• Analytical Science and Technology
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• v.23 no.2
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• pp.179-186
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• 2010

The oxidative metabolism of ibuprofen in healthy male urine collected at 3, 6, 9, 12 and 15 h after oral administration of ibuprofen was studied by GC/MS assay. To detect conjugated metabolites of ibuprofen, urine sample was acid-hydrolyzed with 6 M HCl at $100^{\circ}C$ for 30 min. To effectively extract ibuprofen and its metabolites, liquid-liquid extraction (LLE) was conducted at pH 3, 5, and 7, respectively. As a result, LLE at pH 3 was shown to be the best extraction condition. For the determination of trace amounts of ibuprofen and its metabolites in extract, trimethylsilylation (TMS) with BSTFA was applied and followed by GC/MS analysis. In this study, main 5 metabolites including parent drug were detected and these metabolites were assigned as three hydroxylated forms and one carboxylated form. Each metabolite was tentatively identified by both interpretation of mass spectrum and comparison with previously reported results. In addition, time profile of urinary excretion rate for parent drugs and metabolites was studied. Finally, the metabolic pathways of ibuprofen were suggested on the basis of the structural elucidation of its metabolites and excretion profiles.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.4
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• pp.343-351
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• 2016

Cryogenic spray characteristics of a nitrogen swirl injector operating in supercritical environment have been numerically investigated. By comparing the equation of states(EOS) used for supercritical condition, SRK EOS was applied to predict the nitrogen thermodynamic property under supercritical environment. A Chung's method was implemented for the calculation of viscosity and conductivity and Takahashi's correlation based on Fuller's Theorem was implemented for the calculation of diffusion coefficient. By injecting the nitrogen with 5 bar differential pressure into 50 bar chamber filled with nitrogen, numerical simulation has been conducted. The dynamic Smagorinsky sub-grid scale (SGS) model has been compared with the algebraic Smagorinsky SGS model using FFT frequency analysis. The instability at the liquid film and gas core inside injector and the propagation of pressure oscillation into the injector has been investigated. The spreading angle of swirl injector obtained by numerical calculation has been validated with experimental result.

• Journal of Energy Engineering
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• v.24 no.4
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• pp.211-216
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• 2015

Heat exchanger tube array in a heat recovery steam generator is exposed to the hot exhaust gas flow and it could cause the flow induced vibration, which could damage the heat exchanger tube array. It is needed for the structural safe operation of the heat exchanger to establish the characteristics of flow induced vibration in the tube array. The researches for the flow induced vibration of typical heat exchangers have been conducted by using single cicular tube or circular tube array and the nondimensional PSD(Power Spectral Density) function with the Strouhal number, fD/U, had been derived by experimental method. From the present study, the basis for the application of flow induced vibration to the heat recovery steam generator tube array would be prepared. For the previous mentioned purpose, the present CFD analysis introduced a single fin tube and calculated with the unsteady laminar flow over the single fin tube. The characteristics of vortex shedding and lift fluctuation over the fin tube was investigated. The derived nondimensional PSD was compared with the results of the previous experimental researches and the characteristics of lift PSD over a single fin tube was established from the present CFD study.

• Food Science and Biotechnology
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• v.18 no.1
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• pp.95-102
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• 2009

