• Journal of Pharmaceutical Investigation
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• 제18권1호
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• pp.15-21
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• 1988

An inclusion complex of phenytoin (PT) with ${\beta}-cyclodextrin\;({\beta}-CyD)$ in molar ratio of 1 : 1 was prepared, and the interaction between host and guest molecules was confirmed by infrared spectrometry, differential scanning calorimetry and X-ray diffractometry. Suppositories were prepared by the fusion method. PT and $PT-{\beta}-CyD$ complex were added to PEG 1540 and Witepsol H-15 under the vigorous stirring at $40^{\circ}C$. Content uniformity was tested for different formulations of the PT suppositories. The release rates were dependent on the K.P. V dissolution apparatus and the dialyzing tubing method. Then, the release rates were increased in the following order: $PT-{\beta}-CyD$ complex in PEG 1540>PT in PEG 1540>$PT-{\beta}-CyD$ complex in Witepsol H-15>PT in Witepsol H-15. The area under the curve and maximum blood concentration after rectal administration were increased in the following order: $PT-{\beta}-CyD$ complex in PEG 1540>PT in PEG 1540>$PT-{\beta}-CyD$ complex in Witepsol H-15>PT in Witepsol-15.

• 한국빅데이터학회지
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• 제7권2호
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• pp.75-90
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• 2022

코로나19 팬데믹에 따른 경제사회 환경 변화와 빅데이터 기술의 발달로 교통분석에 대한 요구가 다양화되고 있다. 특히 데이터 3법 개정에 따라 이종 데이터 간 가명정보 결합이 가능해져 다각적인 분석이 가능해졌다. 그러나 개인정보보호 강화로 모빌리티 빅데이터의 결합분석에는 데이터 협력, 비용대비 효과 등에 한계가 있어 새로운 분석방법론이 필요하다. 본 연구에서 제시하는 "모빌리티 빅데이터 가상결합 방법론"은 법제상의 제약 해소 및 다각적인 교통분석을 위한 것으로, 모바일 통신 기지국 데이터, 교통카드 데이터 등 다양한 모빌리티 관련 빅데이터를 간접적으로 결합하여 상세 분석을 수행하기 위한 방법론이다. 가상결합은 모바일 데이터를 바탕으로 특정 인원의 시간대별 위치를 파악할 수 있는 MCGM(Mobility Comprehensive Genetic Map)을 생성하여 패턴을 분석하고, 이를 교통카드데이터 등 교통관련 빅데이터와 결합시켜 분석하는 방법론으로 본 연구에서는 청주, 수도권 대상으로 가상결합 분석을 수행하여 활용가능성을 검증하였다.

• BMB Reports
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• 제28권3호
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• pp.275-280
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• 1995

The respiratory burst oxidase of neutrophils is a multicomponent enzyme, domant in resting cells, that catalyzes the reduction of oxygen to $O_{2}^{-}$ at the expense of NADPH. In the resting neutrophil, some of the components of the oxidase, including proteins p47 and p67, are in the cytosol, while the rest are in the plasma membrane. Recent evidence has suggested that at least some of the cytosolic oxidase components exist as a complex. The cytosolic complex with a molecular weight of ~240 kDa was found to bind to blue-agarose and 2',5'-ADP-agarose, which recognize nucleotide requiring enzymes. In order to identify the nucleotide binding component of the cytosolic complex we purified recombinant p47 and p67 fusion proteins using the pGEX system. Pure recombinant p47 was retained completely on 2',5'-ADP-agarose, whereas pure recombinant p67 did not bind to these affinity beads. On the basis of these results, we infer that p47 may contain the nucleotide binding site.

• 한국수정란이식학회지
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• 제26권4호
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• pp.287-296
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• 2011

Mammalian fertilization is a complex cascade process consisting of sperm migration through the female reproductive tract, physiological changes to sperm such as sperm capacitation and acrosome reaction, and sperm-egg interaction in the oviduct in vivo. On the other hand, in vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the body: in vitro. IVF has been used for a variety of purposes in reproductive biotechnology for human and animals. The discovery of sperm capacitation in 1951 promoted the development of IVF technology. In the initial stage of IVF, sperm capacitation in preincubation medium was shown to be essential to fuse with eggs. Besides, sperms should detour some of the in vivo regulations for IVF. This review introduces a general mammalian fertilization process, including sperm capacitation, removal of cumulus matrix, acrosome reaction, and sperm-egg fusion and focuses on the roles of key biochemical molecules, signal mechanisms, and genes involved during IVF and novel results of sperm-oocyte interaction elucidated in various gene-knockout mice models.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.606-607
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• 2008

Nowadays, noise and vibration phenomena of a disc brake system have been given various names that provide some definitions of sound and vibration emitted such as grind, grunt, moan, squeak, squeal, judder and wire brush. The most common and annoying noise of a disc brake system is squeal noise. It is defined as noise whose frequency content is 1 kHz and higher with excessively high and irrigating sound pressure levels. In this paper, the noise and vibration characteristics of a disc brake system have been investigated to develop the fusion-type friction material, which overcomes the low steel and non-asbestos organic friction materials. For the purpose, both experimental evaluation and complex eigenvalue analysis have been carried out.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 추계학술대회 논문집 Vol.21
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• pp.207-207
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• 2008

