• 농업과학연구
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• 제50권2호
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• pp.241-247
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• 2023

Erwinia amylovora , which causes fire blight disease on apple and pear trees, is one of the most important phytopathogens because of its devastating impact. Currently, the only way to effectively control fire blight disease is through the use of antibiotics such as streptomycin, kasugamycin, or oxytetracycline. However, problems with the occurrence of resistant strains due to the overuse of antibiotics are constantly being raised. It is therefore necessary to develop novel disease control methods through an advanced understanding of the pathogenesis mechanism of E. amylovora . To better understand the pathogenesis of E. amylovora , we investigated unknown virulence factors by random mutagenesis and screening. Random mutants were generated by Tn5 transposon insertion, and the pathogenicity of the mutants was assessed by inoculation of the mutants on apple fruitlets. A total of 17 avirulent mutants were found through screening of 960 random mutants. Among them, 14 mutants were already reported as non-pathogenic strains, while three mutants, TS3128_M2899 (ΔSUFU ), TS3128_M2939 (ΔwcaG ), and TS3128_M3747 (ΔrecB ), were not reported. Further study of the association between E. amylovora pathogenicity and these 3 novel genes may provide new insight into the development of control methods for fire blight disease.

• 동의신경정신과학회지
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• 제30권1호
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• pp.1-11
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• 2019

Objectives: Attention-Deficit/Hyperactivity Disorder (ADHD) is characterized by a persistent pattern of inattention and/or hyperactivity impulsivity that interferes with function or development in children. In traditional Korean medicine (TKM) and traditional Chinese medicine (TCM), ADHD is classified by several patterns based on symptoms and signs. However, currently, there is no objective diagnostic tool for ADHD in traditional medicine. The objective of this study was to develop the Pattern Identification Questionnaire for ADHD (parents-survey style) to be used in Korean medicine, through a literature review and consultation with groups of experts. Methods: The types of pattern identifications of ADHD mentioned in 13 pieces of Korean and Chinese literatures and their symptoms and signs were analyzed. The advisory committee (15 Neuropsychiatrist and 11 Pediatrist in Korean Medicine) assessed the appropriateness of the literature selection and the types of pattern identification selection and their symptoms and signs, and weighed the significance of the symptoms and signs. The Pattern Identification Questionnaire for ADHD was developed using the calculated weights by evaluated significance. The translation of symptoms and signs to the Korean language was achieved through consultation with expert translators. Results: 1. Four pattern identification types and their symptoms and signs were selected according to frequency of appearance in the Korean and Chinese literatures, and were reviewed by the advisory committee: Kidney yin deficiency and liver yang ascendant hyperactivity (腎虛肝亢), Dual deficiencies in the heart and spleen (心脾兩虛), Phlegm-fire harassing the heart (痰火擾心), and Spleen weakness and liver energy preponderance (脾虛肝旺). 2. The weights of all the symptoms and signs in the four patterns were calculated using the means and standard deviations of the symptoms and signs' importance that were obtained from specialists' significance weighting. 3. The Pattern Identification Questionnaire for ADHD (parents-survey style) in Korean medicine composed of 38 questions was suggested. Conclusions: Using a review of the literature and expert advice, Pattern Identification Questionnaire for ADHD (parents-survey style) in Korean medicine was developed. Further clinical study is required to develop a final version of the questionnaire through the evaluation of reliability and validity.

• 동의신경정신과학회지
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• 제31권1호
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• pp.1-12
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• 2020

