• 한국지역지리학회지
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• 제15권5호
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• pp.554-571
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• 2009

본 연구는 네덜란드 동부 라흐닝언과 그 주변에 위치한 식품산업 클러스터인 푸드밸리의 클러스터 구조 특성과 존립기반을 트리플 힐릭스 혁신체계 관점에서 분석한 것이다. 푸드밸리는 대학을 기반으로 성장한 클러스터이나 산 학 연 관 네트워크 체계에 기반하여, 이른바 트리플 힐릭스 혁신체계를 효과적으로 구축함으로써 세계적인 식품산업 클러스터로 발전하게 되었다. 푸드밸리의 트리플 힐릭스 혁신체계는 '기반구축기' $\rightarrow$ '관계형성기' $\rightarrow$ '발전기' $\rightarrow$ '정착기'에 이르는 4단계의 발전과정을 거치면서 혁신 클러스터로 성장하였다. 이 과정에서, 세계적인 교육 및 연구역량을 보유한 라흐닝언 대학 연구센터(WURC)를 중심으로 한 대학 및 연구기판들은 지역 내외의 기업들과 활발한 지식 이전 및 공유 활동을 통해 파트너십을 형성하는데 중추적 역할을 했다. 아울러 지역 기업들은 국제적 경쟁력을 가진 다국적 농식품 기업들과 기술혁신형 창업기업들이 중심이 되어 푸드밸리소사이어티와 같은 학습 커뮤니티를 형성하여 활발한 지식 창출, 이전 및 공유 활동에 참여하고 있다. 여기에 정부 및 지원기관들은 클러스터의 네트워크 촉진자로서 산 학 연의 주체별 혁신역량과 대학과 기업의 지식 창출, 이전 및 공유 메커니즘을 조성하는데 중요한 역할을 담당하고 있다.

• 농업과학연구
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• 제40권1호
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• pp.61-78
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• 2013

The following four aspects should be examined in detail to revitalize North-East Asian agricultural cooperation specialized with Korea, Japan, and China. First, quality and safety standards of agricultural food should be unified. Secondly, it is necessary to build a food security cooperative system in North-East Asia. If three countries build the system, they can overcome a problem such as unstable supply and demand due to natural disaster, and also they can cope with food crisis. Thirdly, to establish North-East Asian Agro-valley is needed. After forming food production belt that connects Korea, Hokkaido in Japan, and the three north-eastern provinces in China, it is possible to realize high value-added agriculture with producing and processing of complementary food for partner country. Lastly, trilateral FTA negotiations should be managed carefully with operating the agricultural special zone and exclusion or prolong period of removal of tariff on sensitive items.

• 식품기술
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• 제23권3호
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• pp.444-449
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• 2010

본 내용은 2010년 3월 14일부터 3월 20일까지 세계 3대 식품클러스터인 네덜란드 와게닝겐 대학 연구센터(Wageningen UR)와 Food Valley를 방문하여 선진농업 가공기술 현황을 조사하고, 관련분야 연구자 그룹과 인프라 구성을 추진한 것이다. 또한 유럽의 독일과 네덜란드 지역의 식문화 동향 조사와 유형별 쌀 가공식품 수집 등을 통하여 향후 수출상품화 제품개발에 접목하고자 한다.

• 자원ㆍ환경경제연구
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• 제11권1호
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• pp.57-79
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• 2002

동 연구는 미국 캘리포니아주 San Joaquin Valley의 고정오염원들로부터 발생되는 ROG(Reactive Organic Gases) 배출량을 저감하기 위하여 명령통제방식(CAC)과 경제적 유인제도를 적용할 경우의 비용효과성을 비교 분석하였다. 경제적 유인제도로서는 UMPS(uniform marketable permit system)와 LMPS(localized marketable permit system) 배출권거래제도를 적용하였다. 분석결과 배출권거래제도(UMPS, LMPS)를 이용한 ROG 배출량 저감이 명령통제방식보다 비용이 적게 드는 것으로 나타났다. 한편, one-to-one permits trading이 허용되는 UMPS의 경우에는 일부 특정 지역에 대한 환경질이 악화되는 결과를 초래하는 경우가 발생하여, 궁극적으로 San Joaquin Valley의 ROG 배출량 저감을 위해서는 UMPS 방식의 배출권거래제도 도입이 보다 바람직한 것으로 나타났다.

