• Tuberculosis and Respiratory Diseases
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• v.50 no.1
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• pp.12-28
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• 2001

Background and Object : Immunostimulatory CpG-oligodeoxynucleotides (ISS CpG-ODN) up-regulate the $T_{H1}$-type immune response and down-regulate the $T_{H2}$-type response. This study was performed to investigate the immune response changes resulting from ISS CpG-ODN on bronchial hyperresponsiveness, eosinophilic inflammation and mucus hypersecretion in rat asthma. Materials and Methods : 10 normal controls(NC) and 26 asthmatic rats, which were generated by ovalbumin(OVA) sensitization and challenge, were studied. The asthmatic rats were randomized into 11 asthma controls(AC) and 15 in the asthma-CpG treatment group(CpG). The CpG group was administered ISS CpG-ODN intramuscularly and the AC group was administered a placebo(0.9% NaCl) on day 15 and 20. After CpG-ODN or placebo administration, we measured the IFN-${\gamma}$($T_{H1}$-type cytokine) and IL-4($T_{H2}$-type cytokine) levels in the bronchoalveolar lavage fluid(BALF), the specific airway resistance(sRaw), eosinophilic fraction in BALF, eosinophilic infiltration, goblet cell dysplasia and MUC5AC gene expression in the lung tissue. Results : In the BALF of the CpG group, the IFN-${\gamma}$ concentration was significantly high and the IL-4 concentration was significantly low when compared with the AC group. Both the sRaw and eosinophilic fraction, and infiltration into the BALF and lung tissue significantly lower in the CpG group when compared with the AC group. However, little difference in goblet cell dysplasia and MUC5AC gene expression was observed between the CpG group and the AC group. Conclusion : ISS CpG-ODN decreases bronchial hyperresponsiveness and eosinophilic inflammation in the rat asthma model through the up-regulation of the $T_{H1}$-type immune response with the down-regulation of the $T_{H2}$-type response. However, the effect of these immune response changes on mucus hypersecretion was is not remarkable in this study.

• Korean Journal of Mathematics
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• v.17 no.3
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• pp.283-291
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• 2009

We investigate the existence of multiple solutions (${\xi},{\eta}$) for perturbations of the parabolic system with Dirichlet boundary condition $$(0.1)\;\begin{array}{lcr}{\xi}_t=-L{\xi}+g_1(3{\xi}+{\eta})-s{\phi}_1-h_1(x,t)\;in\;{\Omega}{\times}(0,\;2{\pi}),\\{\eta}_t=-L{\eta}+g_2(3{\xi}+{\eta})-s{\phi}_1-h_2(x,t)\;in\;{\Omega}{\times}(0,\;2{\pi}).\end{array}$$ We show the existence of multiple solutions (${\xi},{\eta}$) for perturbations of the parabolic system when the nonlinearity $g^{\prime}_1,\;g^{\prime}_2$ are bounded and $3g^{\prime}_1(-{\infty})+g^{\prime}_2(-{\infty})<{\lambda}_1,\;{\lambda}_n<3g^{\prime}_1(+{\infty})+g^{\prime}_2(+{\infty})<{\lambda}_{n+1}$.

• Electronics and Telecommunications Trends
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• v.36 no.6
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• pp.13-24
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• 2021

Industrial networks has been developing various technologies from fieldbus technology to industrial Ethernet and time-sensitive networking. The industry expects that the 5G mobile network will solve the diverse and highly specific industrial site requirements. Accordingly, 3GPP has been developing standard functions to provide ultra-high reliability, ultra-high speed, ultra-connection, and ultra-low latency services, and 3GPP Rel-16 began developing ultra-low latency and ultra-high reliability communication functions for 5G mobile networks to support vertical industries. In this paper, we show the related standardization trends and requirements to apply industrial IoT service scenarios to 5G mobile networks, and in particular, we introduce 5G system features and extended 5G system architecture to provide time sensitive communication and time synchronization services.

