetic diversity between benzimidazole-sensitive and -resistant isolates of M. fructicola in the investigated regions.

• JOURNAL OF ELECTRICAL WORLD
• /
• s.277
• /
• pp.63-68
• /
• 2000

요 몇 해 사이에 고내압$\cdot$대용량 파워디바이스에서는 아주 새로운 진전이 일어나고 있다. 파워일렉트로닉스 장치의 소형화$\cdot$고효율화 및 제어의 고속화 등의 요구에 응할 수 있는 차세대의 새로운 소자가 출현하여 그 제품화가 비약적으로 진전되고 있는 것이다. 새로운 파워디바이스의 대표적인 것으로는 다음의 3가지를 들 수 있다. $\cdot$HVIGBT(High Voltage Insulated Gate Bipolar Transistor Module)$\cdot$HVIPM(High Voltage Intelligent Power Module)$\cdot$GCT(Gate Commutated Turn-off)사이리스터 이들의 파워디바이스를 종래의 GTO(Gate Turn-off) 사이리스터와 비교해 보면 다음과 같은 특징이 있다.(1)GTO 사이리스터가 필요로 했던 스나버회로가 없어도(Snabber-less)턴오프가 가능하며, di/dt 억제용 아노드리액터의 생략 또는 저감이 가능하기 때문에 반도체 부녀회로의 소형화를 기할 수 있다. (2)게이트파워와 전체손실(소자 및 주변회로를 포함)의 저감으로 에너지 절약을 도모할 수 있다. (3)스위칭주파수를 2$\~$3kHz 정도까지 높일 수 있다. 이런 장점 때문에 다음과 같은 용도에의 적용이 기대되고 있다. (1)신간선, 지하철 등의 전철 응용 (2)액티브필터, SVG(무효전력발생장치), SVC(무효전력보상장치) BTB, 가변속 양수발전 스위치 등의 전력응용 (3) 철강압연이나 제지공장용 등의 대용량공업용 컨버터$\cdot$인버터 응용 HVIGBT와 HVIPM은 전철분야에서 신간선의 추진용 컨버터$\cdot$인버터장치와 보조전원장치, 그리고 지하철의 추진용 인버터 장치나 보조전원장치 등에 채용되고 GCT 사이리스터는 전력용 주파수변환기 등에 실용화되고 있다.

• JOURNAL OF ELECTRICAL WORLD
• /
• s.280
• /
• pp.64-70
• /
• 2000

파워디바이스는 산업$\cdot$전력$\cdot$교통$\cdot$정보 등 여러 분야에서 사용되고 그 기기들의 성능은 이 파워디바이스의 성능에 의해 크게 좌우된다. 특히 고도 정보화시대가 되는 21세기에는 전력수요가 점점 더 증가될 것이기 때문에 인버터화 등에 의한 생에너지 대책과 클린에너지 등에 의한 신에너지의 창출이 중요한 과제가 되고 있다. 한편, 지구환경 보호면에서 전기자동차 등의 환경고려형 장치의 보급이 활발해질 것이 예상된다. 이와 같은 사회환경 속에서 파워 일렉트로닉스를 지탱하는 소자로서 파워디바이스는 점점 더 그 역할의 중요성이 커지고 있다. 최근의 파워디바이스로서는 디스크리트, 모듈, IPM(Intelligent Power Module)등 여러 가지의 디바이스가 출현하고 있는데 그 성능을 결정하는 중심이 되는 것이 파워디바이스 칩이다. 파워디바이스 칩 자신도 급속히 진화하여 현재는 MOS계 파워디바이스 칩이 주류를 이루고 있다. 그 중에서도 사용하기 쉽다는 면에서 MOSFET와 IGBT(Insulated Gate Bipolar Transistor)가 주로 실용화되고 있으며, 미세가공기술과 라이프타임 제어기술의 진전에 따라 현저한 성능개선이 진행되고 있다. 한편, 공업용 대용량인버터나 전력응용에서 요구되는 고내압$\cdot$대용량 영역에서는 당분간 저손실이라는 의미에서 바이폴라계의 사이리스터형 디바이스가 주류로 사용되고, 이 영역에서는 GTO에 대체하는 소자로서 GCT(Gate Commutated Turn-off)사이리스터가 개발되어 그 응용이 확대될 것이 기대되고 있다. 또한 전압형 인버터장치에서는 IGBT와 GCT등의 스위칭디바이스와 함께 환류용 다이오드(FWD)가 필요하며 이 FWD의 특징 개선도 스위칭디바이스의 개선과 병행하여 추진되고 있다.

• Journal of Korean Foot and Ankle Society
• /
• v.23 no.2
• /
• pp.74-77
• /
• 2019

Fibroma of the tendon sheath (FTS) was initially described in 1936 by Geschickter and Copeland as a benign firmed soft tissue tumor that is rare and less common than another soft tissue tumors, especially giant cell tumors (GCT) of the tendon sheath. The common distinct feature is a slow-growing least painful rare entity arising from the tendon or tendon sheath. FTS is detected mostly in the fingers, hands and wrists but less commonly in the foot. Very few cases of FTS have been described arising from a flexor tendon of the foot. This article describes a 51-year-old patient with FTS that developed in the extensor tendon of the foot, which is the only known FTS to form in this area. Heterogeneous low signal intensity in both the T1- and T2-weighted images was observed in magnetic resonance imaging. The lesion was excised completely by open surgery. Histologically, it showed randomly arranged, fibroblast-like spindle cells in dense fibrous tissue and had insufficient hemosiderin-laden macrophages that are typical for GCT.

• IMMUNE NETWORK
• /
• v.1 no.2
• /
• pp.135-142
• /
• 2001

Background: A large number of diseases occur in association with specific HLA-B or-C alleles. Recently a new gene, termed maj or histocompatibility complex class I chain-related gene A (MICA), has been identified in close proximity to HLA-B. The function of this gene is still unknown. However, it is structurally similar to HLA class I genes. MICA gene is polymorphic and is potentially associated with several diseases. Methods: To evaluate the association of MICA gene in Korean patients with human immunodeficiency virus 1 (HIV-1) infections, Polymerase chain reaction-Sequence specific primer (PCR-SSP) was done for MICA alleles in the extracellular exons, and a microsatellite analysis for GCT repeat polymorphisms in the TM exon was also completed. Results: In 199 Korean healthy controls, 7 alleles were observed and the frequencies for each allele were MICA008 (44.7%), MICA0 10 (34.2%), MICA002 (31.7%), MICA004 (23.6%), MICA0 12 (2 1.6%), MICA009 (19.6%), and MICA007 (6.5%). When 65 HIV seropositive patients were analyzed, MICA007 allele frequency was significantly higher than in controls (15.4% vs 6.5 %, RR=2.6, p<0.04). In contrast, the frequencies of other MICA alleles and microsatellite alleles in the transmembrane region of MICA gene were not significantly different between HIV seropositive patients and controls. The tight linkage between MICA alleles in the extracellular exons and GCT repeat polymorphisms in the TM exon was observed as follows; MICA002/A9, MICA004/A6, MICA007/A4, MICA008/A5.1, MICA0 10/A5, and MICA0 12/A4 in both groups. No significant difference between patients and controls was observed in the haplotype frequencies of MICA alleles in the extracellular exons and GCT repeat polymorphisms in the TM exon. Conclusion: The data suggest that immune functions related with MICA gene may affect a HIV infections.