• Asian Oncology Nursing
• /
• v.12 no.2
• /
• pp.132-138
• /
• 2012

Purpose: The purpose of this study was to identify the performance status and quality of life (QOL) of patients after hematopoietic stem cell transplantation (HSCT) according to period of survival. Methods: Participants consists of 83 HSCT patients who were being treated regularly at out-patient clinic in two general hospitals in D city. Data were collected using questionnaires that were modified by Functional Assessment of Cancer Therapy-Bone Marrow Transplabtation (FACT-BMT) scale and Eastern Cooperative Oncology Group (ECOG). Results: The unrelated HSCT group's survival period was significantly worse than related HSCT group and autologous HSCT group. Performance status of the group with more than 3 years survival was significantly higher than that of the group with less than a year survival. The mean score of total QOL of HSCT patients was 2.69 out of 4. Total QOL was not significantly different among period of survival less than 1 year, 1-3 years, and more than 3 years. But BMT QOL was shown that the group with more than 3 years survival was higher than the groups with less than a year survival. Conclusion: Performance status and BMT QOL of the group with less than 1 year survival was significantly lowered than the groups with more than 3 years survival.

• Research in Community and Public Health Nursing
• /
• v.19 no.4
• /
• pp.575-586
• /
• 2008

Purpose: The purpose of this study is to identify factors affecting the constipation of the elderly at nursing homes. Method: A total of 184 elders at 7 nursing homes in P City participated. Information about constipation status (Constipation Assessment Scale). functional status (Katz' Activities of Daily Living). nutritional status (Mini-Nutritional Assessment). and depressive symptoms (Geriatric Depression Scale Short Form Korea version) were collected through interviews. Descriptive statistics. Chi-square test. and t-test were used to describe and compare the non constipation group and the constipation group. Multiple logistic regression analysis was used to determine factors affecting constipation status. Results: The prevalence of constipation was 47.5% (Men 37%. women 51%). Elders suffering from a disease (P=.021) and having low sleep satisfaction (P= .000) were more likely to be constipated than those who did not. The factors affecting the constipation of the elderly at nursing homes were gender (OR=3.558), sleep satisfaction (OR=.580), and depressive symptoms (OR=1.132). Conclusion: According to the result, to reduce the constipation rate of old women at nursing homes, we have to develop guidelines that can solve problems related to constipation cause by sleep-satisfaction and depressive symptoms.

• The Korean Journal of Health Service Management
• /
• v.6 no.1
• /
• pp.185-193
• /
• 2012

This study is to observe the effect of oral health of elderly on overall health status and social activity to provide basic data for oral health improvement program for the elderly and development of related policies. The survey was conducted from July 25th to July 29th, 2011, and used 145 copies for this research analysis. As a result of correlation analysis, it is observed that all of 4 sub factors of Geriatric Oral Health Assessment Index have significant static correlation with overall health status of elderly and social activity also has significant static correlation with oral health. As a result of regression analysis, the functional limitation out of sub factors showed significant positive effect on health status and psychological effect has significant positive effect on social activity. Based on the above result, it is observed that, at the time of rapidly entering to an aging society, the life quality related to oral health of elderly which is part of overall health and overall health status and social activity areas that are recognized by the elderly have significant correlation. And, it is important to understand the factors of oral health affecting health status and social activity. Based on the result of this study, more researches on the development of oral health program and development of assessment tool that can be easily employed should be made.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2018.10a
• /
• pp.21-21
• /
• 2018

Natural product substances have historically served as the most significant also be prepared by source of new leads for pharmaceutical development. They can chemical synthesis(both semisynthesis and total synthesis) and have played a important role in the field of organic chemistry by providing synthetic targets. Rcently, they have also been extended for commercial purpose to refer to medicinal products, health functional foods, dietary supplements and cosmetics from natural sources. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. However, with the advent of robotics, bioinformatics, high throughput screening(HTS), molecular biology-biotechnology, combinatorial chemistry, in silico(molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. The strategy for natural prduct industry is now changing from drug approaches to health foods by identifying effective natural products as preparations. In Korea, a lot of development of natural product based drugs have been done, but very few on health functional foods. The concept of natural product based health foods is not active components as lead compounds but standardized extracts or preparation mixed with other medicinal plants. The representative material has been recently known to be a standardized ginseng extract "Ginsana G 115" developed by Swiss Pharmaton company. The purpose of this presentation is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new health functional foods. It is proposed to present the development of high value added health food or health functional foods through scientific investigation on efficacy and standardization of new materials form natural products.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.44 no.5
• /
• pp.524-532
• /
• 2011

