• 제목/요약/키워드: Formulation changes

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Development of a Sunscreen Formulation that Increases UV Blocking Ability by UV Light (자외선에 의해 자외선 차단 효율이 상승하는 선크림 제형 개발)

  • Choi, Minsung;Cho, Hyeongjin;Song, Kyunghee;Song, Seungjin;Kang, Nae-Gyu;Park, Sun-Gyoo
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.45 no.2
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    • pp.139-150
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    • 2019
  • This study is investigated sunscreen formulation that enhances UV absorption efficiency by UV light. Ethylhexyl methoxycinnamate (OMC) is one of the most common UV filters. Many studies have been conducted about photostability of OMC. It is well known that under the UV exposure, trans-OMC could turn to cis-OMC, or produce various photoproducts including its dimers. Those chemical structure changes were understood as the reason of a decrease in UV absorption efficiency upon UV exposure. However, it was found that OMC and isoamyl p-methoxycinnamate (IMC) could even enhance its UV absorption efficiency when it was exposed to UV light in an environment similar to actual use. In order to develop sunscreen formulation that enhances UV absorption efficiency by UV light, emollient with high polarity and compatibility should be avoided from the formular. Those emollient seemed to prevent OMC or IMC from producing photoproducts under UV light. Finally, a sunscreen formulation (UV sensing SPF boosting formular) enhancing UV absorption efficiency by UV was developed by the UV activated SPF boosting technology, and the effect of the sunscreen was evaluated. in vitro SPF of the sunscreen was increased from 50.69 to 72.33 when it was exposed to UV light and its in vivo SPF (53.7) was 56.10% higher than that of the control sunscreen (below 34.4).

Application of Modelling Stress-Strain Relations (Part II) -A Trend of Parameters- (응력-변형률 관계 정식화의 적용성(II) -파라메타의 경향성-)

  • Park, Choon-Sik
    • Journal of the Korean Geotechnical Society
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    • v.29 no.10
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    • pp.19-27
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    • 2013
  • Tatsuoka and Shibuya (1991) suggest a new single formulation applicable not only to a wide range of geo-materials from soft clay to soft rock, but also to a wide range of strain levels from $10^{-6}$ to $10^{-2}$. We have carried out the plain strain compression test employing 7 kinds of research standard sand specimens and 2 kinds of glass beads, which have been used at world-renowned research institutes. With the result applied to Tatsuoka and Shibuya's newly suggested formulation, we studied a trend of parameters. In conclusion, as the value of confining pressure increases, the value of $C_1(X={\infty})$ becomes greater but there are hardly any changes in the value of $C_2(X={\infty})$. The value of $C_1(X={\infty})$ also becomes greater as the ${\delta}$ value increases, regardless of sand types. However, the values of $C_2(X={\infty})$ and $C_2$(X=Xe) do not show any significant changes when there are changes in the value of ${\delta}$, while the values of ${\alpha}$ and ${\beta}$ tend to decrease as the ${\delta}$ value decreases.

Toward Stochastic Dynamic Traffic Assignment Model: Development and Application Experiences (Stochastic Dynamic Assignment 모형의 개발과 활용)

  • 이인원;정란희
    • Journal of Korean Society of Transportation
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    • v.11 no.1
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    • pp.67-86
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    • 1993
  • A formulation of dynamic traffic assignment between multiple origins and single destination was first introduced in 1987 by Merchant and Nemhauser, and then expanded for multiple destination in the late 1980's (Carey, 1987). Based on behavioral choice theory which provides proper demand elasticities with respect to changes in policy variables, traffic phenomena can be analysed more realistically, especially in peak periods. However, algorithms for these models are not well developed so far(working with only small toy network) and solutions of these models are not unique. In this paper, a new model is developed which keeps the simplicity of static models, but provides the sensitivity of dynamic models with changes of O-D flows over time. It can be viewed as a joint departure time and route choice model, in the given time periods(6-7, 7-8, 8-9 and 9-10 am). Standard multinomial logit model has been used for simulating the choice behavior of destination, mode, route and departure time within a framework of the incremental network assignment model. The model developed is workable in a PC 386 with 175 traffic zones and 3581 links of Seoul and tested for evaluating the exclusive use of Namsan tunnel for HOV and the left-turn prohibition. Model's performance results and their statistical significance are also presented.

