• Journal of Mechanical Science and Technology
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• 제14권8호
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• pp.861-866
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• 2000

Flow induced shape change is important for spatial interpretation of vascular response and for understanding of mechanotransduction in a single cell. We investigated the possible shapes of endothelial cell (EC) in a mathematical model and compared these with experimental results. The linearized analytic solution from the sinusoidal wavy wall and Stokes flow was applied with the constraint of EC volume. The three dimensional structure of the human umbilical vein endothelial cell was visualized in static culture or after various durations of shear stress (20 $dyne/cm^2$ for 5, 10, 20, 40, 60, 120min). The shape ratio (width: length: height) of model agreed with that of the experimental result, which represented the drag force minimizing shape of stream-lining. EC would be streamlined in order to accommodate to the shear flow environmented by active reconstruction of cytoskeletons and membranes through a drag force the sensing mechanism.

• 한국인쇄학회지
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• 제23권2호
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• pp.59-75
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• 2005

In gravure printing, the amount of ink from cells has a great effect on the qualities of final printed products. And printability of final products is determined by every kinds variables. Ink transfer process is not verified scientifically because gravure cell is of small size and print speed is rapid. Therefore in order to study of ink transfer mechanism, this study is using the Computational Fluid Dynamics Evaluation. Polyflow 3-10 simulation software is used for considering of non-Newtonian flow. Among the various factors, this study have dealt with gravure cell types used computer simulation in order to define distinctive features in ink flow and transfer. The results of simulation, it defined the distribution of pressure, speed, stream function, viscosity, shear rate during the gravure printing. It is fined out the difficulties and characteristics according to the shape of cell types. Through this study, the condition of gravure printing is depending on the print condition and characteristic of cells.

• 공업화학
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• 제33권6호
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• pp.646-652
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• 2022

Dead ended anode (DEA) 시스템은 수소극(anode) 출구를 막고 압력으로 연료를 공급하는 방식이다. DEA 방식은 시스템 단순화를 통해 연료이용효율과 전력 효율을 향상시킬 수 있다. 하지만 DEA 운전 중 공기극(cathode)에서 수소극으로 질소와 물의 역확산으로 인한 범람(flooding)이 발생한다. 이러한 범람 현상은 연료전지 성능 저하와 전극 열화의 주요 요인이 된다. 따라서 DEA 운전 시 범람을 방지하기 위하여 연료전지 구조와 구성요소가 최적화되어야 한다. 본 연구에서는 DEA 시스템에서 연료전지의 성능과 연료이용효율 향상을 위해 발포 금속을 적용한 다공성 유로에 대한 영향을 조사하였다. 그 결과, 공기극에 다공성 유로를 사용한 경우 효과적인 물 관리로 연료전지 성능과 배출 간격(purge interval)이 개선되었고, 이를 통하여 공기극 유로 구조가 물 역확산에 영향을 미치는 것을 확인하였다. 이에 반해 수소극의 다공성 유로가 연료전지 성능에 미치는 영향은 미미하였다. DEA 시스템에서는 발포 금속 물성이 배출 간격에 영향을 미치며 cell 크기가 큰 발포 금속에서 안정적인 성능을 나타내었다.

• 한국분무공학회지
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• 제22권2호
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• pp.69-79
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• 2017

When designing a redox flow battery system, compression of battery stack is required to prevent leakage of electrolyte and to reduce contact resistance between cell components. In addition, stack compression leads to deformation of the porous carbon electrode, which results in lower porosity and smaller cross-sectional area for electrolyte flow. In this paper, we investigate the effects of electrode compression on the cell performance by applying multi-dimensional, transient model of all-vanadium redox flow battery (VRFB). Simulation result reveals that large compression leads to greater pressure drop throughout the electrodes, which requires large pumping power to circulate electrolyte while lowered ohmic resistance results in better power capability of the battery. Also, cell compression results in imbalance between anolyte and catholyte and convective crossover of vanadium ions through the separator due to large pressure difference between negative and positive electrodes. Although it is predicted that the battery power is quickly improved due to the reduced ohmic resistance, the capacity decay of the battery is accelerated in the long term operation when the battery cell is compressed. Therefore, it is important to optimize the battery performance by taking trade-off between power and capacity when designing VRFB system.

• Journal of Mechanical Science and Technology
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• 제17권7호
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• pp.1104-1110
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• 2003

The present study investigates the hemorheological characteristics of blood flow with applying vibration to a non-aggregating red blood cell suspension. In order to obtain the non-aggregating RBC suspension, blood samples were treated with vibration at a specified condition, which viscosities were taken before and after the treatment, respectively. The viscosity of the blood samples after treatment was higher than before treatment. These treated blood samples were forced to flow through a capillary tube that was vibrated perpendicularly to the direction of the flow. The experimental results showed that vibration caused a reduction of the flow resistance of the non-aggregated blood. The reduction of the flow resistance was strongly dependent on both frequency and amplitude of vibration. These results show potential in treating various diseases in the microcirculation associated with blood cell aggregation.