Objectives: The purpose of this study was to evaluate the reliability and validity of the instrument on pattern identification for insomnia (PIT-Insomnia) and verify the correlation between PIT-Insomnia and psychological tests. Methods: Two evaluators examined the pattern identification of the participants who met insomnia disorder diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-5) and took the Insomnia Severity Index (ISI) score over 15 once manually and twice using the PIT-Insomnia to measure the inter-rater and test-retest reliability. We also conducted the following surveys: the Pittsburgh Sleep Quality Index (PSQI), the Korean version of Beck's depression inventory (K-BDI), the Korean version of the State-Trait Anxiety Inventory (STAI-K), the Korean Symptom checklist-95 (KSCL-95), and the EuroQol-5 dimension (EQ-5D), to measure concurrent validity and correlation between the PTI-Insomnia and psychological tests. Results: 1. The test-retest reliability analysis of the pattern identification results showed moderate agreement, and test-retest reliability analysis of each pattern identification score showed agreements from poor to moderate. 2. The inter-rater reliability analysis of the pattern identification results via manual showed slight agreement, when analysis was performed with calibration, the inter-rater reliability analysis of the pattern identification results via manual showed fair agreement. 3. The concordance analysis between results via manual and the PIT-Insomnia showed poor agreement, when the analysis was performed with calibration, concordance analysis showed fair agreement. 4. The concordance analysis between the PIT-Insomnia and the PSQI showed positive linear correlation. 5. The concordance analysis between the PIT-Insomnia and the PSQI, K-BDI, STAI-K, KSCL-95, and EQ-5D showed that non-interaction between the heart and kidney have positive linear correlation with the K-BDI, anxiety item of KSCL-95, dual deficiency of the heart-spleen have positive linear correlation with somatization item of KSCL-95, paranoia item of KSCL-95, heart deficiency with timidity have positive linear correlation with stress vulnerability item of KSCL-95, parania item of KSCL-95, phlegm-fire harassing the heart have positive linear correlation with K-BDI, paranoia item of KSCL-95, depressed liver qi transforming into fire have positive linear correlation with the anxiety item of KSCL-95, parania item of KSCL-95, all pattern identification have negative linear correlation with EQ-5D. Conclusions: The PIT-Insomnia has moderate agreement of reliability and reflects the severity of insomnia since it has some concurrent validity with the PSQI. There are some correlations between the PTI-Insomnia with specific psychological tests, so we could suggest it can be used appropriately in the clinical situation.

• 대한중풍순환신경학회지
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• 제12권1호
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• pp.16-23
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• 2011

Object : The purpose of this study is to observe the changes of symptoms and signs diagnosised by differentiation of the pattern identification in stroke patients. Methods : Seventy subjects were recruited from patients with stroke within ten days of onset. We chose twenty-nine subjects diagnosised as same differentiation of the pattern identification, and who had at least on follow up session. We had investigated change of symptoms and signs diagnosised by differentiation of the pattern identification. Results : There were five symptoms and signs (thick fur, dry fur, difficult defecation, heat vexation and aversion to heat, normal pulse) and ten (heavy-headedness, frequency of defecation, hard defecation, feel heavy, slippery pulsem, dry mouth, bitter taste in the mouth, feel lazy, look lazy) symptoms and signs that were statistically significant improved in fire-heat patterns and dampness-phlegm pattern, respectively. Conclusions : This study provides evidence that collaborative treatment is effective in improving some symptoms and signs in acute ischemic stroke patients diagnosised by fire-heat pattern and dampness-phlegm pattern. Further studies with larger scale, longer observation period would be required.

• 한국화재소방학회논문지
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• 제30권4호
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• pp.135-140
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• 2016

구급 신고 전화를 받는 상황요원의 신속하고 정확한 신고자 상태 파악과 적확한 조치 판단을 돕고, 정확한 다중출동을 위한 한국형 응급상황관제 시스템의 음성인식 시스템의 자동적인 처리를 지원하기 위하여 실제 구급 신고 전화의 음성 자료 분석을 통해 한국어의 응급 증상 표현 목록을 작성하고 실제 신고전화에 나타난 증상 언어표현의 특징을 파악하였다. 이러한 언어 목록과 특성들은 일선 현장의 상황요원의 교육에도 유용할 것이다.

• 대한원격탐사학회지
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• 제38권5_3호
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• pp.967-977
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• 2022

