• Journal of Dairy Science and Biotechnology
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• v.27 no.1
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• pp.45-51
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• 2009

$\gamma$-aminobutyric acid (GABA) is a ubiquitous nonprotein amino acid that is produced primarily by $\alpha$-decarboxylation of L-glutamic acid (Glu) catalyzed by the enzyme glutamate decarboxylase (GAD). It is well known as a neurotransmitter that regulates inhibitory neurotransmission in the mammalian central nervous system. In addition, GABA has been proved to be effective for lowering blood pressure in mammals. This paper is intended to provide basic information about GABA, including the functional and biological activity of GABA, GABA production by lactic acid bacteria, and the utilization of GABA in the production of dairy products.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1994.10a
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• pp.878-883
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• 1994

최근들어 국내 제조업 분야의 대외 경쟁력을 향상시키기 위해 각 산업체에서는 여러가지 자동화 시스템을 구축하려는 경행이 지배적이다. 자동화 시스템을 구축하는 방법 및 개상은 여러가지가 있을수 있으며 그 중에서 설계를 담당하는 자동화 시스템의 개발은 제품 생산을 위한 독자적인 기술을 확보하기 위해서 반드시 필요한 대상중의 하나이다. 그러나 대개의 경우 설계 과정은 상당히 복잡하고 어려운 작업으로서 최종 제작 도면을 만들어 내기까지에는 몇 가지 단계를 거치게 된다. 이들 과정을 설계를 수행하는 기술자가 보다 쉽고 빠르게 처리할수 있는 자동화 시스템을 구축한다면 제품생산에 상당한 파급효과를 기대할 수 있을 것이다. 본 연구에서는 설계 공리를 이용하여 제품 설계의 전 과정을 분석하고 제품 설계자가 쉽게 설계를 수행할 수 있도록 자동화용 소프트웨어 시스템을 구축하는데 목표를 둔다. 개발된 소프트웨어 대상은 TV브라운관 유리제품(glass bulb) 으로서 현재 수행되고 있는 제품 설계의 전과정을 설계공리의 관점으로 재 조명하고 효율적으로 개선하는 몇 가지 소프트웨어를 구축하였다. 전체 시스템은 메뉴 시스템을 적용한 사용자 인터페이스 기법을 이용하여 사용자가 보다 편리하게 설계과정을 수행할 수 있도록 하였다.

• 한국디지털정책학회:학술대회논문집
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• 2007.06a
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• pp.149-161
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• 2007

This study aims to examine the relationships between job attitude and leadership styles perceived by employees in venture firms. This study have the two purposes, 1) to investigate the relationship between leadership styles and job attitudes(Organizational Commitment and Turnover Intention), 2) to verify the effective leadership style in venture companies. We examined the impact of critical leadership styles on the job attitude of employees in venture firms. Hypotheses on four factors were tested for 26 organizations. In order to test these hypotheses, survey questionnaires were sent to employees of venture firms in Gumi. As a result, the 184 available data were collected from venture companies. Correlation analysis, ANOVA, and regression gad been performed and the results supported first, second, and third hypotheses. However, fourth hypothesis was not supported.

• Food Science and Biotechnology
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• v.15 no.1
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• pp.86-90
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• 2006

Two lactic acid bacteria (LAB) with high ${\gamma}$-aminobutyric acid (GABA)-producing capacity were isolated from naturally aged cheese. Examination of the biochemical features using an API kit indicated that the two strains belonged to Lactobacillus. They were gram positive, rod-type bacteria, and fermented arabinose, melezitose, melibiose and xylose, but did not utilize cellobiose or trehalose. 16S rDNA sequencing analysis confirmed that they were Lactobacillus buchneri and Lactobacillus sp. They were accordingly named as Lactobacillus buchneri OPM-1 and Lactobacillus sp. OPM-2, and could produce GABA from MRS broth supplemented with 10 g/L of monosodium glutamate (MSG) at a productivity of 91.7 and 116.7 mg/L/hr, respectively. Cell extracts of L. buchneri OPM-1 and Lactobacillus sp. OPM-2 showed glutamate decarboxylase (GAD) activity, for which the optimum pH and temperature were 5.5 and $30^{\circ}C$, respectively.

