• The Korean Journal of Pain
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• v.31 no.1
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• pp.43-49
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• 2018

Background: Chronic pain reportedly exerts complex effects on immune function. Natural killer (NK) cells are lymphocytes that play a critical role in cellular and innate immunity. This study examined changes in the subset populations and cytotoxic activity of peripheral blood NK cells in patients with chronic pain. Methods: Thirty patients with chronic moderate-to-severe pain (group P) and age-matched pain-free subjects (group NoP) were enrolled. Peripheral whole blood was analyzed for the percentage and expression of NK cell surface markers (CD56 and CD16) by flow cytometry. Cytotoxic activity was assayed by evaluating CD69 expression on $CD3^-/CD56^+NK$ cells. Results: The percentage of NK cells among total lymphocytes was not significantly different between groups P and NoP ($16.3{\pm}9.3$ vs. $20.2{\pm}10.5%$). Likewise, the percentages of two major NK cell subsets, $CD56^{bright}$ and $CD56^{dim}$, were also not significantly different between the two groups. However, the percentage of $CD56^{bright}/CD16^+$ subset, was slightly but significantly increased in group P ($1.0{\pm}0.9%$; P< 0.01) compared with group NoP ($0.5{\pm}0.6%$). The cytotoxicity of NK cells was not different between the two groups, showing similar CD69 expression (P vs. $NoP=29.2{\pm}15.2$ vs. $32.0{\pm}15.0%$). These findings were not influenced by pain intensity, opioid use, or disease causing pain in group P. Conclusions: NK cell cytotoxic activity and major subset populations, with the exception of an increased percentage of the $CD56^{bright}/CD16^+$ subset, are not significantly altered in patients with chronic severe pain.

• Journal of the Korean Society for Marine Environment & Energy
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• v.10 no.2
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• pp.107-111
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• 2007

A two-dimensional numerical method for inviscid two-fluid flows with evolution of density interface is developed, and an initially stationary two-dimensional fluid sheet surrounded by another fluid is studied. The interface between two fluids is modeled as a vortex sheet, and the flow field with the evolution of interface is solved by using vortex-in-cell/front-tracking method. The edge of the sheet is pulled back into the sheet due to surface tension and a blob is formed at the edge. This blob and fluid sheet are connected by a thin neck. In the inviscid limit, such process of the blob and neck formation is examined in detail and their kinematic characteristics are summarized with dimensionless parameters. The edge recedes at and the capillary wave propagating into the fluid sheet must be considered for better understanding of the edge receding.

• Journal of Korea Water Resources Association
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• v.36 no.5
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• pp.777-785
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• 2003

A numerical model for the solution of two-dimensional free surface flow is developed on unstructured grid. By using fractional step method, the two-dimensional shallow water equations (SWE) are treated as two one-dimensional problems. Thus, it is possible to simulate computational hydraulic problems with higher computational efficiency. The one-dimensional problems are solved using upwind TVD version of second-order Weighted Averaged Flux (WAF) scheme with HLLC approximate Riemann solver. The numerical oscillations which are common with second-order numerical scheme are controlled by exploiting WAF flux limiter, Some idealized test problems are solved using this model and very accurate and stable solutions are obtained. It can be concluded as an efficient implement for the computation of SWE including dam break problems that concerning discontinuities, subcritical and supercritical flows and complex domain.

• Journal of Navigation and Port Research
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• v.38 no.6
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• pp.585-591
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• 2014

The primary objective of the current work is to predict speed performance of the medium patrol boat over $F_N=0.5$ employing experimental materials based on the CFD before model tests. In other words, the predicted brake powers according to ship speeds are assessed satisfying the main engine capacity. The subject ships are selected the two different stern hull forms. The flow computation are conducted considering free surface and dynamic trim using a commercial CFD code(STAR-CCM+). The resistances of the bare-hull are obtained from CFD. Wave patterns, pressures and limiting streamlines on the hull and velocity distribution in the propeller plane for the two hull forms are compared using CFD. The effective powers of the object ships are assessed based on CFD. Resistance increase according to the attached appendages and quasi-propulsive efficiency are employed the experimental datas. Speed performance prediction method concerning high speed vessels like a medium patrol boat is developed employing CFD and experimental data.

• Journal of Korea Water Resources Association
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• v.47 no.12
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• pp.1165-1176
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• 2014

In a river bend the water surface is inclined by the centrifugal force toward the transverse section. If channel slope and flow rate increase, the gradient is rising generally. There are lots of the flood damage at the bends of mountain river because the flood water levels have exceeded frequently the levee levels which are added a free board to the design flood water level. Therefore the superelevation should be considered in designing the mountainous river bend. In present study it was proposed to estimate the superelevation at the bend of mountain river and the superelevation coefficient defined from multiplying the sub-factors. The values of the influence factors for the superelevation coefficient were suggested from analyzing the superelevation measured at the bends in Yangyangnamdae river and the hydraulic experiments in gravel-bed channel with a $90^{\circ}$ bend. The applicability of these methods to estimate the superelevation at the bends in mountain river was verified by the superelevation measured at the bend in Naerin river.

