• Bulletin of the Korean Chemical Society
• /
• v.35 no.9
• /
• pp.2781-2786
• /
• 2014

Human ${\alpha}_1$-antitrypsin (${\alpha}_1$-AT) is a natural inhibitor of neutrophil elastases and has several dozens of genetic variants. Most of the deficient genetic variants of human ${\alpha}_1$-AT are unstable and cause pulmonary emphysema. However, the most clinically significant variant, Z-type ${\alpha}_1$-AT, exhibits retarded protein folding that leads to accumulation of folding intermediates. These aggregate within the endoplasmic reticulum (ER) of hepatocytes, subsequently causing liver cirrhosis as well as emphysema. Here, we studied the role of an ER folding assistant protein Cpr5p on Z-type ${\alpha}_1$-AT folding. Cpr5p was induced > 2-fold in Z-type ${\alpha}_1$-AT-expressing yeast cells compared with the wild type. Knockout of CPR5 exacerbated cytotoxicity of Z-type ${\alpha}_1$-AT, and re-introduction of CPR5 rescued the knockout cells from aggravated cytotoxicity caused by the ${\alpha}_1$-AT variant. Furthermore, Cpr5p co-immunoprecipitated with Z-type ${\alpha}_1$-AT and facilitated its protein folding. Our results suggest that protein-folding diseases may be suppressed by folding assistant proteins at the site of causal protein biosynthesis.

• Journal of the Chungcheong Mathematical Society
• /
• v.18 no.1
• /
• pp.65-72
• /
• 2005

In this paper we will introduce all types of the isotwist foldings of a manifold M into itself. The limits of the isotwist foldings of a manifold are obtained. Also the relations between conditional retraction and this type of the folding are achieved. Finally the variant and invariant of the immersion under the type of folding are deduced.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2012.05a
• /
• pp.697-698
• /
• 2012

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2010.11a
• /
• pp.921-922
• /
• 2010

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.10 no.4
• /
• pp.16-21
• /
• 2011

This paper described an analysis of dynamic mechanism for the industrial two-step folding automatic door using commercial software packages. Two modeling types of operating on the guide rail, the sliding one and the rolling, were adopted to investigate effects of impact force when the door ascends the guide rail. The magnitude of impact force was found very peaklike large over an initial duration of the door's moving up. The amount of damping coefficient for alleviating this shock was controlled to such a moderate degree that the operating conditions can be obtained for the purpose of design. Moreover the behavior of both dynamic stress and deformation were observed for acquirement of structural reliabilities of the combined guide rail and rolling mechanism. This research will be a very useful tool in the near future for the dynamic analysis of the multi-step folding automatic door.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2005.05b
• /
• pp.130-134
• /
• 2005

The objectives of this study are to improve the aerodynamics performance on the down-wind blade system with folding type blade which consists of the folding type rotor blade, wind vane yawing stabilizer and a bevel gearbox. The aerodynamics performance for the new wind turbine system are compared with those of the conventional up-wind blade system. In addition to, a novel multi voltage inverter system is applied for reductions of harmonic.

• Honam Mathematical Journal
• /
• v.35 no.3
• /
• pp.395-406
• /
• 2013

Generalized paper folding sequences $X^n_p$ and $(X_pY_q)^n$ where $X,Y{\in}\{R,L,U,D\}$, and $n,p,q{\in}\mathbb{N}$, and with $p,q{\geq}2$ are classified in this paper. We show that all generalized paper folding sequences $X^n_p$ are classified into one type if we classify generalize paper folding sequences along with the numbers of downwards and upwards. In addition, we investigate the numbers of downwards and upwards in $(X_pY_q)^n$ and prove that all generalized paper folding sequences $(X_pY_q)^n$ are classified into two types.

• Journal of the Korea Furniture Society
• /
• v.13 no.1
• /
• pp.42-47
• /
• 2002

The folding chairs are one of the most necessary furniture for satisfying the moderns' wants which is utilized for limited space rationally. These folding chairs are variously used in interior spaces such as offices, dining areas, and resting areas. They are very easy to move around, so that quiet useful in out door areas, too. Moreover, they play an important role in public spaces as supplementary furniture. The folding chairs have one or several axes, and they are classified according to type of axes like below. 1. Method of divide seating board into 2 and fold, 2. Method of folds seating board and lay on bottom of backboard, 3. Method of fold back board and lay on top of seating board, 4. Method of fold into contact with left and right, 5. Method of gathering legs into one and fold. The folding chairs have to be easy to operate, firm and safe, light for moving around easily, designed for able to change units whenever they have damaged. Change of residential spaces according to the trend towards the nuclear family maximized necessity of limited spaces' use. Therefore, this study provides insights for development of new methods' of folding chairs.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2010.11a
• /
• pp.619-620
• /
• 2010

• Structural Engineering and Mechanics
• /
• v.75 no.2
• /
• pp.229-237
• /
• 2020

The steel slit shear wall (SSSW), made by cutting vertical slits in a steel plate, is increasingly used for the seismic protection of building structures. In the domain of thin plate shear walls, the out-of-plane buckling together with the potential fracture developed at slit ends at large lateral deformation may result in degraded shear strength and energy dissipation, which is not desirable in view of seismic design. To address this issue, the present study proposed a new type of SSSW made by intentionally introducing initial out-of-plane folding into the originally flat slitted plate. Quasi-static cyclic tests on three SSSWs with different amplitudes of introduced out-of-plane folding were conducted to study their shear strength, elastic stiffness, energy dissipation capacity and buckling behavior. By introducing proper amplitude of out-of-plane folding into the SSSW fracture at slit ends was eliminated, plumper hysteretic behavior was obtained and there was nearly no strength degradation. A method to estimate the shear strength and elastic stiffness of the new SSSW was also proposed.