• Journal of the Korean Institute of Landscape Architecture
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• v.18 no.3 s.39
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• pp.137-141
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• 1990

This study was carried out to investigate the propagation methods of the Rhododendron micranthum as a landscape plant The results obtained are as follows :　1. The optimum temperature for seed germination was $20^{\circ}C$, and the seed germination needs light. 2. GA and thiourea did not affect the seed germination under light, but GA gad substitutive effect. 3. 87% and over of germination rates were obtained in room temperature and $5^{\circ}C$ dry storages. 4. The rooting rate was high on sandy loam, vermiculite, and vermiculite 50%+sand 50%, at softwood and hardwood cutting(hardwood ; 45~48%, softwood ; 45~48%). 5. The significant effects on rooting were found with the treatment of NAA 500~2000ppm.

• Earthquakes and Structures
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• v.8 no.1
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• pp.1-18
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• 2015

A simple method of assessing the risk of overturning of precast reinforced concrete columns is presented in this paper. The displacement-based methodology introduced herein is distinguished from conventional force-based codified methods of aseismic design of structures. As evidenced by results from field tests precast reinforced concrete columns can be displaced to a generous limit without sustaining damage and then fully recover from most of the displacement afterwards. Realistic predictions of the displacement demand of such (rocking) system in conjunction with the displacement capacity estimates enable fragility curves for overturning to be constructed. The interesting observation from the developed fragility curves is that the probability of failure of the precast soft-storey column decreases with increasing size of the column importantly illustrating the "size effect" phenomenon.

• Structural Engineering and Mechanics
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• v.71 no.4
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• pp.341-350
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• 2019

Exterior beam-column joint is typically the weakest link in a limited-ductile reinforced concrete (RC) frame structure. The use of diagonal haunch element has been considered as a desirable seismic retrofit option for reducing the seismic demand at the joint. Previous research globally has focused on implementing double haunches, while the use of single haunch element as a less-invasive and more architecturally favorable retrofit option has not been investigated. In this paper, the key formulations and a design procedure for the single haunch system for retrofitting RC exterior beam-column joint are developed. An application of the proposed design procedure is then illustrated through a case study.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.66-73
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• 2016

Objectives : The purpose of this study was to investigate the characteristics of psychosocial factors related to functional dyspepsia(FD) and their effects on quality of life(QOL) in firefighters. Methods : This study examined data collected from 1,217 firefighters. We measured psychological symptoms by Patient Health Questionnaire-9(PHQ-9), Generalized Anxiety Disorder questionnaire(GAD-7), Korean Occupational Stress Scale(KOSS), Ways of Coping checklist(WCCL), Rosenberg's Self-Esteem Scale(RSES) and World Health Organization Quality of Life Scale abbreviated version(WHOQOL-BREF). Chi-square test, independent t-test, Pearson's correlation test, logistic regression analysis, and hierarchical regression analysis were used as statistical analysis methods. Results : For the group with FD, the male participants showed significantly higher frequency(p=0.006) compared to the female participants. The group with FD had higher scores for depressive symptoms(p<.001), anxiety (p<.001), and occupational stress(p<.001), and did lower scores for self-esteem(p=.008), quality of life(p<.001) than those without FD. The FD risk was higher in the following KOSS subcategories: job demand(OR 1.94, 95% CI : 1.29-2.93), lack of reward(OR 2.47, 95% CI : 1.61-3.81), and occupational climate(OR 1.51, 95% CI : 1.01-2.24). In the hierarchical regression analysis, QOL was best predicted by depressive symptoms, self-esteem, and occupational stress. Three predictive variables above accounts for 42.0% variance explained of total variance. Conclusions : The psychosocial factors showed significant effects on FD, and predictive variables for QOL were identified based on regression analysis. The results suggest that the psychiatric approach should be accompanied with medical approach in future FD assessment.

