• Journal of Korean Institute of Industrial Engineers
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• v.39 no.6
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• pp.473-479
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• 2013

This paper introduces user intervention to control simulation states during the execution of a simulation for military engagements. In an engagement simulation, it covers both a discrete event system and a continuous state system. Thus a system for the engagement simulation can have numerous simulation states, because there are lots of factors to decide states of an engagement that are derived during an execution of the simulation (e. g. detection probability, moving speed, moving path, and so on). It means both a result and progression of simulations are important outputs. Configuration of an engagement simulation scenario and expectation of simulation states, though, is hindered by the number of generate-able states. In order to solve the obstacle, the engagement simulation system should be controllable by user intervention during a simulation execution. This paper is to define objects of user intervention, and to design control processes of defined objects.

• Proceedings of the Korean Reliability Society Conference
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• 2005.06a
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• pp.265-269
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• 2005

Cox's proportional hazards model (PHM) has been widely applied in the analysis of lifetime data, and it can be characterized by the baseline hazard function and covariates influencing systems' lifetime, where the covariates describe operating environments (e.g. temperature, pressure, humidity). In this article, we consider the constant baseline hazard function and a discrete random variable of a covariate. The estimation procedure is developed in a parametric framework when there are not only complete data but also incomplete one. The Expectation-Maximization (EM) algorithm is employed to handle the incomplete data problem. Simulation results are presented to illustrate the accuracy and some properties of the estimation results.

• Journal of radiological science and technology
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• v.32 no.1
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• pp.45-52
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• 2009

Digital Mammography is an efficient imaging technique for the detection and diagnosis of breast pathological disorders. Six mammographic criteria such as number of cluster, number, size, extent and morphologic shape of microcalcification, and presence of mass, were reviewed and correlation with pathologic diagnosis were evaluated. It is very important to find breast cancer early when treatment can reduce deaths from breast cancer and breast incision. In screening breast cancer, mammography is typically used to view the internal organization. Clusterig microcalcifications on mammography represent an important feature of breast mass, especially that of intraductal carcinoma. Because microcalcification has high correlation with breast cancer, a cluster of a microcalcification can be very helpful for the clinical doctor to predict breast cancer. For this study, three steps of quantitative evaluation are proposed : DoG filter, adaptive thresholding, Expectation maximization. Through the proposed algorithm, each cluster in the distribution of microcalcification was able to measure the number calcification and length of cluster also can be used to automatically diagnose breast cancer as indicators of the primary diagnosis.

• Journal of Engineering Education Research
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• v.10 no.3
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• pp.21-37
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• 2007

The purpose of this study is to exploring the direction of woman engineering education by the analysis of learner's recognition. In order to investigate the direction of woman engineering education, the literature reviews were explored in the context of the human resource developmentand in the viewpoint of instructional technology. The survey results such as the learner's experience recognition of engineering education were analyzed and they were discussed by experts in the field of education, instructional technology, and engineering. From the analysis result of 399 students(man:206, woman:193) in P university, there were significant differences with man and woman to the factors of (a) understanding, (b) satisfaction, (c) motivation, (d) learning ability, (e) parents' expectation, (f) pleasure in the study, and (g) expectation grade. This study was suggesting the recommendations of woman engineering education in the viewpoints of cognition, emotion, motivation, environment and instructional strategy. The research results will show the cues of human resource development for women in the field of engineering education.

• Journal of Pharmaceutical Investigation
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• v.29 no.2
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• pp.111-115
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• 1999

We have studied the transdermal flux of prostaglandin $E_1$ $(PGE_1)$ from a hydrogel patch through hairless mouse skin, to test the possibility of developing a transdermal delivery system. Karaya gum patch containing $PGE_1$ was prepared by casting method. $PGE_1$ was stable in the patch for 10 weeks. The effect of current application, enhancer (propylene glycol monolaurate : PGML), adhesive and patch thickness on the flux was studied using side-by-side diffusion cell. Passive flux of $PGE_1$ was negligible. Cathodal delivery increased the flux about 20 fold. As the concentrations of PGML increased, flux increased. When 5% PGML was used as the enhancer, maximum flux by cathodal iontophoresis was $55\;{\mu}g/cm^2\;hr$. It increased about 2 folds to $100\;{\mu}g/cm^2\;hr$, when the amount of PGML used was 9%. Large increase in flux and the decrease in time to reach maximum flux were observed when the skin was pretreated with neat PGML (maximum flux obtained was about $200\;{\mu}g/cm^2\;hr$). Use of adhesive decreased the flux significantly. To the contrary of our expectation, increase in current density decreased the flux. These flux data together with the stability data indicate that, though the onset of sufficient delivery occur after 1-2 hours of application, therapeutic amount of $PGE_1$ can be delivered through skin using iontophoresis and penetration enhancer.

• Clinical and Experimental Reproductive Medicine
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• v.42 no.2
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• pp.58-61
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• 2015

Objective: The XIST gene is considered to be an attractive candidate gene for skewed X-chromosome inactivation and a possible cause of primary ovarian insufficiency (POI). The purpose of this study was to investigate whether the XIST gene promoter mutation is associated with idiopathic POI in a sample of the Korean population. Methods: Subjects consisted of 102 idiopathic POI patients and 113 healthy controls with normal menstrual cycles. Patients with the following known causes of POI were excluded in advance: cytogenetic abnormalities, prior chemo- or radiotherapy, or prior bilateral oophorectomy. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The mean age of onset of ovarian insufficiency was $28.7{\pm}8.5years$ and the mean values of serum luteinizing and follicle-stimulating hormones and estradiol in the POI group were $31.4{\pm}18.2mIU/mL$, $74.5{\pm}41.1mIU/mL$, and $30.5{\pm}36.7pg/mL$, respectively. We found no cytosine to guanine (C43G) variation in the XIST gene in both POI patients and controls. Conclusion: The C43G mutation in the promoter region of the XIST gene was not present in the Korean patients with idiopathic POI in our study, in contrast to our expectation, suggesting that the role of XIST in the pathogenesis of POI is not yet clear.

