• Genomics & Informatics
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• v.17 no.4
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• pp.46.1-46.7
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• 2019

The implications of germline de novo variants (DNVs) in diseases are well documented. Despite extensive research, inconsistencies between studies remain a challenge, and the distribution and genetic characteristics of DNVs need to be precisely evaluated. To address this issue at the whole-genome scale, a large number of DNVs identified from the whole-genome sequencing of 1,902 healthy trios (i.e., parents and progeny) from the Simons Foundation for Autism Research Initiative study and 20 healthy Korean trios were analyzed. These apparently nonpathogenic DNVs were enriched in functional elements of the genome but relatively depleted in regions of common copy number variants, implying their potential function as triggers of evolution even in healthy groups. No strong mutational hotspots were identified. The pathogenicity of the DNVs was not strongly elevated, reflecting the health status of the cohort. The mutational signatures were consistent with previous studies. This study will serve as a reference for future DNV studies.

• Journal of the Korea Institute of Military Science and Technology
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• v.12 no.6
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• pp.739-749
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• 2009

Ever since gold was found, this element has fascinated human beings. It is stable in air, and is illuminating for several thousands years without changing its colors. Nanoparticles are the basic nanommaterials, and, particularly gold nanoparticles show unique properties which are not shown in bulk states. Scientists are trying to apply these new properties to catalysts, bioscience, optics, etc. Judging from the current research activities, one can envisage that gold nanoparticles can play a major role in opening a new era in diagnoses and treatment of diseases like cancers. However to apply the nanoparticles one must modify the surface of the nanoparticles in order to give the materials certain functionalities. It certainly is worth to review the current research status and challenges in the area of functional gold nanoparticles.

• Journal of TMJ Balancing Medicine
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• v.7 no.1
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• pp.24-31
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• 2017

Applied Kinesiology (AK) is an evaluation system on the functional balance and integration of the body. Functional aspects of the triad of health are evaluated through muscle testing to see if the balance and integration is in an optimal status or is influenced by a given environmental stimulation. Triad of health refers to the structural, chemical, and psychological aspects of the body. Muscle testing in AK is a functional neurological assessment of muscular response to a given environmental stimulation in a given individual. Meridian system and stomatognathic system as in TMJ balancing medicine serve as one of the theoretical basis of AK. This article reviews core concepts of AK, discusses yin-yang balance medicine perspectives and clinical applications of it.

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.379-379
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• 2005

• 대한예방의학회:학술대회논문집
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• 2002.10a
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• pp.418-419
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• 2002

• Women's Health Nursing
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• v.28 no.3
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• pp.187-196
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• 2022

Purpose: The purpose of this study was to investigate factors related to the levels of health-related quality of life (HRQoL) in elderly women based on Wilson and Cleary's HRQoL model. Methods: This study analyzed data from the eighth Korea National Health and Nutrition Examination Survey 2019 on 868 women over the age of 65 years. Based on the HRQoL model, parameters were categorized as personal, environmental, and physiological characteristics; symptom status; functional status; and perception of health status. The data were analyzed by quantile regression. Results: The overall level of HRQoL was 0.87. Factors related to HRQoL in the 10% quantile were higher education level, higher economic status, economic activity, more walking days, fewer diseases, lower stress, less activity limitation, and higher perceived health status. Factors related to the 25% quantile of HRQoL were more walking days, fewer diseases, less activity limitation, and higher perceived health status. Factors related to the 50% quantile were age, economic activity, more walking days, fewer disease, lower stress, less activity limitation, and higher perceived health status. Factors related to the 75% quantile of HRQoL were smoking, more walking days, fewer diseases, lower stress, less activity limitation, and higher perceived health status. Conclusion: While differing parameters were identified according to the level of HRQoL of elderly women in Korea, there were five common factors. Interventions that focus on increasing walking, mitigating diseases, stress, and activity limitations, and improving perceived health status can improve HRQoL.