• Journal of Korea Water Resources Association
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• v.33 no.1
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• pp.61-72
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• 2000

The purpose of this study is to improve the method of evaluating groundwater recharge by using grid-based soil moisture routing technique. A model which predicts temporal variation and spatial distribution of soil moisture on a daily time step was developed. The model uses ASCII-formatted map data supported by the irregular gridded map of the GRASS(Geographic Resources Analysis Support System)-GIS and can generate daily and monthly spatial distribution map of surface runoff, soil moisture content, evapotranspiration within the watershed. The model was applied to Ipyunggyo watershed($75.6\;\textrm{km}^2$) located in the upstream of Bocheongchun watershed. Seven maps; DEM(Digital Elevation Mode]), stream, flow path, soil, land use, Thiessen network and free groundwater level, were used for input data. Predicted streamflows resulting from two years (l995, 1996) daily data were compared with the observed values at the watershed outlet. The results of temporal variations and spatial distributions of soil moisture are presented by using GRASS GIS. As a final result, the monthly predicted groundwater recharge was presented.sented.

• Journal of Korean Society of Water and Wastewater
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• v.29 no.1
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• pp.77-88
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• 2015

Soil column experiments were evaluated effects of silver nanoparticles (i.e., 0, 2.5, 5, and 10 mg/L) on the microbial viability which is strongly associated with the degradation of organic matter, pharmaceutically active compounds(PhACs) and biological oxidation of nitrogenous compounds during river bank filtration. The addition of silver nanoparticles resulted in almost no change in the aqueous matrix. However, the intact cell concentration decreased with addition of silver nanoparticles from 2.5 to 10 mg/L, which accounted for 76% to 82% reduction compared to that of control (silver nanoparticles free surface water). The decrease in adenosine triphosphate was more pronounced; thus, the number and active cells in aqueous phase were concurrently decreased with added silver nanoparticles. Based on the florescence excitation-emission matrix and liquid chromatograph - organic carbon detection analyses, it shows that the removal of protein-like substances was relatively higher than that of humic-like substances, and polysaccharide was substantially reduced. But the extent of those substances removed during soil passage was decreased with the increasing concentration of silver nanoparticles. The attenuation of ionic PhACs ranged from 55% to 80%, depending on the concentration of silver nanoparticles. The attenuation of neutral PhACs ranged between 72% and 77%, which was relatively lower than that observed for the ionic PhACs. The microbial viability was affected by silver nanoparticles, which also resulted in inhibition of nitrifiers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.4
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• pp.2868-2875
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• 2015

Both the friction velocity and the friction coefficient have to be estimated to determine flow characteristic in an open channel. In spite of the importances in an open channel, the complete interpretation is highly difficult because of free water surface, the complex of cross section and the various hydraulic parameters. The researches related to the friction factor are based on empirical outcome. Therefore, the equations are difficult to be generally applied. For that reason, the new friction factor estimation equation using the entropy concept was proposed in the present study, and the data measured in rectangular and trapezoid cross sections was used to verify the accuracy of equation. The advantage of the proposed equation dose not use the energy slope term which is difficult to be measured and to be estimated in an open channel. In addition, the proposed method showed that the accurate friction factor f can be estimated on the Basis of theoretical background.

• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.2
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• pp.883-898
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• 2019

This paper employs computational tools to predict power increase (or speed loss) and propulsion performances in waves of KVLCC2. Two-phase unsteady Reynolds averaged Navier-Stokes equations have been solved using finite volume method; and a realizable k-ε model has been applied for the turbulent closure. The free-surface is obtained by solving a VOF equation. Sliding mesh method is applied to simulate the flow around an operating propeller. Towing and self-propulsion computations in calm water are carried out to obtain the towing force, propeller rotating speed, thrust and torque at the self-propulsion point. Towing computations in waves are performed to obtain the added resistance. The regular short head waves of λ/LPP = 0.6 with 4 wave steepness of H/λ = 0.007, 0.017, 0.023 and 0.033 are taken into account. Four methods to predict speed-power relationship in waves are discussed; Taylor expansion, direct powering, load variation, resistance and thrust identity methods. In the load variation method, the revised ITTC-78 method based on the 'thrust identity' is utilized to predict propulsive performances in full scale. The propulsion performances in waves including propeller rotating speed, thrust, torque, thrust deduction and wake fraction, propeller advance coefficient, hull, propeller open water, relative rotative and propulsive efficiencies, and delivered power are investigated.

• Journal of the Korean Society for Marine Environment & Energy
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• v.4 no.1
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• pp.38-46
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• 2001

To assess the oil-containment effectiveness of tandem oil fences placed in currents, the movement of oil droplets in the fore and aft region of the fences is investigated by experimental and numerical methods. The effect of the flexibility of the fence skirt of single fence on the fence effectiveness is also investigated. Laboratory experiment is conducted to trace the path of a spherical solid particle of equivalent density to an oil droplet which was released in a uniform stream ahead of a model oil fence. Depending upon the releasing position and the flow condition there, it was observed that the particle floated up to the free surface, collided with the fence, or escaped below the fence. By analyzing the droplet trajectories, a numerical method is developed to predict the region ahead of the fore fence where an oil droplet initiating its motion eventually escapes beneath the fence. The effect of the relative sizes of the drafts of the fore and aft fences, the fence separation, and the bottom depth of the sea bed on the effectiveness of tandem fences is investigated using the numerically obtained trajectories of oil droplets.