• 대한두경부종양학회지
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• 제14권1호
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• pp.81-87
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• 1998

Fine needle aspiration cytology was used widely to select thyroid nodules for surgery. The result could be highly reliable for most malignancies and for benign nodules. The purpose of this study was to determine the value of frozen biopsy by directly comparing the results of preoperative fine needle aspiration cytology to frozen biopsy examination. In our university hospital, 103 patients with thyroid nodule were operated during the years 1996 through 1997. A comparison of accuracy of the fine needle aspiration cytology with frozen biopsy was made for 85 patients who underwent both procedures. The 85 patients were separated into two groups. The group I included 65 patients, whose preoperative fine needle aspiration cytology results were reported as benign or malignant lesion definitely. The group II included 85 patients, the patients whose reported fine needle aspiration cytologic result was suspicious for malignancy were regarded .as malignant lesion and results for follicular neoplasm were regarded as benign lesion. The accuracy of both procedures was compared on two group also. The sensitivity, specificity, and accuracy of frozen biopsy were 76.7%, 93.5%, and 85.2% in group I and 75.6%, 95.5%, and 85.9% in group II, respectively, compared with 63.3%, 87.1%, and 75.4% in group I and 65.4%, 81.8%, and 72.9% in group II for fine needle aspiration cytology. On benign lesion, the accuracy was 95.5% in frozen biopsy and 68.2% in fine needle aspiration cytology, 75.6% in frozen biopsy and 53.7% in fine needle aspiration cytology on malignant lesion. We conclude that although fine needle aspiration cytology is the reliable diagnostic test in the evaluation of thyroid nodule, frozen biopsy should be performed intraoperatively, because fine needle aspiration cytology is insufficiently sensitive for reliable surgical planning.

• 대한수의학회지
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• 제31권1호
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• pp.109-121
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• 1991

소의 지방간(脂肪肝)의 이환율(罹患率)을 조사(調査)하고 fine needle aspiration biopsy에 의한 지방간(脂肪肝)의 세포학적진단(細胞學的診斷)을 시도(試圖)하였다. 육안적(肉眼的) 또는 부유법(浮遊法)에 의한 간장지방함량(肝臟脂肪含量)에 기초(基礎)한 소의 지방간(脂肪肝)의 발생율(發生率)은 한우(韓牛)암소에서 0.30%, 유우(乳牛)암소에서 4.70%, 유우(乳牛)숫소에서 0.15%였다. 지방간(脂肪肝)은 육안적(肉眼的) 소견(所見)으로 간장(肝臟)이 종대(腫大)되고 변연(邊緣)이 둔하며 가볍고 창백(蒼白)에서 주황색(朱黃色) 색조(色調)를 보이나 간장(肝臟)의 색조(色調)와 지방간(脂肪肝)의 중증도간(重症度間)에 환상(桓常) 상관관계(相關關係)가 인정(認定)되지는 않았다. 대부분의 정상간장(正常肝臟)과 중도(重度)의 지방간(脂肪肝)을 제외(除外)하고는 간장(肝臟)의 지방침윤(脂肪浸潤)은 중심정맥주위(中心靜脈周圍)에서는 거대지방구(巨大脂肪球)와 변연부(邊緣部)에서는 소지방구(小脂肪球) 그리고 맥관부(脈管部)에 지방침윤(脂肪浸潤)의 소견(所見)을 보였다. 부유법(浮遊法)에 의한 간장지방함량(肝臟脂肪含量)과 비교(比較)한 세포학상(細胞學上)의 민감도(敏感度), 특이도(特異度), 정확도(正確度)는 정상(正常)에서 94.4%, 95.2%, 94.9%, 경도(輕度)에서 64.3%, 100%, 87.2%, 중등도(中等度)에서 100%, 83.39%, 82.2%, 그리고 중도(重度)에서 모두 100%였다. 세포학적(細胞學的) 소견(所見)은 조직학적(組織學的) 소견(所見)과 잘 일치(一致)하였다. Fine needle aspiraton biopsy에 의한 합병증(合倂症)은 임상적(臨床的)으로 인지(認知)되지 않았다. 결론적(結論的)으로 needle aspiration biopsy에 의한 세포학적(細胞學的) 진단(診斷)은 소의 지방간(脂肪肝) 진단(診斷)에 있어서 조직학적(組織學的) 기법(技法)과 비교(比較)했을 때 단순(單純)하고 신속(迅速)하며 안전(安全)하며 경제적(經濟的)인 방법(方法)으로 사료(思料)된다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4689-4692
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• 2016

