• Journal of the Society of Cosmetic Scientists of Korea
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• 제48권2호
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• pp.113-121
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• 2022

In this study, fermented Lycium chinense (L. chinense) extract was used to analyze the efficacy of nitric oxide (NO) and anti-aging inhibition to verify its usefulness as a functional cosmetic material. L. chinense was extracted with hydrothermal and 70% ethanol as a solvent, fermented, concentrated, and freeze-dried to prepare a sample, followed by MTT assay, NO inhibition assay, western blot assay, and UPLC analysis.As a result of the analysis of NO inhibitory efficacy, fermented L. chinense water extract (FLW) and fermented L. chinense 70% ethanol extract (FLE) showed excellent NO inhibitory efficacy of 47.96% and 56.71%, respectively. As a result of measuring the expression patterns of the wrinkle-related proteins MMP-1, and TRPV-1 through Western blot, both FLW and FLE confirmed the inhibitory efficacy of MMP-1 and TRPV-1. Based on the results of the experiment, the fermented L. chinense extract is expected to have a high application value as a functional cosmetic material related anti-inflammatory, and anti-aging.

• Journal of Life Science
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• 제34권1호
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• pp.28-36
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• 2024

We evaluated the efficacy of Geranium thunbergii (GT), which has so far been understudied as a cosmetic material, and conducted anti-inflammatory-related activity studies. We measured the electron donation ability and ABTS⁺ radical scavenging ability to confirm the antioxidant ability of GT and found values of 91% and 94% at a concentration of 50 ㎍/ml, respectively, confirming that GT had excellent antioxidant ability. Tyrosinase inhibitory activity was measured to evaluate whitening activity, and it was found that inhibitory activity was 24.8% at the highest concentration of 1,000 ㎍/ml. Elastase and collagenase inhibitory activity were measured to determine the wrinkle improvement activity of the GT; 30.6% and 90% inhibitory activity were shown at the highest concentration of 1,000 ㎍/ml, respectively. Excellent inhibitory activity was confirmed through the measurement of collagenase inhibitory activity. Before the cell experiments were conducted, the survival rate of the macrophages Raw 264.7 according to GT treatment was determined based on the MTT assay, and the cell survival rate was greater than 83.6% at a concentration of 100 ㎍/ml. Subsequent cell-related experiments were conducted at concentrations of 100 ㎍/ml or less. The NO production inhibitory activity according to the GT treatment by NO assay was measured, and a 74.9% inhibitory rate was confirmed at a concentration of 100 ㎍/ml. Western blotting was performed to determine protein expression inhibition, and both COX-2 and iNOS factors were concentration-dependently inhibited in GT. Based on these results, GT is considered to have potential as an anti-inflammatory functional cosmetic material.

• Food Science and Industry
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• 제53권4호
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• pp.382-389
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• 2020

"Eating cosmetic" market comes to prominence worldwide. Inner Beauty has established itself as the top trend nowadays and is leading the health functional food market. Another noticeable trend other than beauty-from-within is that products using "plant-based" natural botanical raw material are increasing. Based on these trends above, we have developed a plant extract named Agatri® for skin health using Agastache rugosa. By ingesting Agatri®, it is expected that the formation of skin wrinkles is suppressed, and skin elasticity is increased by suppressing the decrease in collagen content caused by ultraviolet rays. At the same time, it is possible to prevent skin aging by improving skin hydration and trans-epidermal water loss (TEWL). The studies show that it significantly increased production of hyaluronic acid and collagen, and decreased production of matrix metalloproteinases (MMPs). And Agatri® has been approved as an "Individually recognized functional ingredient for skin health by the Ministry of Food and Drug Safety, Korea in 2020. As a result, Agatri® is a good solution for those who are in need of skin protection from exposure to UV and aging.

• Journal of the Society of Cosmetic Scientists of Korea
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• 제49권2호
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• pp.107-116
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• 2023

In this study, to explore the possibility of using discarded by-products of corn as a wrinkle-improving functional material, the active ingredient contained in each part including kernel, cob, husk, and silk of 10 varieties of chodang and waxy corn was identified and the content was analyzed to suggest the possibility of corn by-products as upcycling materials. As a result of evaluating the collagen synthesis efficacy of extracts by part, the cob in chodang and waxy corns showed significant activity at 100 ㎍/mL concentration of 176.5 and 140.0%, respectively. The LC-MS/MS qualitative analysis resulted in the identification of 18 components in the cob, of which N, N'-diferuloylputrescine (DFP) was selected as an active ingredient, and the quantitative analysis was conducted by variety and part. As a result, DFP was confirmed only in the cob and kernel, and it was most frequently detected in the cob of the Goldsugar of chodang corn (39.6 ㎍/g) and Daehakchal of waxy corn (38.4 ㎍/g). The cob is a by-product left over from grain removal, and is expected to create new added value as a material that promotes collagen synthesis. Through this study, we propose the possibility of using discarded cob as a wrinkle-improving functional material.