The aerial parts of garland (Chrysanthemum coronarium L.) were extracted in 80% aqueous methanol (MeOH) and the concentrated extract was then partitioned using ethyl acetate (EtOAc), n-butanol (n-BuOH), and $H_2O$, successively. EtOAc and n-BuOH fractions resulted in 4 glycerides with the application of octadecyl silica gel and silica gel column chromatography. The chemical structures of the glycerides were determined using several spectroscopic methods, including nuclear magnetic resonance (NMR) and mass spectrometry (MS) as (2S)-1-O-palmitoyl-sn-glycerol (1), (2S)-1-O-oleoyl-2-O-oleoyl- 3-O-$\beta$-D-galactopyranosyl-sn-glycerol (2), (2S)-1-O-palmitoyl-2-O-linoleoyl-3-O-phosphorouscholine-sn-glycerol (3), and (2S)-1-O-linolenoyl-2-O-palmitoyl-3-O-[$\alpha$-D-galactopyrasyl-($1{\rightarrow}6$)-$\beta$-D-galactopyranosyl]-sn-glycerol (4). The free fatty acids of these glycerides were determined with gas chromatography (GC)-MS analysis following alkaline hydrolysis and methylation. These glycerides demonstrated an inhibitory effect on acyl-CoA: cholesterol acyltransferase (ACAT, compound 1: $45.6{\pm}0.2%$ at $100{\mu}g/mL$), diacylglycerol acyltransferase (DGAT, compound 1: $59.1{\pm}0.1%$ at $25{\mu}g/mL$), farnesyl protein transferase (FPTase, compound 2: $98.0{\pm}0.1%$; compound 3: $55.2{\pm}0.1%$ at $100{\mu}g/mL$), and $\beta$-secretase ($IC_{50}$, compound 4: $2.6{\mu}g/mL$) activity. This paper is the first report on the isolation of these glycerides from garland and their inhibitory activity on ACAT, DGAT, FPTase, and $\beta$-secretase.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.12B
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• pp.1708-1721
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• 2011

Recent outbreak of cattle diseases such as foot-and-mouth disease(FMD) requires constant monitoring of burial sites of mass cull of cattles. However, current monitoring system takes environmental samples from burial sites with period of between one and two weeks, which makes it impossible for non-stop management of hazardous bio-waste. Therefore, in this study, we suggest an improved real-time environmental monitoring system for such bio-hazardous sites based on wireless sensor networks, which makes constant surveillance of the FMD burial sites possible. The system consists mainly several wireless environmental monitoring sensors(i.e dust, Co2, VOC, NH3, H2S, temperature, humidity) nodes and GPS location tracking nodes. Through analysis of the relayed of the environmental monitoring data via gateway, the system makes it possible for constant monitoring and quick response for emergency situation of the burial sites. In order to test the effectiveness of the system, we have installed a set of sensor to gas outlets of the burial sites, then collected and analyzed measured bio-sensing data. We have conducted simulated emergency test runs and was able to detect and monitor the foul smell constantly. With our study, we confirm that the preventive measures and quick response of bio environmental accident are possible with the help of a real-time environmental monitoring system.

• Journal of the Korean Institute of Telematics and Electronics
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• v.27 no.2
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• pp.81-92
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• 1990

We developed the technologies of wuperlattice and HEMT structures grown by MOCVD, and their characterization. In the case of GaAs/AlGaAs superlattice, the periodicity, interface abruptness and Al compositional uniformity were confirmed through the shallow angle lapping technique and double crystal x-ray measurement. Photoluminesence spectra due to quantum size effect of isolated quantum wells were also observed. The heterojunction abruptness was estimated to be within 1 monolayer fluctuation by the analysis of the relation between PL FWHM(Full Width at Half Maximum) and well width. HEMT structure was successfully grown by MOCVD. The 2 dimensional electron gas formation at heterointerface in HEMT structure were evidenced through the C-V profile, SdH (Shubnikov-de Haas)oscillation and low temperature Hall measurement. Low field mobility were as high as $69,000cm^2/v.sec$ for a sheet carrier density of $5.5{\times}10^{11}cm^-2$ at 15K, and $41,200cm^2/v.sec$ for a sheet carrier density of $6.6{\times}10^{11}cm^-2$ at 77K. In addition, well defined SdH oscillation and quantized Hall plateaues were observed.

