• 한국유전체학회:학술대회논문집
• /
• 한국유전체학회 2005년도 The 14th Korea Genome Conference
• /
• pp.55-55
• /
• 2005

• 국제물리치료학회지
• /
• 제6권2호
• /
• pp.840-845
• /
• 2015

Improvement in functional gait is one of treatment goals in treatment of cerebral palsy children. This study intended to examine the effects of insoles for postural correction on gait in spastic cerebral palsy patients by investigating changes in gait temporal spatial parameters. As the subjects, 15 spastic bilateral cerebral palsy patients participated in this study. Temporal spatial parameters of gait were measured using GAITRite system under three gait conditions. Bare foot gait, gait in shoes, and gait in insoles for postural correction were conducted. In order to look at differences in temporal spatial parameters according to three gait conditions, repeated one way analysis of variance was conducted. As post hoc test, Bonferroni was conducted. A significant level was set at ${\alpha}=.05$. According to the result of this study, gait velocity, cadence, step length, stride length of the left lower extremity significantly changed. When the subjects put on customized insoles for postural correction, the effect was greatest. There were no significant changes in stance time, single support time, double support time, swing % of gait, and stance % of cycle. Therefore, gait with insoles for postural correction positively influenced functional gait improvement and will be able to be usefully employed for spastic cerebral palsy children as one of gait assistance devices.

• 대한안전경영과학회지
• /
• 제16권1호
• /
• pp.69-77
• /
• 2014

The environment and requirements of modern war fields have been affected and thus changed by a variety of issues. To this end, the development of safety-critical weapon systems frequently need to meet those changes even in the operational phase. The necessity of the changes may be due to the preparation for mass-production or the request originated from the user military forces. To meet such a need can be even tougher in the development of safety-critical weapon systems since the integration of the requirements for both systems design and systems safety would make it troublesome. To handel the matter in this paper, utilization of architecture DB is proposed. Specifically, the situation in demand has first been analyzed and then a problem-solving process to accommodate the design changes has been constructed. In doing so, the concept of the aforementioned integration is particularly focused on the functional architecture, which could be a core concept of our approach to solving the problem. The result of a case study demonstrating the method studied using a computer-aided systems engineering tool is also presented.

• The Korean Journal of Physiology and Pharmacology
• /
• 제20권1호
• /
• pp.1-8
• /
• 2016

Damage in the periphery or spinal cord induces maladaptive plastic changes along the somatosensory nervous system from the periphery to the cortex, often leading to chronic pain. Although the role of neural circuit remodeling and structural synaptic plasticity in the 'pain matrix' cortices in chronic pain has been thought as a secondary epiphenomenon to altered nociceptive signaling in the spinal cord, progress in whole brain imaging studies on human patients and animal models has suggested a possibility that plastic changes in cortical neural circuits may actively contribute to chronic pain symptoms. Furthermore, recent development in two-photon microscopy and fluorescence labeling techniques have enabled us to longitudinally trace the structural and functional changes in local circuits, single neurons and even individual synapses in the brain of living animals. These technical advances has started to reveal that cortical structural remodeling following tissue or nerve damage could rapidly occur within days, which are temporally correlated with functional plasticity of cortical circuits as well as the development and maintenance of chronic pain behavior, thereby modifying the previous concept that it takes much longer periods (e.g. months or years). In this review, we discuss the relation of neural circuit plasticity in the 'pain matrix' cortices, such as the anterior cingulate cortex, prefrontal cortex and primary somatosensory cortex, with chronic pain. We also introduce how to apply long-term in vivo two-photon imaging approaches for the study of pathophysiological mechanisms of chronic pain.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제12권1호
• /
• pp.17-26
• /
• 2006

The demand for long-term care is continuously on the rise as number of elders among the population increases. Due to the rapid growing demand for long-term care in Korea, there have been discussions for the introduction of new long-term care system into Korean society. The purpose of this study in to analyze changes of elderly care facilities in Japan after the beginning of long-term care system in 2000. The functional and architectural changes of Japanese facilities were researched to be used as references for predicting changes in Korean facilities. In Japan, after the execution of long term care system, the alterative aspect of facilities is divided into some categories; in sum, the change of environment for long term care, the effort to spread specialized facilities in a whole community, and the tendency to complex a variety of function of facilities such as an facility for home care service, and the like.

