• Clinical and Experimental Pediatrics
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• v.53 no.11
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• pp.921-930
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• 2010

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve interaction with specific immunogenetic predispositions, and result in heterogeneous clinical manifestations. An arthritic joint exhibits cardinal signs of joint inflammation, such as swelling, pain, heat, and loss of function; any joint can be arthritic, but large joints are more frequently affected. Extra-articular manifestations include high fever, skin rash, serositis, and uveitis. The first 2 types of JRA are regarded as T helper 1 (Th1) cell-mediated inflammatory disorders, mainly based on the abundance of activated Th1 cells in the inflamed synovium and the pathogenetic role of proinflammatory cytokines that are mainly produced by Th1 cell-stimulated monocytes. In contrast, the pathogenesis of systemic onset disease differs from that of other types of JRA in several respects, including the lack of association with human leukocyte antigen type and the absence of autoantibodies or autoreactive T cells. Although the precise mechanism that leads to JRA remains unclear, proinflammatory cytokines are thought to be responsible for at least part of the clinical symptoms in all JRA types. The effectiveness of biologic therapy in blocking the action of these cytokines in JRA patients provides strong evidence that they play a fundamental role in JRA inflammation.

• Korean Institute of Interior Design Journal
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• no.13
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• pp.3-10
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• 1997

The purpose of this study was to identify the design concepts embedded in our traditional interior space. The majority of this research was achieved through literature review as well as examining traditional Korean houses. The major findings were summarized as follows : First, traditional Korean interior space is contemplative. This is created possible by the careful placement of indispensable furnitures and accessaries resulting in an abundance of unoccupied space. Therefore, the room assumes a peaceful atmosphere which calms the mind and creates a tranquil setting. To enjoy the placidity of Korean interior space a humble demeanor and contemplative thought are required. Next, traditional Korean interior space is modest. This is created by the moderate proportions that do not challenge human scale. Traditional Korean interior space does not dominate its surroundings but rather conforms with them. This contrasts with traditional western houses which utilizes an overbearing scale sacrificing intimate space. Thirdly, traditional Korean interior space is raw. In other words, the materials used in house retain their self-evident natural state and are not artifically manipulated to hide their inherent properties. The fundamental conceptual belief that interior space should not defy nature but instead become part of it. Lastly, traditional Korean interior space is not decorative Rooms are not congested with frivolous aesthetics. Although this does not immediately attract the people's attention, eventually the interior space establishes a unique line of communication with them.

• Tribology and Lubricants
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• v.25 no.2
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• pp.81-85
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• 2009

Interests in micro/nano-particles have been greatly increasing due to their wide applications in various fields such as environmental and medical sciences as well as engineering. In order to obtain a fundamental understanding of the tribological characteristics at particle-surface contact interface, frictional behaviors according to load/pressure and materials were obtained by using atomic force microscope(AFM) cantilevers with different stiffnesses and tips. Lateral contact stiffnesses were observed in various tip-surface contact situations. Experimental results show that stick-slip friction behavior occurs even when the colloidal probes with a particle of a few micrometers in diameter, which have a relatively large contact area and lack a well-shaped apex, were used. This indicates that atomic stick-slip friction may be a more common phenomenon than it is currently thought to be. Also, experimental results were investigated by considering the competition between the stiffness of the interatomic potential across the interface and the elastic stiffnesses of the contacting materials and the force sensor itself.

• Lingua Humanitatis
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• v.8
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• pp.95-127
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• 2006

This paper is a study of "poetry therapy", a subject now in lively in literary discussion circles. Modern literary text attaches great importance to the readers' response. As such, there is growing interest in the effects of communication brought on by the interaction of participants in a discourse. Poetry, in essence, has therapeutic attributes of treating, through an aesthetic psychology, destruction resulting from the alienation from life and psychological pain of distortion. The rise of the concept of eco-poetry and the capacity for psychological cleansing and adjustment (which restores balance through communication and psychological circulation) is a reflection of new trend in research - approaching the alienation felt by modern people through restoration of sense of life. Although Kim Hyun-seung's life and the road his poetry took was not smooth, he nevertheless was firm in his sustained effort to unify socio-ethical conscience and conscience of faith through the process of spiritual inquiry. The most outstanding aspects of Kim Hyun-seung's aesthetic achievement lie in his contribution toward the therapeutic capacity of modern poetry. Kim Hyun-seung's poetryhas the following effects: 1)The therapeutic capacity of modern poetry, through catharsis at large, does not remain only at the level of cleansing and adjustment. 2)The therapeutic capacity of modern poetry has the function of emptying out the self through more fundamental spiritual awakening and insight. 3)Only then can one truly realize the transcendence of being a true self as well as the balanced inquiry of spirituality which can be described as "emptying out".

• Journal of the Korean Institute of Educational Facilities
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• v.14 no.1
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• pp.14-22
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• 2007

This study is to examine the present situation relating to the works for landscape architecture in the universities of Korea with the aim of efficient landscape architecture in university campus and to provide the fundamental data of the logical and organized approach to the plans for campus landscape architecture. A survey of the staffs for landscape architecture in 20 national universities all over the country was carried out on the lot utilization ratio of each university, the development of landscape architecture department and its professionals in universities, the establishing status of the plans for landscape architecture of each university, and the satisfaction level of landscape architecture staffs. The results show that most universities pay a little attention to the whole campus landscape architecture according as they don't conduct the systematic works for landscape architecture and some which are done partially attach importance only to maintenance work such as simple controls of open space and trees. As a consequence, the active utilization of potential lot on campus and the organization of professionals and specialized teams for landscape architecture should be realized in order to make the works for campus landscape architecture effective. Besides, in policies, it is thought that the development of general plans and budgets for landscape architecture at the stage of establishing the medium-and long-tenn growth schemes of the universities is required.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.3
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• pp.117-133
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• 2014

