• Environmental Analysis Health and Toxicology
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• v.27
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• pp.10.1-10.7
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• 2012

Objectives: In recent years, a number of structurally diverse Histone deacetylase (HDAC) inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. This study aimed at investigating the antitumor activity of newly synthesized HDAC inhibitor, 3-(4-dimethylamino phenyl)-N-hydroxy-2-propenamide (IN-2001) using human breast cancer cells. Methods: We have synthesized a new HDAC inhibitor, IN-2001, and cell proliferation inhibition assay with this chemical in estrogen receptor-positive human breast cancer MCF-7 cells. Cell cycle analysis on MCF-7 cells treated with IN-2001 was carried out by flow cytometry and gene expression was measured by RT-PCR. Results: In MCF-7 cells IN-2001 showed remarkable anti-proliferative effects in a dose- and time-dependent manner. In MCF-7 cells, IN-2001 showed a more potent growth inhibitory effect than that of suberoylanilide hydroxamic acid. These growth inhibitory effects were related to the cell cycle arrest and induction of apoptosis. IN-2001 showed accumulation of cells at $G_2$/M phase and of the sub-$G_1$ population in a time-dependent manner, representing apoptotic cells. IN-2001-mediated cell cycle arrest was associated with HDAC inhibitor-mediated induction of CDK inhibitor expression. In MCF-7 cells, IN-2001 significantly increased $p21^{WAF1}$ expression. Conclusions: In summary, cyclin-dependent kinase (CDK) induced growth inhibition, possibly through modulation of cell cycle and apoptosis regulatory proteins, such as CDK inhibitors, and cyclins. Taken together, these results provide an insight into the utility of HDAC inhibitors as a novel chemotherapeutic regime for hormone-sensitive and insensitive breast cancer.

• Smart Media Journal
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• v.9 no.4
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• pp.44-51
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• 2020

Since the mid-to-late 1990s, there have obviously been many changes in the North Korean economy. Since the change has been more pronounced since Kim Jong Un took power in 2012, the purpose of the paper is to track the trend of economic policy by timing. In this paper, I use LDA Topic Modeling, a text-mining analyzer method, to analyze the economics journal "Economic Research," which is a representative literature in the economic field published in North Korea. An in-depth analysis of the "economic research," which has an unrivaled position as an economic journal produced in North Korea, can be said to be an essential task in tracking the reality, limitations facing the economy and alternatives that North Korean authorities are aware of. Through the "Economic Research," where various topics of debate on the North Korean economy are hidden, the North Korean leader's economic policy flow is examined and the contents of the "change" intended by the current Kim Jong-un regime are analyzed.

• Korean Chemical Engineering Research
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• v.58 no.4
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• pp.642-650
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• 2020

In general, the circulation path of the fluidized particles in a CFB (Circulating Fluidized Bed) boiler is such that the particles entrained from a combustor are collected by a cyclone and recirculated to the combustor via a sealpot which is one of non-mechanical valves. However, when a fluidized bed heat exchanger (FBHE) is installed to additionally absorb heat from the fluidized particles, some particles in the sealpot pass through the FBHE and then flow into the combustor. At this time, in the FBHE operated in the bubbling fluidization regime, if the heat flow is not evenly distributed by poor mixing of the hot particles (800~950 ℃) flowing in from the sealpot, the heat exchanger tubes would be locally heated and then damaged, and the agglomeration of particles could also occur by formation of hot spot. This may affect the stable operation of the circulating fluidized bed. In this study, the unevenness of heat flow arising from structural problems of the FBHE of the domestic D-CFB boiler was found through the operating data analysis and the CPFD (Computational Particle Fluid Dynamics) simulation using Barracuda VR. Actually, the temperature of the heat exchanger tubes in the FBHE showed the closest correlation with the change in particle temperature of the sealpot. It was also found that the non-uniformity of the heat flow was caused by channeling of hot particles flowing in from the sealpot. However, it was difficult to eliminate the non-uniformity even though the fluidizing velocity of the FBHE was increased enough to fluidize hot particles vigorously. When the premixing zone for hot particles flowing in from the sealpot is installed and when the structure is changed through the symmetrization of the FBHE discharge line for particles reflowing into the combustor, the particle mixing and the uniformity of heat flow were found to be increased considerably. Therefore, it could be suggested that the structural modification of the FBHE, related to premixing and symmetric flow of hot particles, is an alternative to reduce the non-uniformity of the heat flow and to minimize the poor particle mixing.

