• Journal of Acupuncture Research
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• v.22 no.2
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• pp.19-32
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• 2005

Objectives : to evaluate the analgesic effect of bee venom acupuncture on Choksamni (ST36) in the collagen-induced arthritis rats and investigate the role played by serotonergic receptor subtypes (5-HT1a, 5-HT2a) in the antinociceptive effect of bee venom acupuncture in a thermal hyperalgesia test Methods : Experiments were performed on 5 week-aged 60 male Sprague-Dawley rats according to National Institute of Health guidelines and the ethical guidelines of the International Association for the Study of Pain (IASP). Arthritis was induced with arthrogenic collagen emulsion (Bovine type II collagen ${\mu}g$ with incomplete Freund's adjuvant $100\;{\mu}g$). The onset of arthritis was considered to be present when erythema and swelling were detected in at least one joint. The thermal hyperalgesia was evaluated weekly with tail flick test in the rats of severity grade 3 without any injury at tail and foot (including inflammation, ulceration, snap). In the fourth week after first immunization, the analgesic effect of bee venom acupuncture (Choksamni, ST36) was measured with consecutive tail flick latency after intraperitoneal injection of spiroxatrine (1mg/kg) and spiperone (1mg/kg). Results : Chronic inflammatory pain was induced as time elapsed after the immunization of arthrogenic collagen and the maximum value was reached from third to fifth week. Chronic inflammatory pain induced by CIA was inhibited by bee venom acupuncture on the left ST36. The analgesic effect of bee venom acupuncture was inhibited by intraperitoneal injection of 5-HT1a antagonist spiroxatrine and 5-HT2a antagonist spiperone. Conclusions : Therefore, a conclusion. that the analgesic effect of bee venom acupuncture in the chronic inflammatory pain is partially mediated by 5-HT1a and 5-HT2a receptors can be made.

• The Journal of the Convergence on Culture Technology
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• v.10 no.4
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• pp.235-240
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• 2024

We designed this study because it is necessary to take health care from middle age for to healthy old age. The purpose of this study was to confirm the effect of middle-aged women on the walking mechanism by applying an exercise program that can achieve the maximum effect through simple exercise regardless of time and place. A total of 20 subjects were selected from middle-aged women aged 45 years or older, with 10 calf-enhancing exercise groups and 10 control groups. As a result of comparing before and after exercise in the calf-enhancing exercise group, the step length left and right, and double support, step time, and speed were improved. As a result of comparing the walking mechanisms of the calf-enhancing exercise group and the non-exercise group after exercise, the step length left and right, and step time left and right were improved. The positive effect of the walking mechanism was shown through the calf-enhancing exercise regardless of time and place. In particular, it is judged that the stride was widened, resulting in an increase in the speed of walking due to the strength of the lower extremities and the shortening of the one-foot support section, resulting in meaningful results. In future studies, it is considered desirable to present measurement data for each life cycle by evaluating all ages, such as adolescents and the elderly, and to provide it as basic data for causing social problems due to lack of normal exercise.

• 한국HCI학회:학술대회논문집
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• 2008.02a
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• pp.420-425
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• 2008

The technique for synthesizing reactive motion in real-time is important in many applications such as computer games and virtual reality. This paper presents a dynamic motion control technique for creating reactive motions in a physically based character animation system. The leg to move in the next step is chosen using the direction of external disturbance forces and states of human figures and then is lifted though joint PD control. We decide the target position of the foot to balance the body without leg cross. Finally, control mechanism is used to generate reactive motion. The advantage of our method is that it is possible to generate reactive animations without example motions.

• CELLMED
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• v.2 no.3
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• pp.23.1-23.7
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• 2012

The healing properties of medicinal maggots (larval stage of Lucilia sericata) are widely used in the chirurgical debridement of non-healing wounds including diabetic foot ulcers, venous and pressure ulcers, where classical approaches have failed. Several kinds of wounds are prone to complications coming out of a specific wound bed environment. There are multi-resistant bacterial species present, their pathogenic impact is multiplied by their ability to form a biofilm. Moreover, immunological events in chronic wounds differ from those in acute wounds. Non-healing wounds are cycled in the early inflammation phase with increased levels of inflammation attributes like inflammation cytokines and matrix metalloproteinases produced by inflammation phase cells. Application of larval therapy promotes progress in the healing process to the next stages involving tissue granulation and re-epithelisation. Larval debridement is an effective method of cleaning the wound of cell debris, necrotic tissue and bacterial load. This happens in a mechanical and biological manner, but the whole complex mechanism of the maggot healing activity is still not fully elucidated. Centuries of clinical practice brings noticeable proof of the maggots' beneficial effect in wound healing management. This long history led to the investigation of the bioactive components of the larval body and its extracts in vitro. We introduce a review which describes the immunomodulation impact of maggot body components on the cellular and molecular levels of the wound healing process.

