• Tuberculosis and Respiratory Diseases
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• 제65권3호
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• pp.177-182
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• 2008

연구배경: Isoniazid (INH, H)는 4제 표준 항결핵치료의 근간이 되는 중요한 약제이지만 INH를 제외하여도 치료효과에 차이가 없다는 일부 보고들이 있다. 본 연구는 초기 결핵 생쥐 모델을 이용하여 항결핵 표준병합치료에서 INH의 유용성을 평가하였다. 방 법: 140마리의 C57BL/6 생쥐를 Glas-Col 장비를 이용하여 약 100개의 H37Rv가 호흡기로 감염되도록 하였다. 감염 4주 후부터 다양한 약제의 조합으로 4~8주간 치료를 시행한 후 감염 후 28주까지 주기적으로 각각 4마리에서 폐와 비장을 적출하여 결핵균 수를 측정하였다. 1군은 약물치료를 시행하지 않은 대조군이었으며, 2군은 INH, rifampicin (RMP, R), ethambutol (EMB, E), pyrazinamide (PZA, Z)로 4주 치료하였고(4HREZ), 3군은 1HREZ/3REZ, 4군은 4REZ, 5군은 4HREZ/4HRE, 6군은 1HREZ/3REZ/4RE, 7군은 4REZ/4RE이었다. 결 과: 4주 치료한 군(2~4군)은 치료종료 시점에 폐에서 균이 배양되지 않았으나 치료 종료 12주, 20주 시점에서 다시 균이 검출되었다. 8주 치료한 군(5~7군)은 모두 치료시작 1주까지는 균수가 증가하였다가 2주 후부터 감소하여 치료시작 4주 시점에는 모두 균이 배양되지 않았다. 이후 8주간의 치료를 종료하고 종료 후 16주간 경과 관찰할 때까지(감염 후 28주) 모두에서 균이 배양되지 않았다. 비장에서는 감염 4주 후부터 균이 배양되었다. INH를 전혀 사용하지 않은 7군에서는 치료시작 4주 시점부터 균이 배양되지 않고 이후 감염 28주 시점까지 지속적으로 균이 배양되지 않았다. 반면에 INH를 지속적으로 사용하거나 일시적으로 사용한 5, 6군에서는 치료시작 4주 이후시점에도 간헐적으로 균이 배양되었다. 결 론: 초기 결핵 생쥐 모델에서 INH의 제외는 표준요법의 치료효과에 영향을 미치지 않았다. 향후 만성 결핵생쥐 모델을 이용한 추후 연구가 필요하다.

• Journal of Korean Neurosurgical Society
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• 제64권5호
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• pp.732-739
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• 2021

Objective : Early successful reperfusion is associated with favorable outcomes in acute ischemic stroke (AIS). The purpose of this study was to achieve successful recanalization by a combined mechanical thrombectomy technique, the Aspiration-Retriever Technique for Stroke (ARTS), which is composed of a flexible large lumen distal access catheter and a retrievable stent as the first-line strategy of mechanical thrombectomy. Methods : We retrospectively reviewed 62 patients with AIS who underwent mechanical thrombectomy from 2018 to 2019 at our institute by a senior neurointerventionalist. Among them, patients who were treated using the ARTS technique with the soft torqueable catheter optimized for intracranial access (SOFIA^®; MicroVention-Terumo, Tustin, CA, USA) as the first-line treatment were included. Patients who had tandem occlusions or underlying intracranial artery stenosis were excluded. The angiographic and clinical outcomes were evaluated. The angiographic outcome was analyzed by the rate of successful recanalization, defined as a Thrombolysis in Cerebral Infarction score of 2b or 3 at the end of all procedures and the rate of successfully achieving the first pass effect (FPE), defined as complete recanalization with a single pass of the device. The clinical outcomes included the National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale (mRS), and mortality. Results : A total of 27 patients (mean age, 59.3 years) fulfilled the inclusion criteria. The successful recanalization rate was 96% (n=26) while the FPE rate was 41% (n=11). The mean post-procedural NIHSS change was -3.0. Thirteen patients (48%) showed good clinical outcomes after thrombectomy with the ARTS technique (mRS at 90 days ≤2). Postoperative complications occurred in seven of 25 patients : hemorrhagic transformation in six patients (22%) and distal embolization in one patient (4%). Mortality was 15% (n=4). Conclusion : Although the clinical outcomes using the ARTS technique with a flexible large lumen distal access catheter performed as the frontline thrombectomy in patients with AIS were not significantly superior than those of other studies, this study showed a high rate of successful endovascular recanalization which was comparable to that of other studies. Therefore, ARTS using the SOFIA^® catheter can be considered as the first choice of treatment for AIS due to large vessel occlusion.

