• Computational Structural Engineering : An International Journal
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• v.1 no.2
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• pp.107-116
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• 2001

The present paper investigates the nonlinear behavior of reinforced concrete shear walls with a crank based on a finite element analysis. The loading type is a horizontal cyclic one such as earthquake loads. Experiments of the shear walls with and without cranks, performed previously to see flow the behavior changes depending on the crank, are compared with the results obtained from the finite element analysis. The finite element analysis is based on an isoparametric degenerated shell formulation. The nonlinear constitutive equations fur concrete are modeled adopting the formulation based on a concept of Ring Typed-Lattice Model. The experiments indicate that the shear walls with a crank have low stiffness and relatively low carrying capacity compared with an ordinary plane shear wall without cranks and that they are more ductile, and the tendency is a1so confirmed based on the finite element analysis. Moreover, a good agreement between the experiments and analyses is obtained, accordingly, it is confined that the present numerical analysis scheme based on the Lattice Model is a powerful one to evaluate the behavior of reinforced concrete shear walls with cranks and without cranks.

• BMB Reports
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• v.41 no.3
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• pp.242-247
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• 2008

MSS, a comprising mixture of maesil (Prunus mume Sieb. et Zucc) concentrate, disodium succinate and Span80 (3.6 : 4.6 : 1 ratio) showed a significant improvement of memory when daily administered (460 mg/kg day, p.o.) into the normal rats for 3 weeks. During the spatial learning of 4 days in Morris water maze test, both working memory and short-term working memory index were significantly increased when compared to untreated controls. We investigated a molecular signal transduction mechanism of MSS on the behaviors of spatial learning and memory. MSS treatment increased hippocampal mRNA levels of NR2B and TrkB without changes of NR1, NR2A, ERK1, ERK2 and CREB. However, the protein levels of pERK/ERK and pCREB/CREB were all significantly increased to $1.5{\pm}0.17$ times. These results suggest that the improving effect of spatial memory for MSS is linked to MAPK/ERK signaling pathway that ends up in the phosphorylation of CREB through TrkB and/or NR2B of NMDA receptor.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.04c
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• pp.50-53
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• 2008

In this work, the $TiO_2$ pigment influence in HDPE dielectric strength was analyzed. Chemical and structural characterizations were made to identify changes during the processing and your influence in the electrical properties. Formulations containing 0, 0.5, 1, 2.5, 4 and 6 of titanium dioxide were processed by extrusion and injection molding with stabilization-antioxidants, ultraviolet stabilizers and plasticizers. The electrical strength tests were analyzed by the statistical distribution of Weibull, and the maximum likelihood method. The high concentrations present lower values to electrical strength. The $\beta$ parameter could be using to insulator particles dispersion. The $TiO_2$ concentration variation shows that these incorporations implicate strength values increase has a maximum (5,35MV/cm). High pigment concentration induces a little falls in property values. Observing the $\beta$ parameter, minimum experiment electric field (Ebmin) and electric strength value, found that the best electric perform formulation was the formulation with 2.5% $TiO_2$ weight.

• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.6
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• pp.31-39
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• 2013

A virtual chassis platform for Fuel Cell Hybrid Electric Vehicles(FCHEV) has been developed, and a virtual platform similar to the actual system has been composed. In addition, major components such as a motor, fuel cell and battery for the virtual platform have been constructed by using a mathematical formulation. The FCHEV virtual platform using a detailed model based on the mathematical formula is capable of simulating various conditions according to changes of the control logic and component modules to evaluate performance, considering the vehicle dynamic characteristics. Usability of the mathematical model has been verified by comparative simulations according to the motor current control variation. In addition, reliability of the developed virtual chassis platform has been verified by simulating its fuel consumption with the UDDS(Urban Dynamometer Driving Schedule) FTP-72 velocity profile.

• Structural Engineering and Mechanics
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• v.74 no.4
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• pp.495-502
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• 2020

This study investigated the effects of prestressing force on the natural frequency of concrete beams considering changes in the self-weight of the beam. For this, a finite element formulation was derived to account for the increase in the stiffness of a beam-tendon system due to the axial force and deformation induced by prestressing of the tendon. The developed finite element formulation was validated with the data obtained in laboratory experiments. The experimental natural frequencies of the small prestressed concrete (PSC) beam specimens were consistent with those obtained using the proposed method. The first natural frequency increased almost linearly as the prestressing force increased. The proposed method was then applied to four actual PSC bridges typically employed in the field. Different from the laboratory specimens, the first natural frequencies of the actual PSC bridges barely changed or increased with increasing prestressing force. The results of an analytical parametric study showed that the increase in the natural frequency strongly depended on the magnitude of the prestressing force relative to the total weight of the structure. Thus, the variation in the natural frequencies of the actual PSC bridges with high total weight relative to the prestressing force was negligible due to the application of the prestressing force.