The intertidal benthic macroalgal floras of 19 uninhabited islands were investigated in the Goheung area, South Sea, Korea, in June 2008. Seaweed community structures on the rocky shores of four (Naemaemuldo, Ceoldo, Araedombaeseom, and Jinjioedo) of the 19 islands were also examined. Eighty macroalgal species were identified, including 13 green, 19 brown, and 48 red algae. The maximum number of species was found at Naemaemuldo, with 35 species, and the minimum was at Aredombaeseom, with 21 species. Seaweed biomass ranged from 21.39-76.22 g dry wt/$m^2$, with a maximum at Naemaemuldo, and minimum at Jinjioedo. Sargassum thunbergii was a representative species, distributed widely in the intertidal zone of the four islands. Subdominant seaweeds were Corallina pilulifera and Ulva pertusa at Naemaemuldo and Jinjioedo, respectively. Also, Ishige okamurae was dominant at Ceoldo and Araedombaeseom. Six functional seaweed forms were found at each study site, except for Araedombaeseom, which had four functional groups. On the rocky shores of the four sites, a coarsely-branched form was the most dominant functional group ranging from 44.44-61.90% in species number and 72.42-91. 09% in biomass. In conclusion, among the four study sites, the shore of Naemaemuldo Island had the best ecological status, with the highest number of species, and greatest biomass (mainly brown and red algae) and functional form diversity of seaweeds. Furthermore, on the rocky shore of Naemaemuldo, coarsely branched- and joint calcareous-form seaweeds, which grow in clean and undisturbed environmental conditions, were the representative functional forms.

• Journal of Plant Biotechnology
• /
• v.37 no.2
• /
• pp.115-124
• /
• 2010

As the completion of genome sequencing, large collection of expression data and the great efforts in annotating plant genomes, the next challenge is to systematically assign functions to all predicted genes in the genome. Functional genome analysis of plants has entered the high-throughput stage. The generations and collections of mutants at the genome-wide level form technological platform of functional genomics. However, to identify the exact function of unknown genes it is necessary to understand each gene's role in the complex orchestration of all gene activities in the plant cell. Gene function analysis therefore necessitates the analysis of temporal and spatial gene expression patterns. The most conclusive information about changes in gene expression levels can be gained from analysis of the varying qualitative and quantitative changes of messenger RNAs, proteins and metabolites. New technologies have been developed to allow fast and highly parallel measurements of these constituents of the cell that make up gene activity. We have reviewed currently employed technologies to identify unknown functions of predicted genes including map-based cloning, insertional mutagenesis, reverse genetics, chemical mutagenesis, microarray analysis, FOX-hunting system, gene silencing mutagenesis, proteomics and chemical genomics. Recent improvements in technologies for functional genomics enable whole-genome functional analysis, and thus open new avenues for studies of the regulations and functions of unknown genes in plants.

• Korean Journal of Veterinary Research
• /
• v.38 no.3
• /
• pp.642-651
• /
• 1998

The accuracy of ultrasonography for determining the presence of a functional corpus luteum in subestrous dairy cows was investigated, using a radioimmunoassay for progesterone in plasma. Luteal status (high or low progesterone concentrations) was diagnosed in 534 cows, using B-mode transrectal ultrasonography. Accuracy of ultrasonography was 96.3% and 88.8% in the cows with and without functional corpus luteum, respectively. In 362 cows diagnosed with functional corpus luteum by ultrasonographic examination, 20 cows were diagnosed with the non-functional corpus luteum by analysis of plasma progesterone concentrations (false positive). In 172 cows with non-functional corpus luteum by ultrasonographic examination, 13 cows were diagnosed with the functional corpus luteum based on plasma progesterone assay (false negative). Most of the corpus luteum with well-defined border and homogeneous echotexture were diagnosed with functional corpus luteum. All cows that were not detected a corpus luteum by ultrasonographic examination were diagnosed as non-functional corpus luteum. The corpus luteum of cows that were diagnosed with false positive appeared homogeneous echotexture and above 15 mm in diameter, but the corpus luteum was the non-functional corpus luteum within Day 5 (Day 0 is ovulation day) or after Day 19. The corpus luteum of cows that were diagnosed with false negative appeared heterogeneous echogenicity and below 15 mm in diameter, but the corpus luteum was the functional corpus luteum after Day 5 or around Day 17. It was concluded that accuracy of ultrasonography was excellent for determining the presence of a functional corpus luteum in subestrous dairy cows. The corpus luteum that was diagnosed with false positive or false negative was the developing or regressing states. Thus, ultrasonography was required a serial examination of two or three times accurately diagnosing these corpus luteum.

