• Design & Manufacturing
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• v.16 no.1
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• pp.55-61
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• 2022

As meters become digital and smart, energy data such as electricity, gas, heat, and water can be accurately and efficiently measured with a smart meter, providing consumers with data on energy used, so that real-time demand response and energy management services can be utilized. Although it is developing from a simple metering system to a smart metering industry to create a high value-added industry fused with ICT, illegal counterfeiting of electronic meters is causing problems in intelligent crimes such as manipulation and hacking of SW. The meter not only allows forgery of the meter data through arbitrary manipulation of the SW, but also leaves a fatal error in the metering performance, so that the OIML requires the validation of the SW from the authorized institution. In order to solve this problem, a quantitative confirmation device was developed in order to eradicate the act of cheating the fuel oil quantity through encoder pulse operation and program modulation, etc. In order to prevent the act of deceiving the lubricator, a device capable of checking pulse forgery was developed, manufactured, and verified. In addition, the performance of the device was verified by conducting an experiment on the meter being used in the actual field. It is judged that the developed quantitative confirmation device can be applied to other flow meters other than lubricators, and in this case, accurate measurement can be induced.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.3
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• pp.191-196
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• 2022

In this study, the anisotropic mechanical property of fused deposition modeling three-dimensional (3D) printing based on lamination direction was verified by a tensile test. Moreover, the property was applied to solid isotropic materials with penalization-based topology optimization. The case of the lower control arm, one of the automotive suspension components, was considered as a benchmark problem. The optimal topological results varied depending on the external load and anisotropic property. Based on these results, two test specimens were fabricated by varying the lamination direction of 3D printing; a tensile test utilizing 3D non-contact strain gauge was also conducted. The measured strain was compared with that obtained by computer-aided engineering response analysis. Quantitatively, the measurement and analysis results are found to have good agreement. The effectiveness of topology optimization considering the lamination direction of 3D printing was confirmed by the experimental result.

• The Journal of the Acoustical Society of Korea
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• v.25 no.4
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• pp.164-171
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• 2006

If the velocities of longitudinal, transverse and leaky surface acoustic waves in an isotropic material are given, the elastic constants and density of the material can be deduced analytically. Those velocities have been measured using three ultrasonic transducers with different vibrational modes so far. In this paper a line-focusing PVDF transducer with divided electrodes was newly proposed and designed for measuring approximate velocities of the three waves. The measurement method established in this study for each waves using the transducer was applied to several isotropic materials including fused quartz. The elastic stiffness constants and densities of the materials were calculated using the measured velocities, and the accuracies were discussed. It was shown that the obtained results are in good accord with the reference values.

• The Journal of the Korea institute of electronic communication sciences
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• v.19 no.1
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• pp.301-307
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• 2024

This study introduces a novel cascade fusion architecture aimed at enhancing thermal images across various scale conditions. The processing of thermal images at multiple scales has been challenging due to the limitations of existing methods that are designed for specific scales. To overcome these limitations, this paper proposes a unified framework that utilizes cascade feature fusion to effectively learn multi-scale representations. Confidence maps from different image scales are fused in a cascaded manner, enabling scale-invariant learning. The architecture comprises end-to-end trained convolutional neural networks to enhance image quality by reinforcing mutual scale dependencies. Experimental results indicate that the proposed technique outperforms existing methods in multi-scale thermal image enhancement. Performance evaluation results are provided, demonstrating consistent improvements in image quality metrics. The cascade fusion design facilitates robust generalization across scales and efficient learning of cross-scale representations.