Purpose: To study the clinical application value of ultrasound guided thyroid fine needle aspiration biopsy and thinprep cytology testing in diagnosis of thyroid disease. Methods: A total of 78 patients with thyroid nodules were enrolled, 34 males and 44 females, aged 33-64 years old with mean age of 47.6 years. All underwent thyroid module fine needle puncture after surgery to assess cell pathology and histopathological features. Results: Sufficient specimens were obtained from all of 78 patients, the cytological results of 73 cases (93.6 %) being consistent with pathological results. While 20 cases (25.6 %) were malignant tumors, 44 (56.4 %) were benign and 9 (11.5 %) were non-tumor lesions. The sensitivity of benign and malignant thyroid nodule by thyroid fine needle puncture was 90.9 %, specificity was 98.1 % and the positive predictive value was 96.3 %. Conclusions: It is demonstrated that ultrasound-guided thyroid fine needle aspiration biopsy and thinprep cytology testing have diagnostic value in clinical application for thyroid disease,showing good diagnostic coincidence rates with histopathological examination. They can thus be regarded as safe and effective for preoperative diagnosis and providing an appropriate basis for selection of surgery.

• 대한두경부종양학회지
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• 제23권1호
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• pp.54-57
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• 2007

Fine needle aspiration biopsy(FNAB) has been used for many decades in the diagnosis of benign and malignant tumors of thyroid gland. Complications of thyroid fine-needle aspiration biopsy(FNAB) are extremely rare. Hematoma formation is the most commonly encountered complication. However, massive intrathyroid unilateral hemorrhage and hematoma formation inducing upper airway distress rarely occurs. Here, we report two cases diagnosed as having hematoma that caused upper airway distress after FNAB for thyroid nodule.

• 대한세포병리학회지
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• 제13권2호
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• pp.51-59
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• 2002

To determine the usefulness on fine needle aspiration cytology(FNAC) of bone lesions and the complementary role of FNAC and percutaneous needle biopsy, 75 cases of FNAC taken from bone lesions were analyzed. Correlations with histopathology were possible in 47 cases, including 14 cases of simultaneous core biopsy and 33 cases of subsequent open biopsy due to inadequate aspirates. Among 75 cases, 4 cases were benign tumors and tumor-like lesion, 11 cases were malignant primary bone tumors, 17 cases were metastatic tumors, and 43 cases were nonneoplastic bone lesions. The aspirates were adequate in 35 cases(46.7%), in all of which the discrimination between benignancy and malignancy was possible. The main reason for Inadequate aspirates was due to hypocellularity. In the cases of aspiration and core biopsy simultaneously done, the diagnostic accuracy of aspiration, core biopsy, and both were 57%(8/14), 78.6%(11/14), and 92.9%(13/14), respectively. We conclude that a final diagnosis based on cytology is possible with the adequate aspirates and the clinical and radiological findings. Also we confirm the complementary role between FNAC and core biopsy in bone lesions.

• 대한세포병리학회지
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• 제9권1호
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• pp.55-61
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• 1998

To compare the diagnostic yields and complication rates of transthoracic fine needle aspiration cytology(FNAC) and gun biopsy in the diagnosis of pulmonary mass, a retrospective review was performed in 125 cases. Under the fluoroscopic guide, FNAC was performed by 20G Chiba needle in 91 cases, core biopsy was done by 18.5 G vaccum needle attached with automated biopsy gun in 74 cases and both procedures were done together in 37 cases. Overall sensitivity was 88.4% in FNAC and 87.5% in gun biopsy. For malignant pulmonary tumors, correct type correlation with final diagnosis was obtained in 33(76.7%) out of 43 cases by FNAC and 30(75.0%) out of 40 cases by gun biopsy. For benign pulmonary lesions, there were correct type correlation in 14(35.0%) out of 40 cases by FNAC and 14(53.8%) out of 26 cases by gun biopsy. The complication was pneumothorax and hemoptysis. Pneumothorax occured in 11.1% of FNAC, 10.9% of gun biopsy and 10.9% of both technique, among which chest tube drainages were necessary in one patient by gun biopsy and in three patients by both technique. Although no significant difference of diagnositc accuracy and complication rate was found between FNAC and gun biopsy, gun biopsy was more helpful in the diagnosis of pulmonary benign lesions than FNAC.