산불의 발생과 강도는 기후 변화로 인하여 증가하고 있다. 산불 연기에 의한 배출가스 대기질과 온실 효과에 영향을 미치는 주요 원인 중 하나로 인식되고 있다. 산불 연기의 효과적인 탐지를 위해서는 위성 산출물과 기계학습의 활용이 필수적이다. 현재까지 산불 연기 탐지에 대한 연구는 구름 식별의 어려움 및 모호한 경계 기준 등으로 인한 어려움이 존재하였다. 본 연구는 우리나라 환경위성 센서인 Geostationary Environment Monitoring Spectrometer (GEMS)의 Level 1, Level 2 자료와 기계학습을 이용한 산불 연기 탐지를 목적으로 한다. 2022년 3월 강원도 산불을 사례로 선정하여 산불 연기 레이블 영상을 생성하고, 랜덤 포레스트 모델에 GEMS Level 1 및 Level 2 자료를 투입하여 연기 픽셀 분류 모델링을 수행하였다. 훈련된 모델에서 입력변수의 중요도는 Aerosol Optical Depth (AOD), 380 nm 및 340 nm의 복사휘도 차, Ultra-Violet Aerosol Index (UVAI), Visible Aerosol Index (VisAI), Single Scattering Albedo (SSA), 포름알데히드, 이산화질소, 380 nm 복사휘도, 340 nm 복사휘도의 순서로 나타났다. 또한 2,704개 픽셀에 대한 산불 연기 확률(0≤p≤1) 추정에서 Mean Bias Error (MBE)는 -0.002, Mean Absolute Error (MAE)는 0.026, Root Mean Square Error (RMSE)는 0.087, Correlation Coefficient (CC)는 0.981의 정확도를 보였다.

• 동의신경정신과학회지
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• 제16권1호
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• pp.1-17
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• 2005

Objective : This empirical research is performed to recognize diagnostic concept, pattern identification, and clinical features of Hwa-byung. In other words, the aims of this research are to examine the differences of the diagnosis between Hwa-Byung and the other psychiatric disorders, and to find out pattern identification, and clinical characteristics of Hwa-Byung for prescriptions of this syndrome. Method : In the experiment, there were participated 30 patients who were met for our criterions according to HBDIS (Hwa-Byung Diagnostic interview Schedule). These patients were diagnosed as Axis1 according to criterions of DSM-IV with administering SCID-I. OMS-prime was utilized for finding out pattern identification of oriental medicine. Symptom Check List-90-Revision(SCL-90-R), Hemilton rating Scale for Depression(HRSD), Heart Rate Variability(HRV), and Digital Infrared Thermographic imaging(D.I.T.I.) were also utilized to discover clinical characteristics of Hwa-Byung Patients. Results : 1. Regarding Sex-ratio, male subjects were 3(10%), and female subjects are 27(90%). The age of subjects ranged from 22 year old to 75 $(51.87{\pm}11.04;\:Mean{\pm}SD)$ 2. In the results of diagnosis on the basis of DSM-IV, the 17(56.67%) patients were MOD (Major Depressive Disorder), the 5(16.67%) patients were USD (Undifferentiated Somatoform Disorder), the 4(13.33%) patients were Dysthymic Disorder, the 3(10%) patients were GAD (Generalized Anxiety Disorder), and the 1(3.33%) was Panic Disorder. Two of the patients who diagnosed as MOD were diagnosed as Panic Disorder too, and one of them was diagnosed as Pain Disorder too. 3. Regarding pattern identification, Hwa-Byung is positively correlated to deficiency of Heart(心). and then to stagnancy of Liver-Gall bladder. Hwa-Byung is correlated deficiency symptom-complex rather than excessiveness symptom-complex. That is also correlated positively to Pathological heat and fire. 4. In SCL90-R, the mean of PSDI was $(75.3{\pm}10.7;\:Mean{\pm}SD)$. The each mean of the other 11 factors was distributed between50-70. 5. The mean of HRSD was $(17.9{\pm}5.6;\:Mean{\pm}SD)$ in the entire subject's group. Then the group of MDD was $20.9{\pm}4.4$ and the group of USD was $12.0{\pm}4.8$ 6. In the results of HRV. the mean of TP is $972.4{\pm}1174(Mean{\pm}SD)$, this is lower than normal range 1000-200. The other factors were within normal range. Then, there were no significant differences between them (p<0.05). 7. The temperatures of each acupoint have significant differences between HNl(印堂) and PC6(內關), between CV17(顫中) and PC6(內關), between HN1(印堂) and CV8(神闕), between CV17(顫中) and CV8(神闕) in comparison with the average of body temperature in the use of D.I.T.I. (p<0.01) 8. In the analysis of correlation between SCL-90-R, HRSD, HRV. and D.I.T.I. there were no significant results. According to results that the correlation was analyzed with only the MDD group as subjects, there was negative correlation between RMSSD of HRV and HRSD, between LF of HRV and PDSIof SCL-90-R, and between LF/HF of HRV and ANX, PSY, and PDSI of SCL-90-R. Conclusion : In the observation of clinical features of 30 cases of Hwa-Byung patients by using diverse structured tests, there could make diverse diagnosis as depressive disorder, anxiety disorder, and Somatoform Disorder. Particularly. MDD was highly distributed. Considering oriental medicine's pattern identification of Hwa-Byung, this syndrome is related strongly to Heart, and there were demonstrated deficiency symptom-complex, and Pathological heat and fire. One of the limits of this study is lack of control subject's group, therefore, in the future study, it requires reexamination through a comparative research with these data to complete this study.