• Korean Journal of Veterinary Service
• /
• v.27 no.1
• /
• pp.41-52
• /
• 2004

To establish the differential diagnosis and functional status in ovarian cystic cows, progesterone(P$_4$) and estrogen(E$_2$) level of cystic follicular fluid, ultrasonography for measuring the cystic diameter and thickness of cystic wall, and histological findings were investigated in cystic ovaries from slaughtered Korean native cows. Ovarian follicles were classified as systic if the diameter was greater than 25 mm by ultrasonography. Ovarian cysts < 3 mm of cystic wall thickness, < 10 ng/ml P$_4$ concentration and >10 ng/ml E$_2$ concentration were classified follicular cyst, ovarian cysts 3 mm of cystic wall thickness, 10 ng/ml P$_4$ concentration and <10 ng/ml E$_2$ concentration were classified luteal cyst, and ovarian cysts 3 mm of cystic wall thickness, < 10 ng/ml P$_4$ concentration and <10 ng/ml E$_2$ concentration were classified non-functional ovarian cyst, respectively. Also ovarian cysts were classified 8 types by anatomical and hisctological findings. Ovarian cysts with corpus luteum were 3 of 73 cows and ovarian cysts without corpus luteum were 70 cows. The incidence rates of 8 various types of ovarian cysts were as follows; 2Aa 56.2%, 2Ba 20.5% and 2Ab 15.1%, respectively. The incidence rates of ovarian cysts without corpus luteum were follicular cyst 76.7% and luteal cyst 19.2%. The thickness of cystic wall were lAb 3.9 mm, 2Ab 3.3 mm and 2Bb 3.2 mm, and the cystic fluid P$_4$ concentrations were above 10.0 ng/ml in lAb, 2Ab and 2Bb, respectively. There was significantly correlations between the thickness of cystic wall and cystic fluid P$_4$ concentration in ovarian cysts(p<0.05). The ovarian cyst was classified follicular cysts, luteal cyst and non-functional ovarian cyst by hormone analysis. The luteal cyst was accuratly dignosed by cystic wall thickness. But follicular cysts was misdiagnosed 13 cows of 56 cystic cows. The 13 cystic cows was determined as had non-fuctional ovarian cysts. The cystic fluid P$_4$ concentration was 3.3 ng/ml in follicular ovarian cysts and 30.1 ng/ml luteinized ovarian cysts. There was significantly positive correlations between thickness of cystic wall and serum P$_4$ concentration in follicular(r$^2$ =0.59, p<0.001) and luteal cysts(r$^2$=0.65, p<0.001). These results indicated that ovarian cysts had various stages of degeneration and luteal cyst was accuratly diagnosed measurement of cystic wall thickness by ultrasonography, but follicular cysts was not diagnosed only cystic diameter and cystic wall thickness. In conclusion, it is suggest that ovarian cysts was diagnosed by combination of clinical sign and anatomical cystic features.

• The Journal of the Korea Contents Association
• /
• v.21 no.6
• /
• pp.404-414
• /
• 2021

This study was to investigate the differences of functional health status and medical service experience and needs between general and vulnerable older people in community. This study is a cross-sectional descriptive research. The data obtained through direct visit surveys from November to December 2016. The target population of the study was older people over 65 years old, the final study subjects were 444 older people residing in one district of Seoul. The chi-square test was conducted to confirm the difference in their functional health areas and medical service experiences, and the necessity of medical service utilization in accordance to the social class. In the experience of abnormality in functional health, the vulnerable older people had higher experience in cognitive function, nutrition, hydration, pain, and falling than the general older people. The rate of experience of using medical service to solve the cognitive function problem for general older people was 31.9%, higher than that of the vulnerable older people. In contrast, the medical service utilization needs of the vulnerable older people in the pain management category was significantly higher than that of the general older people. In setting policy of public medical service programs for general and vulnerable older people in community may be differentially developed based on this study. In order to improve the medical accessibility of the vulnerable older people, public medical institutions should be actively supported to overcome obstacles to medical use due to economic barriers.

• Korean Journal of Community Nutrition
• /
• v.27 no.2
• /
• pp.81-93
• /
• 2022

Objectives: This study was conducted to investigate the experience and perception among adult women regarding weight control and the consumption of weight-control foods or health functional foods based on their body mass index (BMI). Methods: The subjects were 634 adult women from the Chungcheong province, Korea, and data were collected through a self-administered questionnaire from July 2021 through September 2021. The subjects were divided into four groups based on their BMI status: underweight (< 18.5 kg/m², 7.6%), normal weight (18.5 ~ 22.9 kg/m², 53.3%), overweight (23 ~ 24.9 kg/m², 19.7%), and obese (≥ 25 kg/m², 19.4%). Results: Over the past 3 years, almost two-thirds (68.6%) of the adult women had tried weight control measures, despite the fact that a significant proportion of them were normal or underweight. More importantly, 57.6% of subjects reported the consumption of weight-control foods, with a lower proportion in the underweight (35.4%) group compared to the normal (56.2%), overweight (62.4%), and obese (65.0%) groups. The food items used for weight control were mostly salads, chicken breasts, low fat (soy) milk, slimming tea, protein shakes, low-calorie cereals, and energy/protein bars among others. In addition, one-third (31.1%) of the subjects reported the use of health functional foods containing ingredients for fat reduction. A significantly higher proportion of these was from the overweight (36.0%) and obese (38.2%) groups compared to the underweight (20.8%) and normal weight (28.1%) groups. Products containing Garcinia cambogia extract, green tea, or Cissus extract, were popular among users. Subjects who were obese had a poorer perception of their health and body. Most subjects felt the need for correct information regarding weight control, but this number was significantly more in the higher BMI groups. Conclusions: Our results suggest that the use of weight-control foods or health functional foods is popular among adult women, especially those who are obese. Thus, nutrition education courses covering facts about weight control and practice need to be developed and provided based on the BMI status of subjects.