• Title/Summary/Keyword: Fluctuation effect

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The Effect of Seasonal Rhythm on the Gentamicin Pharmacokinetics in Healthy Volunteers (계절리듬이 겐타마이신의 약물동태에 미치는 영향)

  • Choi, Jun Shik;Kim, Jin;Baek, Chae Sun;Do, Nam Yong;Kim, Sung Hwan;Park, Young Jin
    • Korean Journal of Clinical Pharmacy
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    • v.8 no.2
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    • pp.89-94
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    • 1998
  • Seasonal rhythmic changes in gentamicin pharmacokinetics was evaluated in 10 healthy male volunteers after single intravenous 80 mg administration of gentamicin at 9:00 a.m. during summer and winter. The mean terminal half-life and AUC of gentamicin were $3.56\pm0.14\;hr\;and\;25.03\pm2.84\;{\mu}g/ml{\cdot}hr$ in winter and $3.08\pm0.41\;hr\;and\;21.84\pm2.51\;{\mu}g/ml{\cdot}hr$ in summer. The mean total body clearance $(CL_t)$ and elimination rate constant $(k_{10})$ of gentamicin was $3.17\pm0.43\;L/hr,\;0.458\pm0.06\;hr^{-1}\;in\;winter\;and\;3.66\pm0.45\;L/hr,\;0.561\pm0.07\;hr^{-1}$ in summer, The mean volumn of distribution $(V_{dss})$ of gentamicin at steady state was $12.65\pm1.09$L in winter and $12.39\pm1.25$ L in summer. Serum concentrations of gentamicin in winter were increased significantly during 4-8 hr (p<0.05) compared to those of gentamicin in summer. The elimination rate constant $(k_{10})$ of gentamicin in winter was decreased significantly $(p<0.05)$ compared to that of gentamicin in summer. The mean volume of distribution at steady state $(V_{dss})$, AUC, mean total body clearance ($CL_t$) and terminal half-life of gentamicin in the winter were increased but were not significant. The mean intrasubject fluctuations in terminal half-life, AUC and $CL_t$ between winter and summer were 8.2, 11.0 and $6.0\%$ respectively.

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An Empirical Study on the Political Cost in Korean Shipping Industry (한국해운산업의 정치적 비용에 관한 실증연구)

  • Jo, Joon-Gul;Ahn, Ki-Myung;Pai, Hoo-Seok
    • Journal of Navigation and Port Research
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    • v.28 no.8
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    • pp.687-697
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    • 2004
  • This paper is aimed to guide ocean-going companies to reasonable decisions and to increase the competitiveness of Korean shipping industry by clarifying the determinants of political costs of ocean-going companies, which only depend for the enormous amount of money to introduce the operating fixed assets, or the vessels, upon the supporting policy from the government or the loan from the related financial institutions. As independent variables of the political costs, 5 elements were settled such as company size(sales, total assets and market share), debit ratio, capital concentration ratio, profitability(operating profit) and marine risk(sales fluctuation). To verify the relations and the effect level between dependent variables and political costs, the Multiple Regression Analysis Model was applied The result of the analysis shows significantly positive relations between size variables and political cost of shipping industry. Moreover, debt ratio and profitability were proved significant related with political costs of shipping industry.

Electrochemical Characteristics in Sea Water of Al-3%Mg Arc Spray Coating Layer for Corrosion Protection with Sealing Treatment (후처리 적용에 따른 방식용 Al-3%Mg 용사코팅 층의 해수 내 전기화학적 특성)

  • Park, Il-Cho;Kim, Seong-Jong
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.40 no.5
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    • pp.974-980
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    • 2015
  • Arc thermal spray coating using Al-3%Mg thermal spray wire was carried out to prevent steel from corrosion damage under the marine environment. Post-sealing was applied to Al-3%Mg spray coating treatment using organic/inorganic composite ceramics in order to improve the corrosion resistance of the as-sprayed coating. The results of various electrochemical experiments with sealing treatment indicated that the improvement in corrosion resistance was observed due to low current density in all applied potential range during anodic and cathodic polarization experiments. Futhermore, the natural potential measurement exhibited severe potential fluctuation due to influence of micro-crack presence on the surface of sealed thermal spray coating layer. In addition, the sealed layer was easily eliminated during anodic polarization. Nevertheless, Al-3%Mg spray coating layer improved corrosion resistance by sealing treatment because the sealed coating efficiency was determined to be 92.11%, indicating the exterior environment barrier effect which is based on the Tafel analysis.

