• Herbal Formula Science
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• v.23 no.2
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• pp.209-224
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• 2015

Objective : The main purpose of this study is to find a reasonable solutions for utilization of herbal formulas based on the medical classics. Methods : We used official Ten 'Selected Korean Medical Classics(SKMC)'. For input of formulas from SKMC, we had to select proper editions of them. After consultations with experts of 'The Korean Medicine Society for the Herbal Formula Study' and 'Korean Society of Medical History', we chose the proper editions of SKMC, and according to those books, we built formulas database using microsoft office excel sheets, respectively. Results : After whole input procedures, we requested several experts to inspect the results and also, to correct errors in them. Input categories were name of formula, name of classic, classification, original source, composition herb, weight, unit of weight, weight conversion index, converted weight, basic formula, indications, reason for modification, preparing method, taking method and contraindications. Final number of whole formulas in DB was 32,882. Conclusions : We used SKMC and built database using excel program. Through this procedure, we can provide a developmental ways to make a foundation for herbal formulas from the medical classics, so that we can make herbal formulas be standardized or industrialized more efficiently.

• Journal of the East Asian Society of Dietary Life
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• v.7 no.1
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• pp.87-95
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• 1997

One- to three-month-old infants (n=232) were compared their upper arm cumference and skinfold thickness(triceps, subscapular) by feeding methods in cross-sectional study. There were two groups : breast-fed(BF) and formula-fed groups(FF). As reported previously, weight, length, head and chest circumferences of these infants were good, and overall growth status was not significantly different by feeding methods, but weight, weight velocity and chest circumference of formula-fed infants were higher than breast-feds at 3month, significantly. Hear, the triceps skinfold thickness of infants at 1, 2, and 3 postpartum months were 7.4, 9.5 and 10.5 mm, respectively. The triceps skinfold thickness of breast-fed infants were higher than formula-feds at 1 and 2 postpartum month, but at 3 month that of formula-fed infants was greater than breast-fed infants, insignificantly. The subscapular skinfold thickness of infants were 6.4, 9.2 and 10.6 mm at 1 to 3 postpartum months, respectively. The upper arm circumference of infants were 11.7, 13.4, 14.3cm, and the arm muscle diameter were 34.5,39.3 and 41.7cm at one to three postpartum months, respectively. The upper arm circumference of male infants was higher than females at 2, 3 postpartum months. Overall, there were no signifiant differences between feeding methods in triceps and subscapular skinfold thickness, upper arm circumference and arm muscle diameter. But 3-month-old formula-fed male infant showed bigger significantly in arm circumference than the breast-feds. From this survey, long-term survey on growth and body composition of large scales might be necessary to determine the effect of feeding methods of infants after 3 months and to set proper body composition standard for infant.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.18 no.4
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• pp.217-223
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• 2015

The obesity epidemic is a worldwide problem. Factors predisposing to obesity include genetics, race, socioeconomic conditions, birth by cesarean section, and perinatal antibiotic use. High protein (HP) content in infant formulas has been identified as a potential culprit predisposing to rapid weight gain in the first few months of life and leading to later obesity. In a large multicountry study the effects of lower protein (LP) formula (1.77 and 2.2 g protein/100 kcal, before and after the 5th month, respectively) were compared to those of higher protein (2.9 and 4.4 g protein/100 kcal, respectively). Results indicated that at 24 months, the weight-for-length z score of infants in the LP formula group was 0.20 (0.06, 0.34) lower than that of the HP group and was similar to that of the breastfed reference group. The authors concluded that a HP content of infant formula is associated with higher weight in the first 2 years of life but has no effect on length. LP intake in infancy might diminish the later risk of overweight and obesity. At 6 years of age HP children had a significantly higher body mass index (by 0.51; 95% confidence interval [CI], 0.13-0.90; p=0.009) and a 2.43 (95% CI, 1.12-5.27; p=0.024) fold greater risk of becoming obese than those who received the LP. In conclusion, several factors may influence development of metabolic syndrome and obesity. Breastfeeding should always be encouraged. An overall reduction of protein intake in formula non breastfed infants seems to be an additional way to prevent obesity.

