• Proceedings of the Korean Geotechical Society Conference
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• 2000.11a
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• pp.729-736
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• 2000

For nonhomogeneous and anisotropic rocks such as schist, shale, etc, a method to determine the anisotropic elastic constants was proposed. Many authors have investigated in detail the behavior elastic constants of anisotropy rocks(Pinto 1970, Amadei 1983, 1992, Amadei & Savage 1989). They concluded that equations of elastic constants E$_1$, E$_2$ and G$_2$ can be derived from the measured strains in arbitrary three directions. And, modulus of elasticity varies according to the inclination of discontinuity in specimens. If we attach three strain gages in accordance with the directions of anisotropy on the rock specimen under uni-axial compression and diametral compression tests, anisotropy elastic constants can be determined by these equations. With this method, the degree of anisotropy will be easily evaluated by simple laboratory test. This paper presents the results of elastic constants due to the angle of bedding planes of anisotropic rock, such as shale, in uni-axial compression and diametral compression tests

• The Journal of the Acoustical Society of Korea
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• v.17 no.2
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• pp.43-49
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• 1998

본 논문에서는 고성능 CELP 음성 압축기를 위한 "Boaseline 코드벡터"와 "Implied 코드벡터"로 구성되는 새로운 구조의 코드북을 제안한다. Implied 코드벡터는 피치 주기 이 전의 합성음으로부터 구하여지며 여기(勵起)신호의 피치 구조를 강화하여 합성음의 음질을 향상시킨다. Implied 코드벡터는 전달되지 않고 인코더 및 디코더에서 각각 합성음을 이용 하여 독립적으로 구하여진다. 또한 펄스와 랜덤 성분을 모두 가지는 복합 여기방식을 이용 하여 음질을 더욱 향상시킨다. 제안된 코드북 구조를 이용하여 10msec프레임을 가지는 8kbps CELP 음성 압축기를 설계하여 하나의 DSP칩에 실시간 구현 하였고, 이것의 성능을 SNRseg와 MOS로 측정하였다. 평균 SNRseg는 12.14dB로 CS-ACELP의 SNRseg보다 6dB 높고, 조용한 환경에서의 MOS는 3.80으로 G.729 CS-ACELP의 MOS보다 0.02 높다.

• Proceedings of the IEEK Conference
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• 2007.07a
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• pp.423-424
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• 2007

In this paper, we propose a scalable high-quality speech reconstruction method for distributed speech recognition (DSR). It is difficult to reconstruct speech of high quality with MFCCs at the DSR server. Depending on the bit-rate available by the DSR system, we can send additional information associated with speech coding to the DSR sorrel, where the bit-rate is variable from 4.8 kbit/s to 11.4 kbit/s. The experimental results show that the speech quality reproduced by the proposed method when the bit-rate is 11.4 kbit/s is comparable with that of ITU-T G.729 under both ideal channel and frame error channel conditions while the performance of DSR is maintained to that of wireline speech recognition.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.139-142
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• 2002

본 연구에서는 VoIP와 같은 패킷망에서 G.729 CS-ACELP 음성부호화기에 패킷 손실 은닉 알고리즘을 적용하여, 패킷 손실로 인한 음질 저하의 완화에 관한 실험을 수행하였다. 패킷 손실 은닉은 수신된 패킷으로부터 복호된 파형을 저장해두었다가, 손실이 발생하면 피치 동기가 맞도록 선택한 파형을 손실된 패킷자리에 대체하는 방법과 연속적인 손실 이후에 음성부호화기의 메모리를 초기화하는 방법에 기반하고 있다. 실제 VoIP 통화 실험에서 측정한 패킷 손실 분포에 대해 패킷 손실로 인한 음질 저하를 완화할 수 있음을 확인하였다.