LES Studies on the Combustion Instability with Inlet Configurations in a Model Gas Turbine Combustor (모형 가스터빈 연소기의 입구 형상변화에 따른 연소 불안정성에 관한 LES 연구)

  • Hwang, Cheol-Hong;Lee, Chang-Eon
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.32 no.5
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    • pp.342-350
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    • 2008
  • The effects of combustion instability on flow structure and flame dynamics with the inlet configurations in a model gas turbine combustor were investigated using large eddy simulation (LES). A G-equation flamelet model was employed to simulate the unsteady flame behaviors. As a result of mean flow field, the change of divergent half angle($\alpha$) at combustor inlet results in variations in the size and shape of the central toroidal recirculation (CTRZ) as well as the flame length by changing corner recirculation zone (CRZ). The case of ${\alpha}=45^{\circ}$ show smaller size and upstream location of CTRZ than those of $90^{\circ}$ and $30^{\circ}$ by the development of higher swirl velocity. The flame length in the case of ${\alpha}=45^{\circ}$ is shorter than other cases, while the case of ${\alpha}=30^{\circ}$ yields the longest flame length due to the decrease of effective reactive area with the absence of CRZ. Through the analysis of pressure fluctuation, it was identified that the case of ${\alpha}=45^{\circ}$ shows the largest damping effect of pressure oscillation in all configurations and brings in the noise reduction of 2.97dB, compared to that of ${\alpha}=30^{\circ}$ having the largest pressure oscillation. These reasons were discussed in detail through the analysis of unsteady phenomena related to recirculation zone and flame surface. Finally the effects of flame-acoustic interaction were evaluated using local Rayleigh parameter.

Price Escalation Clause of Letter of Credit (신용장의 에스컬레이션 조항)

  • Park, Sae-Woon
    • International Commerce and Information Review
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    • v.16 no.2
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    • pp.89-109
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    • 2014
  • The purpose of price escalation clauses has the effect of increasing the L/C value subject to external pricing mechanisms. This will be found inter alia in metals and oil products transactions. Such a clause gives rise to a question. That is, whether it is enforceable or whether it constitutes a letter of credit. The problem is what to reference to a source outside the context of a letter of credit constitutes a non-documentary condition rendering the undertaking something other than a letter of credit. Reference to an objective and readily available index is not something that renders the undertaking obscure and is not "non-documentary in the sense that it is possible to make an objective verification of the data. The possible solution is that not every non-documentary condition will be disregarded. For example, an index specified in the credit will not be disregarded as stipulated in ISP98 and URDG758. If a non-documentary is "central and fundamental", it seems that the parties intended a dependent payment obligations. The most common means of overcoming this conflicts of interests is to issue an instrument incorporatingan escalation clause, but capping the bank's maximum payment obligation.

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Analysis of Random Variations and Variation-Robust Advanced Device Structures

  • Nam, Hyohyun;Lee, Gyo Sub;Lee, Hyunjae;Park, In Jun;Shin, Changhwan
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.14 no.1
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    • pp.8-22
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    • 2014
  • In the past few decades, CMOS logic technologies and devices have been successfully developed with the steady miniaturization of the feature size. At the sub-30-nm CMOS technology nodes, one of the main hurdles for continuously and successfully scaling down CMOS devices is the parametric failure caused by random variations such as line edge roughness (LER), random dopant fluctuation (RDF), and work-function variation (WFV). The characteristics of each random variation source and its effect on advanced device structures such as multigate and ultra-thin-body devices (vs. conventional planar bulk MOSFET) are discussed in detail. Further, suggested are suppression methods for the LER-, RDF-, and WFV-induced threshold voltage (VTH) variations in advanced CMOS logic technologies including the double-patterning and double-etching (2P2E) technique and in advanced device structures including the fully depleted silicon-on-insulator (FD-SOI) MOSFET and FinFET/tri-gate MOSFET at the sub-30-nm nodes. The segmented-channel MOSFET (SegFET) and junctionless transistor (JLT) that can suppress the random variations and the SegFET-/JLT-based static random access memory (SRAM) cell that enhance the read and write margins at a time, though generally with a trade-off between the read and the write margins, are introduced.

Current Effect on the Motion and Drift Force of Cylinders Floating in Waves (주상체(柱狀體)의 운동(運動) 및 표류력(漂流力)에 미치는 해류(海流)의 영향(影響))

