• 통합자연과학논문집
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• 제9권4호
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• pp.241-248
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• 2016

Corticotropin-releasing factor receptors (CRFRs) activate the hypothalamic-pituitary-adrenal axis, which is an integral part of the fight or flight response to stress. Increase in CRH level is observed in Alzheimer's disease and major depression and hypoglycemia. Here, we report on the relevant physicochemical parameters required for the CRFR inhibitors. Comparative molecular similarity indices analysis (CoMSIA) was performed with the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolinesas CRFR inhibitors. The best predictions were obtained for the best CoMSIA model with a $q^2$ of 0.576 with 6 components and $r^2$ of 0.977. The statistical parameters from the generated CoMSIA models indicated that the data are well fitted and have high predictive ability. CoMSIA contour maps could be useful in the designing of more potent and novel CRFR derivatives.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2000년도 추계학술발표대회 논문집
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• pp.187-190
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• 2000

Cyclocopter is air vehicle to vertically take-off and land like a helicopter. This is an efficient and quiet means of being able to direct thrust compared to a helicopter. The rotor consists of several blades rotating about a horizontal axis perpendicular to the direction of normal flight. The direction of blade span is parallel to rotating axis and both end roots are connected to the hub to resist centrifugal force and to transmit the power. The pitch of the individual blades to the tangent of the circle of the blade's path is varied cyclically to gain thrust. In the paper, the design and manufactures of cyclocopter rotor blades are presented. Stress at the roots of cyclocopter blades is great due to centrifugal and aerodynamic forces and aeroelastic instabilities appear. The blades consist of main spar, front spar, polyurethan foam, weight, and skin and spars and skin are made of glass/epoxy composite.

• 한국추진공학회지
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• 제22권6호
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• pp.126-133
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• 2018

액체로켓엔진은 비행 중에 극심한 진동 환경뿐만 아니라 추진제의 고압, 추력, 극저온 산화제나 고온 연소 가스에 의한 열하중 등의 다양한 정적 하중을 겪는다. 엔진 개발 단계에서는 구조 안정성을 위해 엔진 시스템에 대한 구조 해석과 지상 연소 시험에서 측정된 변형율을 분석이 필요하다. 여기서는 75톤급 엔진의 지상 연소 시험에서 얻어진 변형율 특성을 분석하였다.

• 중독정신의학
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• 제18권1호
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• pp.17-22
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• 2014

Virtual reality (VR) provides an immersive and interactive 3-dimensional system, which allows an individual to become immersed in a computer-generated situation. VR technology has been administered in the exposure-based treatment of a variety of psychiatric disorders, including acrophobia, fear of flight, and post-traumatic stress disorder. Furthermore, VR systems have also been developed for the use of research and treatment in addiction. They might have advantages in cue exposure therapy, by increasing the salience of cues, as well as assessments of cue reactivity in addiction. This article summarizes the application of VR in the field of psychiatry. More importantly, it suggests the possibilities of clinical use of VR technology, in the treatment of addiction.

• 항공우주시스템공학회지
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• 제12권3호
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• pp.38-44
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• 2018

군용항공기는 다양한 임무의 수행을 통한 비행시간 누적과 예상 불가능한 외기 환경에 의한 복합적인 요인으로 구조적으로 취약한 부위에서 피로균열이 발생할 수 있다. 피로 균열은 점차 진전되어 극심한 경우 해당 구조가 파괴될 위험이 있으며 이는 비행 안전성에 큰 영향을 미칠 수 있다. 본 논문에서는 항공기 주익과 동체의 연결부위를 보호하기 위해 장착한 페어링 내부의 지지대에서 주기검사 중 균열 현상을 개선하기 위한 일련의 품질개선에 관한 연구를 수행하였다. 균열의 원인파악을 위해 주익 조립 공정에 따른 예하중 발생 여부에 대해 조사하고 파단면 분석을 수행하였다. 또한, 균열의 재발방지를 위해 지지대의 설계를 개선하는 방안을 제시하였고, 응력 및 피로 수명해석을 통해 구조 건전성을 검증하였다.

• 한국작물학회지
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• 제62권1호
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• pp.40-50
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• 2017

Seed storage proteins are used as carbon and nitrogen sources for the nutritional improvement of seeds. Since the composition of proteins from the Korean cultivars of proso millet is unknown, this study was conducted to obtain a reference map of millet seed proteins and identify the functional characteristics of the identified proteins. Proteins extracted from proso millet seeds of various cultivars were investigated using proteomic techniques such as 2-D electrophoresis coupled with mass fingerprinting; 1152 (differentially expressed) protein spots were detected on the 2-D gels. Among them, 26 reproducible protein spots were analyzed using matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry. Out of the 26 proteins, 2 proteins were upregulated in all the millet cultivars, while 13 proteins were upregulated and 11 proteins were downregulated in 2 cultivars. Abundance of most of the identified protein species associated with polysaccharide and starch metabolism, transcription, and pathogenesis was significantly enhanced, while that of other protein species involved in glycolysis, stress response, and transduction was severely reduced. Taken together, the results suggest that the differential expression of the proteins from the four millet cultivars may be cultivar-specific. By conducting a proteomic investigation of millet seeds from different cultivars, we sought to better understand the functional categorization of individual proteins on the basis of their molecular functions. We believe that the identified proteins may help in investigating genetic variations in millet cultivars.

