• Journal of Biomedical Engineering Research
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• v.20 no.4
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• pp.503-513
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• 1999

A general expression for the beam patterns of various synthetic aperture(SA) techniques was derived based on a unified SA model. This model was used to analyze and compare the performance of existing SA methods. Based on the theoretical studies, we propose a new synthetic aperture technique that is best suitable for the linear-scan imaging. The proposed method enables dynamic tow-way focusing in real imaging so that the B-mode image resolution can be greatly improved. Compared to the conventional focusing technique, the focused beam pattern by the proposed shows the mainlobe width reduced by half and comparable sidelobe levels. Computer simulation results demonstrated the validity of the theoretical analysis and the proposed SA method.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.8
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• pp.33-41
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• 2021

Recently, many studies have been conducted on substituting fossil fuels with bio-refineries in existing industrial systems using biomass. Among the various bio-refineries, microalgae have received wide attention because it uses inorganic compounds to produce useful substances, which are extracted by a cell disruption process. Although numerous cell disruption methods exist, cell disruption efficiency has been studied by ultrasonic treatment. Ultrasound is a high-frequency (20 kHz or higher) sound wave and causes cell disruption by cavitation when passing through a solvent. In this study, we used the microalgal species Chlorella sp., which was cultured in a plate-type photobioreactor. The experiment was conducted using a continuous low-frequency processing device. The reduction of cells with time due to cell disruption was fitted using a logistic model, and optimum conditions for highly efficient cell disruption were determined by conducting experiments under multiple conditions.

• Clinical Pain
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• v.18 no.2
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• pp.138-141
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• 2019

Lateral epicondylopathy represents pain in the lateral (radial aspect) of the elbow caused by degeneration in the common extensor tendon. Calcium deposit frequently developes in lateral epicondylopathy, with the prevalence up to 46%. There are considerable debates on its treatment protocols for lateral epicondylopathy so far, likewise, the effective treatment method for calcific lateral epicondylopathy has not been established. We report here a case of chronic intractable calcific lateral epicondylopathy treated with ultrasound-guided barbotage and focused type extracorporeal shock wave therapy (ESWT). To our knowledge, this is the first report of calcific lateral epicondylopathy treated by ultrasound-guided barbotage combined with ESWT.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1700-1703
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• 2008

The purpose of this study was to examine the effects of various mechanical stimuli for MC3T3-E1 cells. Among the several mechanical stimulations, we focused on compressive stain and ultrasound. In this study, we developed a bioreactor capable of applying controlled stimuli to scaffolds. PLLA/PCL scaffold was fabricated by using salt-leaching method. We performed dynamic cell culture using preosteoblasts MC3T3-E1 cells with 1MHz, 30mW/cm2 ultrasound and 10% of compressive strain. Result of CCK-8 analysis at 1, 4, 7, 10 days showed that mechanical stimuli had no significant effect for cell proliferation. However, those stimuli influenced ALP(Alkaline phopatase) activity, which is one of differentiation marker.

• Journal of the Korean Society for Nondestructive Testing
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• v.26 no.3
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• pp.181-189
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• 2006

A 2D finite-element numerical simulation has been developed to investigate the generation of ultrasonic waves in a homogeneous isotropic elastic slab under a line-focused laser irradiation. Discussing the physical processes involved in the thermoelastic phenomena, we describe a model for the pulsed laser generation of ultrasound in a metal slab. Addressing an analytic method, on the basis of an integral transform technique, for obtaining the solutions of the elastodynamic equation, we outline a finite element method for a numerical simulation of an ultrasonic wave propagation. We present the numerical results for the displacements and the stresses generated by a line-focused laser pulse on the surface of a stainless steel slab.

• Journal of the Korean Society for Nondestructive Testing
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• v.25 no.6
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• pp.446-450
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• 2005

We have built a spherically focused, not using acoustic mirrors, capacitive micromachined air-coupled ultrasonic transducer. A flexible backplate of a copper/polyimide backplate is used, permitting it to conform to a spherically shaped substrate. The backplate is patterned with $40-{\mu}m$ depressions having $80-{\mu}m$ center-to-center spacing. A $6-{\mu}m$ thick aluminized Mylar film completing the transducer is deformed to allow it to conform to the spherical backplate. The device's frequency spectrum is centered at 805kHz with -6dB points at 440 and 1210kHz.

