• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.09a
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• pp.35-40
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• 2005

The demand for small and high-capacity optical data storage devices has rapidly increased. The areal density of optical disk is increased using higher numerical aperture objective lens and shorter wavelength source. A wafer-scale stacked micro objective lens with a numerical aperture of 0.85 and a focal length of 0.467mm for the 405nm blue- violet laser was designed and fabricated. A diffractive optical element (DOE) was used to compensate the spherical aberration of the objective lens. Among the various fabrication methods for micro DOE, the UV-replication process is more suitable for mass-production. In this study, an 8-stepped DOE pattern as a master was fabricated by photolithography and reactive ion etching process. A flexible mold was fabricated for improving the releasing properties and shape accuracy in UV-molding process. In the replication process, the effects of exposing time and applied pressure on the replication quality were analyzed. Finally, the shapes of master, mold and molded pattern were measured by optical scanning profiler. The deviation between the master and the molded DOE was less than 0.1um. The efficiency of the molded DOE was measured by DOE efficiency measurement system which consists of laser source, sample holder, aperture and optical power meter, and the measured value was $84.5\%$.

• Journal of Life Science
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• v.26 no.4
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• pp.475-483
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• 2016

The current study was conducted to evaluate beneficial effects of a new formula (CWC-9) using four traditional Oriental medicinal herbs, Cynanchum wilfordii, Rehmannia glutinosa, Polygala tenuifolia, and Acorus gramineus, on hippocampal cells and memory function. To examine the neuroprotective effects of a new four-herb extract, cell viability, cytotoxicity, and reactive oxygen species (ROS) assays were performed in HT22 cells and behavioral tests (Morris water maze and passive avoidance retention), Western blot, and immunohistochemistry were performed in a mouse model of focal cerebral ischemia. In HT22 hippocampal cells, pretreatment with CWC-9 resulted in significantly reduced glutamate-induced cell death with suppression of ROS accumulation caused by glutamate. In a mouse model of focal cerebral ischemia, we observed significant improvement of spatial and short-term memory function by treatment with CWC-9. Phosphorylated p38 mitogen-activated protein kinases (MAPK) in hippocampus of ischemic mice were decreased by treatment with CWC-9, but phosphorylated phosphatidylinositol-3 kinase (PI3K) and cAMP response element binding protein (CREB) were significantly enhanced. By immunohistochemical analysis, we confirmed higher expression of phosphorylation of CREB in the hippocampal neurons of CWC-9 treated mice. These results suggest that new multi-herb formula CWC-9 mainly exerted beneficial effects on cognitive function through regulation of neuro-protective signaling pathways associated with CREB.

• The Journal of the Acoustical Society of Korea
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• v.33 no.5
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• pp.300-308
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• 2014

Photoacoustic imaging is a useful tool for the diagnosis of atherosclerosis because it is capable of providing anatomical and pathological information at the same time. A photoacoustic signal detector is a pivotal element to achieve high spatial resolution, so that it should have broadband spectrum with a high center frequency. Since a photoacoustic imaging probe is directly inserted into blood vessel to diagnose atherosclerosis, the total size of the photoacoustic signal detector should be less than 1 mm. The main purpose of this paper is to demonstrate that PVDF can be used as an active material for the photoacoustic signal detector with a high frequency and broadband characteristic. The photoacoustic signal detector developed in this study was a single element ultrasound transducer with an aperture of $0.5{\times}0.5mm$ and the total size of 1 mm. In the design stage, the natural focal depth was adjusted for an effective focal area to cover the region of interest, i.e., 1~5 mm in depth. This was because geometrical focusing could not be used due to the small aperture. Through a pulse-echo test, it was ascertained that the developed photoacoustic signal detector has the -6 dB bandwidth ranging between 40.1 and 112.8 MHz and the center frequency of 76.83 MHz.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.33 no.3
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• pp.116-123
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• 2023

A high intensity focuses ultrasound (HIFU) is one of the emerging technologies in the biomedical field. The piezoelectric HIFU transducer is a device that utilizes the thermal energy generated by high ultrasound energy. Recently an operating frequency of the HIFU transducer is to expand above a 7 MHz. In this study, the acoustic pressures and temperature distributions in the tissue that generated by the HIFU transducer at 10 MHz were calculated with the finite element method. In addition, the pressure focusing characteristics of the device were analyzed. The geometrical variables are the piezomaterial thickness, lens shape, water height, and film thickness. The results shown that the acoustic pressure increased and saturated gradually when the height/radius (H_L/R_L) ratio of the lens increased. Moreover, the focal area was gradually decreases with H_L/R_L ratio of the lens. In case of the optimized HIFU transducer, the maximum pressure and temperature were analyzed about 19 MPa and 65℃ respectively. And the -3 dB focused distances in the axial and lateral direction are around 2.3 mm and 0.23 mm respectively.