• Journal of Microbiology and Biotechnology
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• 제27권6호
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• pp.1090-1097
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• 2017

Rhus verniciflua Stokes (RVS), an herbal medicine found in East Asia, was extracted and further fractionated to investigate its antioxidant capacity and neuroprotective effects. The RVS ethyl acetate (EtOAc) fraction had the highest level of total phenolics and antioxidant capacity among all solvent fractions tested. Pretreatment of PC-12 cells with the EtOAc fraction effectively attenuated $H_2O_2$-induced oxidative damage. Furthermore, the EtOAc fraction significantly attenuated caspase-3 activity, resulting in inhibition of $H_2O_2$-induced apoptosis. We identified and quantified fustin, sulfuretin, and butein in the EtOAc fraction using accurate mass quadrupole time-of-flight mass spectrometry and reversed-phase high-performance liquid chromatography. The intracellular antioxidant capacity and superoxide dismutase (SOD) activity were significantly increased in PC-12 cells treated with the EtOAc fraction and with individual flavonoids. When cells were pretreated with the EtOAc fraction or individual flavonoids and then co-incubated with diethyldithiocarbamic acid (an inhibitor of SOD activity), cell viability against $H_2O_2$-induced oxidative stress was attenuated. These results suggest that the RVS EtOAc fraction and its flavonoid constituents protect PC-12 cells against $H_2O_2$-induced neurotoxicity through their antioxidant properties.

• 한국항공우주학회지
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• 제41권12호
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• pp.959-966
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• 2013

이 논문에서는 설계정보가 없는 노후 항공기를 사용한 P-3CK 해상초계기 사업을 바탕으로, 끝단거리 부족 결함 수리를 위한 패스너 홀 구조특성 연구를 수행하였다. 이를 위해 끝단거리 결함이 많이 발생했던 낫셀 론저론 부분을 선택하고, 1.5, 1.8, 2.0배 끝단거리에 대한 정적 해석을 수행하여 보수적인 응력을 구하였다. 이 응력을 바탕으로 TWIST의 표준하중 스펙트럼을 적용하여 비행하중을 생성하고, 이 비행하중을 이용하여 균열성장 피로해석을 수행하였다. 이 결과를 통하여 P-3CK 사업 중 수리된 패스너 홀의 유효성을 평가하고 정비주기 및 기준을 설정하였다.

• International Journal of Oral Biology
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• 제34권1호
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• pp.29-36
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• 2009

Cyclosporin A (CsA) has been used clinically as an immunosuppressive drug to prevent organ transplant rejection and in basic research as a mitochondrial permeability blocker. It has been reported that CsA has a protective role in severed neurons and a neurotrophic effect in neuronal cells. However, the molecular mechanisms underlying the stimulation of neuronal cell proliferation by CsA have not yet been elucidated. In our current study, we investigated CsA responsive proteins in PC12 cells using a systematic proteomic approach. The viability of these cells following CsA treatment increased in a dose- and time-dependent manner. Proteins in the CsA-treated PC12 cells were profiled by two-dimensional gel electrophoresis (2-DE) and identified by matrix-assisted laser desorption ionization time-of flight (MALDI-TOF) and electrospray ionization quadupole time-of-flight mass spectrometries (EIQ-TOFMS). This differential expression analysis showed significant changes for 10 proteins (6 up-regulated and 4 down-regulated) upon CsA treatment that were related to cell proliferation, metabolism and the stress response. These proteomics data further our understanding of the proliferation mechanisms of PC12 cells exposed to CsA and demonstrate that our methodology has potential to further elucidate the mechanisms and pathways involved.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.75-78
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• 2004

Various jet engines (Turbine engine family and RAM Jet engine) have been developed for high speed aircrafts. but their application to hypersonic flight is restricted by principle problems such as increase of total pressure loss and thermal stress. Therefore, the development of next generation propulsion system for hypersonic aircraft is a very important subject in the aerospace engineering field, SCRAM Jet engine based on a key technology, Supersonic Combustion. is supposed as the best choice for the hypersonic flight. Since Supersonic Combustion requires both rapid ignition and stable flame holding within supersonic air stream, much attention have to be given on the mixing state between air stream and fuel flow. However. the wider diffusion of fuel is expected with less total pressure loss in the supersonic air stream. So. in this study the direction of fuel injection is inclined 30 degree to downstream and the total pressure of jet is controlled for lower penetration height than thickness of boundary layer. Under these flow configuration both streams, fuel and supersonic air stream, would not mix enough. To spread fuel wider into supersonic air an aerodynamic force, baroclinic torque, is adopted. Baroclinic torque is generated by a spatial misalignment between pressure gradient (shock wave plane) and density gradient (mixing layer). A wedge is installed in downstream of injector orifice to induce an oblique shock. The schlieren optical visualization from side transparent wall and the total pressure measurement at exit cross section of combustor estimate how mixing is enhanced by the incidence of shock wave into supersonic boundary layer composed by fuel and air. In this study non-combustionable helium gas is injected with total pressure 0.66㎫ instead of flammable fuel to clarify mixing process. Mach number 1.8. total pressure O.5㎫, total temperature 288K are set up for supersonic air stream.