• Membrane Journal
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• v.5 no.1
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• pp.35-43
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• 1995

For several years lots of attempts have been made to establish the liquid membrane-based techniques for separations of gas mixtures especially containing carbon dioxide. A more effective system to separate $CO_{2}$ from flue gases, a circulatory hollow-fiber membrane absorber(HFMA) consisting of absorption and desorption modules with vacuum mode, has been considered in this study. Gas-liquid mass transfer has been modeled on a membrane module with non-wetted hollow-fibers in the laminar flow regime. The influence of an absorbent flow rate on the separation performance of the circulatory HFMA can be predicted quantitatively by obtaining the $CO_{2}$ concentration profile in a tube side. The system of $CO_{2}/N_{2}$ binary gas mixture has been studied using pure water as an(inert) absorbent. As the absorbent flow rate is increased, the permeation flux(i.e., defined as permeation rate/membrane contact area) also increases. The enhanced selectivity compared to the previous results, on the other hand, shows the decreasing behavior. It has been found obviously that the permeation flux depends on the variations of pressure in gas phase of desorption module. From an accurate comparison with the results of conventional flat sheet membrane module, the advantageous permeability of this circulatory HFMA can be clearly ascertained as expected. Our efforts to the theoretical model will provide the basic analysis on the circulatory HFMA technique for a better design and process.

• Advances in aircraft and spacecraft science
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• v.4 no.5
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• pp.503-514
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• 2017

The attitude control of an aircraft is usually fulfilled by means of thrusters at high altitudes. Therefore, the possibility of using also aerodynamic surfaces would produce the advantage of reducing the amount of fuel for the thrusters to be loaded on board. For this purpose, Zuppardi already considered some aerodynamic problems linked to the use of a wing flap in a previous paper. A NACA 0010 airfoil with a trailing edge flap of 35% of the chord, in the range of angle of attack 0-40 deg and flap deflections up to 30 deg was investigated. Computer tests were carried out in hypersonic, rarefied flow by a direct simulation Monte Carlo code at the altitudes of 65 and 85 km of Earth Atmosphere. The present work continues this subject, considering the same airfoil and free stream conditions but two flap extensions of 45% and 25% of the chord and two flap deflections of 15 and 30 deg. The main purpose is to compare the influence of the flap dimension with that of the flap deflection. The present analysis is carried out in terms of: 1) percentage variation of the global aerodynamic coefficients with respect to the no-flap configuration, 2) increment of pressure and heat flux on the airfoil lower surface due to the Shock Wave-Shock Wave Interaction (SWSWI) with respect to the same quantities with no SWSWI or in no-flap configuration, 3) flap hinge moment. Issues 2) and 3) are important for the design of the mechanical and thermal protection system and of the flap actuator, respectively. Under the above mentioned test and geometrical conditions, the flap deflection is aerodynamically more effective than the flap extension, because it involves higher variation of the aerodynamic coefficients. However, tests verify that a smaller deflection angle involves the advantage of a smaller increment of pressure and heat flux on the airfoil lower surface, due to SWSWI, as well as a smaller hinge moment.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.12
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• pp.1031-1038
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• 2017

In order to improve the performance of the air breathing engines, it is important to maximize the total pressure recovery through air intake. In this study, we investigated whether the Oswatitsch method, which guarantees the maximum pressure recovery for supersonic intake, is effective at hypersonic speed by compressing the intake air with the same intensity at each ramp. The non-linearity of the shock wave normal Mach number at each ramp stage was analyzed by comparing the compression ramp angle and the number of ramp to the inflow Mach number in terms of compressible thermodynamics and the operation limits of the inlet. Based on this analysis, the Oswaitisch technique yields valid conditions not only in supersonic but also hypersonic flight regime.

• Journal of The Korean Society of Agricultural Engineers
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• v.51 no.6
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• pp.53-62
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• 2009

The EFDC (Environmental Fluid Dynamics Code), a numerical model for simulating three-dimensional (3D) flow, transport, and biogeochemical processes in surface water systems including rivers, reservoirs, and estuaries, was applied to assess the effect of sea water and fresh water exchange rates ($Q_e$) on the mixing characteristics of a conservative pollutant (tracer) induced from upstreams and salinity in Saemangeum Lake, Korea. The lake has been closed by a 33 km estuary embankment since last April of 2006, and now seawater enters the lake partially through two sluice gates (Sinsi and Garyuk), which is driving the changes of hydrodynamic and water quality properties of the lake. The EFDC was constructed and calibrated with surveyed bathymetry data and field data including water level, temperature, and salinity in 2008. The model showed good agreement with the field data and adequately replicated the spatial and temporal variations of the variables. The validated model was applied to simulated the tracer and salinity with two different gate operation scenarios: RUN-1 and RUN-2. RUN-1 is the case of real operation condition ($Q_e=25,000,000\;m^3$) of 2008, while RUN-2 assumed full open of Sinsi gate to increase $Q_e$ by $120,000,000\;m^3$. Statistical analysis of the simulation results indicate that mixing characteristics of pollutants from upstream can be significantly affected by the amount of $Q_e$.

