• Molecular & Cellular Toxicology
• /
• v.4 no.1
• /
• pp.31-44
• /
• 2008

The forced swim test (FST) is the most widely used model for assessing potential antidepressant activity. Although it has been shown that lateral septum is involved with the FST-related behavior, it is not clear whether antidepressant treatments could alter the FST-induced gene expression profile in the lateral septum. In the present study, the gene expression profiles in response to FST and reboxetine pretreatment were observed in the lateral septum of rats. Reboxetine is known as a most selective serotonin norepinephrine reuptake inhibitor. In addition, we compared the changes in gene expression profile between reboxetine response and nonresponse groups, which were determined by counting FST-related behavior. After FST, lateral septum from controls and reboxetine pretreated group were dissected and gene expression profiles were assessed using an Affymetrix microarray system containing 15,923 genes. Various genes with different functions were changed in reboxetine response group compared with reboxetine nonresponse group, In particular, pleiotrophin, orexin receptor 2, serotonin 2A receptor, neuropeptide Y5 receptor and thyroid hormone receptor $\beta$ were decreased in reboxetine response group, but Lim motif-containing protein kinase 1 (Limk1) and histone deacetylase 1 (HDAC1) were increased. Although further studies are required for direct roles of these genes in reboxetine response, the microarray may provide tools to find out potential target genes and signaling pathways in antidepressant response.

• Journal of KSNVE
• /
• v.8 no.6
• /
• pp.1144-1149
• /
• 1998

A two degree-of-freedom model of suspended cables is studied for forced resonant response. The method of averaging is used to obtain first-order approximations to the response of the system. A bifurcation analysis of the averaged system is performed in the case of 2-to-1 internal resonance. Nonlinear coupled-mode motions are found to bifurcate from single-mode responses and further bifurcate to limit cycle motions via Hopf bifurcations. The limit cycle solutions undergo period doubling bifurcations to chaos.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 1995.04a
• /
• pp.615-619
• /
• 1995

The unbalance response analysis is one of the essential area in the forced vibration analysis of rotor-bearing systems. Local bearing parameters in ortor-bearing systems are the major sources which give rise to a difficulty in unbalance response computation due to the complicated dynamic properties such as rotational speed dependency and anisotropy. In the present paper, an exact condensation procedure is introduced to easily take into account bearing parameters in computation of unbalance responses for rotor bearing systems. The present method is illustrated through a numerical example and compared with the conventional method.

• Proceedings of the Earthquake Engineering Society of Korea Conference
• /
• 2002.03a
• /
• pp.117-124
• /
• 2002

The major purpose of this study is to determine the dynamic behavior of soil-pile-structure interaction system considering the underground cavity. For the analysis, a numerical method fur ground response analysis using FE-BE coupling method is developed. The total system is divided into two parts so called far field and near field. The far field is modeled by boundary element formulation using the multi-layered dynamic fundamental solution that satisfied radiational condition of wave. And this is coupled with near field modeled by finite elements. For the verification of dynamic analysis in the frequency domain, both forced vibration analysis and free-field response analysis are performed. The behavior of soil non-linearity is considered using the equivalent linear approximation method. As a result, it is shown that the developed method can be an efficient numerical method to solve the seismic response analysis considering the underground cavity in 2D problem.

• Structural Engineering and Mechanics
• /
• v.75 no.3
• /
• pp.357-367
• /
• 2020

The objective of this article is investigation of dynamic response of thick multilayer functionally graded (FG) beam under generalized dynamic forces. The plane stress problem is exploited to describe the constitutive equation of thick FG beam to get realistic and accurate response. Applied dynamic forces are assumed to be sinusoidal harmonic, sinusoidal pulse or triangle in time domain and point load. Equations of motion of deep FG beam are derived based on the Hamilton principle from kinematic relations and constitutive equations of plane stress problem. The numerical finite element procedure is adopted to discretize the space domain of structure and transform partial differential equations of motion to ordinary differential equations in time domain. Numerical time integration method is used to solve the system of equations in time domain and find the time responses. Numerical parametric studies are performed to illustrate effects of force type, graduation parameter, geometrical and stacking sequence of layers on the time response of deep multilayer FG beams.

