• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3835-3838
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• 2016

Background: Breast cancer is one of the most frequent cancer types within female populations. Silibinin is a chemotherapeutic agent ative against cancer. Niosomes are biodegradable, biocompatible, safe and effective carriers for drug delivery. Objective:To prepare nanoniosomal silibinin and evaluate its cytotoxicity inthe T-47D breast cancer cell line. Materials and Methods: Niosomes were prepared by reverse phase evaporation of a mixture of span 20, silibinin, PEG-2000 and cholesterol in chloroform and methanol solvent (1:2 v/v). The solvent phase was evaporated using a rotary evaporator and the remaining gel phase was hydrated in phosphate buffer saline. Mean size, size distribution and zeta potential of niosomes were measured with a Zetasizer instrument and then nanoparticles underwent scanning electron microscopy. The drug releasing pattern was evaluated by dialysis and the cytotoxicity of nanoniosomes in T-47D cells was assessed by MTT assay. Results: Particle size, size variation and zeta potential of the niosomal nanoparticles were measured as $178.4{\pm}5.4nm$, $0.38{\pm}0.09$ and $-15.3{\pm}1.3mV$, respectively. The amount of encapsulated drug and the level of drug loading were determined $98.6{\pm}2.7%$ and $22.3{\pm}1.8%$, respectively; released drug was estimated about $18.6{\pm}2.5%$ after 37 hours. The cytotoxic effects of nanoniosome were significantly increased when compared with the free drug. Conclusions: This study finding suggests that silibinin nanoniosomes could serve as a new drug formulation for breast cancer therapy.

• Steel and Composite Structures
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• v.6 no.1
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• pp.71-85
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• 2006

This paper presents the results of a series of tests carried out on cold-formed steel rectangular hollow and concrete infilled beam to column connections and frames. A stub column was chosen such that overall buckling does not influence the connection behaviour. The beam chosen was a short-span cantilever with a concentrated load applied at the free end. The beam was connected to the columns along the strong and weak axes of columns and these connections were tested to failure. Twelve experiments were conducted on cold-formed steel direct welded tubular beam to column connections and twelve experiments on connections with concrete infilled column subjected to monotonic loading. In all the experiments conducted, the stiffness of the connection, the ductility characteristics and the moment rotation behaviour were studied. The dominant mode of failure in hollow section connections was chord face yielding and not weld failure. Provision of concrete infill increases the stiffness and the ultimate moment carrying capacity substantially, irrespective of the axis of loading of the column. Weld failure and bearing failure due to transverse compression occurred in connections with concrete infilled columns. Six single-bay two storied frames both with and without concrete infill, and columns loaded along the major and minor axes were tested to failure. Concentrated load was applied at the midspan of first floor beam. The change in behaviour of the frame due to provision of infill in the column and in the entire frame was compared with hollow frames. Failure of the weld at the junction of the beam occurred for frames with infilled columns. Design expressions are suggested for the yielding of the column face in hollow sections and bearing failure in infilled columns which closely predicted the experimental failure loads.

• Journal of Technologic Dentistry
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• v.25 no.1
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• pp.111-118
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• 2003

I measured the movement range on the hinge articulator and the movement range in an oral. And then I studied to analyze the gap. I got wax records by the movement on the hinge articulator, the movement in an oral and the movement on the hand articulating. I measured the distance of the cusp tips that are close to the mesial direction and the distal direction, the buccal direction and the lingual direction then I compared gaps. As I saw results on data, I knew that the hinge articulator represented the range of mandibular movement restrictively. I could find the decisive contradiction that the sliding movement finished on the hinge articulator although it did not finish in an oral. If the sliding movement does not reappear exactly, it brings a fatal failure to the dental prosthesis. In addition it is impossible that the hinge articulator restores the movement in an oral because the lateral condyle inclination and the horizontal condyle inclination are fixed previously. Therefore dental prosthesisses were made by the hinge articulator, they will interfere with a mastication. I have obtained the following results; 1. The distance of sliding movement on the hinge articulator showed shorter than the distance of sliding movement in oral. This means the increase of cusp inclination of the dental prosthesis that was made on the hinge articulator. Therefore, when the lateral movement occurs in oral, there is a possibility to become the premature as the increase of cusp inclination. 2. The results that were impressed records in oral and impressed records on the hand articulating have many congruities. I think that the simple crown etc. that were made by the hand articulating method except the long span bridge and the free end case that can not measure the vertical dimension exactly can represent similarly the mandibular movement. 3. If we want to represent the mandibular movement similarly, we have to use the articulator that can adjust the horizontal condyle inclination and the lateral condyle inclination at least.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.915-921
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• 2015

Context: In the last half century, discovering, developing and introducing of clinical agents from marine sources have seen great successes, with examples including the anti-cancer compound trabectedin. However, with increasing need for new anticancer drugs, further exploration for novel compounds from marine organism sources is strongly justified. Objective: The major aim of this study was to evaluate the antitumor and antioxidant potential of Sargassum tenerrimum J.Agardh (Sargassaceae) on Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Materials and Methods: An ethanol extract of S. tenerrimum (EEST) from whole algae was used to evaluate cytotoxicity followed by in vivo assessment of toxicity, using biochemical parameters including hepatic and non-hepatic enzymes. Antioxidant properties were examined in animals bearing EAC treated with daily oral administration of 100-300 mg/kg extract suspension. Results: Antitumor effects of EEST in EAC bearing mice was observed with LD50 1815 mg/kg. Parameters like body weight, tumor volume, packed cell volume, tumor cell count, mean survival time and increase in life span in animals in the EAC bearing animals treated with EEST 300 mg/kg was comparable with control group. Significant differences were also seen with changes in total protein content, hepatic enzymes contents, MDA level, and free radical scavenging enzymes in untreated vs. EEST treated group animals. Conclusions: Evaluation of antioxidant enzymes and hepatic enzymes in the EAC animal model treated with EEST exhibited similar effects as the positive control drug 5-flurouracil. S. tenerrimum extracts contain effective antioxidants with significant antitumor activity.