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A study of how proprietary medicines during the Japanese colonial period led to transforms in Korean medicine and Korean medicine prescriptions (일제강점기 매약을 통해 본 한약의 제형 변화와 새로운 한약 처방의 경향성에 대한 고찰)

  • Hwang, Jihye;Kim, Namil
    • The Journal of Korean Medical History
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    • v.33 no.1
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    • pp.99-112
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    • 2020
  • In this study, we examine the changes to Korean medicine that occurred when 'proprietary medicines' (賣藥) swept through the pharmaceutical market during the Japanese occupation (1910-1945 C.E.). Proprietary medicine during the Japanese colonial period took various forms including ready-made, over-the-counter, patent, and nostrum type pharmaceuticals. This paper examines how Korean medicine, which was the dominant form of medicine during the Joseon Dynasty, was forced to adapt to the rise of proprietary medicines. We found that the prescription of Korean medicine herbal decoctions became more like proprietary medicine in the way that they were formulated. In addition, prescriptions in Korean medicine books were reformulated with prescriptions and medicines from outside the tradition. Proprietary medicines, many of which were made with secret recipes handed down in a family, also attracted attention. Such prescriptions were made famous through advertisements and further influenced future Korean medicine doctors. New prescriptions took advantage of the trust and authority existing in traditional Korean medicine by introducing ginseng and traditional medicinal herbs such as deer antler velvet (鹿茸, Cervi Parvum Cornu). This paper argues that proprietary medicine of the Japanese colonial period distorted the concept of traditional herbal medicine.

DDM Rotordynamic Design Sensitivity Analysis of an APU Turbogenerator Having a Spline Shaft Connection

  • Lee, An-Sung;Ha, Jin-Woong
    • Journal of Mechanical Science and Technology
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    • v.17 no.1
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    • pp.57-63
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    • 2003
  • An eigenvalue design sensitivity formulation of a general nonsymmetric-matrix rotor-bearing system is devised. using the DDM (direct differential method). Then, investigations on the design sensitivities of critical speeds are carried out for an APU turbogenerator with a spline shaft connection. Results show that the dependence of the rate of change of the critical speed on the stiffness changes of bearing models of spline shaft connection points is negligible, and thereby their modeling uncertainty does not present any problem. And the passing critical speeds up to the 4th critical speed are not sensitive to the design stiffness coefficients of four main bearings. Further, the dependence of the rate of change of the critical speed on the shaft-element length changes shows quantitatively that the spline shaft has some limited influence on the 4th critical speed but no influence on the 1st to 3rd critical speeds. With no adverse effect from the spline shaft, the APU system achieves a critical speed separation margin of more than 40% at a rated speed of 60,000 rpm.

Using fourth order element for free vibration parametric analysis of thick plates resting on elastic foundation

  • Ozdemir, Y.I.
    • Structural Engineering and Mechanics
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    • v.65 no.3
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    • pp.213-222
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    • 2018
  • The purpose of this paper is to study free vibration analysis of thick plates resting on Winkler foundation using Mindlin's theory with shear locking free fourth order finite element, to determine the effects of the thickness/span ratio, the aspect ratio, subgrade reaction modulus and the boundary conditions on the frequency paramerets of thick plates subjected to free vibration. In the analysis, finite element method is used for spatial integration. Finite element formulation of the equations of the thick plate theory is derived by using higher order displacement shape functions. A computer program using finite element method is coded in C++ to analyze the plates free, clamped or simply supported along all four edges. In the analysis, 17-noded finite element is used. Graphs are presented that should help engineers in the design of thick plates subjected to earthquake excitations. It is concluded that 17-noded finite element can be effectively used in the free vibration analysis of thick plates. It is also concluded that, in general, the changes in the thickness/span ratio are more effective on the maximum responses considered in this study than the changes in the aspect ratio.