  • Sei-Chang,Lee
    • Bulletin of the Society of Naval Architects of Korea
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    • v.23 no.4
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    • pp.25-34
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    • 1986
  • A two-dimensional linear method has been developed for the motion and the second-order steady force arising from the hydrodynamic coupling between waves and currents in the presence of a body of arbitrary shape. Interaction between the incident wave and current in the absence of the body lies in the realm beyond our interest. A Fredholm integral equation of the second kind is employed in association with the Haskind's potential for a steadily moving source of pulsating strength located in or below the free surface. The numerical calculations at the preliminary stage showed a significant fluctuation of the hydrodynamic forces on the surface-piercing body. The problem is approximately solved by using the asymptotic Green function for $U^2{\rightarrow}0$. The original Green function, however, is applied for the fully submerged body. Numerical calculations are made for a submerged and for a half-immersed circular cylinder and extensively for the mid-ship section of a Lewis-form. Some of the results are compared with other analytical results without any available experimental data. The current has strong influence on roll motion near resonance. When the current opposes the waves, the roll response are generally negligible in the low frequency region. The current has strong influence on roll motion near resonance. When the current opposes the wave, the roll response decreases. When the current and wave come from the same direction, the roll response increases significantly, as the current speed increases. The mean drift forces and moment on the submerged body are more affected by current than those on the semi-immersed circular cylinder or on the ship-like section in the encounter frequency domain.

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Performance Criterion of Bispectral Speckle Imaging Technique (북스펙트럼 스펙클 영상법의 성능기준)

  • 조두진
    • Korean Journal of Optics and Photonics
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    • v.4 no.1
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    • pp.28-35
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    • 1993
  • In the case of an imaging system affected by aberrations which are not precisely known, the effect of aberrations can be minimized and near-diffraction-limited images can be restored by introducing artificial random phase fluctuations in the exit pupil of the imaging system and using bispectral speckle imaging. In order to determine the optimum value of the correlation length for Gaussian random phase model, computer simulation is performed for 50 image frames of a point object in the presence of defocus, spherical aberration, coma, astigmatism of 1 wave, respectively. In terms of the criterion of performance, the FWHM of the point spread function, normalized peak intensity, MTF and visual inspection of the restored object are employed. The optimum value for the rms difference $\sigma$ of aberration on the exit pupil in the interval of Fried parameter ${\Upsilon}_0$ is given by 0.27-0.53 wave for spherical aberration, and 0.24-0.36 wave for defocus and astigmatism, respectively. It is found that the bispectral speckle imaging technique does not give good results in the case of coma.

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Effect of Fiber Orientation on Ionic Conductivity of Electrospun Polyimide Nanofibers Mats (전기방사 폴리이미드 나노섬유매트의 섬유배향이 이온전도도에 미치는 영향)

  • Huh, Yang-Il;Kim, Young-Hee;Ahn, Jou-Hyeon;Lee, Hong-Ki;Nah, Chang-Woon
    • Elastomers and Composites
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    • v.45 no.1
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    • pp.40-43
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    • 2010
  • In this study, polyimide(PI) nanofibers mats were prepared by electrospinning and three different fiber morphologies of random, uniaxial, and biaxial orientation were prepared by controlling the speed of drum-shaped collector and other parameters. The SEM studies reveal that the aforesaid morphologies were obtained on the nano-fibrous mats prepared. The ionic conductivity was measured using an in-plane type conductivity tester for the PI mats soaked in the mixture of 1M lithium trifluoro-methane-sulfonate and tetra-ethylene glycol dimethyl ether. The ionic conductivity was surprisingly higher for the biaxial PI mats. For the uniaxially-oriented mats, the ionic conductivity was found to be higher in the parallel direction compared to the perpendicular direction of the fiber orientation. A curious cyclic fluctuation was found in the ionic conductivity with time. The observed behavior was explained by considering the distance between fibers and transport speed of ions used in this study.

Fluctuation of Rhizosphere Microflora in Paddy Rice by Long-Term Fertilization (동일비료 장기연용에 따른 벼 근권 미생물상의 변화)

  • Lee, Gye-Suk;Lee, Jae-Chan;Kang, Ui-Gum;Park, Chang-Young;Kim, Chang-Jin
    • Applied Biological Chemistry
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    • v.49 no.3
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    • pp.175-179
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    • 2006
  • This study was carried out to investigate the change of rhizosphere microflora in paddy soils of long-term application of same fertilizer by single cropping. Treatments consisted of no fertilizer, NPK, PK, NK, NP and NPK + compost and the same fertilizer has been applied to the soil of each treatment for thirty five years. Any remarkable difference of the microbial population structure was not detected from the rhizosphere of Hwayeongbyeo and that of Hwasambyeo. However, slight difference of dominant microbial species in the rhizosphere was recognized between different fertilization practice. The bacterial population in the rhizosphere was steadily reduced over time after rice plant setting out, while actinomycetal population was increased over time. The increase of actinomycetal population was the highest in the NPK + compost treatment, suggesting the effect of organic matters in the change of actinomycetal population. As for the aerobic culturable bacterial diversity, Bacillus megaterium, B. mycoides, B. licheniformis and B. subtilis were dominants in genus Bacillus, and Streptomyces spororaveus, S. canus, S. tauricus and S. galbus in genus Streptomyces and genus Micromonospora was another dominant in actinomycetes.