Modern industry has focused on processing that produce low- loss dielectric substrates used complex micron-sized devices using tick film technologies such as tape casting and slip casting. However, these processes have inherent disadvantages fabricating high density interconnect with embedded passives for high speed communication electronic devices. Here, we have successfully fabricated porous alumina dielectric layer infiltrated with polymer solution by using inkjet printing process. Alumina suspensions were formulated as dielectric ink that were optimized to use in inkjet process. The layer was confirmed by field emission scanning electron microscope (FE-SEM) for measuring microstructure and volume fraction. In addition, the reaction kinetics and electrical properties were characterized by FT-IR and the impedance analyzer. The volume fraction of alumina in porous dielectric alumina layer is around 70% much higher than that in the conventional process. Furthermore, after infiltration on the dielectric layer using polymer resins such as cyanate ester. Excellent Q factors of the dielectric is about 200 when confirmed by impedance analyzer without any high temperature process.

• 제어로봇시스템학회논문지
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• 제13권2호
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• pp.93-100
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• 2007

The mobile robots to rescue a life in a disaster area and to explore planets demand high mobility as well as recognition of the environment. To avoid unknown obstacles exactly in unknown environment, accurate sensing is required. This paper proposes a sensor fusion to recognize unknown obstacles accurately by using low-cost sensors. Ultrasonic sensors and infrared sensors are used in this paper to avoid obstacles. If only one of these sensors is used alone, it is not useful fer the mobile robots to complete their tasks in the real world since the surrounding environment in the real world is complex and composed of many kinds of materials. So infrared sensor may not recognize transparent or reflective obstacles and ultrasonic sensor may not recognize narrow obstacles, far example, columns of small diameter. Therefore, I selected six ultrasonic sensors and five infrared sensors to detect obstacles. Then, I fused ultrasonic sensors with infrared sensors in order that both advantages and disadvantages of each sensor are utilized together. In fusing sensors, fuzzy algorithm is used to cope with the uncertainties of each sensor. TAMRY which is terrain-adaptive mobile robot is used as the mobile robot for experiments.

• Journal of Welding and Joining
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• 제30권5호
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• pp.13-15
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• 2012

Stainless steels is widely used in various industries due to its high strength and excellent corrosion resistance. However, in the case of fusion welding for stainless steel, chromium deficiency layer produced by chromium carbide precipitation during welding process causes corrosion-resistance to be lower and formation of intergranular corrosion. It requires a inevitable complex procedure such as pre-heating and post-heating process etc. to prevent such weld defects. From this viewpoint, the new welding process such as a solid state welding method is suited for welding of stainless steels due to its advantages over the fusion welding. Therefore this paper intends to investigate the research trend on friction stir welding, one of solid state welding processes for stainless steels.

• Smart Structures and Systems
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• 제15권3호
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• pp.645-663
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• 2015

Recently, an indirect displacement estimation method using data fusion of acceleration and strain (i.e., acceleration-strain-based method) has been developed. Though the method showed good performance on beam-like structures, it has inherent limitation in applying to more general types of bridges that may have complex shapes, because it uses assumed analytical (sinusoidal) mode shapes to map the measured strain into displacement. This paper proposes an improved displacement estimation method that can be applied to more general types of bridges by building the mapping using the finite element model of the structure rather than using the assumed sinusoidal mode shapes. The performance of the proposed method is evaluated by numerical simulations on a deck arch bridge model and a three-span truss bridge model whose mode shapes are difficult to express as analytical functions. The displacements are estimated by acceleration-based method, strain-based method, acceleration-strain-based method, and the improved method. Then the results are compared with the exact displacement. An experimental validation is also carried out on a prestressed concrete girder bridge. The proposed method is found to provide the best estimate for dynamic displacements in the comparison, showing good agreement with the measurements as well.

• Korean Journal of Geomatics
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• 제4권2호
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• pp.39-45
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• 2004

Building reconstruction attempts to generate geometric and radiometric models of existing buildings usually from sensory data, which have been traditionally aerial or satellite images, more recently airborne LIDAR data, or the combination of these data. Extensive studies on building reconstruction from these data have developed some competitive algorithms with reasonable performance and some degree of automation. Nevertheless, the level of details and completeness of the reconstructed building models often cannot reach the high standards that is now or will be required by various applications in future. Hence, the use of terrestrial sensory data that can provide higher resolution and more complete coverage has been intensively emphasized. We developed a fusion framework for building reconstruction from terrestrial sensory data, that is, points from a laser scanner, images from digital camera, and absolute coordinates from a total station. The proposed approach was then applied to reconstructing a building model from real data sets acquired from a large complex existing building. Based on the experimental results, we assured that the proposed approach cam achieve high resolution and accuracy in building reconstruction. The proposed approach can effectively contribute in developing an operational system producing large urban models for 3D GIS with reasonable resources.