• Molecules and Cells
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• v.42 no.1
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• pp.8-16
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• 2019

Mutations in the ${\beta}-catenin$ gene (CTNNB1) have been implicated in the pathogenesis of some cancers. The recent development of cancer genome databases has facilitated comprehensive and focused analyses on the mutation status of cancer-related genes. We have used these databases to analyze the CTNNB1 mutations assembled from different tumor types. High incidences of CTNNB1 mutations were detected in endometrial, liver, and colorectal cancers. This finding agrees with the oncogenic role of aberrantly activated ${\beta}-catenin$ in epithelial cells. Elevated frequencies of missense mutations were found in the exon 3 of CTNNB1, which is responsible for encoding the regulatory amino acids at the N-terminal region of the protein. In the case of metastatic colorectal cancers, in-frame deletions were revealed in the region spanning exon 3. Thus, exon 3 of CTNNB1 can be considered to be a mutation hotspot in these cancers. Since the N-terminal region of the ${\beta}-catenin$ protein forms a flexible structure, many questions arise regarding the structural and functional impacts of hotspot mutations. Clinical identification of hotspot mutations could provide the mechanistic basis for an oncogenic role of mutant ${\beta}-catenin$ proteins in cancer cells. Furthermore, a systematic understanding of tumor-driving hotspot mutations could open new avenues for precision oncology.

• Journal of the Korean Society of Clothing and Textiles
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• v.44 no.6
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• pp.1178-1188
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• 2020

This study obtains preliminary data through a multifaceted examination of work undertaken by soldiers and factors that should be considered in the development of wearable robots; in addition, the study explores the development direction for such robots in this segment. This study conducted a survey on males who had military experience in order to analyze work practices. The results of the survey indicate that there has been an existing need for wearable robots for soldiers and that soldiers prefer robots equipped with functions to support specific physical activities and those that offer comfort while being worn. In addition, it was found that the method to wear robots should be developed according to the body part that considered movements performed by soldiers. It was also found that strengthening functionality over aesthetic factors is extremely important. Soldiers desired wearable robots that could assist their main activities, protect their bodies, and incorporated an excellent system in terms of wearability.

• Journal of Acupuncture Research
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• v.38 no.1
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• pp.79-84
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• 2021

The degenerative spinal cord disease cervical spondylotic myelopathy (CSM), and cervical myelopathy caused by trauma, can result in debilitating symptoms affecting quality of life. This study used acupotomy and other Korean medicine treatments (acupuncture, herbal medicine, and physical therapy) to improve the symptoms of CSM and cervical myelopathy. The visual analog scale, the modified Japanese Orthopaedic Association scale (mJOA scale), the Nurick grading system, and the American Spinal Injury Association impairment scale were used as the evaluation criteria to determine the effectiveness of treatment. The functional status of both patients improved from mild to moderate, with improved gait, local sensation, and level of pain. The degree of spinal cord injury remained the same. The findings of this study suggest that combined Korean medicine treatments including acupotomy may be helpful in the treatment of CSM and cervical myelopathy.

• Archives of Craniofacial Surgery
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• v.23 no.3
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• pp.95-102
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• 2022

The challenges of successful nasal reconstruction, which are related to the anatomical complexity of the region, have been extensively studied. Revisional operations are often required to achieve proper nasal reconstruction, with results resembling the premorbid nasal status. This is necessary to ensure the quality of life of skin cancer patients. Fundamental nasal reconstruction requires both proper soft tissue coverage and proper function. However, earlier studies in the field primarily focused on the functional aspect of nose reconstruction, although the cosmetic aspect is also an important factor to consider. In response to this need, many recent studies on nose reconstruction have proposed various refinement strategies to improve aesthetic satisfaction. Most plastic surgeons accept the nasal aesthetic subunit principle as a standard for nasal reconstruction. This review outlines the commonly used surgical refinement options and management strategies for postoperative complications based on the subunit principle. In patients with nasal defects, a proper technical strategy might help minimize revision operations and optimize the long-term results.

• Nuclear Engineering and Technology
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• v.54 no.7
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• pp.2453-2466
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• 2022

Nuclear power plant operators in the main control room are exposed to stressful conditions in emergency situations as immediate and appropriate mitigations are required. While emergency operating procedures (EOPs) provide operators with the appropriate tasks and diagnostic guidelines, EOPs have static properties that make it difficult to reflect the dynamic changes of the plant. Due to this static nature, operator workloads increase because unrelated information must be screened out and numerous displays must be checked to obtain the plant status. Generally, excessive workloads should be reduced because they can lead to human errors that may adversely affect nuclear power plant safety. This paper presents a framework for an operator support system that can substitute the initial responses of the EOPs, or in other words the immediate actions and diagnostic procedures, in the early stages of an emergency. The system assists operators in emergency operations as follows: performing the monitoring tasks in parallel, identifying current risk and latent risk causality, diagnosing the accident, and displaying all information intuitively with a master logic diagram. The risk causalities are analyzed with a functional modeling methodology called multilevel flow modeling. This system is expected to reduce workloads and the time for performing initial emergency response procedures.