• 대한방사선기술학회지:방사선기술과학
• /
• 제16권2호
• /
• pp.87-94
• /
• 1993

In order to investigate radiation effects on the liver, functional changes of liver were analyzed after irradiation. Doses of 10 Gy, 15 Gy and 20 Gy were exposed partially to the liver of male rats(Sprague-Dawley) with X-ray(4MV linear accelerator) at room temperature. On 1, 2, 4 and 8 weeks after irradiation, liver tissues and sera of the animals were compared with those of unirradiated animal by liver function tests. Enzyme activities in sera such as alanine aminotransferase, aspartate aminotransferase, malondialdehyde. The content of malondialdehyde in the activities of many enzymes including alanine aminotransferase, aspartate aminotransferase in sera were increased slightly with increasing exposure dose in all experiments and the activities of these enzymes increased markedly in 20 Gy irradiated groups. From these above results, functional changes of the liver were induced in all irradiated groups. Damaged liver was recovered along with time collapse after irradiation to the doses of 10 Gy and 15 Gy while no recovery was deteced within 8 weeks after irradiation to 20 Gy. These results suggest that careful attention must be paid to liver not to be included in exposure field in radiation therapy.

• 대한물리의학회지
• /
• 제14권1호
• /
• pp.35-41
• /
• 2019

PURPOSE: This study examined the effects of a vestibular stimulation training program on the walking ability of chronic stroke patients over a six month period. METHODS: Forty stroke patients were enrolled in this study. The patients were divided randomly into a control group (n=20) and experimental group (n=20). A general exercise program was applied to Group I and vestibular stimulation training was applied to Group II(30 min, three times a week for six weeks). The changes in straight walking ability, curved walking ability, and functional walking ability were measured using a 10 m walking test figure-of-eight-walking test, and dynamic gait index, respectively. The measures before and after the program were compared using a paired t-test for a comparison of each group and an independent t-test for a comparison between groups. RESULTS: The changes in each group were examined according to the measurement period. The Experimental group showed significant functional improvement in all three tests after the vestibular stimulation training program, but the control group did not show significant improvement in any of the tests after the general exercise program. A comparison of the changes between groups revealed the experimental group to show significantly higher improvement than the control group in all tests. CONCLUSION: The vestibular stimulation training program helps improve the gait function of stroke patients. Based on the results of this study, it is expected that various vestibular stimulation training programs will be developed and applied in a range of places.

• 융합신호처리학회논문지
• /
• 제14권3호
• /
• pp.147-153
• /
• 2013

기능성 게임은 놀이와 학습의 결합 형태이며 미래 지향적 도구로, 기존의 게임이 가지고 있는 역기능을 최소화하고 순기능을 최대화할 수 있으며 게임 산업 및 게임 문화를 바꿀 수 있는 새로운 대안으로 자리매김하고 있다. 최근의 게임 및 교육시장은 사용자의 자율성과 동기를 강조하는 보다 진보된 형태의 학습 콘텐츠 개발로 이동하고 있다. 이와 맞물려 게임 시장 또한 게임 중독 및 학업 부진과 같은 사회 역기능적인 요소를 배제하며, 정신과 육체의 건강을 중시하고 과학적인 교육 효과를 추구하는 인간 친화적 형태의 엔터테인먼트 사업으로의 확장을 다각화하고 있다. 또한, 기능성 게임은 의료보조 및 의료학습, 군사 시뮬레이션, 건강. 보조도구, 특수교육 및 학습 도구같은 전문적인 영역에서 일상적인 교육 및 정신 건강 등으로 확대되고 있으며, 시장도 꾸준히 성장하고 있는 추세이다. 그러나 이러한 시장 특수성에 부응하여 현재 기획 및 개발되고 있는 기능성 게임의 대부분은 그 기능에 대한 정확한 과학적 측정과 효과 검증이 이루어지지 못하고 있으며, 대부분 게임 개발자의 직관과 경험에 의존하여 개발되고 있다. 또한, 전반적으로 단순한 과제를 반복하거나 간단한 퍼즐 형태의 게임으로 실제적 재미 요소와 학습의 효과를 효과적으로 결합시키지 못하고 있으며, 인간기능의 측정보다는 막연한 기능 증진을 기대하는 비과학적인 방법의 게임이 대부분이다. 이에 본 논문에서는 시각 및 청각 자극 변화에 따른 기능성 게임의 몰입도 및 집중도 변화를 분석하여 기능성 게임의 효과적인 시청각 자극 제시 방안과 관련한 연구를 수행하였다. 이를 위하여 본 논문에서는 2D 형태의 기능성 게임(가청 주파수 대역의 게임 음향), 3D 형태의 기능성 게임(가청 주파수 대역의 게임 음향), 3D 형태의 기능성 게임(가청 주파수 대역의 게임 음향 및 초음파 영역 게임 보조 음향)을 활용한 3단계의 시각 및 청각 자극 변화 실험 수행하며 사용자의 뇌파를 측정 및 분석한 결과를 제시한다.