• Journal of Korea Water Resources Association
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• v.41 no.4
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• pp.395-404
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• 2008

It is important to understand the complex, various migration features of the alluvial channels for river engineering. In this study, the morphological changes and migration features of alluvial channels were investigated by analyzing the aerial photographs of active channels between 1972 and 2004 in Hapyeong Intake Station, Nakdong river. The lower channels were migrated from left bank to right bank and showed the features of braided channel in 2004. The instability of lower channels was increased due to the increased channel slope and width. The sinuosity of lower channels was decreased with time. As time increased, the increasing rate of lower channel and lateral migration rate were decreased. As a result of meso-scale regime analysis by using bankfull discharge, multiple row bars were developed, and suspended sediment load was governed in the flow as a sand bed channel.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.5
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• pp.173-181
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• 1993

Under natural conditions, rivers do not in general take straight courses but instead take winding courses. This is known as meandering of rivers. Meandering of rivers are so complicated because of the mutual interactions between flow and movable boundaries. In quantitative information, it is important to predict the future location of a river channel(channel migration) because in selecting a bridge site or a location of a road. It may be valuable to know the future impact of a nearby river on those structures. When the prediction model of the migration of channel is used in domestic rivers with high coefficient of river regime, it is rational to use the periodical dominant discharge (PDD), which is named firstly by the author, instead of the average discharge. According to the analysis of the erosion coefficient, the mean deviation on the channel migration, and the bed scour factor, it can bring shedding light on the fact that the discharge is one of the dominant components in channel migration. In project area, the discharge that can shift the channel is slightly greater than 6,000CMS. The prediction model of the migration of channel estimated the erosion coefficient, $E_0$ by the data from the South Han River. This estimated value from the South Han River was also used to predict the migration of the South Han River in year 2000.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.236-236
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• 2011

진천지역의 지하수 유동체계를 분석하기 위해 진천지역 내 530개 공의 지하수위를 1년간 관측하였다. 이중 360개 공에서는 분기별로 한번씩 총 4회, 130개 공에서는 월1회씩 총 12회 지하수위를 관측하였으며, 40개 공에 대해서는 1시간 간격으로 자동관측을 실시하였다. 관측결과를 수집하여 지하수위의 변동특성, 지하수위 분포, 지하수 심도분포 등을 실시하였으며, 이와 같은 지하수위 분석 결과를 바탕으로 지하수 유동체계를 분석하였다. 조사지역의 평수기 지하수위 분포에 대해 수리학적인 접근법(hydraulic approach) 및 동수역학적 접근법(hydrodynamic approach)에 근거하여 수리수두(hydraulic head) 및 전수두(total head)를 분석하여 2차원 및 3차원 수리경사도를 작성하였다. 이러한 지하수위 분포에 따른 분석 성과와 지형 및 수문지질을 고려하여 함양 및 배출지역을 분류하였으며, 이와 함께 기분석된 지하수위 등고선에 따른 유선망도를 작성하였다. 지하수는 지하수위의 표고 및 압력에 따른 위치 에너지 차에 의하여 대수층 매질을 통하여 유동하며 수두가 높은 곳에서 낮은 곳으로 일정한 수리경사를 갖고 지하수 등수위선에 연직 방향으로 형성된 유선을 따라 이동한다. 따라서 지하수의 유동방향은 지하수 수리경사 분석이 이루어진 8개 방향의 지하수위 경사 중 최대경사를 갖는 방향으로 지하수 유동이 발생하므로, 이를 지하수위 유동방향으로 결정하였다. 이와 같이 분류된 지하수 함양 중간 및 배출 지역과 지하수의 함양과 배출의 양적인 측면에 서 유동체계의 규모를 고려하여 조사 지역을 8단계로 구분하였다. 또한 조사지역의 지하수 유동체계를 종합적으로 규명하기 위하여 기 분석한 조사지역의 지하수위 등고선, 지하수위 등심도선, 지하수 수리경사, 지하수 유동방향 및 지하수 함양-배출체계와 지형기복, 그리고 주요 하천 등의 제반 요소를 중첩 분석하여 종합적으로 규명하고, 그 결과를 지하수 유동체계도로 작성하였다. 지하수 유동체계 분석결과는 수문지질 평가와 오염취약성 평가 및 지하수 관리 방안 수립에 활용될 수 있을 것으로 기대된다.