• Molecules and Cells
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• v.46 no.12
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• pp.764-777
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• 2023

Recombinant immunotoxins (RITs) are fusion proteins consisting of a targeting domain linked to a toxin, offering a highly specific therapeutic strategy for cancer treatment. In this study, we engineered and characterized RITs aimed at mesothelin, a cell surface glycoprotein overexpressed in various malignancies. Through an extensive screening of a large nanobody library, four mesothelin-specific nanobodies were selected and genetically fused to a truncated Pseudomonas exotoxin (PE24B). Various optimizations, including the incorporation of furin cleavage sites, maltose-binding protein tags, and tobacco etch virus protease cleavage sites, were implemented to improve protein expression, solubility, and purification. The RITs were successfully overexpressed in Escherichia coli, achieving high solubility and purity post-purification. In vitro cytotoxicity assays on gastric carcinoma cell lines NCI-N87 and AGS revealed that Meso(Nb2)-PE24B demonstrated the highest cytotoxic efficacy, warranting further characterization. This RIT also displayed selective binding to human and monkey mesothelins but not to mouse mesothelin. The competitive binding assays between different RIT constructs revealed significant alterations in IC₅₀ values, emphasizing the importance of nanobody specificity. Finally, a modification in the endoplasmic reticulum retention signal at the C-terminus further augmented its cytotoxic activity. Our findings offer valuable insights into the design and optimization of RITs, showcasing the potential of Meso(Nb2)-PE24B as a promising therapeutic candidate for targeted cancer treatment.

• Korea Science and Art Forum
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• v.29
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• pp.305-318
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• 2017

The need for recognizing the crime in the urban spaces as a social problem and finding out specific approaches such as the study of space design and various guidelines for crime prevention is increasing. In this regard, "Crime Prevention Through Environmental Design" (marked as "CPTED") is actively underway. Yeomri-dong Salt Way is the first place to which the Seoul Crime Prevention Design Project was appled. The business objective of improving the local environment has been implemented rationally through cooperation and voluntary participation between subject of the project executives and community members. Since its efficiency has been proven, the sites have been expanded since then and becomes a benchmarking example of each local government.This kind of problem solving effort has the same context in purpose and direction of the 'Village Art Project' which has been implemented since 2009 with the aim of promoting the culture of the underdeveloped area and encouraging the participation of the residents by introducing the public art. It is noteworthy that this trend is centered around the characteristics of community functions and values. The purpose of this study is to propose the application method of community furniture as a way to increase the efficiency of CPTED to improve the 'quality of life' of residents. To do this, we reviewed CPTED, community design, public art literature and prior research, and identified the problems and implications based on the site visit Yeomri-dong of Seoul and Gamcheon Village of Pusan which is the successful model of "Seoul Root out Crime by Design" and 'Maeulmisul Art Project' respectively. The common elements of the two case places identified in this study are as follows: First, the 'lives' of community residents found its place in the center through the activation of community by collaborative activities in addition to the physical composition of the environment. Second, community design and introduction of public art created a new space, and thereby many people came to visit the village and revitalize the local economy. Third, it strengthened the natural monitoring, the territoriality and control, and the activity increase among the CPTED factors. The psychological aspect of CPTED and the emotional function of public art are fused with the 'community furniture', thereby avoiding a vague or tremendous approach to the public space through a specific local context based on the way of thinking and emotion of local people and it will be possible to create an environment beneficial for all. In this way, the possibility and implication of the fusion of CPTED and public art are expected to be able to reduce the social cost through the construction of the crime prevention infrastructure such as expansion of the CPTED application space, and to suggest a plan to implement the visual amenity as a design strategy to regenerate city.

• The Journal of Korean Academy of Prosthodontics
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• v.56 no.4
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• pp.323-329
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• 2018

Traditional options for posterior edentulous treatment include removable partial dentures and implant fixed prostheses. Recently, the concept of implant assisted removable partial denture, in which two treatments are fused, has been introduced in consideration of systemic health and patient's needs, costs, residual alveolar bone status and so on. Implant assisted removable partial denture has the advantage of increasing the retention and stability of the denture and improving its esthetics in cases of large bone defects or biomechanical disadvantages. In addition, it is possible to strategically place the implants in a site where the alveolar bone is relatively sufficient, thereby overcome the limit of the conventional removable partial denture design as well as reducing the burden on a wide range of implant surgery. Cost reduction is also expected. In this case, the patient was treated by placing the implant in both premolar sites of the mandible and fabricating the distal extension removable partial denture with the implant fixed prosthesis as an abutment. After delivering the definitive prosthesis, the patient showed satisfaction with the masticatory function and esthetics. and has been regularly followed-up for more than one year. The following 20-months follow-up case report describes the design of an implant-assisted-removable partial denture (IARPD) in which two cementretained implant crowns used to provide support and stability.

