• 정보처리학회논문지C
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• 제11C권4호
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• pp.527-538
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• 2004

본 논문에서는 MPLS에서 전체 플로우의 수를 줄이고 확장성(scalability) 문제를 해결할 수 있는 테이블 관리 방안으로서 플로우 집적화와 플로우 유지 시간 제어 알고리즘을 제안하였다. 목적지 주소 기반 플로우 집적화 방식은 인터넷에서 전체 플로우의 수를 감소시키고 레이블을 효율적으로 사용할 수 있도록 관리하여 전체 패킷의 스위칭 비율을 향상시킬 수 있는 방식이며, 플로우 유지 시간 제어 알고리즘은 불필요한 플로우에게 할당되어 있는 레이블을 가능한 빨리 해제함으로써 레이블의 과도한 낭비를 줄일 수 있는 방법이다. 본 논문에서는 실제 인터넷 트래픽 트레이스를 이용하여 시뮬레이션을 수행함으로써 제안한 두 가지 방식의 성능을 검증하였다. 성능검증에서는 레이블 사용 효율, 평균 fp이블 사용량, 그리고 스위칭 된 패킷수와 스위칭 된 비율을 이용하였다.

• Nuclear Engineering and Technology
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• 제56권2호
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• pp.624-635
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• 2024

In two-fluid simulations of flow boiling, the modeling of the mean bubble diameter is a key parameter in the closure relations governing the intefacial transfer of mass, momentum, and energy. Monodispersed approach proved to be insufficient to describe the significant variation in bubble size during flow boiling in a heated pipe. A population balance model (PBM) has been employed to address these shortcomings. During nucleate boiling, vapor bubbles of a certain size are formed on the heated wall, detach and migrate into the bulk flow. These bubbles then grow, shrink or disintegrate by evaporation, condensation, breakage and aggregation. In this study, a parametric analysis of the PBM aggregation and breakage models has been performed to investigate their effect on the radial distribution of the mean bubble diameter and vapor volume fraction. The simulation results are compared with the DEBORA experiments (Garnier et al., 2001). In addition, the influence of PBM parameters on the local distribution of individual bubble size groups was also studied. The results have shown that the modeling of aggregation process has the largest influence on the results and is mainly dictated by the collisions due to flow turbulence.

• Journal of Ginseng Research
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• 제35권4호
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• pp.442-448
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• 2011

We previously reported that in vitro anti-platelet activity of tissue-cultured mountain ginseng (TCMG) ethanol extracts show improved efficacy when compared with commercial ginseng products such as Korean red ginseng and Panax ginseng. However, information on the anti-platelet activity of the ethyl acetate fraction from TCMG adventitious roots is limited. Therefore, in this study, we further investigated the effects of an ethyl acetate extract of TCMG (EA-TCMG) adventitious roots on in vitro antiplatelet activity in whole human blood and its effect on peripheral blood flow in mice. We found that EA-TCMG inhibited platelet aggregation with $IC_{50}$ values of 271, 180, and 147 ${\mu}g$/mL induced by collagen, adenosine-5'-diphosphate, and arachidonic acid, respectively. Among the three agonists used, thromboxane $A_2$ formation induced by arachidonic acid was markedly suppressed. Furthermore, EA-TCMG improved the peripheral circulatory disturbance by improving vascular blood flow. In conclusion, these results suggest that ethyl acetate extracts from TCMG adventitious roots might inhibit vascular platelet aggregation and thrombus formation.