• Journal of Microbiology and Biotechnology
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• v.9 no.1
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• pp.50-55
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• 1999

To develop a new form of controlled release dosage for administering for indomethacin (IND), two formulations of IND-loaded nanoparticles were designed based on polysaccharide (guar) derivatives. Nanoparticles prepared by the dialysis method were characterized with respect to morphology, size distribution, drug content, and in vitro drug release. Morphological studies by scanning electron microscopy (SEM) indicated that guar acetate (GA) nanoparticles were spherical in shape and had a smooth surface. The particle size distributions of formulation I (40mg of GA) and formulation II (80mg of GA) were shown to be $250.78\pm185.13nm$ and $718\pm145.90nm$ in distilled water ($20$^{\circ}C$), respectively. The drug loading efficiencies of nanoparticles were approximately 26% and 31% for formulations I and II, respectively. The differential scanning calorimetry (DSC) results indicated that the IND was perfectly distributed within GA nanoparticles. We also found, from the X-ray diffractometry analysis, that a decrease in the degree of crystallinity of the drug occurred in the nanoparticles. No changes between the original IND and the released IND from GA nanoparticles were detected by FT-IR. Using guar acetate, it is possible to design nanoparticles which allow the controlled release of IND over an extended period of time.

• Archives of Pharmacal Research
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• v.29 no.9
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• pp.795-799
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• 2006

Peptides, although high efficacy and specificity in their physiological function, usually have low therapeutical activities due to their poor bioavailability when administrated orally. Nanoparticles have been regarded as a useful vector for targeted drug delivery system because they can protect drug from being degraded quickly and pass the gastrointestinal barriers. Here we described a novel oral N-trimethyl chitosan nanoparticles formulation containing thymopentin (Tp5-TMC-NP). N-trimethyl chitosan (TMC) was synthesized and then used to prepare Tp5-TMC-NP by ionotropic gelation. A three-factor, five-level CCD (Central Composite Design) design was used in the optimization procedure, with HPLC as the analyzing method. The resulting Tp5-TMC-NP had a regular spherical surface and a narrow particle size range with a mean diameter of 110.6 nm. The average entrapment efficiency was 78.8%. The lyophilized Tp5-TMC-NP formulation was stable in $4^{\circ}C\;or\;-20^{\circ}C$ after storage of 3 months without obvious changes in morphology, particle size, pH and entrapment ratio. The results of the flow cytometer determination showed that the ratio of $CD4^+/CD8^+$ of Wistar female rat given Tp5-TMC-NP (ig) was 2.59 time that of the group given Tp5 (ig).

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8419-8423
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• 2016

Purpose: Anti-cancer activity evaluation of aqueous extract of CRUEL (herbomineral formulation) capsules on renal cell carcinoma cell lines, and exploration of mechanisms of cell death. Materials and Methods: To detect the cytotoxic dose concentration in renal cell carcinoma (RCC) cells, MTT assays were performed and morphological changes after treatment were observed by inverted microscopy. Drug effects against RCC cell lines were assessed with reference to cell cycle distribution (flow cytometry), anti-metastatic potential (wound healing assay) and autophagy(RT-PCR). Results: CRUEL showed anti-proliferative effects against RCC tumor cell lines with an IC50 value of ${\approx}4mg/mL$ in vitro., while inducing cell cycle arrest at S-phase of cell cycle and inhibiting wound healing. LC3 was found to be up-regulated after drug treatment in RT-PCR resulting in an autophagy mode of cell death. Conclusions: This study provides the experimental validation for antitumor activity of CRUEL.

• Advances in Traditional Medicine
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• v.7 no.2
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• pp.128-132
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• 2007

Diarun plus, a polyherbal formulation containing herbal ingredients of folkloric Antidiabetic effect, was investigated for its effect on glycemic status in rats and mice. In contrast to conventional chemical induced diabetic animal models, changes in glycemic states were induced by physiological maneuvers. Results revealed that in euglycemic animals Diarun plus elicited little change (-10 to +10%), which was insignificant. In food deprivation/swim exercise induced hypoglycemia, Diarun plus reduced the degree of hypoglycemia in both rats and mice (from 38% to 27% in rats and 45% to 32% in mice). Similarly, the marked hyperglycemia induced by dextrose (70% in rats and 95% in mice) was reduced markedly to 8% and 25% respectively. The findings of the present study suggests that the ingredients of Diarun plus have the unique property of maintaining near euglycemic state irrespective of the altered glycemic state, and that have no significant effect in euglycemic condition.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.3
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• pp.12-19
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• 2013

Objectives Children's unique taste bud often gives them difficult time to take oriental medicines. To overcome, survey was conducted focusing on useful and practical tips on how to take them. Methods The survey was carried out by posting mail questionnaire. Target clinics for the survey were selected by the internet search engine, Google, Daum, and Naver, and typing in "oriental treatment + pediatrics", "pediatrics + oriental medicine", "pediatric oriental clinic". 24 clinics were searched, but they were further narrowed down to the specialized pediatric oriental clinics. Also, total of 38 inquiry leaflets were distributed to 14 University Oriental Hospitals. Results If children refuse to take the medicine, mixture with sweeteners can be prescribed for them. Among them, oligosaccharide is the most recommended followed by sugar and honey. To avoid rejection to medication, use of different formulation, such as distillation medicine, soft X-Section, granulated medicine, and character printing can be used. Conclusions The most effective method is to investigate the mixture first, and then the alternative formulations.