• Journal of the korean academy of Pediatric Dentistry
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• v.38 no.1
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• pp.95-100
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• 2011

Fibrodysplasia ossificans progressiva(FOP) is characterized by episodes of permanent heterotopic ossifications of soft tissues throughout the body. FOP is inherited in an autosomal dominant pattern, but most cases result from new mutations in the ACVR1 gene. Even minimal trauma can cause permanent ossifications of soft tissues and give rise to complications following routine dental care. Dental block anesthesia, severe stretching of the jaw and biopsies are all contraindicated in children with FOP. There is no effective treatment. Since the prevalence of FOP is very low and most patients with FOP are misdiagnosed during childhood, they undergo dangerous and unnecessary treatment that can lead to permanent harm. For patients with FOP, early diagnosis and prevention of complications are most important. This study aims at contemplating the characteristic features and consideration factors for the dental treatment of FOP patients in relation to the case of an eight years-and-one month old boy who was referred to Pediatric Dentistry due to prolonged retention of mandibular right and left deciduous central incisors after being diagnosed with sporadic FOP at Pediatric Orthopaedics, Seoul National University Hospital, and received dental treatment without the exacerbation of the FOP symptoms.

• The Korean Journal of Food And Nutrition
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• v.28 no.4
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• pp.620-627
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• 2015

The present study was carried out to investigate the biological activity of ethanol extracts from fermented Opuntia humifusa with 3 different mushroom mycelia: Phellinus linteus, Lentinula edodes, and Pleurotus ostreatus. Fermented Opuntia humifusa by Phellinus linteus (FOP) and Lentinula edodes (FOL) showed more DPPH and ABTS radical scavenging activities than non-fermented Opuntia humifusa (NFO) and fermented Opuntia humifusa by Pleurotus ostreatus (FOPO). At a concentration of 250 ppm, the ABTS radical scavenging activities of the FOP and FOL were similar to that of BHA, a synthetic antioxidant. The total polyphenol content had a similar tendency to that of the radical scavenging activity. However, the flavonoid content was increased in the order of NFO, FOL, FOPO, and FOP. At all concentrations, the tyrosinase inhibitory activity of FOP and FOPO were significantly higher than that of kojic acid. During adipocyte differentiation, NFO and FOL showed no significant difference in lipid accumulation in 3T3-L1 cells. FOP and FOPO showed a higher fat accumulation inhibitory effect than NFO and FOL. These results provide baseline data for Opuntia humifusa as a novel functional food.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.6
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• pp.100-107
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• 2011

Since transmission and distribution neutral wires are connected with a substation grounding grid, it is very difficult to measure grounding resistance of isolated substation grounding grid after the substation is energized. It is impractical to isolate the grounding grid from other parallel connections such as distribution line neutrals and overhead ground wires for grounding resistance measurement only. In this paper, we proposed and demonstrated a novel measurement method of grounding resistance of isolated substation grounding grid. For this method, grounding current division factor and conventional FOP(Fall-Of-Potential) profiles were measured at power supplying 154[kV] substation. The obtained FOP profile was processed with the measured grounding current division factor to produce the grounding resistance of isolated grounding grid. Simulated FOP profile agreed well with the measured one showing the validity of the proposed method.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.55 no.5
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• pp.195-201
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• 2006

Tower footing resistance and fault current division factor are important design factors for evaluation of the lightning performance of the transmission line and/or design of the grounding electrode system. The periodic measurement of those factors are also important to verify that the grounding performance of the towers has been maintained good. However, the direct measurement of those factors in operating or energized condition is very difficult because of many practical reasons, such as the difficulty of disconnecting overhead groundwires from the tower under test. With supports by GECOL (General Electricitiy Company of Libya), we had a special chance to conduct Fall-Of-Potential (FOP) test on the energized 220 kV transmission towers before and after disconnecting the overhead groundwires from the towers under test. In this paper, the FOP test results on the towers and the fault current division factors estimated from the comparision of the FOP tests with and without overhead groundwires were presented. The computer models for the FOP test simulations were also constructed to find that the simulated results agreed very well with the measured ones.

• Journal of Microbiology and Biotechnology
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• v.26 no.9
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• pp.1613-1619
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• 2016

Francisella tularensis is a highly virulent pathogen of humans and other mammals. Moreover, F. tularensis has been designated a category A biothreat agent, and there is growing interest in the development of a protective vaccine. In the present study, we determine the in vitro and in vivo immune responses of a subunit vaccine composed of recombinant peptides Tul4 and FopA from epitopes of the F. tularensis outer membrane proteins. The recombinant peptides with adjuvant CpG induced robust immunophenotypic change of dendritic cell (DC) maturation and secretion of inflammatory cytokines (IL-6, IL-12). In addition, the matured DCs enabled ex vivo proliferation of naive splenocytes in a mixed lymphocyte reaction. Lastly, we determined the in vivo immune response by assessment of antibody production in C57BL/6 mice. Total IgG levels were produced after immunization and peaked in 6 weeks, and moreover, Tul4-specific IgG was confirmed in the mice receiving peptides with or without CpG. Based on these results, we concluded that the recombinant peptides Tul4 and FopA have immunogenicity and could be a safe subunit vaccine candidate approach against F. tularensis.

