• Toxicological Research
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• 제14권4호
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• pp.501-505
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• 1998

The acute toxicity study of combined antibiotic (Cefatrizine / Clavulanic Acid), a formulation consisting of cafatrizine and clavulanic acid in a ratio of 2 : 1, was evaluated in rats. The antibiotic was orally administered with single dose in dose levels up to 5 g/kg (0, 1.25, 2.5, 5 g/kg). Treatment-related effects were limited to soft stool excretion and caecal dilatation, but histologically no morphological changes could be detected in caecum. In hematology, serum-chemistry parameters and histopathology, no drug-related changes were found. The results of the present study indicate that cefatrizine / clavulanic acid has a low toxic potential and the oral $LD_{50}$values exceed 5 g / kg in rats

• Earthquakes and Structures
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• 제16권3호
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• pp.359-368
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• 2019

This paper focuses on the study of dynamic analysis of thick plates resting on Winkler foundation. The governing equation is derived from Mindlin's theory. This study is a parametric analysis of the reflections of the thickness / span ratio, the aspect ratio and the boundary conditions on the earthquake excitations are studied. In the analysis, finite element method is used for spatial integration and the Newmark-${\beta}$ method is used for the time integration. While using finite element method, a new element is used. This element is 17-noded and it's formulation is derived from using higher order displacement shape functions. C++ program is used for the analyses. Graphs are presented to help engineers in the design of thick plates subjected to earthquake excitations. It is concluded that the 17-noded finite element is used in the earthquake analysis of thick plates. It is shown that the changes in the aspect ratio are more effective than the changes in the aspect ratio. The center displacements of the reinforced concrete thick clamped plates for b/a=1, and t/a=0.2, and for b/a=2, and t/a=0.2, reached their absolute maximum values of 0.00244 mm at 3.48 s, and of 0.00444 mm at 3.48 s, respectively.

• Elastomers and Composites
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• 제37권4호
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• pp.234-243
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• 2002

A general scheme of a rubber structure is proposed. Using the thermomechanical method(TMA), some changes in the molecular and topological structures for uncured and cured, and unfilled and filled rubbers during processing are shown. In our investigations as region it is understood a complex structure, which is expressed at the thermomechanical curve(TMC) as a zone differed from others in thermal expansion properties. This zone is between the noticed temperatures of relaxation transitions, usually on the level like those determined by DMTA at 1Hz. These regions, which shares, are not stable, and differ in molecular-weight distribution(MWD) of chain fragments between the junctions. Differences in dynamics of the formation of the molecular and topological structures of a vulcanizate are dependent on the rubber formulation, mixing technology and curing time. Some of characteristics of these regions correlate with mechanical properties of vulcanizates what is shown for NR rubbers containing ENR or CPE as a polymeric additive. It is well known that the state of order influences diffusivity of low-molecular substances into the polymer matrix. Because of this, the two topological amorphous regions should influence the distribution of the ingredients and resulting in rubber compounds' heterogeneity, and related properties of cured rubber. Investigation of this problem is expected to be, in the future, one of the essential factors in determining further improvement of polymeric materials properties by compounding with additives and in reprocessing of rubber scrap.

• 정보화정책
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• 제17권4호
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• pp.23-43
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• 2010

한국의 정보화는 짧은 시간 동안에 커다란 변화를 경험했다. 정보화 정책의 형성과 집행과정에 수많은 인물과 조직이 참여하여 정책의 전개에 영향을 주면서 정보화 정책이 역동적으로 변화하였다. 그러면 국가사회담론으로서 자리 매김한 정보화정책의 확장적 변화와 특성에 영향을 미친 인물이 누구이며, 인적 연결망에 따라 어떠한 변화와 특징을 드러냈는가? 이러한 문제에 대한 해제탐색을 위해 시도된 이 연구의 분석결과, 한국 정보화의 정책전개 및 확장과정에서 정책 관료의 역할이 지배적이었다. 여기에 산업계 및 학계 인사들이 참여하였다. 반면 정치인의 역할은 미약한 것으로 나타났다. 통상 인맥은 학 지 혈연 등에 의해 형성되었지만 정보화정책은 기존의 연(緣)에 의해서라기보다는 정보통신기술을 매개로 한 정책공간에서 형성되었다. 정보통신인맥구성이 이질혼합적임에도 정책줄기가 공고하게 유지될 수 있었던 것은 정보화 중요성, 시급성의 공감대 바탕에서 정보통신기술, 지식과 전문성에 바탕을 둔 연대 또는 유대감이 강하게 작용했기 때문에 가능했던 것으로 판단된다.

