• The Korean Journal of Physiology and Pharmacology
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• 제20권4호
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• pp.357-366
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• 2016

Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of PTSD induced by a single prolonged stress (SPS) procedure. The effects of IBU on inflammation and BDNF modulation in the hippocampus and the mechanisms underlying for anxiolytic action of IBU were also investigated. Male Sprague-Dawley rats were given IBU (20 or 40 mg/kg, i.p., once daily) for 14 days. Daily IBU (40 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index in the EPM test, and increased the time spent in the center of an open field after SPS. IBU administration significantly decreased the expression of pro-inflammatory mediators, such as tumor necrosis $factor-{\alpha}$, $interleukin-1{\beta}$, and BDNF, in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. These findings suggest that IBU exerts a therapeutic effect on PTSD that might be at least partially mediated by alleviation of anxiety symptoms due to its anti-inflammatory activity and BDNF expression in the rat brain.

• Journal of Microbiology and Biotechnology
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• 제21권9호
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• pp.947-953
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• 2011

A fungal strain, Aspergillus terreus strain GA2, isolated from an agricultural field cultivating sweet sorghum, produced feruloyl esterase using maize bran. In order to obtain maximum yields of feruloyl esterase, the solid state fermentation (SSF) conditions for enzyme production were standardized. Effective feruloyl esterase production was observed with maize bran as substrate followed by wheat bran, coconut husk, and rice husk among the tested agro-waste crop residues. Optimum particle size of 0.71-0.3 mm and moisture content of 80% favored enzyme production. Moreover, optimum feruloyl esterase production was observed at pH 6.0 and a temperature of $30^{\circ}C$. Supplementation of potato starch (0.6%) as the carbon source and casein (1%) as the nitrogen source favored enzyme production. Furthermore, the culture produced the enzyme after 7 days of incubation when the C:N ratio was 5. Optimization of the SSF conditions revealed that maximum enzyme activity (1,162 U/gds) was observed after 7 days in a production medium of 80% moisture content and pH 6.0 containing 16 g maize bran [25% (w/v)] of particle size of 0.71-0.3 mm, 0.6% potato starch, 3.0% casein, and 64 ml of formulated basal salt solution. Overall, the enzyme production was enhanced by 3.2-fold as compared with un-optimized conditions.

• 한국결정성장학회지
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• 제28권3호
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• pp.112-117
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• 2018

금속 알콕사이드인 CuCo-glycerate 나노구의 용매열합성 과정을 통해 단분산된 Cu-Co 이중 금속 황화물 계층적 중공 구조의 나노구($CuCo_2S_4$ HMHNSs)를 합성하는데 성공하였다. 이 반응 메커니즘에서 용매열합성 온도와 보조 계면활성제인 glycerol의 양은 CuCo-glycerate 나노구의 형태를 최적화하는데 중요한 역할을 한다. 또한 $CuCo_2S_4$ HMHNSs는 glycerate와 황 이온 간의 음이온 교환 반응을 통해 10시간의 최적화된 황화 반응 조건하에서 성공적으로 합성되었다. 최종적으로 합성된 물질의 구조적, 화학적 특성은 SEM, TEM, XRD와 전기화학적 특성 평가에 의해 확인되었다.

• Journal of the Korean Data and Information Science Society
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• 제27권4호
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• pp.887-898
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• 2016

본 연구에서는 H/W 전공자들의 확률 및 통계 학습능력 증대를 위한 목적으로, 첫째, H/W 전공교과과정에서 개설된 프로그래밍관련 교과목과 멀티미디어 신호처리 교과목에 확률 및 통계를 연계한 교수법을 개발하여 교수-학습함으로써, 연구대상 학생들의 학업성취도 향상에 효과가 있는가를 검증하고 회귀분석을 활용하여 그 교육효과를 분석하고자 했다. 둘째, H/W 전공교과과정에서 설문조사와 확률 및 통계 연계 교육사례를 실시하고 통계적으로 분석하여 향후 확률 및 통계 학습능력을 함양하기 위한 효율적 교수-학습 운영방안에 관하여 제안하고자 했다. 마지막으로, 확률 및 통계는 H/W 분야와 연계함으로써 새로운 기술개발 및 지속적인 경쟁역량 강화를 유지해 나가는 필수교과임을 제시하고자 했다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2001년도 추계종합학술대회
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• pp.517-520
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• 2001