• 한국실내디자인학회논문집
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• 제13권4호
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• pp.110-117
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• 2004

Recently the hospitals or clinics tend to get out of the functional and technological aspect so as to gradually emphasize service for patients. While qualitative rather than quantitative alteration is noticeable, the scale of clinics is getting larger. Especially, the opulence resulted from economic, social and cultural development has enabled more people to visit dermatology or plastic surgery besides treatment for disease. Responding to this tendency, dermatology is focusing on skin beauty, plastic operation, controlling obesity, etc. for women rather than ordinary treatment. Thus, dermatology is in need of space for skin control as well as ordinary treatment, which raises the immediate necessity of new plan for space and interior environment. In order to meet such necessity of dermatology, it is required to fully study and consider the plan for interior space. First, the purpose, scope and method of research will be defined in the introduction. Second, the concept of clinic as well at the characteristic of dermatology will be studied by theoretical investigation. Third, the general concept of dermatology will be analyzed by examining the characteristic of each room in dermatology, the moving line of nurses and patients, the color of dermatology and the design factor of finishing materials through general investigation on dermatology. Fourth, in order to look into the general case of dermatology, the object of examination will be selected for examination through literature and visiting. After examining data, the result will be analyzed and evaluated to prepare the ground for interior plan of dermatology.

• Clinical and Experimental Pediatrics
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• 제64권9호
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• pp.459-467
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• 2021

Mycoplasma pneumoniae (MP) is the most common cause of childhood bacterial pneumonia. Although macrolide is known to be effective as a first-line therapy, the proportion of macrolide resistance in MP pneumonia has strikingly increased during recent 2 decades in East Asia. This is challenging to physicians since they have to decide more often whether to use secondary treatment. Diagnostic methods to detect macrolide-resistance of MP are currently not available in Korean hospitals. Even in the diagnosis of MP infection, both serologic and molecular test have limitation: inability to differentiate current illness from carriage or asymptomatic infection. Combining these 2 diagnostic methods and excluding infection caused by other respiratory pathogens allow a more reliable diagnosis. This effort is even more demanding in recent years to keep children from unnecessary exposure to secondary antibiotics. Although several observational studies have reported that tetracycline and fluoroquinolone, which are considered in the treatment of refractory MP pneumonia, have efficacy of shortening the duration of fever and respiratory symptoms, those findings need to be proven by well-designed prospective studies. The use of tetracycline and fluoroquinolone in children is generally tolerable, as supported by many observational data. However, since concerns about side effects still remain, careful consideration about benefits and risks is needed to decide their use.

• Genomics & Informatics
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• 제18권4호
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• pp.37.1-37.11
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• 2020

BET inhibitor, as an epigenetic regulator inhibitor, reduces the expression of oncogenes such as Myc and Bcl-2, which affects cancer growth and development. However, it has modest activity because of the narrow therapeutic index. Therefore, combination therapy is necessary to increase the anti-tumor effect. Paclitaxel, an anti-mitotic inhibitor, is used as second-line therapy for gastric cancer (GC) as a monotherapy or combination. In this study, we performed RNA sequencing of GC cells treated with iBET-151 and/or paclitaxel to identify the differentially expressed genes associated with possible mechanisms of synergistic effect. We also performed Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses to determine the most enriched terms and pathways of upregulated and downregulated genes. We found 460 genes in which iBET-151 and paclitaxel combination treatment changed more than single-treatment or no-treatment. Thus, additional functional studies are needed, but our results provide the first evidence of the synergistic effect between iBET-151 and paclitaxel in regulating the transcriptome of GC cells.

