• The Korean Journal of Physiology and Pharmacology
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• 제25권1호
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• pp.1-14
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• 2021

Cardiovascular disease (CVD) accounts for approximately 30% of all deaths worldwide and its prevalence is constantly increasing despite advancements in medical treatments. Cardiac remodeling and dysfunction are independent risk factors for CVD. Recent studies have demonstrated that cardiac structure and function are genetically influenced, suggesting that understanding the genetic basis for cardiac structure and function could provide new insights into developing novel therapeutic targets for CVD. Regular exercise has long been considered a robust nontherapeutic method of treating or preventing CVD. However, recent studies also indicate that there is inter-individual variation in response to exercise. Nevertheless, the genetic basis for cardiac structure and function as well as their responses to exercise training have yet to be fully elucidated. Therefore, this review summarizes accumulated evidence supporting the genetic contribution to these traits, including findings from population-based studies and unbiased large genomic-scale studies in humans.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2246-2251
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• 2003

This paper proposes shape design of frame structures for vibration suppression and weight reduction. The $H_{\infty}$ norm of the transfer function from disturbance sources to the output points where vibration should be suppressed, is adopted as the performance index to represent the magnitude of vibration transfer. The design parameters are the node positions of the frame structure, on which constraints are imposed so that the structure achieves given tasks. For computation of Pareto optimal solutions to the two-objective design problem, a number of linear combinations of the $H_{\infty}$ norm and the total weight of the structure are considered and minimized. For minimization of the scalared objective function, a Lagrange function is defined by the objective function and the imposed constraints on the design parameters. The solution for which the Lagrange function satisfies the Karush-Kuhn-Tucker condition, is searched by the sequential quadratic programming (SQP) method. Numerical examples are presented to demonstrate the effectiveness of the proposed design method.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.602-606
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• 2005

A systematic procedure of probability analysis for general distributions is developed based on the first four moments estimated from polynomial interpolation of the system response function and the Pearson system. The function approximation is based on a specially selected experimental region for accuracy and the number of function evaluations is taken equal to that of the unknown coefficient for efficiency. For this purpose, three error-minimizing conditions are proposed and corresponding canonical experimental regions are formed for popular probability. This approach is applied to study the stochastic properties of the performance functions of a MEMS structure, which has quite large fabrication errors compared to other structures. Especially, the vibratory micro-gyroscope is studied using the statistical moments and probability density function (PDF) of the performance function to be the difference between resonant frequencies corresponding to sensing and driving mode. The results show that it is very sensitive to the fabrication errors and that the types of PDF of each variable also affect the stochastic properties of the performance function although they have same the mean and variance.

• Wind and Structures
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• 제6권4호
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• pp.249-262
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• 2003

The purpose of this study is to propose a procedure for evaluating quantitatively the increase of the equivalent damping ratio of a structure with passive/active vibration control systems subjected to a stationary wind load. A Lyapunov function governing the response of a structure and its differential equation are formulated first. Then the state-space equation of the structure coupled with the secondary damping system is solved. The results are substituted into the differential equation of the Lyapunov function and its derivative. The equivalent damping ratios are obtained from the Lyapunov function of the combined system and its derivative, and are used to assess the control effect of various damping devices quantitatively. The accuracy of the proposed procedure is confirmed by applying it to a structure with nonlinear as well as linear passive/active control systems.

• 대한산업공학회지
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• 제12권1호
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• pp.63-71
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• 1986

In the organization with a hierarchical network queue structure a production function is derived whose input factors are the numbers of servers at nodes and output is the number of served customers. Its useful properties are investigated. Using this production function, the contributions of servers to the number of served customers are studied. Also given an expected waiting time in the system for each customer, the optimal numbers of servers at nodes are obtained minimizing a cost function.