• Herbal Formula Science
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• v.25 no.2
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• pp.193-207
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• 2017

Objectives : This study was designed to investigate anti-obesity effects of DF in a ob/ob mouse model. Methods : Fifteen-week-old ob/ob mice were divided into four groups: a normal lean group given a standard diet, an ob/ob control group given a standard diet, and DF(1) and DF(2) groups given a standard diet with DF(1) (300 mg/kg), and DF(2) (600 mg/kg), respectively. After 10 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : Body weight gain and fat mass were significantly decreased in DF(1) and DF(2) groups compared with control. The extent of decreases was eminent in DF(2) group. Feeding efficiency ratio were significantly decreased in DF(2) group compared with control. Consistent with their effects on body weight gain and fat mass, circulating concentrations of LDL, total cholesterol, free fatty acid, and insulin were decreased in DF(2) group compared with control. The size of adipocytes were significantly decreased by DF(2) compared with control. Consistent with their effects on body weight gain, hepatic lipid accumulation and liver weights were reduced in DF compared with control. Conclusions : In conclusion, these results suggest that DF not only decrease feeding efficiency ratio, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF also inhibits hepatic lipid accumulation.

• Herbal Formula Science
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• v.19 no.2
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• pp.47-59
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• 2011

Objectives : We investigated the effects of gambigyeongsinhwan2(GGH(2)) on body weight and examined whether blood triglyceride levels and visceral fat are inhibited by it in high fat diet-fed obese male mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 5 groups: C57BL/6N normal, control, GGH(2)-1, GGH(2)-2 and GGH(2)-3. After mice were treated with GGH(2) for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also did histological analysis for liver and fat on the mice. Results : 1. Compared with controls, GGH(2)-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in GGH(2)-3. 2. Compared with controls, GGH(2)-treated mice had lower feeding efficiency ratio, the magnitude of which was prominent in GGH(2)-3. 3. Compared with controls, GGH(2)-treated mice had lower blood plasma triglyceride level. 4. Blood plasma AST and ALT concentrations were not changed by GGH(2), indicating GGH(2) do not show any toxic effects. 5. Consistent with their effects on body weight gain, the size of adipocytes were significantly decreased by GGH(2), whereas the adipocyte number per unit area was significantly increased, suggesting that GGH(2) decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by GGH(2). Conclusions : These results demonstrate that GGH(2) effectively reduces body weight gain, feeding efficiency ratio, blood plasma triglyceride level and improves abdominal fat.

• Herbal Formula Science
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• v.16 no.2
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• pp.205-217
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• 2008

Objectives : We investigated the effects of Herba Ephedrae and Rhizoma Amorphophalli on high fat diet induced obese male mice. Methods : 8 weeks old, high fat diet induced obese male mice were divided into 5 groups: C57BL/6 normal control, obese vehicle control, GGEx55 (Herba Ephedrae), GGEx61 (Rhizoma Amorphophalli), GGEx62 (Herba Ephedrae + Rhizoma Amorphophalli). After mice were treated with GGEx for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, rectal temperature, fat weight, plasma leptin and lipid levels. We also took micro-computerized axial tomography (micro-CT) on the mice. Results : 1. GGEx55 and GGEx62 groups significantly decreased body weight gain and feeding efficiency ratio compared with vehicle control. But they significantly increased rectal temperature. 2. Plasma total cholesterol and LDL-cholesterol concentrations were significantly increased by GGEx55 groups, whereas were significantly decreased by GGEx62 groups compared with vehicle control. 3. GGEx55 and GGEx62 groups significantly decreased total, subcutaneous and visceral fat as well as fat areas in micro-CT analysis of abdomen compared with vehicle control. 4. Plasma GOT and GPT concentrations were significantly increased by GGEx55 groups compared with vehicle control. Conclusions : These results demonstrate that GGEx55 and GGEx62 effectively reduces body weight gain, feeding efficiency ratio in high fat diet induced obese mice, leading to the modulation of obesity. In addition, GGEx55 and GGEx62 decreases visceral adipose tissue mass and improves plasma lipids, suggesting that GGEx55 and GGEx62 may act as a therapeutic agent for obesity.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.4
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• pp.397-404
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• 2005