• The Journal of the Convergence on Culture Technology
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• 제9권6호
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• pp.993-1000
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• 2023

Recently, enviromentally friendly natural substances derived from plants have been attracting attention as cosmetic materials, and research on various physiological activities of natural substances is being actively conducted. This study investigated the antioxidant, anti-inflammatory, moisturizing, and antibacterial effects of three types of extracts of mixtures containing different mixing ratios, Polygala tenuifolia, Angelica dahurica, and Elsholtzia splendens, known to have various physiological activities. The mixing ratio is 7 conditions (M1, 1:1:1; M2, 0.5:1.5:1; M3, 1.5:0.5:1; M4, 0.1:0.95:0.95; M5, 0.5:0.5:2; M6, 0.95 :1.95:0.1; M7, 1.45:0.1:1.45), and the optimal mixing ratio was confirmed for use as a cosmetic material. DPPH and ABTS radical scavenging activities showed scavenging abilities of 75.37% and 99.19%, respectively, at 1,000 ㎍/mL of M6. At a concentration of 200 ㎍/mL of M6, it showed 50% of nitric oxide production inhibition compared to the lipopolysaccharide-treated that induced an inflammatory response. It was confirmed that M3 and M6 produced hyaluronic acid 1.47 and 1.49 times higher than the control at a concentration of 50 ㎍/mL, respectively. Through the disc diffiusion test, the clear zone was 9.75 mm at 8 ㎍/mL of M6, confirming the inhibition of growth of staplylococcus aureus strain. Based on the above results, it is believed that the mixed extract of Polygala tenuifolia, Angelica dahurica, and Elsholtzia splendens can be used as a functional natural material for cosmetics.

• Journal of Korean Society of Industrial and Systems Engineering
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• 제43권4호
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• pp.133-141
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• 2020

Up to date cosmetic OEM/ODM (original equipment manufacturing/original development manufacturing) industry receives attention as a future growth engine due to steady growth. However, because of limited research and development capability, many companies have employed commercial management platforms specialized for large-sized companies; thus, overall system effectiveness and efficiency is low. Especially, MRP (material requirement planning) system introduced originally in 1970s is employed to calculate the requirement of the parts. However, dynamic nature of production lead time usually results in incorrect requirements. In addition, its algorithm does not consider the capability of the production resources. Also, because the commercial MRP system calculates all subcomponent for fixed period, the more goods have subcomponent, the slower calculation is. Therefore, conventional MRP system cannot respond complicated situation in time. In this study, we will suggest a new method that can respond to complicated situations resulting from short lead time and urgent production order in Korean cosmetic market. In particular, a distributed MRP system is proposed, that consists of multi-functional and operational modules, based on the characteristic of the BOM (bill of material). The distributed MRP system divides components (i.e. products and parts) into several fields and decrease the problem size; thus, we can respond to dynamically changed data any time. Through this solution, we can order components quickly, adjust schedules and planned quantity, and manage stocks reasonably. In addition, a prototype of the distributed MRP system is presented in this paper, in which ERP (enterprise resource planning) sever data is associated with an excel spreadsheet via MSsql. System user interface is implemented by a VBA (visual basic for applications) tool. According to a case study, response rate for delivery and planning achievement rate were enhanced about 20%, and inventory turnover was also decreased. Consequently, the proposed system improves overall profit.

• Journal of Life Science
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• 제23권7호
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• pp.879-885
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• 2013

Baby powder is an astringent powder used to prevent diaper rash. It also has other cosmetic uses. In general, it is composed of talc powder (talcum powder). Talc powder is harmful if inhaled because it can cause significant lung damage. With the aim of developing a new rice-based baby powder, three kinds of rice varieties were selected and pulverized. To determine the cost-effectiveness of the different states of rice powder, several milling processes were tried, and the powder characteristics of the resulting rice powder, such as particle size, biological activities, digitalized color value, and moisture content before and after coating treatment with essential oil and silicon oil, were examined. "Goami" showed good flour characteristics with respect to lightness (92.0, $L^*$[D65] value) and particle size ($8.9{\mu}m$). SEM analysis showed that the rice powder particles coated in the essential oil and silicon oil showed a smoother and rounder appearance than those of the talc powder. In addition, the average particle size was decreased by the essential oil and silicon oil coating. The silicon oil coating solved the problem of moisture absorption in rice flour. Rice flour properly coated with essential oil and silicon oil shows great potential as a new material source of powder.