• Journal of Korean Biological Nursing Science
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• v.24 no.2
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• pp.86-94
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• 2022

Purpose: Patients experiencing chemotherapy-induced peripheral neuropathy (CIPN) apply various palliative care as well as drugs in their daily life to alleviate symptoms. There is a need to identify the influence of these efforts and patients' psychosocial status on the relief of CIPN symptoms. This short-term prospective study investigated how prescription drugs, non-pharmacological behaviors (exercise, massage, and heat therapy), and psychological states (social support, depression, and anxiety) affected CIPN symptoms. Methods: Participants scheduled to receive postoperative platinum or taxane-based chemotherapy were enrolled consecutively. CIPN was measured with the Neurotoxicity-12 subscale of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity-12 instrument. Data were collected three times during the 4 or 5 cycles of chemotherapy. Results: At the end of the 2nd chemotherapy cycle, 93.1% of participants reported CIPN symptoms. Multiple regression analyses showed that a heat therapy (β= -.34, p< .001), massage (β= -.21, p= .012), and walking 5 times or more per week (β= -.26, p= .021) provided relieve for CIPN symptoms. Depression (β= .19, p= .027) significantly exacerbated CIPN symptoms. Conclusion: These results suggested that a comprehensive management program that includes walking, heat therapy, massage, and mood therapy should be encouraged. Moreover, patients should be educated at chemotherapy initiation to understand appropriate interventions that can relieve CIPN symptoms.

• Journal of the Korean Society of Clothing and Textiles
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• v.45 no.2
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• pp.253-270
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• 2021

This survey provides research into developing knee braces to protect the knee against damage, reduce knee pain, and strengthen the knee. A total of 235 surveys were conducted from December 2019 to January 2020. The subjects were adults in their 20s and over who lived in the Seoul metropolitan area and had experience of using knee braces. In terms of age differences, subjects over 60 years of age purchased knee braces mostly to secure a reduction of pain (ROP), whereas subjects in their 20s and 30s purchased knee braces for physical shock protection (PSP). Subjects in their 40s and 50s purchased knee braces for improvement of muscle movement (IMM). There was no significant difference in shape, material, and locking method based on the reason for wearing the knee brace. These results show that it is conceivable and maybe preferable to produce different knee braces-with a variety of shapes, materials, and locking materials-according to the reason behind wearing a knee brace. Knee braces are worn currently without any differentiation despite the findings of this study. In particular, we argue the need for functional and differentiated development of knee braces specifically for PSP, ROP, and IMM.

• Journal of Marine Bioscience and Biotechnology
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• v.14 no.2
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• pp.124-132
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• 2022

By-products from fisheries produced in Korea are of the same industrial material as imported raw materials and are valuable resources for marine bioindustries. Securing raw materials for the mass production of functional materials is one of the main objectives for marine bioindustrial development. The use of fishery by-products as raw materials is anticipated to increase rapidly as the biomarket is growing into a promising industry. In this study, data were acquired from an open-source environment to perform exploratory data analysis, and various visualization methods were used to compare fishery production to the production of marine processed products in the year 2020. This study suggested that the amount of seafood processing, types of processing items, and areas where fishery processing residue is generated, should be able to secure hygienic raw material supply in large quantities. Thus far, it has been found that the Gyeonggi-do and Busan province, where HACCP-certified processing facilities are concentrated, and the local government Seafood Cluster and the Smart Aquaculture Cluster are at the forefront of stable, mass production of raw materials.

• Journal of Fashion Business
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• v.26 no.6
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• pp.47-63
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• 2022

This study aimed to examine the changes in women's fashion, focusing on the repercussions that bicycles had on women's life and fashion, centered on France in the 19th century, and then it examines the significance of the period to women's cycling clothing and its contribution to fashion. The research is based on literature and visual materials extracted from 19th century French newspapers, magazines, and posters. As a result of this study, the appearance of bicycles in the 19th century contributed to fashion as follows. First, the need for clothing suitable for outdoor activities promoted development of new designs with practical and functional features. Second, the clothing worn by female cyclists contributed to the introduction and propagation of new clothing, and pioneering wearing trousers. Third, the boom of bicycles in the 1890s led to the expansion of ready-to-wear items in department. The significance of the period to women's cycling clothing in the 19th century France is as follows. First, the era challenged customs and attitudes towards women's bicycle clothing and led to modernization. Second, a new and reasonable clothing design was presented that required a compromise to be accepted by the public. Third, although the clothing reform movement was not active in France, bloomer-style bicycle clothing was popular among fashionable women in Paris, revealing only its visual status as the capital of fashion in the 19th century.

• Journal of Korean Academy of Nursing
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• v.52 no.3
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• pp.245-260
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• 2022

Purpose: This study aimed to investigate the effects of an advanced practice nurse-led psychoeducational program on distress, anxiety, depression, coping with cancer (CWC), health promotion behavior (HPB), and quality of life (QOL) among colorectal cancer survivors. Methods: This study was designed as a quasi-experimental study with a non-equivalent control group pretest-posttest. The participants were survivors of colorectal cancer who underwent follow-up care. There were 39 survivors: 19 in the experimental group and 20 in the control group. The experimental group performed a psychoeducational program for 120 minutes per session, once a week for a total of six weeks, while the control group received routine education and counseling. Distress, anxiety, depression, CWC, HPB, and QOL were investigated before, immediately after, and 4 weeks after the intervention. The data were analyzed with SPSS/WIN ver. 24.0, using repeated measures ANOVA. Results: There were significant interactions between time and group for distress and anxiety. In addition, CWC interacted with the total of CWC and interpersonal coping, and QOL interacted with the total of QOL and functional status. However, there were no significant differences in the depression or HPB scores. Conclusion: Based on the results of this study, we expect that this program can be used as an effective intervention for colorectal cancer survivors.