• 대한두경부종양학회지
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• 제31권1호
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• pp.1-4
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• 2015

Fine needle aspiration cytology(FNAC) holds a main role in assessing thyroid nodules. But nonnegligible rate of thyroid cytology is reported as uncertain, indeterminate or inadequate for diagnosis. Recently, the microhistologic evaluation by core needle biopsy(CNB) under ultrasound sonographical guidance has been reported to show high accuracy for the diagnose of thyroid nodules. Aim of this review was to furnish the state of the art of this topic by summarizing previous published data about indication, diagnostic performance, and complication of CNB in thyroid lesions compared with FNAC

• 대한기관식도과학회지
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• 제6권2호
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• pp.164-171
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• 2000

Background and Objectives： Necrotizing lymphadenitis or Kikuchi's disease is characterized by cervical lymphadenopathy of unknown etiology with unique histologic findings in young female patients. The importance of this disease lies in the fact that it can be easily misdiagnosed as malignant lymphoma, hence, clinicians need to aware of this disease entity. The purpose of this study is to report the clinicopathologic findings, radiographic findings, and many laboratory tests in order to contribute to the diagnosis and treatment of necrotizing lymphadenitis. Materials and Methods： We evaluated 31 patients, who were diagnosed as necrotizing lymphadenitis by excisional biopsy or fine needle aspiration cytology or ultrasound guided 18G cutting needle biopsy, retrospectively. Result : The median age was 24.8 years (range 12 to 43 years) and the male to female ratio was 1 : 2.4(9：22), with 14 females (45.1%) under 30 years. The common chief complaints were neck mass, easy fatigue and fever. Lymph node enlargement was limited to the cervical area in most cases (28cases : 90.3%). The involved lymph nodes were usually multiple (20cases : 64.5%), unilateral (26cases 83.9%) and small sized. Leukopenia (19cases : 61.3%) and elevation of ESR (18cases : 58.1%) appeared most frequently in the abnormal laboratory data. These symptoms will be gone spontaneoulsy without any specific treatment in several weeks or months. Conclusion : We should consider open biopsy or fine needle aspiration cytology or ultrasound guided cutting needle biopsy with lymph node in patients who have cervical lymphadenopathy with easy fatigue and fever, especially young women to exclude other conditions such as malignant lymphoma and tuberculosis, etc.

• 대한세포병리학회지
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• 제5권2호
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• pp.120-129
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• 1994

Fine needle aspiration biopsy cytology is a widely recognized and useful technique which can provide diagnosis in lesions of the head and neck, enabling appropriate management plans for individual patient to be made. Fifty one fine needle aspirates from salivary gland masses were examined. Four aspirates (8%) were inadequate for examination. Of the remaning 47 samples, 42 cases (82%) were benign lesions which consist of 30 pleomorphic adenoma(58%), 7 inflammatory lesion (14%), 4 Warthin's tumor(8%) and 1 benign lesion(2%). Two cases(4%) were atypical lesions. Three cases(6%) were malignant lesions consisting of 2 adenoid cystic carcinomas(4%) and 1 mucoepidermoid carcinoma (2%). The cytologic diagnoses were compared with the subsequent histologic diagnosis of surgical resected specimen in 24 cases. 19 cases of 21 aspirates from benign tumors were correctly diagnosed by fine needle aspiration cytology, with a specificity of 90%. All 3 aspirates from the 3 patients with malignant tumor were correctly diagnosed by fine needle aspiration cytology, with a sensitivity at 100%. Overall acurracy was 88%. Diagnostic error was encountered in adenoid cystic carcinoma, mucoepidermoid carcinoma and Warthin's tumor Correct histologic diagnosis was made in 86% of benign tumors(84% for pleomorphic adenoma and 100% for Warthin's tumor) and in 100% of malignant tumors.

• Journal of Chest Surgery
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• 제29권4호
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• pp.458-460
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• 1996

경피적 폐생검술은 폐 및 늑막 질환의 진단에 보편적으로 흔히 시행되며 이에 의한 합병증의 발생 빈도는 매우 낮다. 이중 매우 드물지 만 치명적 일 수 있는 합병증 중의 하나는 경피적 폐생검술 후 바늘의 경로를 통한 암세포의 흉벽으로의 전이이다. 환자는 59세 된 여자로 편평상퍼 세포 폐암으로 진단되어 우측폐 상엽절제술을 시행한 후 외래 추적 관찰 6개월째 수술 전 시행한 경피적 폐생검 부위에 종괴가 촉지되어 폐암의 흉벽 전이로 판단하고종 괴를 포함하여 주변 근육들과 함께 확대 절제하였고 이후 방사선 치료 및 항암제 치료를 병 행하였다. 본 인제대학교 의과대학 흉부외과학교실 상계 백병 원에서는 1 례의 폐암 환자에서 경피적 폐생검술 후 암세포가 흉벽으로 전이되 어 외과적으로 치험하였기에 보고하는 바이다.