• Preventive Nutrition and Food Science
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• 제12권4호
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• pp.197-201
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• 2007

Genistein is an active component of legumes and other related food shown to be associated with prevention of degenerative diseases such as cancer through inducing signaling pathways. Treatment of genistein resulted in the induction of apoptosis in the cultured cancer cells. This induction of apoptosis was demonstrated by the Tunel assay in these cells. Unveiling the potential of genistein in cytotoxicity via apoptosis when it is treated with estrogen can predict the therapeutic capability of genistein in breast cancers in the presence of endogenous estrogen. We have found that apoptosis induced by genistein treatment in the presence of estrogen is agonistic or antagonistic depending on the concentrations and treatment periods applied in MCF-7 breast cancer cells. For the suppression of cell survival, 24 hr of treatment was required to induce a synergistic agonistic response between estrogen and genistein at low concentrations of genistein. After this period, the agonistic pattern of genistein to estrogen disappeared. The decrement of COX-2 expression in MCF-7 cells treated with genistein was accompanied with the activation of AMPK only at a high concentration of genistein. This association between AMPK activation and down-regulation of COX-2 by genistein was dampened in the presence of estrogen. It was also demonstrated that genistein and estrogen regulate cell survival and apoptosis by modulating p53 and caspase-3 in the opposite direction. These results suggest that genistein has the potential to control breast cancer development, and co-treatment with estrogen can cause agonistic or antagonistic action on breast cancer cell control.

• Journal of Nutrition and Health
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• 제43권5호
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• pp.443-452
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• 2010

Elevated plasma concentration of total homocysteine (ptHcy) is known as an independent risk factor of cardiovascular disease (CVD) and oxidative stress is also commonly implicated in CVD. An association between ptHcy and oxidative stress has recently been suggested. The study objective is to examine the relationship between ptHcy and oxidative stress markers in 103 healthy college students (62 males and 41 females). Plasma levels of ptHcy, oxidative stress markers (conjugated diene, erythrocyte catalase, TRAP, lymphocyte DNA damage), antioxidant vitamins ($\alpha$-tocopherol, $\gamma$-tocopherol, carotenoids), and lipid parameters (total cholesterol, triglyceride, HDL cholesterol) were determined. The results show that the concentration of ptHcy was significantly higher in male subjects ($22.17\;{\pm}\;2.14\;{\mu}mole/L$) than in female subjects ($12.28\;{\pm}\;0.45\;{\mu}mole/L$). There was a negative association between ptHcy and plasma ${\beta}$-carotene in male subjects (p $lt; 0.05), but no correlation between ptHcy and other plasma antioxidant vitamin levels in either gender. However, there were the negative correlations between ptHcy and plasma ${\alpha}$-carotene or ${\beta}$-carotene, and a positive correlation between ptHcy and lymphocyte DNA damage. A significantly low level of ${\alpha}$-carotene or ${\beta}$-carotene was found in male subjects with elevated ptHcy (${\geq}\;15\;{\mu}mol/L$), as compared to those with lower plasma homocysteine. These study results confirmed the views on the association between plasma homocysteine and oxidative stress markers in humans and support the hypothesis that homocysteine promotes the oxidative environment by counteracting the antioxidant defense mechanism.

• 한국환경복원기술학회지
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• 제17권5호
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• pp.43-49
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• 2014

Fairy Pittas use the forest around the valley and Gotjawal as breeding places. This survey was conducted to investigate the characteristic of earthworms, specifically its population density, body size around the breeding site in Gotjawal and the forest around the valley areas from the middle of July to the end of July 2013. A total of 405 individual earthworms were collected in the 100 small established quadrats, in which 315 were found in Gotjawal and 90 were found in the forest around the valley area. The density of earthworms in Gotjawal was significantly higher compared to that forest around the valley area. It was also observed that the body size of earthworms was significantly different between Gotjawal and the forest around the valley area. Proportion of number of individuals which are larger than 7cm in body size was 43%(n=135) in Gotjawal and 84%(n=76) in the forest around the valley area, respectively. Soil area was not important factor to the density of earthworms. We suggest that Gotjawal can be considered as a suitable breeding site for Fairy Pitta because of the richness of its primary food in this area.

