• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.930-938
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• 2003

The purpose of the present study was to investigate the effects of Hyunhosaiksan (HHS) on antithrombotic actions which include blood activation, thrombus removal, warming of circulating blood, and the control of pain on abdomen and lower and upper burning spaces. HHS significantly inhibited platelet aggregation induced by ADP and epinephrine in a HHS dose-dependent manner when analyzed by the Sigmoid Emax model in WinNonlin. EC50 values of HHS were 1.71 ㎍/ml and 0.004 ㎍/ml for ADP and epinephrine respectively. In the vivo study, HHS inhibited pulmonary embolism induced by collagen and epinephrine, which was however statistically insignificant. HHS increased number of platelets, APTT and volume of fibrinogen significantly as compared with the control group in dextran-induced thrombus model. Furthermore, HHS stimulated levels of blood flow in vivo though its effect was not observed in vitro. These results suggest that Hyunhosaiksan (HHS) can be used for treating numerous diseases related with blood aggregation and circulation problems. Further systematic investigations on the synergic effects among drugs used in the oriental medicine as well as in the western medicine in relation to thrombosis therapy would provide an important insight into the potential therapeutic applications.

• Journal of Electrical Engineering and Technology
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• v.7 no.4
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• pp.501-512
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• 2012

Social welfare maximization in a double-sided auction market is performed by implementing an aggregation-based particle swarm optimization (CAPSO) algorithm for optimal placement and sizing of one Static Synchronous Series Compensator (SSSC) device. Dallied simulation results (without/with line flow constraints and without/with SSSC) are generated to demonstrate the impact of SSSC on the congestion levels of the modified IEEE 14-bus test system. The proposed CAPSO algorithm employs conventional quadratic smooth and augmented quadratic nonsmooth generator cost curves with sine components to improve the accurate of the model by incorporating the valve loading effects. CAPSO also employs quadratic smooth consumer benefit functions. The proposed approach relies on particle swarm optimization to capture the near-optimal GenCos and DisCos, as well as the location and rating of SSSC while the Newton based load flow solution minimizes the mismatch equations. Simulation results of the proposed CAPSO algorithm are compared to solutions obtained by sequential quadratic programming (SQP) and a recently implemented Fuzzy based genetic algorithm (Fuzzy-GA). The main contributions are inclusion of customer benefit in the congestion management objective function, consideration of nonsmooth generator characteristics and the utilization of a coordinated aggregation-based PSO for locating/sizing of SSSC.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.1
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• pp.79-95
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• 2016

In order to improve the Quality-of-Service (QoS) of latency sensitive applications in next-generation cellular networks, multi-path is adopted to transmit packet stream in real-time to achieve high-quality video transmission in heterogeneous wireless networks. However, multi-path also introduces two important challenges: out-of-order issue and reordering delay. In this paper, we propose a new architecture based on Software Defined Network (SDN) for flow aggregation and flow splitting, and then design a Multiple Access Radio Scheduling (MARS) scheme based on relative Round-Trip Time (RTT) measurement. The QoS metrics including end-to-end delay, throughput and the packet out-of-order problem at the receiver have been investigated using the extensive simulation experiments. The performance results show that this SDN architecture coupled with the proposed MARS scheme can reduce the end-to-end delay and the reordering delay time caused by packet out-of-order as well as achieve a better throughput than the existing SMOS and Round-Robin algorithms.

• Journal of Lipid and Atherosclerosis
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• v.7 no.2
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• pp.88-97
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• 2018

The prevalence of atherothrombotic disease continues to rise, presenting an increasing number of challenges to modern society and creating interest in functional foods. Platelet activation, adhesion, and aggregation at vascular endothelial disruption sites are key events in atherothrombotic disease. Physiological challenges such as hyperlipidemia, obesity, and cigarette smoking are associated with vascular changes underlying platelet aggregation and inflammatory processes. However, it is difficult to determine the beneficial response of functional foods in healthy subjects. To address this problem, challenge models and high-risk models related to smokers, obesity, and dyslipidemia are proposed as sensitive measures to evaluate the effects of functional foods in healthy subjects. In this review, we construct a model to evaluate the effects of functional food such as natural products on blood flow based on a human intervention study.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.1
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• pp.110-124
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• 2009

