• Bulletin of the Korean Chemical Society
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• v.32 no.7
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• pp.2286-2300
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• 2011

We synthesized eight G8 molecular transporters (MTs) based on 4 different monosaccharide scaffolds, and studied their biological properties with a special focus on possible mitochondrial targeting and tissue selectivity. The mitochondrial affinity of these MTs was found to be clearly related to the scaffold stereochemistry and also tenuously with the lipophilicity. It may be suggested that in the practical delivery strategy of drugs for the brain and mitochondrial diseases the BBB permeability and mitochondrial affinity should be considered as key parameters, and that an enhanced mitochondrial affinity appears possible by further research on the structure-property relationship of guanidine-rich molecular transporters.

• English Language & Literature Teaching
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• v.12 no.2
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• pp.127-152
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• 2006

For the past 20 years the process approach to writing has been popular in second language writing classrooms. However, there have been very few studies conducted in Korea with regard to the composing processes and the effects of proficiency on writers' usage. The present study attempts to begin to fill this gap. Three groups of college students with different writing proficiency participated in the study: the advanced group, the intermediate group, and the beginning group. The verbal protocol of their writing processes revealed that they approached writing tasks differently. While the advanced writers focused on generating texts and ideas and examined their writing at both global and local levels, the other two groups of students tended to focus on evaluating text at the local level and generated fewer ideas and less text. The findings from this study are then compared to those of some major studies of the composing process as conclusions are subsequently drawn about the specific needs of Korean college writers.

• Proceedings of the Safety Management and Science Conference
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• 2002.05a
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• pp.135-143
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• 2002

On a conceptual point of SCM, as a order of development, physical distribution, logistics management, basic supply chain management and advanced supply chain management etc. they are magnifying gradually, confusing with information and analysis techniques which seems possible. But on executing, it has a lot of problems because it is so complex and wide, so the enterprise which knows necessity of SCM, they don't have a total execution solution. On this paper, we will focus a proposal of alternatives with reasonableness of manufacturing and making a profit of sales department like most of enterprises to overcome carelessness and unready strategy of investment. And we will find a element through a analysis of cases, a statistical method of effective SCM, and actual survey to propose a alternative proposal. And, we will prove the facts that it could be a guiding company which has a ability of cooperation with entities through the founding of supply chain.

• Journal of Industrial Technology
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• v.26 no.B
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• pp.191-198
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• 2006

In this paper, we focus on a question. Which is better between time-based location update method and movement-based location update method? Or, does any other method combining the two methods show better performance? For the question, we propose a hybrid location update scheme, which integrates the time-based and the movement-based methods. In the proposed scheme, a mobile terminal updates its location after n cell boundary crossing and a time interval of T, or the inverse. We derive an analytical solution for the performance of the hybrid scheme with exponential cell resident time. From the numerical analysis, we conclude that the movement-based method seems to have better performance than the time-based and hybrid methods, that is the optimal costs occur at T=0.

• BMB Reports
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• v.49 no.9
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• pp.459-473
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• 2016

Neurodegenerative diseases (NDs) often involve the formation of abnormal and toxic protein aggregates, which are thought to be the primary factor in ND occurrence and progression. Aged neurons exhibit marked increases in aggregated protein levels, which can lead to increased cell death in specific brain regions. As no specific drugs/therapies for treating the symptoms or/and progression of NDs are available, obtaining a complete understanding of the mechanism underlying the formation of protein aggregates is needed for designing a novel and efficient removal strategy. Intracellular proteolysis generally involves either the lysosomal or ubiquitin-proteasome system. In this review, we focus on the structure and assembly of the proteasome, proteasome-mediated protein degradation, and the multiple dynamic regulatory mechanisms governing proteasome activity. We also discuss the plausibility of the correlation between changes in proteasome activity and the occurrence of NDs.

• Management Science and Financial Engineering
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• v.11 no.3
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• pp.47-60
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• 2005

Well-known e-CRM strategy is to focus on profitable customers and pay less attention to unprofitable ones. Moreover, some researchers recommend not serving unprofitable ones any more. However, it often neglects customers indirect value. Deselecting unprofitable customers can raise the issue of bad word-of-mouth publicity especially in the age of the Internet. Some studies pointed out that a customers decision to buy a product or service is often strongly influenced by others. In this paper, we consider customers' word-of-mouth effect on quality learning of inexperienced customers. We show that firms implementing e-CRM must take the effect into the consideration when deselecting unprofitable customers.

• Journal of Korean Society of Rural Planning
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• v.10 no.1 s.22
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• pp.57-64
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• 2004

This study focus on the revitalization of green tourism by the agricultural landscape conservation policy. Today, agricultural landuse for food production is restricted by agricultural products import. In this context, agricultural land use policy should be paradigm shift to the consumers needs which accelerates the green tourism in the rural areas. This research screen the agricultural landscape conservation policy of Japan' system and construct the new policy implementation for agricultural landscape conservation in Korea. For this purpose, agricultural landscape guideline and support system should be established in line with the revitalization of green tourism and agricultural income diversification in the rural areas.

• Journal of environmental and Sanitary engineering
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• v.17 no.1
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• pp.52-56
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• 2002

The study was carried out to evaluate the characteristics of biodegradation by Pseudomonas putida G7 in soil column. The reactor system was used to investigate mass transfer of VOCs as Toluene in a column of unsaturated soil. Determination of the fate of VOCs in unsaturated soil is necessary to evaluate the feasibility of natural attenuation as a VOCs remediation strategy. The objective of this study was to develop a mechanistically based mathematical model that would consider the interdependence of VOC transport, microbial activity, and sorptive interactions in a moist, unsaturated soil. Because the focus of the model was on description of natural attenuation, the advective VOCs transport that is induced in engineered remediation processes such as vapor extraction was not considered. It can be concluded that the coefficient for gas liquid mass-transfer was found to be a key parameter controlling the ability of bacteria to VOCs. Finally, it appeared that bioremediation technology of VOCs which are difficult to be decomposed by chemical methods.

• Asia pacific journal of information systems
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• v.10 no.1
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• pp.165-187
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• 2000

The computer game market has grown rapidly with numerous games produced all over the world. Most games have been developed to make gamers have fun while playing the games. However, there has been little research to address the elements of games that create the perception of being fun. The objectives of this research are to focus on which features provide fun, and then analyze these aspects both qualitatively and quantitatively. This study, through surveys with game players and developers, provides several inputs regarding what it is, that makes certain computer games fun. There are many common characteristics which fun games share, and through grouping and organizing these traits, then compiling the data for use in an AHP(Analytic Hierarchy Process), we measured the disparity in the 'fun' perception between game developer and game user.

• The Journal of Korean Physical Therapy
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• v.16 no.4
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• pp.11-22
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• 2004

The concept of segmental stabilization has been one of the most exciting advancements in the field of physical therapy. Specific deep stabilizing muscle have proven to reverse motor control deficits that occurs after back injury. After an injury, a new motor programming strategy is adopted and there is excessive recruitment of the large , strong , global muscular system works instead of small segmental deep muscle recruitment for stability. Many physical therapists and doctors mistakenly prescribe therapeutic exercise for low back pain to use larger, superficial musculature to strengthen the spine for stability and pain control. But motor control coordination of local segmental muscle is actually the key to stability and pain control, not strengthening of global muscle. A recent focus in physiotherapy management of patients with chronic back pain has been the specific training of muscles surrounding the lumbar spine whose primary role is considered to be the provision of dynamic stability and segmental control to the spine. These are the deep transverse abdominis muscle and lumbar multifudus.