• The Journal of Fisheries Business Administration
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• v.49 no.4
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• pp.37-52
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• 2018

Busan is a representative of ocean cities in South Korea, which attracts many Chinese tourists. As a number of Chinese tourists increase, Chinese tourists' evaluations of sightseeing resources in Busan appear extremely important. However, there are few researches on Chinese tourists' evaluations of sightseeing in Busan. The purpose of this paper is to analyze Chinese tourists' evaluations of Busan tourism. Chinese tourists who travel to Busan are chosen as research objects and several aspects including marine, fisheries and general tourism are investigated to evaluate the tourists' overall satisfaction of the tourism in Busan. IPA analysis, factor analysis multiple regression analysis are used for the research. The results are as follows. Chinese tourists' evaluations of the importance and performance level of variables on Busan tourism were significantly different (total 19 of 25 variables) and the performance was lower than importance. This means the outputs of the various Busan tourism elements do not live up to their expectations. The findings show that Chinese visitors have high satisfaction on infrastructures of fisheries tourism (e.g. cleanness of aquatic product tourism facilities and sanitary state on fishery products), but low satisfaction in terms of the contents (e.g. unique cooking method experience of seafood and traditional seafood cooking consumption). The factors of fisheries tourism (e.g. product services of fisheries tourism and the attractiveness of seafood in Busan) never affect their satisfaction and intention to revisit and recommend the city.

• Child Health Nursing Research
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• v.13 no.3
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• pp.318-328
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• 2007

Purpose: Because it is important to prevent adolescents from becoming involved in smoking, this study was done to explore important factors influencing cigarette use and the increase in smoking frequency. Method: For this study the Korea Youth Panel Survey (KYPS) was analyzed. Because the KYPS is longitudinal, a fixed effect regression method was used to control for the effects of time-independent factors. More specifically, a logistic regression was used to explore factors affecting cigarette use, and a Poisson regression was used to explore smoking frequency. Result: As the adolescents got older, the number of male adolescents who tried smoking increased, while the number of female adolescents who tried smoking decreased. Also, the frequency of cigarette use among male and female smokers increased over time. Significant factors affecting cigarette use were friends who smoked, delinquent behavior, and loneliness at schools. Important factors affecting the increase in smoking frequency were grade (e.g., the 2nd- and 3rd-year of middle school), friends who smoked, delinquent behavior, monthly pocket money, expectation for the highest level of education, and attack tendency. Conclusions: To solve the problems linked to adolescent smoking, it is critical to develop intervention programs that target specific homogeneous subgroups of smokers, and that take into consideration gender difference in smoking and factors affecting levels of smoking behavior.

• Journal of The Korean Society of Agricultural Engineers
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• v.49 no.2
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• pp.61-74
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• 2007

A mathematical modeling program called Hydrological Simulation Program-FORTRAN (HSPF) developed by the United States Environmental Protection Agency (EPA) was applied to Hwaseong watershed. It was run under BASINS (Better Assessment Science for Integrating Point and Nonpoint Sources) program, and the model was validated using monitoring data of $2002{\sim}2005$. The model efficiency of runoff ranged from good to fair in comparison between simulated and observed data, while it was from very good to poor in the water quality parameters. But its reliability and performance were within the expectation considering complexity of the watershed and pollutant sources. The nonpoint source (NPS) loading for T-N and T-P during the monsoon rainy season (June to September) was about 80% of total NPS loading, and runoff volume was also in a similar range. However, NPS loading for BOD ($55{\sim}60%$) didn't depend on rainfall because BOD was mostly discharged from point source (more than 70%). And water quality was not necessarily high during the rainy season, and showed a decreasing trend with increasing water flow. BASINS/HSPF was applied to the Hwaseong watershed successfully without difficulty, and it was found that the model could be used conveniently to assess watershed characteristics and to estimate pollutant loading including point and nonpoint sources in watershed scale.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.291-312
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• 2003

Reactive oxygen species are capable of damaging biomolecules such as lipids, proteins, and DNA, which can not only lead to various diseases, but also oxidative damage resulting aging. In our previous study, Cercis chinensis (Leguminosae) showed a potent antioxidant activity. Nineteen compounds were isolated through antioxidant activity-guided fractionation. The C. chinensis extract and some of the constituents exhibited a potent antioxidant activity on the free radicals and lipid peroxidation and a notable protective effect on the t-BuOOH induced oxidative damage. In vivo test of skin damage induced by UVB irradiation, the extract of C. chinensis and a constituent, piceatannol, exhibited a significant protective effect. The life-span of the HEK-N/F cells were extended by 1.21-2.12 fold as a result of the continuous administration of 3 $\mu\textrm{g}$/ml of the C. chinensis extract and the active constituents compared to that of the control. These observations were attributed to the inhibitory effect of the C. chinensis extract and its constituents on the age-dependent shortening of the telomere. Thus, C. chinensis was demonstrated to protect the skin cells against oxidative stress and inhibit thereby the cellular aging, followed by expectation as anti-aging cosmetic ingredient.