• Journal of Animal Science and Technology
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• v.52 no.1
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• pp.9-16
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• 2010

A previous study has shown that the g.17924G>A polymorphism of fatty acid synthase (FASN) is associated with unsaturated fatty acid composition in the Hanwoo beef, hence this study was conducted to evaluate the effect of single nucleotide polymorphisms (SNPs) within FASN gene on the selection phenotypes of Hanwoo breeding stock. A total of 925 progeny test steers were used to genotype g.11280G>A, g.13125T>C, and g.17924G>A polymorphisms and significant associations were found among g.11280G>A, g.17924G>A, and carcass traits, such as carcass weight, backfat thickness, and beef quantity index. No significant association was found between g.13125T>C and carcass traits. Although the degree of linkage disequilibrium (LD) was not strong among g.11280G>A, g.13125T>C, and g.17924G>A in the LD analysis, four major haplotype classes were formed with the genotypic information within the FASN gene; the frequencies of the halpotypeswere -GCG-[0.378], -ATG-[0.301], -GTA-[0.191], and -ACG-[0.063], respectively. Phenotypic association was performed among these haploptypes, and the haplotype 2 (-ATG-)was significantly associated with higher carcass weight when compared to the other haplotypes, i.e. haplotype 1 (-GCG-) and haplotype 3 (-GTA-). A copy number of the FASN haplotype 3 (-GTA-) had also a significant association with carcass weight of subjects. In conclusion, it was observed that two polymorphisms (g.11280G>A and g.17924G>A) and their haplotypes within the FASN gene are consistently associated with carcass traits. Therefore, it is desirable to use the FASN polymorphisms for pre-selection program as genetic marker with improved carcass yield and beef quality of the Hanwoo sire at the Hanwoo Improvement Center as well as for commercial Hanwoo producers, the FASN genotypic information can be used for a part of selecting Hanwoo dam for superior calf production.

• Korean Journal of Mathematics
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• v.24 no.1
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• pp.65-70
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• 2016

J. G. Stampfli proved that if a bounded linear operator T on a Hilbert space ${\mathfrak{H}}$ satisfies ($G_1$) property, then the Riesz projection $P_{\lambda}$ associated with ${\lambda}{\in}iso{\sigma}$(T) is self-adjoint and $P_{\lambda}{\mathfrak{H}}=(T-{\lambda})^{-1}(0)=(T^*-{\bar{\lambda}})^{-1}(0)$. In this note we show that Stampfli''s result is generalized to an nilpotent extension of an operator having ($G_1$) property.

• Honam Mathematical Journal
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• v.29 no.1
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• pp.41-54
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• 2007

In this paper, we introduce the notion of $g{\cdot}{\gamma}$-closed sets and study its basic properties. Also we introduce the notion of ${\gamma}-T_*$ spaces and investigate relationships among these spaces and ${\gamma}-T_i$ spaces (i = 0,1/2,1) due to Ogata [5].

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.203-206
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• 1998

열가소성 탄성체(Thermoplastic elastomers)의 일종인 polyurethane은 상온보다 높은 유리전이온도(T$_{g}$)를 갖는 hard segment(HS)와 낮은 T$_{g}$를 갖는 soft segment(SS)간의 열역학적 불친화성으로 인해 미세 상분리 구조를 갖는다. SS는 낮은 T$_{g}$로 인해 상온에서 rubbery한 성격을 나타내며 HS는 높은 T$_{g}$로 인해 물리적 가교 역할과 충진제 역할을 한다. Polyurethane은 중합당시의 조성이나 중합방법에 따라 다양한 내부구조를 갖으며 이런 내부구조의 변화에 따른 물리적 성질의 변화 역시 다양하다. (중략)

• Journal of Life Science
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• v.19 no.6
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• pp.765-769
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• 2009