• Journal of Chest Surgery
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• 제49권3호
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• pp.145-150
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• 2016

Background: Extracorporeal circulation (ECC) can induce alterations in blood viscoelasticity and cause red blood cell (RBC) aggregation. In this study, the authors evaluated the effects of pump flow pulsatility on blood viscoelasticity and RBC aggregation. Methods: Mongrel dogs were randomly assigned to two groups: a nonpulsatile pump group (n=6) or a pulsatile pump group (n=6). After ECC was started at a pump flow rate of 80 mL/kg/min, cardiac fibrillation was induced. Blood sampling was performed before and at 1, 2, and 3 hours after ECC commencement. To eliminate bias induced by hematocrit and plasma, all blood samples were adjusted to a hematocrit of 45% using baseline plasma. Blood viscoelasticity, plasma viscosity, hematocrit, arterial blood gas analysis, central venous $O_2$ saturation, and lactate were measured. Results: The blood viscosity and aggregation index decreased abruptly 1 hour after ECC and then remained low during ECC in both groups, but blood elasticity did not change during ECC. Blood viscosity, blood elasticity, plasma viscosity, and the aggregation index were not significantly different in the groups at any time. Hematocrit decreased abruptly 1 hour after ECC in both groups due to dilution by the priming solution used. Conclusion: After ECC, blood viscoelasticity and RBC aggregation were not different in the pulsatile and nonpulsatile groups in the adult dog model. Furthermore, pulsatile flow did not have a more harmful effect on blood viscoelasticity or RBC aggregation than nonpulsatile flow.

• Korea-Australia Rheology Journal
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• 제19권2호
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• pp.61-66
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• 2007

The aggregation characteristics of red blood cells (RBCs) are known as important factors in the microvascular flow system, and increased RBC aggregation has been observed in various pathological diseases, such as thrombosis and myocardial infarction. This paper describes a simple microfluidic device for measuring the RBC aggregation by integrating a microfluidic slit rheometry and laser-backscattering technique. While a decreasing-pressure mechanism was applied to the microfluidic rheometry, a syllectogram (the light intensity versus time) showed an initial increase and a peak caused by the high shear stress-induced disaggregation, immediately followed by a decrease in the light intensity due to RBC aggregation. The critical shear stress (CST) corresponding to the peak intensity was examined as a new index of the RBC aggregation characteristics. The CST of RBCs increased with increasing aggregation-dominating protein (fibrinogen) in the blood plasma. The essential feature of this design was the combination of the rheometric-optic characterization of RBC aggregation with a microfluidic chip, which may potentially allow cell aggregation measurements to be easily carried out in a clinical setting.

• Journal of Mechanical Science and Technology
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• 제17권7호
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• pp.1104-1110
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• 2003

The present study investigates the hemorheological characteristics of blood flow with applying vibration to a non-aggregating red blood cell suspension. In order to obtain the non-aggregating RBC suspension, blood samples were treated with vibration at a specified condition, which viscosities were taken before and after the treatment, respectively. The viscosity of the blood samples after treatment was higher than before treatment. These treated blood samples were forced to flow through a capillary tube that was vibrated perpendicularly to the direction of the flow. The experimental results showed that vibration caused a reduction of the flow resistance of the non-aggregated blood. The reduction of the flow resistance was strongly dependent on both frequency and amplitude of vibration. These results show potential in treating various diseases in the microcirculation associated with blood cell aggregation.

• 대한지리학회지
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• 제46권2호
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• pp.197-211
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• 2011

공간 상호작용의 복잡성, 공간적 재현과 모델링의 필요성에 의해서 공간 상호작용 데이터의 합역이 불가피하다. 이러한 상황에서 본 연구의 목적은 공간 상호작용 데이터를 스케일을 달리하여 합역하거나 혹은 동일 스케일에서 합역 방식을 달리하여 합역하였을 때, 공간 상호작용 모델의 결과가 어떻게 달라지는지 평가하는 것이다. 공간 상호작용 데이터의 합역은 공간단위 수정가능성의 문제(Modifiable Areal Unit Problem: MAUP)를 야기한다. 공간 상호작용 데이터의 합역을 위하여 무작위로 구역 시드를 선정한 후 인접한 공간단위를 할당하는 방법, 구역 시드와 공간단위 사이의 연구 가중 거리를 최소화하는 방법, 구역 내 상호작용 비율을 최대화하는 방법, 구역 내 상호작용 비율을 최소화하는 방법을 사용하였다. MAUP의 영향을 평가하기 위한 공간 상호작용 모텔로 기원지-목적지 제약 포아송 회귀 모델을 이용하였다. 분석 결과는 모델 잔차의 공간적 특성뿐만 아니라 파라미터 추정값, 적합도 등이 MAUP의 영향을 받는다는 것을 보여주었다. 모델은 합역 방식 보다는 합역 수준에 더 민감하게 반응하였고, 모델에 대한 스케일 효과는 구획 방식에 따라 상이하게 나타났다.