Purpose: This study was performed to evaluate anti-thrombotic effect of Jogantanggagambang extract (JGTG). Methods: Blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD solution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that was caused from the administration of platelet aggregation regent. Results: 1. JGTG inhibited the platelet aggregation induced by ADP, epinephrine, collagen and arachidonic acid as compared with the control group. 2. JGTG inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 37.5%). 3. JGTG increased platelet number and fibrinogen amount significantly and also JGTG shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. 4. JGTG increased blood flow rate significantly as compared with the control group in vivo. Conclusion: These results suggest that JGTG can be used for treating various female diseases caused by thrombosis.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.1
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• pp.79-94
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• 2009

Purpose: This study was performed to evaluate anti-thrombotic effect of Cheongyeoljohyeoltangkamibang extract (CYJHT). Methods: Blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD soulution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. Results: 1. CYJHT inhibited the platelet aggregation induced by ADP, epinephrine, collagen and arachidonic acid as compared with the control group. 2. CYJHT inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 50%). 3. CYJHT increased platelet number and fibrinogen amount significantly and also CYJHT shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. 4. CYJHT increased blood flow rate insignificantly as compared with the control group in vivo. Conclusion: These results suggest that CYJHT can be useful in treating various female diseases caused by thrombosis, such as menstrual pain, menstrual disorder and so on.

• Journal of Korean Society of Transportation
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• v.23 no.3 s.81
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• pp.109-123
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• 2005

The goals of this paper are two folds: i) to evaluate whether the data collected by a license plate matching AVI equipment being operated on some segment of a national highway are suitable or not for use in travel time estimation of interrupted traffic flows; ii) to study the statistical methodologies to be used for the determination of the optimal aggregation interval for travel time estimation. In this study it was found that the AVI data are not representative because the data are collected on some selected lanes of a roadway where main traffic is thru-traffic and, thus the AVI data are different from those collected from all lanes in traffic characteristics. For the determination of the optimal aggregation interval for travel time estimation. two statistical methods. namely point estimation and interval estimation. were tested. The test shows that the point estimation method is more sensitive and gives more desirable results in determing the optimal aggregation interval than the interval estimation method. And it turned out that the optimal aggregation interval on interrupted traffic flows has been calculated as 5 minute and thus the existing aggregation interval. 5 minute is proper.

• Journal of Korean Institute of Industrial Engineers
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• v.28 no.1
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• pp.1-13
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• 2002

We study a multi-component production/inventory system in which individual components are made to meet various demand types. We assume that the demands arrive according to a Poisson process, but there is a fixed probability that a demand requests a particular kit of different components. Each component is produced by a flow line with several stations. The production of each component is operated by the CONWIP control mechanism. To analyse this system, we propose an approximation method based on aggregation method. In application of the aggregation method, a product-form approximation technique as well as a matrix-geometric method is used. Comparisons with simulation show that the approximation method provides fairly good results.

• Proceedings of the KIEE Conference
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• 1990.07a
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• pp.113-120
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• 1990

This paper presents a new aggregation method of induction motors for the load flow and transient stability analysis. The proposed method aggregates a group of motors into a single motor considering the variations of the system voltage and frequency so that the aggregated model represents the dynamic characteristics of the system accurately. The performance of the Method is shown by numerical simulation and is compared with that of LOADSYN algorithm.

• The Journal of Korean Medicine
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• v.31 no.2
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• pp.167-176
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• 2010

Objectives: The purpose of this study was to report the effect of Kamitongkyung-tang on adenomyosis. Methods: Three women who were diagnosed with adenomyosis were enrolled in this study. They were supposed to have blood aggregation, so received oriental treatments to decrease blood aggregation and promote blood flow. They took Kamitongkyung-tang internally 3 times a day and were taken acupuncture therapy 3 times a week during about 3 months. Results: The most common symptoms of adenomyosis were menorrhagia and dysmenorrhea. After the treatment, symptoms of adenomyosis decreased and ultrasonography showed good results. Conclusion: These clinical cases indicated that Kamitongkyung-tang was effective in the treatment of adenomyosis. More clinical data and studies are needed about the treatment of adenomyosis.