• 한국화재조사학회지
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• 제3권1호
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• pp.12-15
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• 2003

The purpose of this study is to distinguish the causes of broken glass from doors or windows when it is found being originally kept among the remains on the floor in fire site - whether it was broken due to heating or by outer power through test and the properties of the broken plane including the pattern on the plane. Addition to it, the study tries to find characteristics for judging the point and direction of breakdown through the analysis of glass broken by outer power. With two causes assumed - a. breakdown due to heating and b. breakdown due to outer power - 3 pieces of glass plates $(30cm{\times}30cm{\times}5mm)$ for each case were tested, getting the results as following: 1. For the glass broken due to the change of temperature The broken plane is of slow curve and smooth without any pattern. 2. For the broken due to outer power With the impact point as the center, the shows breakdown of radial type and the side shows breakdown of near-perpendicular type. The far the broken piece is from the impact point, the bigger the size is. The broken piece at the impact point is of long triangle type and the two long planes of the triangle shows semi-arc with the center of breakdown point and the other plane shows opposite pattern 3. Change of the pattern and type of the glass due to outer power The pattern and type of the glass due to outer power shows change due to heatihg.

• 동의생리병리학회지
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• 제22권6호
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• pp.1378-1382
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• 2008

This study is aim to evaluate pulse diagnosis as indicators for classification of the pattern identifications in stroke patients. To get the clinical information, we recruited the onset 1 month stroke patients through the multicenter network which consists of 13 oriental hospitals. The clinical informations about three pairs of pulse wave form and levels of their significancy based on the case report form (CRF) were collected and their distribution in each pattern identification were analyzed. The results are as follows Fire-Heat group shows high portions of floating pulse, rapid pulse and solid pulse. Qi Defficiency group has a greater portion of deep pulse, slow pulse, deficient pulse. The well-defined character of Phlegm-Retained Fluid, Yin Defficiency, Static Blood groups cannot be explained by pulse wave form. These results show a rough relationship between the pulse diagnosis and pattern identifications of stroke therefore, further studies are required to determine the pulse diagnosis as significant indicators of stroke pattern identification.

• 한국안전학회지
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• 제32권3호
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• pp.160-171
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• 2017

US national research laboratories developed the first Vital Area Identification (VAI) method for the physical protection of nuclear power plants that is based on Event Tree Analysis (ETA) and Fault Tree Analysis (FTA) techniques in 1970s. Then, Korea Atomic Energy Research Institute proposed advanced VAI method that takes advantage of fire and flooding Probabilistic Safety Assessment (PSA) results. In this study, in order to minimize the burden and difficulty of VAI, (1) a set of streamlined VAI rules were developed, and (2) this set of rules was applied to PSA fault tree and event tree at the initial stage of VAI process. This new rule-based VAI method is explained, and its efficiency and correctness are demonstrated throughout this paper. This new rule-based VAI method drastically reduces problem size by (1) performing PSA event tree simplification by applying VAI rules to the PSA event tree, (2) calculating preliminary prevention sets with event tree headings, (3) converting the shortest preliminary prevention set into a sabotage fault tree, and (4) performing usual VAI procedure. Since this new rule-based VAI method drastically reduces VAI problem size, it provides very quick and economical VAI procedure. In spite of an extremely reduced sabotage fault tree, this method generates identical vital areas to those by traditional VAI method. It is strongly recommended that this new rule-based VAI method be applied to the physical protection of nuclear power plants and other complex safety-critical systems such as chemical and military systems.