급속한 정보통신의 발달로 정보통신 기반을 이용한 전자상거래, 인터넷뱅킹, 주식거래 등 다양한 서비스가 이루어지고 있다. 이때 가장 중요한 문제는 서비스 이용자가 본인임을 확실하게 인증할 수 있어야 한다는 것이다. 그러나 현재 본인임을 인증할 수 있는 방법으로 대부분 쓰이고 있는 개인 비밀번호는 도용 당할 위험이 크다. 이 문제를 해결하기 위해 본 논문에서는 서비스 이용자가 본인임을 확실하고 간단하게 인증할 수 있는 안전한 방법으로 1대1 지문매칭을 이용한 스마트 카드 인증 시스템을 제안한다. 스마트 카드는 정보보호 및 보안성이 뛰어나며 사용이 편리하다. 그리고 지문은 여러 생체인식분야 중 본인임을 인증할 수 있는 가장 우수한 방법으로 주목받고 있다. 본 논문에서 구현한 시스템은 PC를 기반으로 하며 스마트 카드에 지문정보인 특징점을 저장하고 서비스 이용시 이용자의 특징점과 스마트 카드에 저장된 특징점을 비교하여 본인임을 인증함으로써 서비스 이용자가 본인임을 확실하게 인증할 수 있다. 본 논문에서는 구현한 시스템을 다양한 서비스 분야에 응용할 경우 서비스 이용의 안전도를 높일 수 있는 가능성을 제시한다.

• 한국전기전자재료학회논문지
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• 제29권12호
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• pp.764-768
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• 2016

To investigate excess $Na^+$ effect, $Bi_{0.5}(Na_{0.78+x}K_{0.22})_{0.5}TiO_3$ ($0{\leq}x{\leq}0.05$) (BNKT) ceramics were prepared by using a conventional solid-state reaction method. The structure and ferroelectric properties of BNKT ceramics were characterized by XRD (X-ray diffraction) and polarization dependence by external electric field. Also, the temperature dependence of dielectric constant and loss were studied. From these results, it was found that appropriate excess $Na^+$ into BNKT ceramics compensate the volatility and induce dense ceramics. The enhanced piezoelectric coefficient (158 pC/N) and depolarization temperature ($202^{\circ}C$) were obtained for the x=0.01 composition.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제51권5호
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• pp.185-190
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• 2002

Capacitor material utilized in the downsizing passive devices and dynamic random access memory(DRAM) requires the physical and electrical properties at given area such as capacitor thickness reduction, relative dielectric constant increase, low leakage current and thermal stability. Common capacitor materials, $SiO_2$, $Si_3N_4$, $SiO_2$/$Si_3N_4$,TaN and et al., used until recently have reached their physical limits in their application to several hundred angstrom scale capacitor. $Ta_2O_{5}$ is known to be a good alternative to the existing materials for the capacitor application because of its high dielectric constant (25 ~35), low leakage current and high breakdown strength. Despite the numerous investigations of $Ta_2O_{5}$ material, there have little been established the clear understanding of the annealing effect on capacitance characteristic and conduction mechanism, design and fabrication for $Ta_2O_{5}$ film capacitor. This study presents the structure-property relationship of reactive-sputtered $Ta_2O_{5}$ MIM capacitor structure processed by annealing in a vacuum. X-ray diffraction patterns skewed the existence of amorphous phase in as-deposited condition and the formation of preferentially oriented-$Ta_2O_{5}$ in 670, $700^{\circ}C$ annealing. On 670, $700^{\circ}C$ annealing under the vacuum, the leakage current decrease and the enhanced temperature-capacitance characteristic stability. and the leakage current behavior is stable irrespective of applied electric field. The results states that keeping $Ta_2O_{5}$ annealed at vacuum gives rise to improvement of electrical characteristics in the capacitor by reducing oxygen-vacancy and the broken bond between Ta and O.

