• Korean Journal of Food Science and Technology
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• v.36 no.4
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• pp.637-642
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• 2004

Effects of defatted sesame and perilla methanol extracts on cognitive function and antioxidant activity of learning- and memory-impaired animal model SAMP8 mice. Animals were divided into 4 groups and fed with diets containing 0.3%(w/w) defatted sesame (S) or defatted perilla methanol extracts (P) for 12 weeks. Step through latency of SAMP8 control group was significantly higher than that of SAM R1 normal group, whereas significantly increased in S and P groups compared with SAMP8 control on passive avoidance test (p<0.001). Acetylcholinesterase activity of brain in SAMP8 increased compared with SAMR1 but no difference between SAMP8 control group and sample-treated group. Brain TBARS contents of SAMP8 control significantly increased compared with SAMR1 and were lowered significantly by supplementation of defatted sesame and perilla methanol extracts. Defatted sesame and perilla methanol extracts attenuated increased brain superoxide dismutase and glutathione peroxidase activities in SAMP8. These results suggest defatted sesame and perilla methanol extracts could attenuate cognitive deficits induced by aging possibly through activation of antioxidant activity of defatted sesame and perilla methanol extracts.

• The korean journal of orthodontics
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• v.44 no.5
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• pp.263-267
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• 2014

Objective: To three-dimensionally elucidate the effects of occlusal hypofunction on the periodontal ligament and alveolar bone proper of rat molars by micro-computed tomography (micro-CT). Methods: Occlusal function in the molar area was restricted by attaching an anterior bite plate on the maxillary incisors and a metal cap on the mandibular incisors of 5-week-old male Wistar rats for 1 week. The periodontal ligament space and alveolar bone proper around roots of the mandibular first molar were assessed by histology and micro-CT. Results: The periodontal ligament space was narrower and the alveolar bone proper was sparser and less continuous in the hypofunction group than in the control group. Further, both the volume of the periodontal ligament and the volumetric ratio of the alveolar bone proper to the total tissue in the region of interest were significantly lower in the hypofunction group (p < 0.05). Conclusions: Occlusal hypofunction induces atrophic changes in the periodontal ligament and alveolar bone proper of rat molars.

• Korean Journal of Clinical Pharmacy
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• v.27 no.3
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• pp.161-170
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• 2017

Background: There is recent evidence that insulin resistance is responsible for increasing the risk of developing cognitive dysfunction. To systematically review the influence of intranasal insulin treatment on the cognitive function in Alzheimer's disease patients. Methods: Randomized controlled trials comparing the cognitive effects of intranasal insulin therapy in Alzheimer's disease patients with controlled interventions were retrieved from Pubmed, Medline, Embase and Cochrane library. Meta-analysis was conducted on the cognitive measurements with a subgroup analysis by dose, gender and apolipoprotein E allele 4 (ApoE ${\varepsilon}4$) status. Results: Seven randomized controlled trials were eligible for inclusion. Intranasal insulin had a positive influence on the cognitive function as compared to placebo without a statistical significance (standardized mean difference; SMD = 0.109; 95% confidence interval; CI -0.04 to 0.26; P=0.14). In subgroup analysis, a 20 IU dose of intranasal insulin induced a significant improvement in cognitive function (SMD = 0.14; 95% CI 0.05 to 0.24; P=0.004), but 40 IU did not show this effect (SMD = -0.01; 95% CI -0.11 to 0.09; P=0.82). ApoE ${\varepsilon}4$ positive patients showed a significant decline in cognitive function as compared to ApoE ${\varepsilon}4$ positive patients in the control group (SMD = -0.213; 95% CI -0.38 to -0.04; P=0.015). Such an effect was not apparent in ApoE ${\varepsilon}4$ negative patients. Gender had no influence on the cognitive outcomes. Conclusion: The results indicate that intranasal insulin may have beneficial effect in improving the cognitive function in Alzheimer's disease patients.