• Research in Community and Public Health Nursing
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• v.21 no.4
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• pp.448-457
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• 2010

Purpose: This study attempted to identify differences in elders' health status, quality of life, and satisfaction with customized home visiting health service depending on connection to volunteerism. Methods: A total of 400 subjects participated in this research. Data were collected from May to August of 2009 and the measurement tool used for this study was the house visiting health service recording sheet recommended by the Ministry of Health. Results: According to the results of this research on elders' health status in customized home visiting health service depending on connection to volunteerism, elders' connected to volunteerism positively showed a high level in functional health status areas such as daily life performance ability, instrumental daily life performance ability and Joint exercise capacity, and in the quality of life area. Conclusion: The results of this study can be utilized as complementary information when resources and networks are used for the effective management of house visiting health service subjects.

• Korean Journal of Health Education and Promotion
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• v.13 no.1
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• pp.28-44
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• 1996

The purpose of this study is to examine the associated risk factors for adolescent cigarette smoking. In February 1995, a total of 1793 students from 17 general high schools in Seoul were assessed with a self-completing questionnaire pertaining current smoking status and school.family.peer environmental factors. The results are as follows; 1. The overall proportion of current smoker among students in the study was 17.3%; 27.7% in males and 6.6% in females. 2. There was significant association between smoking status and all school environmental factors (ranks at school, satisfaction at school, study hours after school, extracurricular activity) examined. 3. Siblings smoking in males and family structure in females were significantly associated with the smoking status of students. 4. Functional aspect of family environmental factors, such as APGAR score, parental supervision, attachment to father or to mother were related to smoking status of students. 5. Association with friends who smoke was significantly associated with smoking status of students. 6. In males, association with friends who smoke, ranks at school, siblings smoking were significant positive predictors and APGAR score, parental supervision, attchment to mother were significant negative predictors. In females, association with friends whosmoke, ranks at school, satisfaction at school were significant positive predictors and parental supervision, attchment to father were significant negative predictors. These findings suggest that strategies that influence smoking behavior need to be directed not only to the individual student but also to their peer group, family and school environment.

• Journal of muscle and joint health
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• v.26 no.1
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• pp.46-53
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• 2019

Purpose: The aim of this study was to examine the quality of life (QOL) and its associated factors in hepatocellular carcinoma patients with Transarterial Chemoembolization. Methods: A descriptive correlational study was used, 106 hepatocellular cancer patients participated through convenient sampling. Data were collected by self-report questionniares or face to face interviews during the period from June to December in 2014. Satisfaction for pain control, perceived health status, professional support and QOL were measured by Assessment of Patient Satisfaction for Pain Management, Health Self-Rating, Relationship Questionnaire, Functional Assessment Cancer Therapy-General. Results: The mean age of participants was 63.7 years and most of them were male (86.8%) and married (84.9%). The mean score of QOL was 67.42. QOL was significantly different by religion. Number of other disease and perceived health status were positively correlated to QOL. Pain intensity was negatively correlated to QOL. As a result of stepwise multiple regression analysis, perceived health status and religion were explained 41.0% (p<.001) of the variance in QOL. Conclusion: Perceived health status should be considered when developing nursing intervention to improve QOL among hepatocellular cancer patients with Transarterial Chemoembolization.

• The Korean Journal of Community Living Science
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• v.21 no.4
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• pp.469-479
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• 2010

Using data from the 2001 National Long-Term Care Survey database, this study analyzed gender differences in factors affecting caregiver burdens of spouse caregivers in Korea. Multiple regression was used to estimate factors influencing caregiver burdens of caregiving wives and caregiving husbands respectively. The results showed that there was a significant variability in predictors of caregiver burdens of spouses who take care of the impaired elderly. ADL functional status of care recipients and social support were significant for both the caregiving wives model and caregiving husbands model in influencing caregiving burdens. It was noticeable to report that a caregiver's self-rated health status, monthly caregiving expenses, a care recipient's self-rated health status were unique predictors for the caregiving wives model. These findings suggest that it is vital for planners and providers to take gender differences in spousal caregiving into account when designing and formulating community-based long-term care service programs.