• The Korea Journal of Herbology
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• 제29권6호
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• pp.157-163
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• 2014

Objectives : Gamisoyo-san complex prescription were made with Angelicae Gigantis Radix, Paeoniae Radix, Atractylodes rhizome white, Hoelen, Bupleuri Radix, Moutan Cortex Radicis, Gardeniae Fructus, Zingiberis Rhizoma Crudus, Menthae Herba. The purpose of this study was to research the whitening effect of the extract from Gamisoyo-san, which is one of the used herbal complex prescription. Methods : This study investigated inhibitory effect of Gamisoyo-san in tyrosinase activity. Cell viability were performed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Then, Gamisoyo-san measured reversed-transcription-PCR for mRNA expression using B16F10 mouse melanoma cells. Results : For whitening effects, the tyrosinase inhibition effect of extract was shown to 52.4% at $5,000{\mu}g/m{\ell}$ concentration. The cell viability on B16F10 melanoma cells of Gamisoyo-san extract showed higher than 75% at $1,000{\mu}g/m{\ell}$ concentration. In this study, an experiment was performed by setting the non-toxic concentration range of 50, 150, $250{\mu}g/m{\ell}$. The Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a positive control. The microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), tyrosinase related protein-2 (TRP-2), tyrosinase mRNA expression inhibitory by reverse transcription-PCR of Gamisoyo-san extract were decreased by 95.3%, 98.8%, 96.3% and 49.5% at $250{\mu}g/m{\ell}$ which the highest concentration. Conclusions : All these findings could verify that whitening effects of Gamisoyo-san extract by tyrosinase inhibitory activity and mRNA expression. The Gamisoyo-san could be used as material for functional cosmetics, such as skin whitening products.

• Journal of the Korean Applied Science and Technology
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• 제37권5호
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• pp.1116-1124
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• 2020

In this study, in order to evaluate the possibility of applying apple leaf extract as a cosmetic material, we conducted an experiment by extracting with 70% ethanol. Apple leaf extract is analyzed by GC/MS, and toxicity is evaluated through polyphenol, flavonoid content and DPPH radical scavenging activity, antioxidant, and cell viability (MTT assay) OK, and nitric oxide (NO). It was confirmed that the NO production amount decreased 4.6 times in the group treated with the apology leaf extract through the measurement of the production inhibition of), and the anti-inflammatory effect was investigated. The total polyphenol content was 78.80 ± 0.25 mg /g and the total flavonoids were 65.25 ± 6.62 mg /g. It was confirmed that the DPPH scavenging activity increased sogonun at 79.8 ± 0.99,% at an extract concentration of 0.25%, 88.13 ± 0.89% at 0.5%, and 96.83 ± 2.00% at 1%. The cell viability was evaluated at 91.19 ± 3.49% even at a high concentration of 1000 ppm, confirming a viability of 80% or more. As a result of component analysis of GC-MS, it can be used as an antioxidant cosmetic material such as catechol (5.65%), DL-Gluciol (12.05%), Ascorbic acid (2.41%), Phytol (13.88%), Hexanoic acid (5.47%). Conceivable. The result of this experiment will be used as an important basic material in the development of natural functional cosmetic materials using apple leaf extract.

• Journal of the Society of Cosmetic Scientists of Korea
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• 제40권1호
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• pp.1-10
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• 2014

At present, there are few research papers on skin penetration of cosmeceutical ingredients. What is worse is that in vivo studies are hard to find. In this study, we measured skin epidermal penetration of cosmeceutical ingredients using in vivo Raman spectroscopy and compared with the results obtained from experiments using in vitro franz cell. Results showed that ascorbyl-2-glucoside, retinol, retinyl palmitate, and kojic acid were good for penetration ratio in measurement in vitro and retinol, vitamin C, and arbutin were good in measurement in vivo. Among them, retinol was best in skin penetration in vivo experiment using Raman spectroscopy and ascorbyl-2-glucoside was best in skin penetration in vitro experiment using Franz cell system. It is estimated that the differences were originated from the experimental procedures of two different methods; in vivo Raman experiment can be sensitive to the effect of epidermis and dermis as characteristics of matter by estimating the stratum corneum and in vitro measurement is evaluation of material to penetrate skin of hairless mouse. However, most penetration barrier is the stratum corneum, thus it is important to examine movement of material in the stratum corneum. We expect that these results provided useful information for many cosmetic related research.