• 대한한방내과학회지
• /
• 제29권4호
• /
• pp.871-886
• /
• 2008

Objective : Gypsum fibrosum has been traditionally used in treatment of febrile diseases and recently been shown to have anti-inflammatory effect. Chronic renal failure has a serious clinical symptoms including proteinuria, azotemia, anemia, and hyperlipidemia and has characteristic histopathological changes, glomerular hypertrophy, infiltration of inflammatory cells, and crescentic sclerosis, We investigated the effects of gypsum fibrosum on renal functional and histopathological disorder in chronic renal failure rat model induced 5/6 nephrectomy. Methods : Using Sprague-Dawley rats, CRF was induced by 5/6 nephrectomy. The rats were divided into 3 groups, normal, conrol, and gypsum administered orally with gypsum fibrosum 500mg/kg/day. Body weight, 24 hr proteinuria, hematologic analysis, and histological morphologic changes were followed up after 8 weeks. The glomerular macrophage/monocyte infiltration, $TGF-{\beta}_1$, type IV collagen, and angiotensin II type1 receptor($AT_1$) were evaluated by immunohistochemistry. Resuls : In the CRF control group, functional parameters and histopathologic changes clearly indicated the development of CRF. 24 hr proteinuria significantly increased in the CRF control group over the normal group, and serum creatinine level was lower in the gypsum group than in the control group, LDL-cholesterol was significantly lower in the gypsum group than in the control group. Morphological investigations showed a variety of characteristic features of CRF, glomerular hypertrophy, increasing cellular density of glomerulus, deposition of extra-cellular matrix, fibrotic change, and glomerular sclerosis in the control group, but in the gypsum group, these features diminished significantly. In observation of renal type IV collagen and $AT_1$ expression, positive area significantly increased in the control group over the normal group, and it significantly decreased in the gypsum group compared to the control group. Conclusions : Our findings suggest that gypsum fibrosum inhibits $AT_1$ and type IV collagen expression in renal tissues and attenuates progression of glomerulosclerosis and interstitial fibrosis in chronic renal failure rats, which lead to amelioration of renal function. From these results, we suggest that gypsum fibrosum may have renoprotective effects and could be a useful remedy agent for treating chronic renal failure.

• Safety and Health at Work
• /
• 제8권2호
• /
• pp.183-188
• /
• 2017

Background: Recommendations have been proposed for minimum aerobic fitness among firefighters but it is unclear if those criteria relate to performance on the fireground. Less fit individuals fatigue more quickly than fit individuals when working at comparable intensity and may have gait changes, increasing risk of falls. We evaluated the effect of fatigue during a live burn evolution on gait parameters and functional balance comparing them to aerobic fitness levels. Methods: A total of 24 firefighters had gait and balance tested before and after a live burn evolution. Data were stratified by aerobic fitness of greater/less than 14 metabolic equivalents (METs). Results: Analysis of gait cycles measurements before and after the live burn evolution revealed that single leg stance, cycle, and swing time decreased (p < 0.05) but there were no differences in the other measures. There were no differences in time to complete the functional balance test, or errors committed before or after a live burn evolution. When firefighters were sorted by fitness level of 14 METs, there were no differences for errors or time before or after the live burn evolution. Balance data were analyzed using a linear regression. Individuals with lower fitness levels required more time to complete the test. Conclusion: A 14-MET criterion failed to distinguish gait or balance characteristics in this group. However, less fit firefighters did require more time to complete the balance test (p = 0.003). Aerobic fitness alone does not predict gait changes among firefighters following a live burn evolution but does appear to influence functional balance.