Shear locking-free earthquake analysis of thick and thin plates using Mindlin's theory

  • Ozdemir, Y.I.;Ayvaz, Y.
    • Structural Engineering and Mechanics
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    • v.33 no.3
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    • pp.373-385
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    • 2009
  • The purpose of this paper is to study shear locking-free parametric earthquake analysis of thick and thin plates using Mindlin's theory, to determine the effects of the thickness/span ratio, the aspect ratio and the boundary conditions on the linear responses of thick and thin plates subjected to earthquake excitations. In the analysis, finite element method is used for spatial integration and the Newmark-${\beta}$ method is used for the time integration. Finite element formulation of the equations of the thick plate theory is derived by using higher order displacement shape functions. A computer program using finite element method is coded in C++ to analyze the plates clamped or simply supported along all four edges. In the analysis, 17-noded finite element is used. Graphs are presented that should help engineers in the design of thick plates subjected to earthquake excitations. It is concluded that 17-noded finite element can be effectively used in the earthquake analysis of thick and thin plates. It is also concluded that, in general, the changes in the thickness/span ratio are more effective on the maximum responses considered in this study than the changes in the aspect ratio.

An Experimental Study on the Effect of the Air Temperature on the Air-Side Heat-Transfer Coefficient and the Friction Factor of a Fin-and-Tube Heat Exchanger (외기 온도 변화가 핀-관 열교환기의 공기측 열전달계수와 마찰계수에 미치는 영향에 관한 실험적 연구)

  • Kim, Nae-Hyun;Cho, Honggi
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.29 no.4
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    • pp.149-158
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    • 2017
  • In general, the air-side j and f factors of evaporators or condensers are obtained through single-design tests performed under air-dry and wet-bulb temperatures. Considering that the indoor or outdoor air temperatures vary significantly during the operation of an air conditioner, it is necessary to confirm that the experimentally-obtained j and f factors are widely applicable under variable air conditions. In this study, a series of tests were conducted on a two-row slit-finned heat exchanger to confirm the applicability. The results showed that, for the dry-surface condition, the changes of the tube-side water temperature, water-flow rate, and air temperature had virtually no effect on the air-side j and f factors. For the wet condition, however, the f factor was significantly affected by these changes; contrarily, the j factor is relatively independent regarding this change. The formulation of the possible reasoning is in consideration of the condensation behavior underneath the tube. The wet-surface j and f factors are larger than those of the dry surface, with a larger amount for the f factor.

Effect of Oral Administration of Processed Sulphur on Hepatotoxicity (법제 유황 경구투여가 간독성에 미치는 영향)

  • Song, In-Sun;Youn, Dae-Hwan;Yoo, Hwa-Seung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.4
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    • pp.898-906
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    • 2007
  • This study was to evaluate the effects of oral administration of Processed Sulphur on Hepatotoxicity. Processed Sulphur was administered orally to rats for 28 days. We measured the body and liver weight index, heamtological and biomedical parameters. We also observed the histopathological changes of liver in rats. No significant differences in body weight, liver weight index, heamtological and biomedical parameters and histopathological changes of hepatocyte between control and Processed Sulphur fed group were found. Our data indicate that hepatotoxicity was not caused by oral medication of Processed Sulphur up to 60mg/200g/day for 28 days in rats. Therefore, Processed Sulphur appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) in rats is established at 60mg/200g/day. The data could provide satisfactory preclinical evidence of safety to launch clinical trial on standardized formulation of mineral extracts.

Changes in the Earth's Spin Rotation due to the Atmospheric Effects and Reduction in Glaciers

  • Na, Sung-Ho;Cho, Jungho;Kim, Tu-Hwan;Seo, Kiweon;Youm, Kookhyoun;Yoo, Sung-Moon;Choi, Byungkyu;Yoon, Hasu
    • Journal of Astronomy and Space Sciences
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    • v.33 no.4
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    • pp.295-304
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    • 2016
  • The atmosphere strongly affects the Earth's spin rotation in wide range of timescale from daily to annual. Its dominant role in the seasonal perturbations of both the pole position and spinning rate of the Earth is once again confirmed by a comparison of two recent data sets; i) the Earth orientation parameter and ii) the global atmospheric state. The atmospheric semi-diurnal tide has been known to be a source of the Earth's spin acceleration, and its magnitude is re-estimated by using an enhanced formulation and an up-dated empirical atmospheric S2 tide model. During the last twenty years, an unusual eastward drift of the Earth's pole has been observed. The change in the Earth's inertia tensor due to glacier mass redistribution is directly assessed, and the recent eastward movement of the pole is ascribed to this change. Furthermore, the associated changes in the length of day and UT1 are estimated.