• Genomics & Informatics
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• v.7 no.1
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• pp.13-19
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• 2009

Osteoporosis is characterized by impaired osteogenesis. BMD is a major determinant of bone strength. The role of the VDR gene in predisposition to primary osteoporosis has been recognized. However, population-based case-control studies have been reported controversial results for known candidate genes in an ethnically distinct group. To determine the genetic effects of VDR variants on osteoporosis and BMD, we directly sequenced the VDR gene in 24 unrelated Korean individuals and identified eighteen sequence variants. We investigated the potential involvement of eight SNPs in osteoporosis in postmenopausal women (n = 729). Two SNPs (LD) in intron 2, -5294G>C (rs2238135) and -4817G>A (rs17882443) showed the evidence of association with enhanced BMD of the femoral neck ($p_{additive}$=0.031 for rs2238135; $p_{additive}$=0.017 and $p_{dominant}$= 0.019 for 17882443). Moreover, VDR -4817G>A was significantly associated with protective effect on all fracture risk ($p_{recessive}$=0.035, OR=0.2, 95% CI=$0.05{\sim}0.89$), and tended to be higher BMD values at various proximal femur sites. Therefore, we suggest that the -4817G>A may be useful genetic marker for vitamin D-related metabolism and may have an important role in the increased BMD of the proximal femur in postmenopausal Korean women.

• Microbiology and Biotechnology Letters
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• v.27 no.4
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• pp.320-326
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• 1999

The effects of operating pressure, lactate concentration, impurities, and pH on solution flux and lactate rejection in nanofiltration were investigated with model sodium lactate solutions (lactate 10~200g/L) as a model system. In the tested range of pressure(80~140 psig), the solution flux was observed to be proportional to the operating pressure and the rejection of lactate increased only slightly with the pressure. Both of the flux and the rejection decreased with lactate concentration, while the recovery rate of lactate increased. The effects of glucose and yeast extract as impurities on lactate rejection were negligible, but the flux decreased significantly with the addition of yeast extract. At low lactate concentrations, the rejection of lactate increased with pH due to the increased repulsion (Donnan exclusion effect) between lactate ions and membrane surface. But, at high lactate concentrations, the donnan effect was observed to be overwhelmed by the effect of sodium ions added to adjust the pH, and the rejection of lactate decreased with pH. When fermentation broth containing about 89g/L of lactate was nanofiltered, the flux and the rejection of lactate were 2.8L/$m^2$h and 5%, respectively at 120psig. Both of them were slightly lower than those with model solutions. The recovery rate was 2.6mol/$m^2$h.

• Journal of the Korean Chemical Society
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• v.40 no.3
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• pp.161-166
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• 1996

6-ethyl-5,6-dihydrouracil($C_6H_10N_2O_2$) is monoclinic, space group $$P2_{1}c}$$ with a=10.302(2), b=10.419(3), $c=7.095(1)\AA$, $\beta=106.6(0)$, Z=4, $V=729.7(3)\AA$^3$$, $D_c=1.29 g/cm^3,\;{\lambda}(MoK\alpha)=0.71073\AA$, $\mu=0.010cm^{-1}$, F(000)=304, and R=0.054 for 1070 unique observed reflection with F>4.0 $\sigma(F).$ The structure was solved by direct methods and refined by full-matrix least-squares refinement with the fixed C-H bond length at $0.96\AA.$ The hydrouracil molecule makes an envelope conformation with the ethyl substituent oriented to an axial position attainable to a varying degree of steric strain. There are two intermolecular hydrogen-bondings via N-H---O interactions, being nearly parallel to the 100 plane. The shortest distance between molecules is $3.187\AA$ of C(4) and O(8) (-x,-y, 1-z).