• 농촌계획
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• 제11권4호
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• pp.17-24
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• 2005

The sustainable development of local communities is faced with limitation due to poor infrastructure and lack of cooperation among stake-holders. To overcome such circumstances and thus to ensure balanced development of the local communities, the central government is driving construction of innovative cities mainly through transfer of public institutions to local cities. In this study, to contribute to the development of plans for the future agropolis' associated with the transfer of public institutions, efficient organization mechanisms of the agropolis such as basic structure and spatial allocation was examined through analyses of advanced cases(Sophia Antipolis, St. Hyacinthe Science Part Food Valley, Stoneleigh Park) of foreign countries. The analyses showed that the organization of agropolis were consisted of three main components; 1) agricultural and food industry complex conducting R&D, 2) service facilities(information, trade, consulting and advertisement) supporting agricultural and food industries and rural enterprise center in charge of a variety of events including exhibition, rural experience, education, and contest, 3) silver facilities such as hospital and town providing medical service and residence. Based on the results, inventories of facilities which are necessary in 'the future agropolis' and their spatial allocation were suggested.

• Nutrition Research and Practice
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• 제11권1호
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• pp.33-42
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• 2017

BACKGROUND/OBJECTIVE: This study aims to measure the in vitro antioxidant capacity of Korean diet (KD) with American diet (AD) as a control group and to examine the ex vivo DNA damage reduction effect on human lymphocytes. MATERIALS/METHODS: The KD applied in this study is the standard one-week meals for Koreans (2,000 kcal/day) suggested by 2010 Dietary Reference Intakes for Koreans. The AD, which is the control group, is a one-week menu (2,000 kcal/day) that consists of foods that Americans would commonly take in according to the National Health and Nutrition Examination Survey. The antioxidant capacity of each menu was measured by means of the total phenolic assay and 3 in vitro antioxidant activity assays (2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, trolox equivalent antioxidant capacity (TEAC), Oxygen radical absorbance capacity ($ORAC_{ROO{\cdot}}$)), while the extent of ex vivo lymphocyte DNA damage was measured by means of the comet assay. RESULTS: When measured by means of TEAC assay, the in vitro antioxidant capacity of the KD of the day was higher than that of the AD (P < 0.05) while there was no significant difference in total phenolic contents and DPPH and ORAC assays. The ex vivo lymphocyte DNA damage protective effect of the KD was significantly higher than that of the AD (P < 0.01). As for the one-week menu combining the menus for 7 days, the total phenolic assay (P < 0.05) and in vitro antioxidant capacity (P < 0.001, DPPH; P < 0.01, TEAC) of the KD menu were significantly higher than those of the AD menu. Likewise, the ex vivo DNA damage reduction rate of the Korean seven-day menu was significantly higher than that of the American menu (P < 0.01). CONCLUSION: This study demonstrates that the high antioxidant capacity and DNA damage protective effect of KD, which consists generally of various plant foods, are higher than those of typical AD.

• Journal of Nutrition and Health
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• 제43권6호
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• pp.570-577
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• 2010

Water gets magnetically charged when it is contacted with a magnet. Although magnetic water products have been promoted since the 1930's, they have received very little recognition due to questionable effectiveness. Diethylnitrosamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver. In this study, the effect of magnetized water supplementation on lymphocyte DNA damage in ICR mice treated with DEN was evaluated using the Comet assay. Mice were divided into 3 groups: control, DEN, and DEN + magnetized water group. Fifteen mice were maintained in each group for the entire experimental period of 6, 12 and 18 weeks. Five mice in each group were sacrificed at 6, 12, and 18th weeks, followed by the Comet assay using the blood obtained from heart puncture of the mice. The level of lymphocyte DNA damage reflected by tail moment and other DNA damage indices of tail DNA (%) or tail length of the magnetized water group were significantly decreased after the 6th, 12th and 18th weeks of supplementation compared with the positive control, the DEN group. The relative DNA damage of the magnetized water groups compared to the DEN control group after 6th, 12th, and 18th weeks of supplementation were 42.2%, 40.8%, and 32.9% for DNA in tail, 31.2%, 32.6%, and 21.3% for tail length, and 33.8%, 33.8%, and 24.6% for tail moment, respectively. This is the first report demonstrating that magnetized water may be involved in the lowering effect of the DNA damage in DEN-treated ICR mice. This result suggests that the magnetized water might have minimized the DNA damage by improving the antioxidant status of the mice. However, further studies are needed to characterize the condition of the magnetization and examine the long-term effect of the water product.