• Corrosion Science and Technology
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• 제19권1호
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• pp.16-22
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• 2020

It is important to realize that benzoate was intercalated into hydrotalcite (HTC-Bz) by the co-precipitation method. In this case, acrylic coating with 0.5 wt% HTC-Bz was deposited on carbon steel using the spin coating method. Next, the HTC-Bz structure was characterized by Field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). In fact, an ultraviolet vision spectroscopy (UV-Vis) was used to determine the benzoate content in HTC-Bz, and the UV absorption ability of HTC-Bz. Using electrochemical techniques, water contact angle measurement, and thermal-gravimetric analysis, we compared the protective properties before and after QUV test, hydrophobicity and the thermal stability of acrylic coating containing HTC-Bz. The obtained results showed that HTC-Bz with a plate-like structure was successfully synthesized; benzoate was intercalated into the interlayer of hydrotalcite with a concentration of 28 wt%. Additionally, it was noted that HTC-Bz has an UV absorption peak at 225 nm. In conclusion, the addition of HTC-Bz enhanced the UV stability, hydrophobicity and the thermal stability of acrylic coating.

• BMB Reports
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• 제53권6호
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• pp.299-310
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• 2020

Chronic liver disease progresses through several stages, fatty liver, steatohepatitis, cirrhosis, and eventually, it leads to hepatocellular carcinoma (HCC) over a long period of time. Since a large proportion of patients with HCC are accompanied by cirrhosis, it is considered to be an important factor in the diagnosis of liver cancer. This is because cirrhosis leads to an irreversible harmful effect, but the early stages of chronic liver disease could be reversed to a healthy state. Therefore, the discovery of biomarkers that could identify the early stages of chronic liver disease is important to prevent serious liver damage. Biomarker discovery at liver cancer and cirrhosis has enhanced the development of sequencing technology. Next generation sequencing (NGS) is one of the representative technical innovations in the biological field in the recent decades and it is the most important thing to design for research on what type of sequencing methods are suitable and how to handle the analysis steps for data integration. In this review, we comprehensively summarized NGS techniques for identifying genome, transcriptome, DNA methylome and 3D/4D chromatin structure, and introduced framework of processing data set and integrating multi-omics data for uncovering biomarkers.

• Geomechanics and Engineering
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• 제21권2호
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• pp.201-206
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• 2020

A stress-induced brittle failure in deep tunneling generates spalling and slabbing, eventually causing a v-shaped notch formation. An empirical relationship for the depth of the notch to the maximum tangential stress assuming an equivalent circular cross-section was proposed (Martin et al. 1999). While this empirical approach has been well recognized in the industry and used as a design guideline in many projects, its applicability to a non-circular opening is worth revisiting due to the use of equivalent circular profile. Moreover, even though the extent of the notch also contributes to notch failure, it has not been estimated to date. When the estimate of both the depth and the extent of notch are combined, a practical and economically justifiable support design can be achieved. In this study, a new methodology to assess the depth as well as the extent of notch failure is developed. Field data and numerical simulations using the Cohesion Weakening Frictional Strengthening (CWFS) model were collected and correlated with the three most commonly accepted failure criteria (σ₁/σ₃, D_is=σ_max/σ_c, σ_dev/σ_cm). For the numerical analyses, the D-shaped tunnel was used since most civil tunnels are built to this profile. Inferential statistical analysis is applied to predict the failure range with a 95% confidence level. Considering its accuracy and simplicity, the new correlation can be used as an enhanced version of failure assessment.