• Computers and Concrete
• /
• v.12 no.6
• /
• pp.803-818
• /
• 2013

In this study, analytical and experimental modal analyses of a scaled bridge model are carried out to extract the dynamic characteristics such as natural frequency, mode shapes and damping ratios. For this purpose, a scaled bridge model is constructed in laboratory conditions. Three dimensional finite element model of the bridge is constituted and dynamic characteristics are determined, analytically. To identify the dynamic characteristics experimentally; Experimental Modal Analyses (ambient and forced vibration tests) are conducted to the bridge model. In the ambient vibration tests, natural excitations are provided and the response of the bridge model is measured. Sensitivity accelerometers are placed to collect signals from the measurements. The signals collected from the tests are processed by Operational Modal Analysis; and the dynamic characteristics of the bridge model are estimated using Enhanced Frequency Domain Decomposition and Stochastic Subspace Identification methods. In the forced vibration tests, excitation of the bridge model is induced by an impact hammer and the frequency response functions are obtained. From the finite element analyses, a total of 8 natural frequencies are attained between 28.33 and 313.5 Hz. Considering the first eight mode shapes, these modes can be classified into longitudinal, transverse and vertical modes. It is seen that the dynamic characteristics obtained from the ambient and forced vibration tests are close to each other. It can be stated that the both of Enhanced Frequency Domain Decomposition and Stochastic Subspace Identification methods are very useful to identify the dynamic characteristics of the bridge model. The first eight natural frequencies are obtained from experimental measurements between 25.00-299.5 Hz. In addition, the dynamic characteristics obtained from the finite element analyses have a good correlation with experimental frequencies and mode shapes. The MAC values obtained between 90-100% and 80-100% using experimental results and experimental-analytical results, respectively.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.13 no.2
• /
• pp.99-107
• /
• 2003

The finite element method(FEM) is the most widely used and powerful method for structural analysis. In general, in order to analyze complex and large structures, we have used the FEM. However, it is necessary to use a large amount of computer memory and computation time for solving accurately by the FEM the dynamic problem of a system with many degree-of-freedom, because the FEM has to deal with very large matrices in this case. Therefore, it was very difficult to analyze the vibration for plate structures with a large number of degrees of freedom by the FEM on a personal computer. For overcoming this disadvantage of the FEM without the loss of the accuracy, the finite element-transfer stiffness coefficient method(FE-TSCM) was developed. The concept of the FE-TSCM is based on the combination of modeling technique in the FEM and the transfer technique in the transfer stiffness coefficient method(TSCM). The merit of the FE-TSCM is to take the advantages of both methods, that is, the convenience of the modeling in the FEM and the computation efficiency of the TSCM. In this paper, the forced vibration analysis algorithm of plate structures is formulated by the FE-TSCM. In order to illustrate the accuracy and the efficiency of the FE-TSCM, results of frequency response analysis for a rectangular plate, which was adopted as a computational model, were compared with those by the modal analysis method and the direct analysis method which are based on the FEM.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.22 no.4
• /
• pp.24-35
• /
• 2018

Impeller blades in the centrifugal compressor are subjected to periodic aerodynamic excitations by interactions between the impeller and the diffuser vanes (DV) in resonant conditions. This may cause high cycle fatigue (HCF) and eventually result in failure of the blades. In order to predict the structural response accurately, the aerodynamic excitation and the major resonant conditions were predicted using unsteady computational fluid dynamics (CFD) and structural analysis. Then, a forced vibration analysis was performed by going through one-way fluid-structure interaction (FSI). A numerical analysis procedure was established to evaluate the structural safety with respect to HCF. The numerical analysis procedure proposed in this paper is expected to contribute toward preventing HCF problems in the initial design stage of an impeller.

• Journal of Ocean Engineering and Technology
• /
• v.19 no.3
• /
• pp.39-46
• /
• 2005

A series of forced oscillation tests on a model mooring chain was carried out to investigate dynamic tension characteristics. The model test was conducted at two different water depths to gather basic data for a 'truncated mooring test' and 'hybrid mooring test'. The truncated and hybrid mooring tests are important for overcoming the limitation of water depth that existed in previous model tests. The resultant tension RAO provides a good possibility of approximation of dynamic tension by equivalent weight adjustment for different water depths. Because the hybrid mooring test is an adequate combination of model test and simulation, an accurate simulation model for the mooring system is essential. The simulation results show good agreement with model test results.

• Journal of Korean Physical Therapy Science
• /
• v.23 no.1
• /
• pp.1-8
• /
• 2016

Purpose : The purpose of this study was to investigate the response of pulmonary function and heart rate recovery of smoker and nonsmoker in males aged 20s after graded maximal exercise. Method : The subjects were composed of smoker group (n=12) and nonsmoker group (n=12) in males aged 20s. Each groups completed an graded maximal exercise with Bruce protocol and were assessed on the pulmonary function(forced vital capacity : FVC, forced expiratory volume-one second : FEV1, FEV1/FVC) and heart rate. Result : The results were as follows: First, heart rate in the measurement point was a statistically significant difference for smoker and non-smoker group after maximal exercise, but FVC, FEV1, FEV1/FVC was no difference. Second, FEV1/FVC between smoker and nonsmoker group was a statistically significant difference after maximal exercise, but FVC, FEV1, heart rate was no difference. Conclusion : The results of this study is that smoking is negative effects on FEV1/FVC of pulmonary function in males aged 20s after maximal exercise.