• Korean Journal of Soil Science and Fertilizer
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• v.49 no.5
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• pp.495-502
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• 2016

Italian Ryegrass (IRG), which is known as high yielding and the highest quality winter annual forage crop, is grown in mid-south area in Korea. The objective of this study was to evaluate the use of unmanned aerial vehicle (UAV) for the monitoring IRG growth. Unmanned aerial vehicle imagery obtained from middle March to late May in Nonsan, Chungcheongnam-do. Unmanned aerial vehicle imagery corrected geometrically and atmospherically to calculate normalized difference vegetation index (NDVI). We analyzed the relationships between $NDVI_{UAV}$ of IRG and biophysical measurements such as plant height, fresh weight, and dry weight over an entire IRG growth period. The similar trend between $NDVI_{UAV}$ and growth parameters was shown. Correlation analysis between $NDVI_{UAV}$ and IRG growth parameters revealed that $NDVI_{UAV}$ was highly correlated with fresh weight (r=0.988), plant height (r=0.925), and dry weight (r=0.853). According to the relationship among growth parameters and $NDVI_{UAV}$, the temporal variation of $NDVI_{UAV}$ was significant to interpret IRG growth. Four different regression models, such as (1) Linear regression function, (2) Linear regression through the origin, (3) Power function, and (4) Logistic function were developed to evaluate the relationship between temporal $NDVI_{UAV}$ and measured IRG growth parameters. The power function provided higher accurate results to predict growth parameters than linear or logistic functions using coefficient of determination. The spatial distribution map of IRG growth was in strong agreement with the field measurements in terms of geographical variation and relative numerical values when $NDVI_{UAV}$ was applied to power function. From these results, $NDVI_{UAV}$ can be used as a new tool for monitoring IRG growth.

• Environmental and Resource Economics Review
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• v.28 no.3
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• pp.415-435
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• 2019

The purpose of this study is to analyze the returns to scale by estimating the bigeye tuna production function of Korean distant longline fisheries in WCFPC waters. In the analysis, number of crews, vessel tonnage, number of hooks, and bigeye tuna biomass are used as input variables and the catch amount of bigeye tuna is used as an output variable in the Cobb-Douglas production function. Prior to the function estimation, the biomass of bigeye tuna was estimated by the Bayesian state-space model. Results showed that the fixed effect model was selected based on the hausman test, and vessel tonnage, hooks, and biomass would have direct effects on the catch amount. In addition, it was shown that the bigeye tuna distant longline fisheries in WCFPC water would have increasing returns to scale.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.246.1-246.1
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• 2014

Over the past several years, colloidal core/shell type quantum dots lighting-emitting diodes (QDLEDs) have been extensively studied and developed for the future of optoelectronic applications. In the work, we fabricate an inverted CdSe/ZnS quantum dot (QD) based light-emitting diodes (QDLED). In order to reduce work function of indium tin oxide (ITO) electrode for inverted structure, a very thin (<10 nm) polyethylenimine ethoxylated (PEIE) is used as surface modifier[1] instead of conventional metal oxide electron injection layer. The PEIE layer substantially reduces the work function of ITO electrodes which is estimated to be 3.08 eV by ultraviolet photoemission spectroscopy (UPS). From transmission electron microscopy (TEM) study, CdSe/ZnS QDs are uniformly distributed and formed by a monolayer on PEIE layer. In this inverted QDLEDs, blend of poly (9,9-di-n-octyl-fluorene-alt-benzothiadiazolo) and poly(N,N'-bis(4-butylphenyl)-N,N'-bis(phenyl)benzidine] are used as hole transporting layer (HTL) to improve hole transporting property. At the operating voltage of 8 V, the QDLED device emitted spectrally orange color lights with high luminance up to 2450 cd/m2, and showed current efficacy of 0.6 cd/A, respectively.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.6
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• pp.518-526
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• 2019