• Journal of Microbiology and Biotechnology
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• v.28 no.1
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• pp.157-164
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• 2018

Francisella tularensis (FT), a highly infectious pathogen, is considered to be a potential biological weapon owing to the current lack of a human vaccine against it. Tul4 and FopA, both outer membrane proteins of FT, play an important role in the bacterium's immunogenicity. In the present study, we evaluated the immune response of mice - humanized with human CD34+ cells (hu-mice) - to a cocktail of recombinant Tul4 and FopA (rTul4 and rFopA), which were codon-optimized and expressed in Escherichia coli. Not only did the cocktail-immunized hu-mice produce a significant human immunoglobulin response, they also exhibited prolonged survival against an attenuated live vaccine strain as well as human T cells in the spleen. These results suggest that the cocktail of rTul4 and rFopA had successfully induced an immune response in the hu-mice, demonstrating the potential of this mouse model for use in the evaluation of FT vaccine candidates.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.2
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• pp.49-54
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• 2005

Measuring ground resistance is a typical way of performance evaluation of a grounding electrode. Among various ground resistance measurement methods, FOP (Fall-Of-Potential) method has been widely used, especially in case of a relatively large grounding electrode such as a substation grounding mesh grid Since FOP measurement line has to be increased as the size of grounding electrode increases, however, it is often that securing long enough FOP-line is practically impossible. In this paper, a sophisticated interpretation method of FOP measurement ma which is applicable to large grounding electrode networks, is presented.

• The korean journal of orthodontics
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• v.28 no.2 s.67
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• pp.255-268
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• 1998

This study was investigated to assess the difference of facial height and occlusal plane inclination between normal occlusion group and class II malocclusion group. The subjects consisted of 50 normal occlusion (male 25, female 25) and 50 class II(male 25, female 25) malocclusion patients. All subjects are adult. lateral cephalogram was taken with standard method traced, and digitized for each subjects. The computerized statiscal analysis was carried out with SPSS program. The results were as follows 1. In class II malocclusion group, variables significant different from normal occlusion group were as follows ; SN-FOP, FH-BOP, MP-BOP, AB-BOP, AB-FOP, Facial plane-BOP, FP-FOP 2. In class II malocclusion group, the posterior facial height -especially posterior lower facial height-was significantly smaller than normal occlusion group.(P<0.05) 3. In class II malocclusion group, the angles between occlusal plane and upper and lower incisor, the angle between upper molar and bisected occlusal plane were significantly larger than those of normal occlusion group. (P<0.05) 4. L1 to Mandibular plane (mm) was a unique factor of occlusal plane position that showed significant difference in class II malocclusion group. 5. The correlation between overbite and occlusal plane inclination existed in class II malocclusion group, but the correlation didn't exist in normal occlusion group.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4877-4883
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• 2014

Cervical cancer is one of the leading causes of morbidity and mortality amongst the gynecological cancers worldwide, especially in developing countries. There are few to no initial symptoms and signs. This study was conducted to assess the awareness level of young Pakistani women about cervical cancer and to educate them about this deadly disease. A detailed questionnaire regarding demographic data and information about cervical cancer was distributed in different cities of Punjab. A total of 873 women took part in this survey and 70.1 percent were totally unaware of this cancer. Only 8.5% of the whole surveyed population knew accurately about cancer of cervix, 7% of the surveyed respondents correctly specified the human papilloma virus as the causative agent. Only 5.2% respondents were able to identify the Pap smear test as a diagnostic measure. Out of all the surveyed population only 4.3% of individuals were found to be vaccinated against this disease and the majority was found from the medical profession. Medical professionals, students, working women, housewives and uneducated individuals took active part in this survey. This study demonstrates a low level of awareness among Pakistani women and a need for an active campaign by media and government to increase understanding as well as introducing measures for improved prevention and treatment of cervical cancer.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.50 no.8
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• pp.382-386
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• 2001

Presently, typical maximum probe spacing of soil resistivity survey(Wenners 4 pin method) is 20 m in case of 154 K substation grounding design of KEPCO. This paper examined the effects of maximum probe spacing of wenner method on the equivalent soil modeling and the accuracy of grounding resistance measurement by comparing the calculated FOP(Fall-of-Potential) curves of various soil models with the measured one at 154kV H substation. The comparison results showed that the inaccurate estimation of deep soil resistivity, which is caused from the short probe spacing of soil resistivity survey, can produce large errors on measurement of grounding resistance. In this paper a quantitative analysis of FOP at H substation has been presented.