• BMB Reports
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• v.42 no.12
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• pp.817-822
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• 2009

Type-1 phosphatase (PP-1) was assessed in foot muscle (FM) and hepatopancreas (HP) of estivating (EST) Otala lactea. Snail PP-1 displayed several conserved traits, including sensitivity to inhibitors, substrate affinity, and reduction in size to a 39 kDa catalytic subunit (PP-1c). During EST, PP-1 activity in FM and HP crude extracts was reduced, though kinetics and protein levels of purified PP-1c isoforms were not altered. PP-1c protein levels increased and decreased in nuclear and glycogen-associated fractions, respectively, during EST. Gel filtration determined that a 257 kDa low $K_m$ PP-1$\alpha$ complex decreased during estivation whereas a 76 kDa high $K_m$ complex increased in EST. Western blotting confirmed that the 76 kDa protein consisted of PP-1$\alpha$ and nuclear inhibitor of PP-1 (NIPP-1). A suppression of PP-1 activity factors in the overall metabolic rate depression in estivating snails and the mechanism is mediated through altered cellular localization and interaction with binding partners.

• IMMUNE NETWORK
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• v.12 no.6
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• pp.291-295
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• 2012

We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-${\alpha}$. The fraction also increased the production of TGF-${\beta}$ and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-${\alpha}$, as well as secretion of VEGF, TGF-${\beta}$ and HS may have a new bioactive material for the treatment of skin wound.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.1
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• pp.85.2-85.2
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• 2012

In this paper, we introduce the 3D modeling of the coronal magnetic field in the solar active region by extrapolating from the 2D observational data numerically. First, we introduce a nonlinear force-free field (NLFFF) extrapolation code based on the MHD-like relaxation method implementing the cleaning a numerical error for Div B proposed by Dedner et al. 2002 and the multi-grid method. We are able to reconstruct the ideal force-free field, which was introduced by Low & Lou (1990), in high accuracy and achieve the faster speed in the high-resolution calculation (512^3 grids). Next we applied our NLFFF extrapolation to the solar active region NOAA 10930. First of all, we compare the 3D NLFFF with the flare ribbons of Ca II images observed by the Solar Optical Telescope (SOT) aboard on the Hinode. As a result, it was found that the location of the two foot-points of the magnetic field lines well correspond to the flare ribbon. The result indicates that the NLFFF well capture the 3D structure of magnetic field in the flaring region. We further report the stability of the magnetic field by estimating the twist value of the field line and finally suggest the flare onset mechanism.

• Korean Journal of Applied Biomechanics
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• v.28 no.3
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• pp.159-164
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• 2018

Objective: The aims of this study were to determine the impact peak force and kinematic variables in running speed and investigate the relationship between them. Method: Thirty-nine male heel strike runners ($mean\;age=21.7{\pm}1.6y$, $mean\;mass=72.5{\pm}8.7kg$, $mean\;height=176.6{\pm}6.1cm$) were recruited in this investigation. The impact peak forces during treadmill running were assessed, and the kinematic variables were computed using three-dimensional data collected using eight infrared cameras (Oqus 300, Qualisys, Sweden). One-way analysis of variance ANOVAwas used to investigate the influence of the running speed on the parameters, and Pearson's partial correlation was used to investigate the relationship between the impact peak force and kinematic variables. Results: The running speed affected the impact peak force, stride length, stride frequency, and kinematic variables during the stride phase and the foot angle at heel contact; however, it did not affect the ankle and knee joint angles in the sagittal plane at heel contact. No significant correlation was noted between the impact peak force and kinematic variables in constantrunning speed. Conclusion: Increasing ankle and knee joint angles at heel contact may not be related to the mechanism behind reducing the impact peak force during treadmill running at constant speed.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.52 no.3
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• pp.181-187
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• 2003

For the moving objects with environmental sensors such as object tracking moving robot with audio and video sensors, environmental information acquired from sensors keep changing according to movements of objects. In such case, due to lack of adaptability and system complexity, conventional control schemes show limitations on control performance, and therefore, sensory-motor systems, which can intuitively respond to various types of environmental information, are desirable. And also, to improve the system robustness, it is desirable to fuse more than two types of sensory information simultaneously. In this paper, based on Braitenberg's model, we propose a sensory-motor based fusion system, which can trace the moving objects adaptively to environmental changes. With the nature of direct connecting structure, sensory-motor based fusion system can control each motor simultaneously, and the neural networks are used to fuse information from various types of sensors. And also, even if the system receives noisy information from one sensor, the system still robustly works with information from other sensors which compensates the noisy information through sensor fusion. In order to examine the performance, sensory-motor based fusion model is applied to object-tracking four-foot robot equipped with audio and video sensors. The experimental results show that the sensory-motor based fusion system can tract moving objects robustly with simpler control mechanism than model-based control approaches.

• Journal of Ginseng Research
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• v.17 no.1
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• pp.22-28
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• 1993

This study was undertaken to determine the effects of ginseng total saponin (GTS) on stress- induced analgesia (SIA) in mice. intermittent foot shock (FS)-SIA was antagonized not by on but by naloxone in the tail flick FS-SIA which was not antagonized by naloxone in the T.F. test. On the other hand, GTS did not antagonize the continuous FS-SIA naloxone antagonized in the T.P. test. Also GTS antagonized psychological (PSIF)-SIA which was not antagonized by naloxone in the T.F. test. However, GTS did not antagonize the PSY-SIA which naloxone antagonized in the T.P. test. Forced swimming (FSIP)-SIA was not affected by both GTS and naloxone. These results suggest that the antapeonisms of intermittent FS-SIA in the T.F. test, continuous FS-SIA and PSY-SIA by GTS are mediated by non-opioid mechanisms but the antagonism of intermittent FS-SIA in the T.P. test by GTS is mediated by opioid mechanism.