• Journal of Microbiology and Biotechnology
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• v.31 no.3
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• pp.349-357
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• 2021

Monoclonal antibodies are widely used as diagnostic reagents and for therapeutic purposes, and their demand is increasing extensively. To produce these proteins in sufficient quantities for commercial use, it is necessary to raise the output by scaling up the production processes. This review describes recent trends in high-density cell culture systems established for monoclonal antibody production that are excellent methods to scale up from the lab-scale cell culture. Among the reactors, hollow fiber bioreactors contribute to a major part of high-density cell culture as they can provide a tremendous amount of surface area in a small volume for cell growth. As an alternative to hollow fiber reactors, a novel disposable bioreactor has been developed, which consists of a polymer-based supermacroporous material, cryogel, as a matrix for cell growth. Packed bed systems and disposable wave bioreactors have also been introduced for high cell density culture. These developments in high-density cell culture systems have led to the monoclonal antibody production in an economically favourable manner and made monoclonal antibodies one of the dominant therapeutic and diagnostic proteins in biopharmaceutical industry.

• Journal of the Korean Ceramic Society
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• v.47 no.6
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• pp.590-597
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• 2010

HTGR using a TRISO coated particles as nuclear raw fuel material can be used to produce clean hydrogen gas and process heat for a next-generation energy source. For these purposes, a TRISO coated particle was prepared with 3 pyro-carbon (buffer, IPyC, and OPyC) layers and 1 silicone carbide (SiC) layer using a CVD technique on a spherical $UO_2$ kernel surface as a fissile material. In this study, a spherical $UO_2$ particle was prepared using a modified sol-gel method with a vibrating nozzle system, and TRISO coating fabrication was carried out using a fluidized bed reactor with coating gases, such as acetylene, propylene, and methyltrichlorosilane (MTS). As the results of this study, a spherical $UO_2$ kernel with a sphericity of 1+0.06 was obtained, and the main process parameters in the $UO_2$ kernel preparation were the well-formed nature of the spherical ADU liquid droplets and the suitable temperature control in the thermal treatment of intermediate compounds in the ADU, $UO_3$, and $UO_2$ conversions. Also, the important parameters for the TRISO coating procedure were the coating temperature and feed rate of the feeding gas in the PyC layer coating, the coating temperature, and the volume fraction of the reactant and inert gases in the SiC deposition.

• Particle and aerosol research
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• v.13 no.2
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• pp.79-85
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• 2017

This study identified the loss of minimum fluidization velocity and pressure in accordance with the superficial velocity of $NiO/MoO_3/MoS_2$, a rare metallic oxide and high value-added material in the lab-scale fluidized bed reactor (L=0.25 m, D=0.05 m). The average pressure loss in L/D 1, 2, and 3 of $NiO/MoO_3/MoS_2$ within the scope of superficial gas velocity between 0.07 and 0.45 m/s based on the L/D 1, 2, and 3 of the specimen was shown to be 290~1952 Pa at decreasing flux and 253~1925 Pa at increasing flux. The comparison between the theoretical value proposed by Wen and the test data showed a difference between 0.021~0.36 magnification. Based on these results, this study was able to determine the operation conditions where rare metallic oxides could be applied in real phenomena.

• Applied Chemistry for Engineering
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• v.33 no.5
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• pp.496-501
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• 2022

In this study, an anode material for lithium secondary batteries was manufactured using petroleum-based residual oil, which is a petroleum refining by-product. Among petroleum-based residual oils, pyrolysis fuel oil (PFO), fluidized catalyst cracking-decant oil (FCC-DO), and vacuum residue (VR) were used as carbon precursors. The physicochemical characteristics of petroleum-based residual oil were confirmed through Matrix-assisted laser desorption/ionization Time-of-Flight (MALDI-TOF) and elemental analysis (EA), and the structural characteristics of anode materials manufactured from residual oil were evaluated using X-ray crystallography (XRD) and Raman spectroscopic techniques. VR was found to contain a wide range of molecular weight distributions and large amounts of impurities compared to PFO and FCC-DO, and PFO and FCC-DO exhibited almost similar physicochemical characteristics. From the XRD analysis results, carbonized PFO and FCC-DO showed similar d₀₀₂ values. However, it was confirmed that FCC-DO had a more developed layered structure than PFO in Lc (Length of a and c axes in the crystal system) and La values. In addition, FCC-DO showed the best cycle characteristics in electrochemical characteristics evaluation. According to the physicochemical and electrochemical results of the petroleum-based residual oil, FCC-DO is a better carbon precursor for a lithium secondary battery than PFO and VR.