• Bulletin of the Korean Chemical Society
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• 제29권7호
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• pp.1412-1414
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• 2008

• 한국해양공학회지
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• 제17권5호
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• pp.57-65
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• 2003

This paper proposes an optimum design method of structural and control systems, using a 2-D truss structure as an example. The structure is subjected to initial static loads and disturbances. For the structure, a FEM model is formed. Using modal transformation, the equation of motion is transformed into modal coordinates, in order to decrease D.O.F. of the FEM model. To suppress the effect of the disturbances, the structure is controlled by an output feedback $H_{\infty}$ controller. The design variables of the combined optimal design of the control-structure systems are the cross sectional areas of truss members. The structural objective function is the structural weight. The control objective function is the $H_{\infty}$ norm, the performance index of control. The second structural objective function is the energy of the response related to the initial state, which is derived from the time integration of the quadratic form of the state in the closed-loop system. In a numerical example, simulations have been perform. Through the consideration of structural weight and $H_{\infty}$ norm, an advantage of the combined optimum design of structural and control systems is shown. Moreover, since the performance index of control is almost nearly optimiz, we can acquire better design of structural strength.

• International Journal of Ocean Engineering and Technology Speciallssue:Selected Papers
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• 제6권1호
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• pp.60-68
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• 2003

This paper proposes an optimum design method of structural and control systems, using a 2-D truss structure as an example. The structure is subjected to initial static loads and disturbances. For the structure, a FEM model is formed. Using modal transformation, the equation of motion is transformed into modal coordinates, in order to decrease D.O.F. of the FEM model. To suppress the effect of the disturbances, the structure is controlled by an output feedback $H_{\infty}$ controller. The design variables of the combined optimal design of the control-structure systems are the cross sectional areas of truss members. The structural objective function is the structural weight. The control objective function is the $H_{\infty}$ norm, the performance index of control. The second structural objective function is the energy of the response related to the initial state, which is derived from the time integration of the quadratic form of the state in the closed-loop system. In a numerical example, simulations have been perform. Through the consideration of structural weight and $H_{\infty}$ norm, an advantage of the combined optimum design of structural and control systems is shown. Moreover, since the performance index of control is almost nearly optimiz, we can acquire better design of structural strength.

• Structural Engineering and Mechanics
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• 제87권2호
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• pp.173-189
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• 2023

For a given structural geometry, the stiffness and damping parameters of the soil and the dynamic response of the structure may change in the face of an equivalent linear soil behavior caused by a strong earthquake. Therefore, the influence of equivalent linear soil behavior on the impedance functions form and the seismic response of the soil-structure system has been investigated. Through the substructure method, the seismic response of the selected structure was obtained by an analytical formulation based on the dynamic equilibrium of the soil-structure system modeled by an analog model with three degrees of freedom. Also, the dynamic response of the soil-structure system for a nonlinear soil behavior and for the two types of impedance function forms was also analyzed by 2D finite element modeling using ABAQUS software. The numerical results were compared with those of the analytical solution. After the investigation, the effect of soil nonlinearity clearly showed the critical role of soil stiffness loss under strong shaking, which is more complex than the linear elastic soil behavior, where the energy dissipation depends on the seismic motion amplitude and its frequency, the impedance function types, the shear modulus reduction and the damping increase. Excellent agreement between finite element analysis and analytical results has been obtained due to the reasonable representation of the model.

• Smart Structures and Systems
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• 제24권2호
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• pp.233-242
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• 2019

In this paper, an inverse approach based on uniform load surface (ULS) is presented for structural damage localization and quantification. The ULS is excellent approximation for deformed configuration of a structure under distributed unit force applied on all degrees of freedom. The ULS make use of natural frequencies and mode shapes of structure and in mathematical point of view is a weighted average of mode shapes. An objective function presented to damage detection is discrepancy between the ULS of monitored structure and numerical model of structure. Solving this objective function to find minimum value yields damage's parameters detection. The teaching-learning based optimization algorithm has been employed to solve inverse problem. The efficiency of present damage detection method is demonstrated through three numerical examples. By comparison between proposed objective function and another objective function which make use of natural frequencies and mode shapes, it is revealed present objective function have faster convergence and is more sensitive to damage. The method has good robustness against measurement noise and could detect damage by using the first few mode shapes. The results indicate that the proposed method is reliable technique to damage detection in structures.