• Journal of the Optical Society of Korea
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• v.1 no.2
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• pp.74-80
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• 1997

300mm F/4.0 telephotolens with diffractive hybrid lens was designed, and its optical performance was tested and compared with a traditional lens system. DOE(Diffractive Optical Element) reconstructs wavefronts using wave phenomena of light to focus the incident light onto the focal point and has negative Abbe number while a traditional lens uses geometrical phenomena of light and has positive Abbe number. Therefore, a diffractive hybrid lens containing both refractive and diffractive elements can remarkably correct chromatic aberration and spherical aberration of an optical system. We investigated and analyzed the optical properties of a diffractive hybrid lens for the visible spectrum, and we used a difractive hybrid lens to design and evaluate a 300mm F/4.0 telephotolens without the special LD(Low Dispersive) glass lens which is costly and difficult to manufacture. Most traditional telephotolenses use the special LD glass for chromatic aberration correcton. Optical performance tests such as resolution and characteristics of aberration of both lens systems using a diffractive hybrid lens and traditional lens were performed.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.8
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• pp.687-692
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• 2015

LAM (Laser-Assisted Machining) is an effective method for processing difficult-to-cut workpieces. The focal length of a LAM system is changed by the change of the workpiece shape during laser preheating; this problem is solved by changing the lens of the laser module. Linear- and rotary-type lens changers were developed to change the laser lens of a LAM system. The linear-type lens changer is operated by a motor with a ball-screw, and the rotary type is operated by a stepping motor. The natural frequency and structural stability of the laser lens changers were confirmed by using a finite element analysis; in addition, the functions of the lens changers were verified by measuring the iterative accuracy. The measured results show that the rotary-type lens changer is more accurate than the linear-type changer.

• Applied Microscopy
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• v.3 no.1
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• pp.45-54
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• 1973

The present study is to determine the toxicity of the fungi isolated from foodstuffs by observing the ultrastructural changes in the mouse liver cells. The results as follows: 1. The toxin-producing fungi were screened by the methods of toxin-screening test(cyto-toxicity test against to HeLa cells and thin layer chromatography). 2. All of the experimental animals treated with isolated fungi were observed the focal necrosis and inflammatory infiltration of liver parenchymal cells. 3. It showed the cytoplasmic changes, such as dilatation of rough endoplasmic reticulum (RER), swelling of mitochondria (mi). increased number of lipid droplet (li) and glycogen (gl), detachment of ribosomes (ri) by observing the electron microscopy. 4. Nuclear and nucleolar alteration were also noted the segregation of nucleolar element and irregularity of nuclear envelopes. 5. As a mass screening, the cytotoxicity test using HeLa cells and thin layer chromatography are feasible methods to detection of the mycotoxin producing fungi from various sources.

• Journal of Korean Ophthalmic Optics Society
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• v.8 no.2
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• pp.99-103
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• 2003

This paper presents lens optimization of the resolution and the distortion for a four-element lens design. In order to have compact optical system, we used the tele-photo type lens composed of a positive and a negative power elements instead of retro-focus lens. The specifications of optical lens design are the focal length of 7.2 mm, the F/number of 2.8 and the field angle of $54.7^{\circ}C$. The MTF values are higher than 0.5 in the spatial frequency range up to 110 lp/mm for all of the designed object heights. Also, it is expected to fulfill all the requirements of a digital still camera lens and especially suited for building low-cost, compact digital cameras because of the low-profile property of the lens design.

• Proceedings of the KWS Conference
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• 2006.10a
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• pp.216-218
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• 2006

The application of aluminium alloy is increasing for lightweight and high quality transport vehicle. In this study, therefore, it is intended to apply the high speed hybrid welding method for marine grade aluminium alloy(A5083) used for shipbuilding that consists of 3 kW CW Nd:YAG laser and MIG welding process. For this purpose, the characteristics of process parameters(laser & arc combine angle and focal position of hybrid head to specimen) are investigated for hybrid fillet joint. This study also describes determination of heat distribution using finite element model of the T-joint fillet weld using the in-house solver which has been validated for different type of welding problems.

• Journal of Sensor Science and Technology
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• v.16 no.6
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• pp.475-483
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• 2007

This paper proposes a readout integrated circuit (ROIC) for $32{\times}32$ infrared focal plane array (IRFPA) detector, which consist of reference resistor, detector resistor, reset switch, integrated capacitor and operational amplifier. Proposed ROIC is designed using $0.35{\;}{\mu}m$ 2P-4M (double poly four metal) n-well CMOS process parameters. Low noise folded cascode operational amplifier which is a key element in the ROIC showed 12.8 MHz unity-gain bandwidth and open-gain 89 dB, phase margin $67^{\circ}$, SNR 82 dB. From proposed circuit, we gained output voltage variation ${\Delta}17{\};mV/^{\circ}C$ when the detector resistor varied according to the temperature.