• Korean Chemical Engineering Research
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• v.61 no.3
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• pp.419-425
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• 2023

This paper presents the research results of analyzing the high-temperature corrosion characteristics of three currently commercialized heat exchanger tube materials under actual operating conditions of a biomass power plant. In order to precisely analyze the high-temperature corrosion characteristics of these materials, a high-temperature corrosion evaluation device was installed in the power plant equipment, which allows for adjusting the surface temperature of the heat exchanger tubes. Experiments were conducted for approximately 300 hours under various temperature and operating conditions. In this study, the commercialized heat exchanger tube materials used were SA213T12, SA213T22, and SA213T91 alloys. In order to objectively analyze the high-temperature corrosion characteristics of each material, an international standard-based process to remove corrosion products was applied to obtain the weight change of the specimens, and the average thickness loss and corrosion rate were derived. Thus, the high-temperature corrosion results for each condition were quantitatively compared and analyzed. In addition, in order to increase the reliability of the high-temperature corrosion evaluation method introduced in this study, the surface and cross-sectional corrosion of the specimens were confirmed by using scanning electron microscopy and energy-dispersive X-ray analysis. Based on these analysis results, it was found that the corrosion resistance of the commercial heat exchanger materials increases as the content of chrome and nickel in the composition increases. Additionally, it was found that the corrosion phenomenon is rapidly accelerated as the surface temperature increases. Finally, the replacement period (lifetime) of the heat exchanger tubes under each condition could be inferred through this study.

• Journal of the Korean Geosynthetics Society
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• v.20 no.2
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• pp.1-11
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• 2021

In this study, a study related to laboratory and pilot test were performed to use an environmental soil stabilizer developed to induce a hardening reaction similar to that of Ordinary Portland Cement (OPC) by using industrial by-products of blast furnace slag and the combustion ash of a circulating fluidized bed boiler as the main material. For this, specimens were prepared using liquid A of sodium silicate and silica sol, and liquid B of an environmental soil stabilizer (or OPC), and laboratory tests were performed to analyze the strength and environmental characteristics. And pilot test was performed on the aging reservoir, field permeability test and electrical resistivity survey were performed in the field to analyze the applicability. As a result of the laboratory test, the homo-gel compressive strength of the chemical injection material using the environmental soil stabilizer as liquid B was about 2.88 to 3.23 times greater than that of OPC. In addition, the elution amount of most heavy metals was lower than that of OPC, and the survival rate in the fish, acute toxicity test was 100%. Therefore, when judged based on the results of the laboratory test, it was analyzed to be superior to OPC in terms of strength and environment. In the results of the pilot test in the aging reservoir, when the environmental soil stabilizer was reinforced with liquid B of the chemical injection material, the coefficient of permeability in the aging reservoir decreased to 1/50 level. In addition, as a result of the electrical resistivity survey, it was analyzed that the electrical resistivity inside the aging reservoir increased as time passed, the saturation zone disappeared, and the overall reinforcement.

