• Annals of Clinical Neurophysiology
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• 제10권2호
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• pp.98-100
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• 2008

Restless legs syndrome (RLS) is a sensorimotor neurological disorder in which the primary symptom is a compelling urge to move the legs, accompanied by unpleasant and disturbing sensations in the legs. Although pathophysiologic mechanism of RLS is still unclear, several evidences suggest that RLS is related to dysfunction in central nervous system involving brain and spinal cord. L-DOPA, as the precursor of dopamine, as well as dopamine agonists, plays an essential role in the treatment of RLS leading to the assumption of a key role of dopamine function in the pathophysiology of RLS. Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration. Iron, as a cofactor in dopamine production, plays a central role in the etiology of RLS. Functional neuroimaging studies using PET and SPECT support a central striatal D2 receptor abnormality in the pathophysiology of RLS. Functional MRI suggested a central generator of periodic limb movements during sleep (PLMs) in RLS. However, to date, we have no direct evidence of pathogenic mechanisms of RLS.

• 재활간호학회지
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• 제1권1호
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• pp.73-82
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• 1998

This study, whose subjects are forty stroke patients in discharging who have been using FIM Western medical (Neurology, Neurosurgery, Rehabilitation Medicine) and Chinese herb medical base of D Hospital in Pusan from the first of May to the eleventh of July, has been made to evaluate the patients' functional conditions and analyze the factors affecting them. The result of study is as followings: FIM total score in discharging is avarage $85.83{\pm}28.96$; the motor FIM score is $57.55{\pm}24.40$ and the cognitive FIM score $29.95{\pm}6.99$. The items recorded the highest score reveal the eating bowel management; the former is $5.68{\pm}1.73$, the latter $5.33{\pm}2.23$. The item recorded the lowest score reveal bathing and stairs, each $2.35{\pm}1.69$ and $3.23{\pm}2.13$. Analysis reveal it is in the case of age(p=.005) and durations of admission(p=.01) that there is significant difference of FIM score when stroke patients in discharging.

• 대한간호학회지
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• 제40권4호
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• pp.533-541
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• 2010

Purpose: This study was designed to test structural equation modeling of the quality of life of stroke survivors in order to provide guidelines for development of interventions and strategies to improve their quality of life. Methods: The participants in the study were patients who visited the neurology outpatient department of a tertiary hospital in Seoul between June 25 and October 15, 2009. Data collection was carried out through one-on-one interviews. Demographic factors, functional independence, social support, nutritional status, post-stroke biobehavioral changes and quality of life were investigated. Results: The final analysis included 215 patients. Fitness of the hypothetical model was appropriate (${\chi}^2$=111.5, p=.000, GFI=.926, AGFI=.880, RMSA=.068, NFI=.911, CFI=.953). Functional dependency, social support and post-stroke biobehavioral changes were found to be significant explaining variance in quality of life. Post-stroke biobehavioral changes had the strongest direct influence on quality of life. Nutritional status had an indirect effect on the quality of life. Conclusion: To improve the quality of life of stroke survivors, comprehensive interventions are necessary to manage post-stroke biobehavioral changes, and strengthening social support networks that can contribute to enhancing the quality of life of stroke survivors.

• Genomics & Informatics
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• 제17권1호
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• pp.11.1-11.7
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• 2019

Athletic performance is a complex multifactorial trait involving genetic and environmental factors. The heritability of an athlete status was reported to be about 70% in a twin study, and at least 155 genetic markers are known to be related with athlete status. Mitochondrial DNA (mtDNA) encodes essential proteins for oxidative phosphorylation, which is related to aerobic capacity. Thus, mtDNA is a candidate marker for determining physical performance. Recent studies have suggested that polymorphisms of mtDNA are associated with athlete status and/or physical performance in various populations. Therefore, we analyzed mtDNA haplogroups to assess their association with the physical performance of Korean population. The 20 mtDNA haplogroups were determined using the SNaPshot assay. Our result showed a significant association of the haplogroup F with athlete status (odds ratio, 3.04; 95% confidence interval, 1.094 to 8.464; p = 0.012). Athletes with haplogroup F ($60.64{\pm}3.04$) also demonstrated a higher Sargent jump than athletes with other haplogroups ($54.28{\pm}1.23$) (p = 0.041). Thus, our data imply that haplogroup F may play a crucial role in the physical performance of Korean athletes. Functional studies with larger sample sizes are necessary to further substantiate these findings.