The purpose of this study was to compare with shopping behavior and satisfaction of who have visited Dongdaemun and Myeongdong and to provide the fundamental data for differentiation strategy of two fashion trading area. The survey was carried out targeting shoppers who were in Dongdaemun and Myeoongdong and then a total of 778 questionnaires were used for the data analysis; frequency, t-test, chi-squre independence test using SPSS. 20. The results of this study were as follows. Main shoppers in Dongdaemun were the teenagers and twenties, and in Myeongdong were twenties and thirtys. The shoppers who have visited Dongdaemun significantly considered 'store factor' such as store size and comfortability, store interior, store location and accessibility, and 'product factor' including material and quality, design, formfitting, and various sizes, while Myeongdong visitors thought 'promotion factor'such as business hours, one stop shopping, sale and event etc. as important factor. The degree of satisfaction for marketing mix of Myeongdong trade area was higher than Dongdaemun's one. The case of impulse buying in two trade area was not high, while intention to revisit Dongdaemun and Myenongdong was all higher than average. Consumers were more intended to recommend Myeongdong over Dongdaemun to others.

• Molecules and Cells
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• v.41 no.1
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• pp.35-44
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• 2018

Mitochondria are responsible for supplying of most of the cell's energy via oxidative phosphorylation. However, mitochondria also can be deleterious for a cell because they are the primary source of reactive oxygen species, which are generated as a byproduct of respiration. Accumulation of mitochondrial and cellular oxidative damage leads to diverse pathologies. Thus, it is important to maintain a population of healthy and functional mitochondria for normal cellular metabolism. Eukaryotes have developed defense mechanisms to cope with aberrant mitochondria. Mitochondria autophagy (known as mitophagy) is thought to be one such process that selectively sequesters dysfunctional or excess mitochondria within double-membrane autophagosomes and carries them into lysosomes/vacuoles for degradation. The power of genetics and conservation of fundamental cellular processes among eukaryotes make yeast an excellent model for understanding the general mechanisms, regulation, and function of mitophagy. In budding yeast, a mitochondrial surface protein, Atg32, serves as a mitochondrial receptor for selective autophagy that interacts with Atg11, an adaptor protein for selective types of autophagy, and Atg8, a ubiquitin-like protein localized to the isolation membrane. Atg32 is regulated transcriptionally and post-translationally to control mitophagy. Moreover, because Atg32 is a mitophagy-specific protein, analysis of its deficient mutant enables investigation of the physiological roles of mitophagy. Here, we review recent progress in the understanding of the molecular mechanisms and functional importance of mitophagy in yeast at multiple levels.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1225-1229
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• 2012

Objective: The aim of this study was to investigate the meaning of "positive attitude" for medical surgical nurses in caring for cancer patients. Methods: A qualitative method was used in this qualitative descriptive study with data from nurses who had volunteered to participate in an in-depth interview that was conducted between January and February 2012. A total of 10 nurses in general medical and surgical wards of a district hospital were interviewed. Results: The study used three broad themes to describe this multifaceted construct: showing empathy, seeing positively and behaving positively. The nurses were aware of their attitudes towards being positive with cancer patients and its significance in support for cancer patients. Conclusions: The findings of this study can serve as a platform upon which educational and other support programmes can be developed in order to meet the needs of those general nurses working with cancer patients. Future studies are recommended to examine nurses' beliefs about cancer that are thought to affect positive attitudes toward cancer patients.

• The Journal of Korean Physical Therapy
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• v.13 no.1
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• pp.219-227
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• 2001

Capsaicin. a vanillyl amide(8-methy1-N-vanilly1-6-nonenamide) with a molecular weight of 305.42, was substance, interrupting the pain conducting pathway Until recently the neurotoxic effects of Capsaicin to adult animals were thought to be limited to the peripheral nervous system. But several reports suggest the possibility of central nervous system changes after Capsaicin administration to the adult rat. Capsaicin desensitization is defined as long lasting, reversible suppression of sensory neuron activity. How fast and for how long the desensitization develops is related to the dose and time of exposure to Capsaicin, and the interval between consecutive dosing. In the long term Capsaicin treatment can lead to morphological degeneration and changes in some small sensory neurons, predominantly unmyelinated C fiber afferent nerve fibers. Clinical interest has recently been roused by evidence that Capsaicin's desensitizing action may be of therapeutic value and that an endogenous Capsaicin-1 ike substance may exist. This study summarizes the fundamental knowledge(mechanism, receptors, et al of Capsaicin) of Capsaicin for physical therapists.

• Journal of the Korean housing association
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• v.14 no.5
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• pp.19-26
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• 2003

The purpose of this paper is to examine and analyse the features of plan type and space composition of the Siheyuan(courtyard house) which is one of the most remarkable types of the traditional dwellings in China. With the passage of time this house developed into one of the chinese house style. The technique of Siheyuan's spatial composition goes so far back in the New Stone Age. The relics of this are the colony layout, the system of four sides, the layout type of a palace, the picture of lacquered ware, the pictured brick, the earthenware of house type, the cave painting, the paintings of painters and others. The fundamental spatial conception of it arranges one or more courtyards to compose, sometimes in a very complex way, a general walled compound. The main longitudinal axis is mainly north-south, but the chief buildings, or halls are always placed transversely to it. These rectangular buildings mayor may not connect, by means of open galleries variously planned, with rows of smaller buildings flanking the courtyards on both sides. On this system, enlargement is never carried out by adding to height, but by continual duplication of existing units, and growth in breadth or preferably depth. The need for family security is thought to have led to the development of this rectangular houses with walls mainly blank on the outside, defensible entrances, and public service facilities in the center of the houses.