• Journal of the Korean GEO-environmental Society
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• v.22 no.3
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• pp.5-13
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• 2021

Due to population growth and industrial development, the amount of industrial waste is increasing every year. In particular, in a thermal power plant using finely divided coal, a large amount of coal ash is generated after combustion of the coal. Among them, fly ash is recycled as a raw material for cement production and concrete admixture, but about 20% is not utilized and is landfilled. Due to the continuous reclamation of such a large amount of coal ash, it is required to find a correct treatment and recycling plan for the coal ash due to problems of saturation of the landfill site and environmental damage such as soil and water pollution. In recent years, the use of a fluid embankment material that can exhibit an appropriate strength without requiring a compaction operation is increasing. The fluid embankment material is a stable treated soil formed by mixing solidifying materials such as water and cement with soil, which is the main material, and has high fluidity before hardening, so compaction work is not required. In addition, after hardening, it is used for backfilling or filling in places where compaction is difficult because higher strength and earth pressure reduction effect can be obtained compared to general soil. In this study, the possibility of use of fluidized soil using high water content cohesive soil and coal ash is considered. And it is intended to examine the flow characteristics, strength, and bearing capacity characteristics of the material, and to investigate the effect of reducing the earth pressure when applied to an underground burial.

• Journal of the Korean Geotechnical Society
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• v.34 no.6
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• pp.17-24
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• 2018

In this study, static load test and dynamic load test were performed to evaluate pile-filling material (ZA-Soil) of soil-cement injected precast pile method which was developed by using the ash of circulating fluidized boiler as a stimulant for alkali activation reaction of blast furnace slag. As a result of the static load test, the allowable bearing capacity of pile was 1,350 kN, which was the same as the result of using ordinary portland cement. And total settlement was 6.97 mm, and net settlement was 1.48 mm. These are similar to the total settlement, 7.825 mm, and net settlement, 2.005 mm of ordinary portland cement. As a result of the dynamic load test and CAPWAP analysis, the skin friction was 375.0 kN, the end bearing capacity was 3,045.9 kN, and the allowable bearing capacity was 1,368.36 kN. These results are similar to the results of using ordinary portland cement as pile-filling material.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.6
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• pp.180-188
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• 2020

To replace Japanese coal ash used in the domestic cement production and to recycle large quantities of domestic pond ash, it is essential to develop the technologies for quality control of cement by using the domestic pond ash. Thus, in this study, the feasibility of using the pond ash as a raw material for cement was investigated through chemical composition and microstructure analysis. As a result, most of the domestic pond ash contained slightly more Fe2O3, chloride, and unburned carbon contents than Japanese coal ash. In particular, the contents of chloride were considerably low in the pond ash that was transferred to fresh water or collected from surface of landfill area. However, since circulating fluidized bed boiler coal ash had relatively high SO3 contents causing durability problems of cement, it was not suitable for use as a raw material for cement. Thus, to replace Japanese coal ash with the domestic pond ash, it is necessary to introduce the adjustment of mixture proportion of cement raw materials and the process of removing chloride in the pond ash.

• Korean Chemical Engineering Research
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• v.57 no.6
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• pp.874-882
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• 2019

In this study, the gasification characteristics of four types of unused woody biomass and one waste wood in a lab-scale bubbling fluidized bed gasifier (Diameter: 0.11 m, Height: 0.42 m) were investigated. Effect of equivalence ratio (ER) of 0.15-0.3 and gas velocity of $2.5-5U_0/U_{mf}$ are determined at the constant temperature of $800^{\circ}C$ and fuel feeding rate of 1 kg/h. The silica sand particle having an average particle size of $287{\mu}m$ and olivine with an average particle size of $500{\mu}m$ were used as the bed material, respectively. The average product gas composition of samples is as follows; $H_2$ 3-4 vol.%, CO 15-16 vol.%, $CH_4$ 4 vol.% and $CO_2$ 18-19 vol.% with a lower heating value (LHV) of $1193-1301kcal/Nm^3$ and higher heating value (HHV) of $1262-1377kcal/Nm^3$. In addition, it was found that olivine reduced most of C2 components and increased $H_2$ content compared to silica sand, resulting in cracking reaction of tar. The non-condensable tar decreases by 72% ($1.24{\rightarrow}0.35g/Nm^3$) and the condensable tar decreases by 27% ($4.4{\rightarrow}3.2g/Nm^3$).