• Journal of the Economic Geographical Society of Korea
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• v.15 no.1
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• pp.77-94
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• 2012

The purpose of this study is to analyze the process of vertical fragmentation of regional industries in Korea using Revealed Comparative Advantage index (RCA) and Average Propagation Length (APL). First of all, the competitiveness in regional export and substitution of regional imports were strong in the Electricity, Gas, and Water supply sector in Gyeongnam, and consumer-oriented Manufacturing sector in Incheon, Gyeongnam, and Gwangju. The high values of the APL were also found in the regions with common similarity with respect to the industrial structure and the sectors with indirect effects. In addition, the industrial sectors with high quality of infrastructure, and endowed services tended to be located in the beginning of the production chain. FInally, since manufacturing and service sectors in Seoul has higher APL, they could lead the growth of other related industries as key sectors, in the production fragmentation.

• Journal of the Korean Ceramic Society
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• v.40 no.1
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• pp.18-23
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• 2003

Composite powder of$B_4C-A1_2O_3$was prepared from a mixed powder of$B_2O_3/A1/C$by SHS under argon pressure instead of using a chemical furnace. A mixture of$B_2O_3,$Al and C powder (equivalent amounts to the reaction,$2B_2O_3+4A1+C=B_4C+2A1_2O_3)$was ball milled for 2 h. The mixed powder was placed in a SHS reactor and filled with 10 atm of argon gas and ignited. The inner and outer products were the same by XRD analysis. It was consisted of a composite powder of$B_4C-A1_2O_3$without $AlB_{12}/C_2$which was always produced using a chemical furnace. The composite powder was about$60~100{mu}m$size which was composed of crystalline particles of about 0.3~l${mu}m$size. But when 15 atm of argon was employed, partial sintering took place to give rise hard composite powder of$15~25{mu}m$$B_4C$with $0.1~0.2{mu}m$$A1_2O_3.$

• Food Science and Preservation
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• v.21 no.1
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• pp.69-74
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• 2014

We tested for residual pesticide levels in school foodservice agricultural products in Seoul, Korea from 2010 to 2012. A total of 316 samples of 23 different types of agricultural products were analyzed via gas chromatography-nitrogen phosphate detector (GC-NPD), an electron capture detector (GC-${\mu}ECD$), a mass spectrometry detector (GC-MSD), and a high performance liquid chromatography-ultraviolet detector (HPLC-UV). We used multi-analysis methods to analyze 185 different pesticide types. Among the selected agricultural products, residual pesticides were detected in 26 samples (8.2%), of which 6 samples (1.9%) exceeded the Korea Maximum Residue limits (MRLs). We detected pesticide residue in more than 65% of the Chwinamul, while 6 among 9 analyzed samples contained pesticide residue, and 1 sample exceeded the Korea MRLs. Among the 185 kinds of pesticides that we have tested, 18 were detected, while 7 of them were detected more than twice. Data obtained were then used for estimating the potential health risks associated with the exposures to these pesticides. The most critical commodity is carbofuran in the perilla leaves, which has contributed 3.8% to the hazard index (HI). These results showed that the detected pesticides could not be considered as a serious public health problem. Nevertheless, constant supervision is recommended.

• Journal of Digital Convergence
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• v.11 no.3
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• pp.415-426
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• 2013

Smart work has recently introduced as a way to solve problems such as greenhouse gas emissions, low birth rate and aging as well as to improve productivity. Because of development of ICT infrastructure and the proliferation of smart devices, the mobile office has the most commonly used within types of smart work in Korea. But the adoption of the mobile office in small businesses is only half of that of large corporations. The security issue appears to be one of the biggest obstacles to the introduction of smart work in small businesses. Therefore, the purpose of this study is to analyze the information security factors that should be considered when the mobile office is introduced to small businesses. By analyzing the previous studies, the information security factors of the mobile office are classified 5 groups composed of 24 factors. 5 groups are terminals, applications and platforms, networks, servers and users. According to the survey result using AHP, 'User' was drawn to the most important group, and 'Data Encryption', 'Wireless LAN Control' and 'Terminal Recovery When Leaving' were drawn to the important information security factors of the mobile office among 24 factors.