• Journal of Communications and Networks
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• 제9권4호
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• pp.419-427
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• 2007

In wavelength-division-multiplexing(WDM) networks a link failure may cause the failure of several high-bit-rate optical channels, thereby leading to large data loss. Recently, various protection and restoration mechanisms have been proposed to efficiently deal with this problem in mesh networks. Among them, dedicated path protection(DPP) is a promising candidate because of its ultra-fast restoration time and robustness. In this work we investigate the issue of planning and optimization of WDM networks with DPP. Integer linear programming(ILP), in particular, is one of the most common exact method to solve the design optimization problem for protected WDM networks. Traditional ILP formalizations to solve this problem rely on the classical flow or route formulation approaches, but both these approaches suffer from a excessively high computational burden. In this paper, we present a variable-aggregation method that has the ability of significantly reducing the complexity of the traditional flow formulation. We compare also the computational burden of flow formulation with variable aggregation both with the classical flow and route formulations. The comparison is carried out by applying the three alternative methods to the optimization of two case-study networks.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1487-1491
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• 2008

Detailed knowledge on the motion of blood cells flowing in micro-channels under simple shear flow and the influence of blood flow is essential to provide a better understanding on the blood rheological properties and blood cell aggregation. The microscopic behavior of red blood cell (RBCs) is numerically investigated using a fluid-structure interaction (FSI) method based on the Arbitrary-Lagrangian-Eulerian (ALE) approach and the dynamic mesh method (smoothing and remeshing) in FLUENT (ANSYS Inc., USA). The employed FSI method could be applied to the motions and deformations of a single blood cell and multiple blood cells, and the primary thrombogenesis caused by platelet aggregation. It is expected that, combined with a sophisticated large-scale computational technique, the simulation method will be useful for understanding the overall properties of blood flow from blood cellular level (microscopic) to the resulting rheological properties of blood as a mass (macroscopic).

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권10호
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• pp.4717-4737
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• 2017

Today, smart grids, smart homes, smart water networks, and intelligent transportation, are infrastructure systems that connect our world more than we ever thought possible and are associated with a single concept, the Internet of Things (IoT). The number of devices connected to the IoT and hence the number of traffic flow increases continuously, as well as the emergence of new applications. Although cutting-edge hardware technology can be employed to achieve a fast implementation to handle this huge data streams, there will always be a limit on size of traffic supported by a given architecture. However, recent cloud-based big data technologies fortunately offer an ideal environment to handle this issue. Moreover, the ever-increasing high volume of traffic created on demand presents great challenges for flow management. As a solution, flow aggregation decreases the number of flows needed to be processed by the network. The previous works in the literature prove that most of aggregation strategies designed for smart grids aim at optimizing system operation performance. They consider a common identifier to aggregate traffic on each device, having its independent static aggregation policy. In this paper, we propose a dynamic approach to aggregate flows based on traffic characteristics and device preferences. Our algorithm runs on a big data platform to provide an end-to-end network visibility of flows, which performs high-speed and high-volume computations to identify the clusters of similar flows and aggregate massive number of mice flows into a few meta-flows. Compared with existing solutions, our approach dynamically aggregates large number of such small flows into fewer flows, based on traffic characteristics and access node preferences. Using this approach, we alleviate the problem of processing a large amount of micro flows, and also significantly improve the accuracy of meeting the access node QoS demands. We conducted experiments, using a dataset of up to 100,000 flows, and studied the performance of our algorithm analytically. The experimental results are presented to show the promising effectiveness and scalability of our proposed approach.