• Journal of Ginseng Research
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• 제44권5호
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• pp.704-716
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• 2020

Background: Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarified yet. Methods: The effect of GRh2 against T. gondii was assessed under in vitro and in vivo experiments. The BV2 cells were infected with tachyzoites of T. gondii RH strain, and the effects of GRh2 were evaluated by MTT assay, morphological observations, immunofluorescence staining, a trypan blue exclusion assay, reverse transcription PCR, and Western blot analyses. The in vivo experiment was conducted with BALB/c mice inoculated with lethal amounts of tachyzoites with or without GRh2 treatment. Results and conclusion: The GRh2 treatment significantly inhibited the proliferation of T. gondii under in vitro and in vivo studies. Furthermore, GRh2 blocked the activation of microglia and specifically decreased the release of inflammatory mediators in response to T. gondii infection through TLR4/NF-κB signaling pathway. In mice, GRh2 conferred modest protection from a lethal dose of T. gondii. After the treatment, the proliferation of tachyzoites in the peritoneal cavity of infected mice markedly decreased. Moreover, GRh2 also significantly decreased the T. gondii burden in mouse brain tissues. These findings indicate that GRh2 exhibits an antieT. gondii effect and inhibits the microglial activation through TLR4/NF-κB signaling pathway, providing the basic pharmacological basis for the development of new drugs to treat toxoplasmic encephalitis.

• 음성과학
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• 제14권1호
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• pp.63-72
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• 2007

In this study, the researchers evaluate the hypothesis that the reaction time (RT) in the brain is largely dependent on age and gender. The researchers tested English and Korean words using two types: reading as visual stimuli, and listening as auditory stimuli. The E-Prime program installed in functional magnetic resonance imaging (f-MRI) was used. There are 136 Korean subjects in three groups: 30 children (5th and 6th grade elementary school students), 76 young adults (college students), and 30 adults (35-53 years old). In the listening test, the variation for the two languages was different among the three age groups, regardless of gender, whereas the data did not show meaningful differences in the reading test. The findings will provide some meaningful information regarding perception and acquisition of a foreign language.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 1998년도 제10회 한글 및 한국어 정보처리 학술대회
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• pp.186-190
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• 1998

정상 피험자에 있어서 수행 성적의 차이를 보이는 음소적 단어 생성과 의미적 단어생성에 관련한 대뇌 피질의 활동양상의 차이를 밝히기 위해 피험자에게 단어 생성의 과제를 주면서 기능적 자기공명 영상술(functional magnetic resonance imaging, fMRI)을 시행하였다. 모두 7명의 정상인에서 음소 단서에 의한 단어생성은 의미 범주 단어에 의한 단어생성보다 광범위한 피질 영역의 활성화를 보였는데, 특히 bilateral posteroinferior temporal cortices, left premotor cortex, right cerebellum, bilateral superior parietal lobules에서 더 높은 활성화를 보였다. 이에 반하여 의미적 단어생성은 주로 bilateral posterior cingulate gyri에서 더 높은 활성화를 보였다. 이런 결과는 음소적 생성은 가능한 자모를 조합하여 어휘를 생성한 후 작업기억에 일시 저장시켜 놓고 verbal rehearsal 과정을 사용하여 단어 여부를 판별하는 것을 시사하며, 의미적 생성은 mental imagery를 통하여 시각적 인출 단서를 찾은 후, 의미 기억으로부터 단어를 직접 인출하는 것으로 보인다.

• Bulletin of the Korean Chemical Society
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• 제31권9호
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• pp.2451-2452
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• 2010

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1996년도 제35차 춘계학술대회 초록집
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• pp.183-183
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• 1996

• Clinical and Experimental Pediatrics
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• 제59권4호
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• pp.155-164
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• 2016

Cognitive impairment associated with childhood-onset epilepsy is an important consequence in the developing brain owing to its negative effects on neurodevelopmental and social outcomes. While the cause of cognitive impairment in epilepsy appears to be multifactorial, epilepsy-related factors such as type of epilepsy and underlying etiology, age at onset, frequency of seizures, duration of epilepsy, and its treatment are considered important. In recent studies, antecedent cognitive impairment before the first recognized seizure and microstructural and functional alteration of the brain at onset of epilepsy suggest the presence of a common neurobiological mechanism between epilepsy and cognitive comorbidity. However, the overall impact of cognitive comorbidity in children with epilepsy and the independent contribution of each of these factors to cognitive impairment have not been clearly delineated. This review article focuses on the significant contributors to cognitive impairment in children with epilepsy.