• BMB Reports
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• v.42 no.10
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• pp.636-641
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• 2009

The penetrating of monoclonal antibodies (mAbs) into solid tumor may be hampered by their large size. The antibody mimetics, composed of two complementarity-determining regions (CDRs) through a cognate framework region (FR), have been demonstrated to have the capacity to penetrate tumors superior to its parental intact IgG. In this study, we used CDR and FR sequences from the humanized anti-HER2 monoclonal antibody trastuzumab to design four antibody mimetics. Then these antibody mimetics were fused to human IgG Fc to generate mimetics-Fc small antibodies. One of the four mimetics-Fc antibodies binds well to HER2-overexpressing SK-BR3 cells and effectively inhibits the binding of trastuzumab. This mimetics-Fc, denoted as HMTI-Fc, was shown to be effective in mediating antibody-dependent cellular cytotoxicity and exhibit an antiproliferative effect in SK-BR3 cells. To our knowledge, the HMTI-Fc antibody shown here is the smallest fully functional antibody and may have a potential for treatment of cancer.

• Journal of the Korean earth science society
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• v.21 no.6
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• pp.719-733
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• 2000

Normally, a digital geologic map can be defined as mappable one whose spatial information with geographic information details and geologic database attribute, recorded in a digital format that is readable by computer. It shows fundamentally two different conceptual perspectives: cartography for digital mapping and analysis for geo-data processing. While, as both aspects basically relate to natural entities and their interpretation of complex features fused with multi-sources, digital geo-data mapping or geologic mapping, it should be distinguished from digital mapping in engineering such as UIS(Urban Infomation System) and AM/FM(Automated Mapping/Facilities Management). Furthermore, according to short-cycled development of GIS(Geographic Information System) software architecture based on IT(Information Technology) and wide expansion of GIS applications' fields, the importance of domain analysis and application model is emphasized at digital geologic informatizaion. In this paper, first terms and concepts of geo-data model with general data modeling aspects are addressed, and then case histories for geo-data modeling and several approaches for data modeling in GIS application fields are discussed. Lastly, tentative conceptual geo-data modeling by using UML(Unified Modeling Language) of OO(Object-oriented) concepts with respect to USGS/AASG geo-data mode is attempted. Through this approach, the main benefits for standardization and implementation lineage with conceptual model in consideration to reusability are expected. Conclusively, it is expected that geo-information system and its architecture by UML is the new coming key approach for the GIS application in geo-sciences.

• Journal of Internet Computing and Services
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• v.8 no.1
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• pp.57-70
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• 2007

This paper is to construct a healthcare database using information obtained from healthcare home environments, and use this one for healthcare home services, Especially, our researching focus in this paper is how to design healthcare database scheme and how to use this constructed database on the Framework for Supporting Healthcare Integrated Service(FSHIS) we developed previously. Healthcare information is designed to database schemes in accordance to the specific save types of the data collected from various typed-sensors. The healthcare database constructed by using this information for the purpose of healthcare home services is divided into the base information with real schemes and the context based information with view schemes. Firstly, the base information includes low data obtained from physical sensors relevant to locations, healths, environments, and the personnel healthy profiles. The other is the context based information that is produced and fused by using the based information. This context based information might be got via various view schemes according to healthcare application services. Finally, for verifying the practical use of healthcare database constructed in this paper, Via interconnecting this database to our FSHIS, we show an example of healthcare home monitoring service using information (basic and context based information), emergency call, home appliance control, and so on needed from living activity area for elderly living alone.