Purpose: Limited means exist to assess gastrointestinal activity in pediatric patients postoperatively. Recently, myoelectric gastrointestinal activity recorded by cutaneous patches has been shown in adult patients to be predictive of clinical return of gastrointestinal function postoperatively. The aim of this case series is to demonstrate the feasibility of this system in pediatric patients and to correlate myoelectric signals with return of bowel function clinically. Methods: Pediatric patients undergoing abdominal surgery were recruited to have wireless patches placed on the abdomen within two hours postoperatively. Myoelectric data were transmitted wirelessly to a mobile device with a user-interface and forwarded to a cloud server where processing algorithms identified episodes of motor activity, quantified their parameters and nominally assigned them to specific gastrointestinal organs based on their frequencies. Results: Three patients (ages 5 months, 4 year, 16 year) were recruited for this study. Multiple patches were placed on the older subjects, while the youngest had a single patch due to space limitations. Rhythmic signals of the stomach, small intestine, and colon could be identified in all three subjects. Patients showed gradual increase in myoelectric intestinal and colonic activity leading up to the first recorded bowel movement. Conclusion: Measuring myoelectric intestinal activity continuously using a wireless patch system is feasible in a wide age range of pediatric patients. The increase in activity over time correlated well with the patients' return of bowel function. More studies are planned to determine if this technology can predict return of bowel function or differentiate between physiologic ileus and pathologic conditions.

• Clinical and Experimental Pediatrics
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• v.61 no.2
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• pp.59-63
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• 2018

Purpose: Cardiomyopathy is becoming the leading cause of death in patients with Duchenne muscular dystrophy because mechanically assisted lung ventilation and assisted coughing have helped resolve respiratory complications. To clarify cardiopulmonary function, we compared cardiac function between the home ventilator-assisted and non-ventilator-assisted groups. Methods: We retrospectively reviewed patients with Duchenne muscular dystrophy from January 2010 to March 2016 at Gangnam Severance Hospital. Demographic characteristics, pulmonary function, and echocardiography data were investigated. Results: Fifty-four patients with Duchenne muscular dystrophy were divided into 2 groups: home ventilator-assisted and non-ventilator-assisted. The patients in the home ventilator group were older ($16.25{\pm}1.85years$) than those in the nonventilator group ($14.73{\pm}1.36years$) (P=0.001). Height, weight, and body surface area did not differ significantly between groups. The home ventilator group had a lower seated functional vital capacity ($1,038{\pm}620.41mL$) than the nonventilator group ($1,455{\pm}603.2mL$). Mean left ventricular ejection fraction and fractional shortening were greater in the home ventilator group, but the data did not show any statistical difference. The early ventricular filling velocity/late ventricular filling velocity ratio ($1.7{\pm}0.44$) was lower in the home ventilator group than in the nonventilator group ($2.02{\pm}0.62$. The mitral valve annular systolic velocity was higher in the home ventilator group (estimated ${\beta}$, 1.06; standard error, 0.48). Patients with Duchenne muscular dystrophy on a ventilator may have better systolic and diastolic cardiac functions. Conclusion: Noninvasive ventilator assistance can help preserve cardiac function. Therefore, early utilization of noninvasive ventilation or oxygen may positively influence cardiac function in patients with Duchenne muscular dystrophy.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.21 no.2
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• pp.108-116
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• 2009

The present study introduces a Legendre interpolation function which is capable of analyzing wave transformation effectively in a finite element method. A Lagrangian interpolation function has been mostly used for a finite element method with a higher-order interpolation function. Although this function has an advantage of giving an accurate result with less number of elements, simulation time increases. Calculation time can be reduced by mass lumping, whereas the accuracy of solution is lowered. In this study, we introduce a modified Lagrangian interpolation function, Legendre cardinal interpolation, which can reduce simulation time with keeping up favorable accuracy. Through various numerical simulations using a Boussinesq equations model, the superiority of the Legendre cardinal interpolation function to a Lagrangian interpolation function was shown.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.4
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• pp.547-554
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• 2016

Analyze the customer daily load patterns, be used to determine the optimal charging and discharging schedule which can minimize the electrical charges through the battery energy storage system(BESS) installed in consumers is an object of this paper. BESS, which analyzes the load characteristics of customer and reduce the peak load, is essential for optimal charging and discharging scheduling to save electricity charges. This thesis proposes optimal charging and discharging scheduling method, using particle swarm optimization (PSO) and penalty function method, of BESS for reducing energy charge. Since PSO is a global optimization algorithm, best charging and discharging scheduling can be found effectively. In addition, penalty function method was combined with PSO in order to handle many constraint conditions. After analysing the load patterns of target BESS, PSO based on penalty function method was applied to get optimal charging and discharging schedule.