• 대한한의학회지
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• 제36권4호
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• pp.19-34
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• 2015

Objectives: This study was performed to investigate the anti-tumor effect of O. japonicus extracts on intrahepatic cholangiocarcinoma cell line SNU-1079. Methods: Cholangiocarcinoma SNU-1079 cells were treated with various concentrations of O. japonicus DW and EtOH extracts ($0-300{\mu}g/ml$) for 24, 48 or 72 h. Cell viability was evaluated through a PMS/MTS assay, and the apoptosis rate was examined through ELISA assay and flow cytometry analysis. The mRNA expression of apoptosis- and cell cycle progression-related genes (Bcl-2, Mcl-1, Bax, Survivin, Cyclin D1, and p21) was evaluated using real-time PCR, and the caspase activity was examined using immunoblot analysis. Results: O. japonicus extracts inhibited cell proliferation and increased apoptosis rate in both ELISA assay and flow cytometry analysis. O. japonicus extracts decreased Bcl-2, Mcl-1, Survivin, and Cyclin D1 mRNA expression and increased Bax mRNA level. O. japonicus extracts also increased Caspase-3 activation. Overall, O. japonicus DW extracts were more effective than EtOH extracts. Conclusions: O. japonicus inhibited cell proliferation and induced apoptosis in SNU-1079 cells via mitochondria -mediated intrinsic pathway, which leads to Caspase-3 activation. The results indicate that O. japonicus is a potential therapeutic herb with anti-tumor effect against intrahepatic cholangiocarcinoma.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2008년도 동계학술발표대회 논문집
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• pp.9-14
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• 2008

The effects of baffles in PEM fuel cell with parallel flow channel has been simulated by using conmmercial program. The simulation has been conducted through the channel and there are four different heights of baffles, No Baffle($H_b$=0), Partially Blocked Baffle(0.25, 0.5, 0.75), Fully Blocked Baffle(1) conditions. The result shows that current density changes while placing a baffle at the various positions along the channel. Current density with a single baffle is higher than that without baffle and current density using Fully Blocked Baffle(FBB) is much higher than current density using Partially Blocked Baffle(PBB). When the baffle is closer to outlet of the channel, current density increases. It is found that pressure is related to current density. If the pressure is higher, the better performance will be expected.

• 한국안전학회지
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• 제31권4호
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• pp.143-149
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• 2016

In this study, a series of numerical simulation of dam break flow was conducted using EFDC model, and input conditions including cell size, time step, and turbulent eddy viscosity were considered to analyze parameter sensitivity. In case of coarse mesh layout, the propagated length of the shock wave front was ${\Delta}_x$ longer than that of other mesh layouts, and the velocity results showed jagged edge, which can be cured by applying fine grid mesh. Turbulent eddy viscosity influenced magnitude of the maximum velocity passing through gate up to 20% and the cell Peclet number less than 2.0 ensured no numerical oscillations.

• 약학회지
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• 제46권3호
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• pp.213-218
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• 2002

In the previous report, we described the in vivo antitumor activity of PJ-4, a protein-polysaccharide fraction prepared from the culture filtrate of an insect-born fungus, Paecilomyces tenuipes DGUM 32001. In the present study, we elucidated the immunomodulating activity of PJ-4 on the BALB/c mouse splenic lymphocytes using flow cytometrical techniques. As a result, PJ-4 was found to stimulate the lymphocytes not only to form lymphoblasts but also to express CD25 (IL-2 receptor $\alpha$ chain) molecule, which is well known as a T cell activation marker. More interestingly, its T cell stimulatory activity was more strongly exerted on CD8$^{+}$ T cells than on CD4$^{+}$ T cells. All these data suggest that PJ-4 exerts its antitumor activity at least partly through stimulation of T cells which play major roles in the cell-mediated immune system.tem.

• 대한기계학회논문집B
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• 제33권11호
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• pp.834-839
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• 2009

A three-dimensional computational fluid dynamics (CFD) analysis is performed to investigate flow characteristics in the anode channels and manifold of the internal reforming type molten carbonate fuel cell (MCFC). Considering the computational difficulties associated with the size and geometric complexity of the MCFC system, the polyhedral meshes that can reduce mesh connectivity problems at the intersection of the channel and the manifold are adopted and chemical reactions inside the MCFC system are not included. Through this study, the gas flow rate uniformity of the anode channels is mainly analyzed to provide basic insights into improved design parameters for anode flow channel design. Results indicate that the uniformity in flow-rate is in the range of ${\pm}$1% between the anode channels. Also, the mal-distributed inlet flow-rate conditions and the change in the size of the manifold depth have no significant effect on the flow-rate uniformity of the anode channels.