• 대한화장품학회지
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• 제17권1호
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• pp.64-80
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• 1991

The SKINTEX Method is based on a two-compartment physico-chemical model which includes a Biomembrane Barrier in compartment one and an organized macromolecular matrix in compartment two. Test samples absorb onto or permeate through the keratin/collagen Biomembrane Barrier and then can interact with the organized macromolecular matrix. Changes in the integrity of the barrier release a dye indicator: Changes in the matrix can alter its transparency. The sum of these two responses is read spectrophotometrically at 470nm. An early investigation of 950 chemicals and formulations in the SKINTEX System produced results which were 89% concordance to in vivo Draize dermal irritation results obtained with 24-hour occluded application of test samples with-out abrasion and standard scoring. Alkaline materials were analyzed in a specialized SKINTEX AMA Protocol. In this early study, the model did not distinguish nonirritant test materials and formulation with PDII(Primary Dermal Irritation Index)in the range from 0 to 1.2, A High Sensitivity Assay Protocol(HSA)was developed to amplify the changes in both compartments of this model and provide more accurate calibration of these changes. A study of 60 low irritation test samples including cosmetics, household products, chemicals and petro-chemicals distinguished nonirritants with PDII $\leq$ 0.7 for 26 of 30 nonirritants. A second protocol was developed to evaluate the SKINTEX model predictability with respect to human irritation. The Human Response Assay (HRA )has been optimized based on differences in penetration and irritation responses in humans and rabbits. An additional 32 test materials with different mechanisms and degrees of dermal toxicity were evaluated by the HRA. These in vitro results were 86% concordant to human patch test results. In order to further evaluate this model, a Standard Chemical Labelling (SCL) Protocol was developed to optimize this system to predict Draize dermal irritation results after a 4-hour application of the test material. In a study of 52 chemicals including acids, bases, solvents, salts, surfactants and preservatives, the SCL results demonstrated 85% concordance to Draize results for a 4-hour application of test samples on non-abraded rabbit skin. The SKINTEX System, including three specialized protocols, provided results which demonstrated good correlation to the endpoint of dermal irritation in man and rabbits at different application times.

• 한국의류산업학회지
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• 제3권5호
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• pp.455-465
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• 2001

Assessing soil removal is of interest to the washing machine industry because of government-mandated energy savings and changes in detergent formulation and consumer laundry practices. We designed this study to examine the laundry process from a holistic perspective by integrating factors perceived to be of importance. Our purpose was to assess the impact of selected variables (fabric and soil type, wash temperature and time. detergent amount, and degree of agitation) on soil removal using accelerated laundry conditions. We used the Taguchi method to develop the research design and ANOVA to analyze the data. Although soil removal was affected by fabric type, soil type, type and amount of detergent, degree of agitation, wash time and temperature, and water hardness and volume, wash temperature was the most significant variable.

• 소성∙가공
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• 제3권1호
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• pp.120-132
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• 1994

Strip drawing of strain-hardening, viscoplastic materials with damage is analyzed by a rigid plastic finite element method. A process model is formulated using two state variables, one for strain hardening from slip dominated plastic distortion and the other for damage from growth of microvoids. Application of the model to aluminum strip drawing is given via implementation in a consistent penalty finite element formulation. The predicted density changes as a result of void growth are compared to those from experiments reported in the literature. The effects of drawing conditions such as drawing speed and die angle on the mechanical property chages are studied.

• 대한기계학회논문집A
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• 제22권3호
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• pp.493-503
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• 1998

The sectional forming analysis considering bending effects from the geometrically deformed shape of two linear membrane finite elements(called super element) was performed under plane strain assumption for analyzing forming processes of an arbitrarily shaped draw-die. For the evaluation of bending effects, the bending equivalent forces are calculated from the bending moment computed using the changes in the interior angle at the middle node of super element, and are agumented to the membrane stretch forces. In order to verify the validity of the bending formulation, the simulation results for the stretch, draw, and bend sections were compared with membrane analysis results and measurements.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.121-122
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• 2006

Paralleled with the development of new materials we need to develop methods and techniques to reveal the environmental interaction and impact of the new materials. Small changes in the chemical structure or product formulation may render the product less environmentally adaptable. Degradation products formed from PLLA were identified after aging in different environments and their assimilation in the biotic environment was shown. Green and degradable hydrogels could be designed from renewable hemicelluloses and lactic acid. Hemicelluloses are a renewable and highly interesting raw material source for new green polymers.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.181-185
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• 2001

This paper deals with the dynamic stability of a disc brake pad taking into account of its shear deformation and rotary inertia. A brake pad can be modeled as a beam like model subjected to distributed friction forces and having two translational springs. The study of this model is intended to provide a fundamental understanding of dynamic stability of drum brake pad. Governing equations of motion are derived from extended Hamilton's principle and their corresponding numerical solutions are obtained by applying the finite element formulation. The critical distributed friction force and the instability types are investigated bt changing two translational spring constants, rotary inertia parameter and shear deformation parameter. Also, the changes of eigen-frequencies of a beam determining instability types are investigated for various combinations of two translational spring constants.