• Journal of the military operations research society of Korea
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• v.34 no.2
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• pp.63-77
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• 2008

With the limited frequency spectrum and an increasing demand for cellular communication services, the problem of channel assignment becomes increasingly important. However, finding a conflict free channel assignment with the minimum channel span is NP hard. The innovations are cellular concept, dynamic channel assignment and hierarchical network design. We consider the frequency assignment problem and the base station placement simultaneously. Our model takes the candidate locations emanating from this process and the cost of assigning a frequency, operating and maintaining equipment as an input. Hierarchical network design using genetic algorithm is the first three-tier (Macro, Micro, Pico) model. We increase the reality through applying to Electromagnetic Compatibility Constraints. Computational experiments on 72 problem instances which have $15{\sim}40$ candidate locations demonstrate the computational viability of our procedure. The result of experiments increases the reality and covers 90% of the demand.

• Journal of Korean Society of Steel Construction
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• v.20 no.6
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• pp.761-771
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• 2008

When the crossing frequency of a train meets the natural frequency of a railway bridge, the bridge is bound to become resonant. There are few available time response samples involving a train that passes a bridge at high speed. Very effective modal-parameter extraction techniques for such special high-speed railway bridge conditions are introduced in this paper. Utilizing the cross-correlations of the free-vibration responses after the train passes, mode shapes and the temporal modal parameters (e.g., natural frequency and damping ratio) are extracted using the TDD and SI techniques, respectively. This approach has been applied to a two-span steel composite bridge in the Kyung-Bu high-speed railway system. The estimation results were compared with those obtained using the existing methods. The results fully coincide with those that were extracted using the existing aforementioned technique.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.1
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• pp.48-55
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• 2018

The purpose of the present study is to compare the reduction rate of natural frequency and the increase rate of damping parameter with structural damage in system. For this purpose, experiment and numerical simulation analysis are performed for the 2-span H-Beam with lower natural frequency and higher damping parameter from free vibration in structure. The response signal by impact load before and after damage is analyzed at 14 locations. The response signals for all locations are performed fast fourier transform to estimate the natural frequency reduction rate and wavelet transform to estimate the damping parameter increase rate. The time domain function corresponding to each scale(frequency) is separated from the response signal by wavelet parameter. The estimation of damping parameter increase rate using wavelet transform is more sensitive than the estimation of natural frequency reduction rate in structure.

• Journal of the Korean Society of Hazard Mitigation
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• v.5 no.3 s.18
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• pp.11-21
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• 2005

This study is performed to understand complex behavior and to investigate the rational analysis methods for seismic design of the curved bridges. To analyze the curved bridges for the seismic loadings, it is used that the finite element analysis program has the 7-dof curved beam and straight beam element. The free vibration characteristics of the curved bridges are compared with the straight bridges that have span length same as the average arc length of inside and outside girder of those. For the same case, the dynamic behavior is compared under seismic loadings. It is found that regular bridges classified by AASHTO are analyzed as if those were straight. To investigate the dynamic behavior of general curved bridges under seismic loading, the seismic loading directions and the subtended angle of curved bridges are varied.

• Journal of Dental Rehabilitation and Applied Science
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• v.32 no.3
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• pp.246-254
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• 2016

Nowadays, 3 dimentional (3D) printing, especially Direct Metal Laser Sintering (DMLS) system is used in dentistry. DMLS system has recently been introduced for fabrication metal framework for metal ceramic crowns to overcome the disadvantages of the casting method and computer aided design/computer aided manufacturing (CAD/CAM) milling system. DMLS system uses a high-temperature laser beam to selectively heat a substructure metal powder based on the CAD data with the framework design. A thin layer of the beamed area becomes fused, and the metal framework is completed by laminating these thin layers. Utilizing DMLS system to fabricate fixed prostheses is expected to achieve free-from shaping without mold and limitations from cutting tools, fabricate prostheses with complex geometry, prevent distortion and fabrication defects that inherent to conventional fabrication methods. The purpose of this case report is to demonstrate various fixed prostheses such as long span fixed prostheses, post to achieve satisfactory results in functional and esthetic aspects.

• Journal of Korean Association for Spatial Structures
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• v.12 no.2
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• pp.109-118
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• 2012

Few paper deal with the dynamic bucking under the load with periodic characteristics, and the behavior under periodic excitation is expected the different behavior against STEP excitation. A space frame structure has high stiffness with a structure resisting external forces in steric conformation. According to many structural conditions, structural stability problems in the space frame are determined and considered very important. This study seeks to understand the space frame collapse mechanism using the 2-free nodes truss model in order to examine static structural instability characteristics of the latticed dome. According to geometrical shape, the star dome, parallel lamella dome and three way grid dome were selected as models. The models were examined for characteristics of instability behavior according to rise-span ratio(${\mu}$) and shape imperfection.