The propose of this study was to investigate taurine intake in formula-fed and breast-fed infants and to estimate the level of taurine of blood and urine in order to determine the requirement of taurine intake in infants. These results will be useful to suggest the guideline of requirement of taurine intake and may contribute toward the proper use of breast milk substitutes. Experimental groups were breast-fed infants (n=10) and formula-fed infants (n=10) of 20 normal delivery infants in general hospital. This study was longitudinal study from birth up to 16weeks (0 week, 4 weeks, 8 weeks, 12 weeks, 16 weeks). The items of test were anthropometry(weight, height, head circumference, chest circumference), intake of taurine, taurine level of blood and urine in breast-fed and formula-fed infants. There were no significant differences between breast-fed and formula-fed infants in weight, height, head and chest circumference. There is a need for future studies of exclusive infants with larger samples to determine which growth pattern should be considered as the norm. Taurine concentration of plasma and urine did not differ between breast-fed and formula-fed infants. Taurine intake recommendations for infants is about 30mg/day from this study. This data will be useful for production of human-like formula milk and suggestion of an index of selection of a consumer in taurine.

• Herbal Formula Science
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• v.24 no.4
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• pp.335-351
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• 2016

Objective : This study was done to clarify ambiguous non-standard weight and measuring units in medical classics. Methods : Using medical classics and research dissertations, we studied the basic definitions of weight and measuring units and the types of non-standard weight and measuring units. We compared non-standard weight and measuring units in the reference literatures, to determine the dose of herbs in the prescriptions. Results : There are three types of units in non-standard weight and measuring units. These are 'Quantity measuring unit', 'Resembrance measuring unit', and 'Eye measuring unit'. And we found historical efforts and progresses for proper ways to convert non-standard weight and measuring units to standard weight and measuring units. Conclusions : This research will be the basic data for the standardization of prescriptions. Additional study was still required for precise weighing and measuring in Korean medicine and pharmacy.

• Nutrition Research and Practice
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• v.14 no.3
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• pp.230-241
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• 2020

BACKGROUND/OBJECTIVES: Inadequate nutrition in infants and young children affects physical growth and neurocognitive development. Therefore, early nutritional intervention is important to promote catch-up growth in young children with faltering growth. The aim of this study was to evaluate the effect of nutritional supplementation with a pediatric concentrated and balanced nutritional supplement formula on promoting growth and improving nutritional status in children with nonorganic faltering growth. SUBJECTS/METHODS: Children aged 12-36 months whose body weight-for-age was < 5^th percentile on the Korean Growth Charts were enrolled. Children born premature or having organic diseases were excluded. Children were instructed to consume 400 mL of formula per day in addition to their regular diet for 6 months. Pediatricians and dietitians educated the parents and examined the subjects every 2 months. Anthropometric parameters were measured at baseline and at 2, 4, and 6 months, and laboratory tests were done at baseline and 6 months. The good consumption group included children who consumed ≥ 60% of the recommended dose of formula. RESULTS: Total 82 children completed the 6-month intervention. At baseline, there were no significant differences in all variables between the good consumption and poor consumption groups. Weight and weight z-scores were significantly improved in the good consumption group compared to the poor consumption group at the end of the intervention (P = 0.009, respectively). The good consumption group showed a significant trend for gaining weight (P < 0.05) and weight z-score (P < 0.05) compared to the poor consumption group during 6 months of formula intake. The concentration of blood urea nitrogen was significantly increased in the good consumption group (P = 0.001). CONCLUSIONS: Nutritional supplementation with a concentrated and balanced pediatric nutritional formula along with dietary education might be an effective approach to promote catch-up growth in children with nonorganic faltering growth.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.1
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• pp.13-20
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• 2022

Aircraft weight is an important factor affecting performance and fuel efficiency. In the conceptual design stage of the aircraft, the process of balancing cost and weight is performed using empirical formulas such as fuel consumption cost per weight in estimating element weight. In addition, when an airline operates an aircraft, it promotes fuel efficiency improvement, fuel saving and carbon reduction through weight management activities. The relationship between changes in aircraft weight and changes in fuel consumption is called the cost of weight, and the cost of weight is used to evaluate the effect of adding or reducing weight to an aircraft on fuel consumption. In this study, the problems of the existing cost of weight calculation method are identified, and a new cost of weight calculation method is introduced to solve the problem. Using Breguet's Range Formula and actual flight data of the A350-900 aircraft, two weight costs are calculated based on take-off weight and landing weight. In conclusion, it was suggested that it is reasonable to use the cost of weight based on the take-off weight and the landing weight for other purposes. In particular, the cost of weight based on the landing weight can be used as an empirical formula for estimating element weight and optimizing cost and weight in the conceptual design stage of similar aircraft.