• Journal of Medicine and Life Science
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• 제19권3호
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• pp.79-89
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• 2022

Whereas systolic blood pressure (SBP) continuously rises with age, diastolic blood pressure (DBP) gradually decreases after the age of 55 years. Therefore, hypertension in the elderly shows the pattern of isolated systolic hypertension. There is evidence on the benefits of controlling blood pressure (BP) in elderly patients with hypertension. The BP lowering effect has also been demonstrated in patients over 80 years of age with hypertension. The BP threshold for the initiation of antihypertensive drug treatment for older adults with hypertension is gradually decreasing. The antihypertensive treatment is recommended if, despite therapeutic lifestyle modifications, SBP ≥140 mmHg or DBP ≥90 mmHg in those aged 65-79 years old, and SBP ≥140-160 mmHg or DBP ≥90 mmHg in those aged ≥80 years old. Although there is no consensus on the target BP for older adults with hypertension, a target SBP of <130-140 mmHg and DBP of <80-90 mmHg are recommended. In older adults over 80 years of age with hypertension, the target SBP is <140-150 mmHg. When the dose of antihypertensive drugs is increased to reach the target SBP, DBP may decrease to less than 70 mmHg, but it should not be <60 mmHg. Thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers can be selected as the first-line drug for older adults with hypertension. Beta-blockers may be selected in case of compelling indications.

• Tuberculosis and Respiratory Diseases
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• 제58권5호
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• pp.465-472
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• 2005

연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로, platinum을 근거로 한 항암화학요법을 시행 받았으나 재발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방 법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel $75mg/m^2$ 또는 $100mg/m^2$을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결 과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3) 중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월-17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95% 신뢰구간: 1.6개월 - 4.5개월)이며, 반응군에서의 중앙반응지속기간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months, p=0.0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, p=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%), 호중구 감소증에 동반된 발열은 6명(19.3%), 감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결 론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암 환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

• 동의생리병리학회지
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• 제16권1호
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• pp.133-140
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• 2002

To evaluate the anti metastatic effect of Antivascular-first(AntiV-F), we investigated cytotoxic effect on B16-F10 and HMCB. gene expression of MMP-9 and nm23-H1, and survival. After treating with AntiV-F, AntlV-F promoted cytotoxic effect on B16-F10 and HMCB as its density, compared with Control. AntiV-F inhibited gene expression of MMP-9 in the L+14 and HMCB cell line compared with Control. On the other hand AntiV-F increases gene expression of nm23-H1 and survival about 30% compared with Control. These results suggest that AntiV-F has effects on anti-metastasis can be used for treatment of cancer patients and preventing recurrence.

• 대한족부족관절학회지
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• 제13권2호
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• pp.193-196
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• 2009

The first metatarsophalangeal joint injury is common in professional soldiers and athletes. But this was rarely reported. A professional soldier has varus instability in the first metatarsophalangeal joint due to hyperextension. In the MR Imaging, weavy appearance in lateral collateral ligament and high signal change in plantar plate was shown. So he has surgical treatment using reconstructive procedure. At first, $4^{th}$ extensor digitorum longus tendon was splitted longitudinally and harvested, second triangular shape reconstruction on lateral joint line was done using harvested tendon. One year later, fifteen degrees was limited compared with intact side. Reconstruction using $4^{th}$ extensor digitorum longus tendon in traumatic dynamic hallux varus was good method.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5391-5396
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• 2013

Aim: To investigate the role of Golgi phosphoprotein 3 (GOLPH3) in tumour growth and metastasis of esophageal squamous cancer. Methods: A lentiviral shRNA-vector was utilized to stably knockdown GOLPH3 in Eca-109 esophageal squamous cancer cells. mRNA transcription and protein expression of GOLPH3 were examined by real-time quantitative PCR and Western blotting, respectively. Cell proliferation activity was assessed by MTT assay and invasion and migration potentials by matrigel invasion and transwell motility assays. Results: Stable knockdown in the GOLPH3 cell line was established. PD-A gene expression was significantly suppressed by lentivirus-mediated RNAi, which resulted in reducing the capacity for cell proliferation, migration, invasion and adhesion in vitro. In vivo, GOLPH3 depletion resulted in inhibition of tumour growth, with stable decrease in the expression of GOLPH3 in tumor xenografts. Conclusions: Our findings suggest that lentivirus mediated silencing of the GOLPH3 gene has a significant anti-tumour effect on esophageal squamous cancer in vitro and in vivo. In addition, the results indicate that GOLPH3 might be an effective molecular target for gene therapy in esophageal squamous cancer.