• Journal of Life Science
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• v.32 no.9
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• pp.729-733
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• 2022

Aggregation of normally soluble proteins can cause disease-related problems. Tryptophan synthase α-subunit (αTS) in E. coli adopts one of most popular structural scaffolds, the TIM barrel fold. Previous mutagenesis of the αTS gene resulted in many aggregation-prone mutant proteins. Here, Y173F (Tyr at residue 173 to Phe) substitution, which imparts increased stability, was tested for its ability to suppress aggregation of aggregation-prone mutant proteins (Y4C, S33L, P28L, P28S, G44S, D46N, P96L, and P96S). Aggregation was suppressed in all eight severe aggregate-forming mutants (all differing in their mutation positions), by the Y173F replacement. P28L αTS, which was available in pure form, was further analyzed and showed reduced secondary structure content, lower stability, and a looser structure with more exposed hydrophobic surface compared to the wild type protein. A double mutant P28L/Y173F protein showed almost no indication of these changes compared to the wild type protein. We hypothesized that Tyr at position 173 in αTS is positioned at the hydrophobic core and may serve to suppress the aggregation of this protein caused by other residues. Important residue (s) could be working widely in the prevention/suppression of protein aggregation.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.12
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• pp.1761-1768
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• 2006

In this study, the comparative effects of transgenic corn (Mon 810 and Event 176) and isogenic corn (DK729) were investigated for their influence on in vitro rumen fermentation. This study consisted of three treatments with 0.25 g rice straw, 0.25 g of corn (Mon810/Event176/DK 729) mixed with 30 ml rumen fluid-basal medium in a serum bottle. They were prepared in oxygen free conditions and incubated at $39^{\circ}C$ in a shaking incubator. The influence of transgenic corn on the number of bacterial population, F. succinogenes (cellulolytic) and S. bovis (amylolytic), was quantified using RT-PCR. Fermentative parameters were measured at 0, 2, 4, 8, 12 and 24 h and substrate digestibility was measured at 12 and 24 h. No significant differences were observed in digestibility of dry matter, NDF, ADF at 12 and 24 h for both transgenic and isogenic form of corns (p>0.05) as well as in fermentative parameters. Fluid pH remained unaffected by hybrid trait and decreased with VFA accumulation as incubation time progressed. No influence of corn trait itself was seen on concentration of total VFA, acetic, propionic, butyric and valeric acids. There were no significant differences (p<0.05) in total gas production, composition of gas (methane and hydrogen) at all times of sampling, as well as in NH3-N production. Bacterial quantification using RT-PCR showed that the population number was not affected by transgenic corn. From this study it is concluded that transgenic corn (Mon810 and Event 176) had no adverse effects on rumen fermentation and digestibility compared to isogenic corn. However, regular monitoring of these transgenic feeds is needed by present day researchers to enable consumers with the option to select their preferred food source for animal or human consumption.

• BMB Reports
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• v.39 no.6
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• pp.722-729
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• 2006

Recently, we have reported that 3-hydrogenkwadaphnin (3-HK), a diterpene ester isolated from Dendrostellera lessertii (Thymealeaceae), is very effective against leukemia cell lines without any detectable effects on normal cells (Moosavi et al., 2005b). In this study, we report that 3-HK induces $G_1$ cell-cycle arrest, differentiation and apoptosis in APL NB4 cell line. Indeed, the drug between 24 to 96 h induced 7-65% growth inhibition of NB4 cells. Cell viability was also decreased by 2-55% between 24 to 96 h treatments with the drug, respectively. These effects of the drug were also dose-dependent. According to flow cytomtry results, 3-HK (15 nM) induced a significant G1-arrest up to 24 h which was consequently followed with appearance of sub-$G_1$ peak at 72 to 96 h. Hoechst 33258 staining and DNA fragmentation assays confirmed the occurrence of apoptosis among the treated cells. On the other hand, NBT reducing assay, Wright-Giemsa staining, phagocytic activity and expression of cell surface markers (CD11b and CD14) confirmed that the inhibition of proliferation is associated with differentiation especially toward macrophage-like morphology. Interestingly, 3-HK at 5 and 10 nM enhanced the effects of all-trans retinoic acid (ATRA) in NB4 cells. Based on these results, 3-HK might become an ideal candidate for treatment of APL patients pending full exploration of its biological functions.