• Journal of Biomedical Engineering Research
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• v.30 no.5
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• pp.418-427
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• 2009

As many people are westernizing their life style and food consumption habits, a number of patients who have malignant tumors which grow very rapidly and hazardously destroy the human body are increasing. Ultrasonic hyperthermia is not only one of the tumor treatment methods which employs the non-radioactive ultrasonic waves to increase the temperature at the tumor region up to $40\sim45^{\circ}C$ to destroy and suppress tumor cells but also has been proved by many studies. Due to the rapid development of High Intensity Focused Ultrasound(HIFU), the ultrasound hyperthemia extensively boosts its applications in clinical field. For those reasons, Computed simulation factor should be needed before inspection to patients. To prove efficiency of ultrasonic hyperthermia, precise acoustic field measurement considering tissue characteristics and a heating experiment with tissue mimicking material phantom were conducted for effectiveness of simulation program. Finally, in this study, the computer simulation program verified the anticipated temperature effects induced by ultrasound hyperthermia. In the near future, it is hoped that this simulation program could be utilized to improve the efficiency of ultrasound hyperthermia.

• Journal of dental hygiene science
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• v.14 no.2
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• pp.101-106
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• 2014

In this study, we investigated the proliferative and adhesional effect of human osteoblast like MG-63 cell treated with low intensity pulsed ultrasound (LIPUS). We tested the effectiveness of LIPUS in human osteoblast like MG-63 cells. Cell proliferation was measured using a water soluble tetrazolium salts-1 assay. The mRNA expression of alkaline phosphate, vascular endothelial growth factor (VEGF), integrin alpha 2, colla 1A1 were performed by reverse transcription-polymerase chain reaction. LIPUS was no cytotoxicity in human osteoblast like MG-63 cells. In addition, the data show that treatment with 1 MHz and 3 MHz LIPUS on increased proliferation 7 days after. There were significant increased in mRNA expression of alkaline phosphatase, osteocalcin, VEGF, integrin alpha 2 and colla 1A1 (p<0.05). Therefore, the LIPUS significantly increased differential expression of mRNA levels in osteoblast like MG-63 cell and new possibilities in dental clinical practice.

• The Journal of the Acoustical Society of Korea
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• v.31 no.6
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• pp.399-409
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• 2012

In this paper we propose a method for measuring the shear modulus of an ultrasound soft tissue phantom using an acoustic radiation force. The proposed method quantitatively determines the shear modulus based on the rise time of a displacement induced by an acoustic radiation force at the focal point of a focused ultrasound beam. The shear wave speed and shear modulus obtained from the proposed method and a shear wave propagation method were compared to verify the validity of the proposed method. In the shear wave propagation method, the shear modulus is first computed by measuring the propagating speed of a shear wave induced in a phantom by a limited-diffraction transmit field, and then was compared to that obtained with the proposed method in an ultrasound data acquisition system calibrated based on the first computed shear modulus. The relative errors between the two methods were found to be 4% for shear wave speed and less than 9% for shear modulus, confirming the usefulness of the proposed method.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.10
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• pp.63-71
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• 2021

Using fossil fuels in existing industrial systems causes a variety of social problems. Recently, many studies have been conducted on bio-refineries, which aim to actively utilize biomass to reduce the use of fossil fuels and solve various social problems. Among them, research using microalgae as a third-generation biomass has attracted considerable attention. Microalgae use inorganic matter to produce organic matter, and cell destruction is necessary to extract useful organic materials from microalgae. The extracted organic materials are currently used in various industrial fields. Numerous cell-destruction methods exist. We have investigated cell disruption by sonication, especially its efficiency. Ultrasound is a sound wave with frequencies above 20 kHz, and destroys cells by sending high energy through a cavitation that occurs, according to the characteristics of the sound wave. The Dunaliella salina microalgae used in this study was cultured in a flat-type photobioreactor. Experiments were performed using a batch low-frequency processing device. Logistic model was applied to analyze the results of cell-destruction experiments using ultrasound. The proper conditions for the most efficient cell destruction were OD 1.4(microalgae concentration)), 54watt(output power) and 200mL(microalgae capacity).