• Korean Journal of Biological Psychiatry
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• v.25 no.3
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• pp.45-52
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• 2018

Objectives The objective of this study was to investigate the differences in sociodemographic and clinical characteristics, temperaments, and quality of life between panic disorder (PD) patients with and without major depressive disorder (PD+MDD and PD-MDD patients, respectively). Methods We compared 411 PD-MDD and 219 PD+MDD patients. All patients who were drug-free for at least 1 month were assessed at initial outpatient visits before the administration of medication. The following instruments were used for assessment: the NEO Personality Inventory-Neuroticism (NEO-N) ; the Temperament and Character Inventory-Harm Avoidance (TCI-HA) ; the State-Trait Anxiety Inventory (STAI) ; the Intolerance of Uncertainty Scale-Short (IUS); the Anxiety Sensitivity Index-Revised (ASI-R); the Beck Depression Inventory (BDI) ; the Beck Anxiety Inventory (BAI); the Penn State Worry Questionnaire (PSWQ) ; the Generalized Anxiety Disorder for 7 item (GAD-7) ; the Albany Panic and Phobia Questionnaire (APPQ) ; the Panic Disorder Severity Scale (PDSS) ; the Early Trauma Inventory Self Report-Short Form (ETISR-SF) ; the Scale for Suicidal Ideation (SSI) ; the World Health Organization Quality of Life Scale Abbreviated Version (WHOQOL-BREF) ; the Sheehan Disability Scale (SDS) ; and the Short Form health survey (SF-36). Results Compared to the PD-MDD patients, the PD+MDD patients were younger and more likely to be unmarried. They showed higher rates of unemployment, lower levels of education and income, younger age of onset, more previous suicide attempts, a greater incidence of agoraphobia, and more previous treatments. The PD+MDD patients showed significantly higher scores on the NEO-N, the TCI-HA, the STAI, the IUS, the ASI-R, the BDI, the BAI, the PSWQ, the GAD-7, the APPQ, the PDSS, the ETISR-SF, and the SSI. In addition, the PD+MDD patients showed significantly lower quality of life than did the PD-MDD patients. In contrast with previous studies, we observed no significant differences between the two groups in terms of gender, duration until treatment, and psychiatric comorbidities. Conclusions This study showed that the PD+MDD patients have more early trauma experiences, higher levels of anxiety-related temperaments, more severe panic and depressive symptoms, and lower quality of life than the PD-MDD patients.

• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.57-72
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• 1998

This study has been carried out to investigate the effects of Ukgansan(UGS) extract on anti-convulsive, antipyretic, analgesic, sedative and GABAergic system of experimental animals. The results of this study were as follows : 1. UGS extract prolonged significantly the beginning time to convulsion and death induced by strychnine. 2. UGS extract prolonged significantly the time to death induced by electrical shock of ECT unit.(3 sec, 200 F, 25 mA) 3. On the experiment of hypothermic effects of UGS extract on the rectal temperature of mouse, UGS extract decreased significantly the rectal temperature of mouse 4. On the experiment of antipyretic effects of UGS extract on the febrile induced by the subcutaneous injection of $150\;{\mu}g/kg$ endotoxin in mouse, UGS extract decreased significantly the rectal temperature of mouse. 5. On the experiment of analgesic effects of UGS extract on the writhing syndrome induced by intraperitoneal injection 0.7% acetic acid 1 ml/100g in mouse, the writhing syndrome induced by acetic acid was reduced significantly by administration of UGS extract. 6. On the experiment of effects of UGS extract on spontaneous motor activity measured by wheel cage method in mice, the spontaneous motor activity was reduced significantly by administration of UGS extract. 7. On the experiment of effects of UGS extract on the activity of GABA-transaminase(GABA-T) in mouse brains after 21 days of oral administration of UGS extract. the activity of GABA-T was reduced significantly by administration of UGS extract. 8. On the experiment of effects of UGS extract on the activity concentration of GABA in mouse brain after 21 days of oral administration of UGS extract, the activity concentration of GABA was reduced significantly by administration of UGS extract. 9 On the experiment of effect of UGS water extract on the activity of GAD in mouse brain after 21 days of oral administration of UGS extract, the activity of GAD was reduced significantly by administration of UGS extract. According to the these results, Ukgansan extracts reveal the effects on the anti-convulsive, antipyretic, analgesic, sedative and GABAergic system.