Journal of Ginseng Research
- Volume 17 Issue 1
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- Pages.22-28
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- 1993
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Effects of Ginseng Total Saponin on Stress-Induced Analgesia
스트레스로 유도된 진통력에 미치는 인삼의 효과
- Kim, Hack-Seang (College of Pharmacy, Chungbuk National University) ;
- Chung, Myeon-Woo (College of Pharmacy, Chungbuk National University) ;
- Jang, Choon-Gon (College of Pharmacy, Chungbuk National University) ;
- Park, Woo-Kyu (College of Pharmacy, Chungbuk National University) ;
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Oh, Ki-Wan
(College of Pharmacy, Chungbuk National University)
- Published : 1993.04.01
Abstract
This study was undertaken to determine the effects of ginseng total saponin (GTS) on stress- induced analgesia (SIA) in mice. intermittent foot shock (FS)-SIA was antagonized not by on but by naloxone in the tail flick FS-SIA which was not antagonized by naloxone in the T.F. test. On the other hand, GTS did not antagonize the continuous FS-SIA naloxone antagonized in the T.P. test. Also GTS antagonized psychological (PSIF)-SIA which was not antagonized by naloxone in the T.F. test. However, GTS did not antagonize the PSY-SIA which naloxone antagonized in the T.P. test. Forced swimming (FSIP)-SIA was not affected by both GTS and naloxone. These results suggest that the antapeonisms of intermittent FS-SIA in the T.F. test, continuous FS-SIA and PSY-SIA by GTS are mediated by non-opioid mechanisms but the antagonism of intermittent FS-SIA in the T.P. test by GTS is mediated by opioid mechanism.