Recent studies have reported that the distribution of HPV-16 sequence variation differs geographically, and more specifically that HPV-16 E6/E7 intratypic variants might carry a high risk for development of ICC (invasive cervical cancer) and CIN (cervical intraepithelial neoplasia) in a given population. To investigate the genetic diversities of HPV-16 E6/E7 oncogene by region, we collected nineteen HPV-16 isolates from sexually high-risk women in Busan, and analyzed the HPV-16 E6/E7 coding regions (nt 34 to 880) with HPV-16 E6/E7 specific PCR amplification. At the nucleotide levet eleven variants of the E6 genes and nine variants of the E7 genes were identified as follows: E6 T178G (n=l1), E6 T178A (n=l), E6 T350G (n=3), E6 A442C (n=2), E6 AI04T, E6 All1G, E6 C116T, E6 G145T, E6 T183G, E6 C335T, E6 G522C and E7 A647G (n=12), E7 A645C, E7 A777C, E7 G663A, E7 T732C, E7 T760C, E7 A775T, E7 T789C and E7 T795G, respectively. At the amino acid levet the isolated HPV-16 E6 and E7 genes showed eleven E6 variants: E6 D25E (n=12), E6 L83V (n=4), E6 E113D (n=2), E6 MIL, E6 Q3R, E6 P5S, E6 Q14H, E6 D25N, E6 127R, E6 H78Y, E6 C140S and three E7 variants: N29S (n=12), L28F, T72S. HPV16 E6 L83V, the dominant variant in the Caucasian population, showed relatively low frequencies in our study population. We elucidated that the dominant HPV-16 E6/E7 variants were HPV-16 E6 D25E (63.2%) and HPV-16 E7 N29S (63.2%), which were phylogenetically included in Asian lineage. Further study is needed to evaluate the risk of cervical cancer related HPV-16 E6/E7 intratypic variants in the Korean population.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.12
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• pp.1689-1695
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• 2008

Leptin, the hormone product of the obese gene, is secreted predominately from white adipose tissue and regulates feed intake, energy metabolism and body composition. It has been considered a candidate gene for performance, carcass and meat quality traits in beef cattle. The objective of this study was to identify SNPs in the promoter region of the leptin gene and to evaluate the possible association of the SNP genotypes with carcass and meat quality traits in Korean cattle. We identified a total of 25 SNPs in the promoter region (1,208-3,049 bp upstream from the transcription start site) of the leptin gene, eleven (g.1508C>G, g.1540G>A, g.1545G>A, g.1551C>T, g.1746T>G, g.1798ins(G), g.1932del(T), g.1933del(T), g.1934del(T), g.1993C>T and g.2033C>T) of which have not been reported previously. Their sequences were deposited in GenBank database with accession number DQ202319. Genotyping of the SNPs located at positions g.2418C>G and g.2423G>A within the promoter region was performed by direct sequencing and PCR-SSCP method to investigate the effects of SNP genotypes on carcass and meat quality traits in Korean cattle. The SNP and SSCP genotypes from the two mutations of the leptin promoter were shown to be associated with the BF trait. The average BF value of animals with heterozygous SNP genotype was significantly greater than that of animals with the homozygous SNP genotypes for the g.2418C>G and g.2423G>A SNPs (p<0.05). Analysis of the combined genotype effect in both SNPs showed that animals with the AC SSCP genotype had higher BF value than animals with BB or AA SSCP genotypes (p<0.05). These results suggest that SNP of the leptin promoter region may be useful markers for selection of economic traits in Korean cattle.

• Korean Journal of Agricultural Science
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• v.47 no.3
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• pp.403-414
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• 2020

Gradient concentrations of Tithonia diversifolia green leaves and phosphate rocks were used to investigate their contributions as a fertilizer to the yield and quality improvement of a rainfed rice cultivar. Six treatments were compared: (1) T0, no fertilization (control); (2) T1, 1.28 g of phosphate rocks; (3) T2, 250 g of organic matter; (4) T3, 500 g of organic matter; (5) T4, 250 g of organic matter + 1.28 g of phosphate rocks; (6) T5, 500 g of organic matter + 1.28 g of phosphate rocks. The results showed that the germination percentage recorded 15 days after sowing varied from 58 - 76% between T0 and T5. The number of panicles ranged between 2 (T0) to 6.3 (T5). Moreover, the recorded length of the panicles ranged between 7.5 (T1) to 15.8 cm (T2), and the number of grains per panicle ranged between 25.5 (T1) to 273.5 (T3). The plant height was significantly increased in the T5 (79.27 cm) group compared to the T1 (33.63 cm) and control treatment (T0) (40.08 cm) groups. Although the plant height in the T2, T3, and T4 groups was slightly lower than the T5 group, the difference was not statistically significant. The average of the grain number per plant was high in the T3 (273.6 grains) group compared to the T1 and T0 (25.5 and 32.8 grains) groups, respectively. These results suggest that the combination of T. diversifolia leaves and phosphate rocks as a natural fertilizer would be beneficial when integrated into soil fertility management strategies and would contribute to improving crop yield and quality.