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Association between p16 Promoter Methylation and Thyroid Cancer Risk: A Meta-analysis

  • Wu, Wei;Yang, Sheng-Fu;Liu, Fei-Fei;Zhang, Ji-Hong
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.16
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    • pp.7111-7115
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    • 2015
  • Background: The aim of the meta-analysis was to derive a more precise assessment of the association between p16 promoter methylation and thyroid cancer risk. Materials and Methods: The PubMed, Web of Science databases and Chinese CNKI were searched for relevant articles. Ultimately, seventeen case-control studies were included with a total of 804 thyroid cancer cases and 487 controls analysis by R Software (R version 3.1.2) including meta. Crude odds ratios with 95% confidence intervals were calculated using the random-effects model which were used to assess the strength of relationship between p16 methylation and lung carcinogenesis. Funnel plots were carried out to evaluate publication bias. Results: The meta-analysis results showed that the frequency of p16 promoter methylation in cancer tissue/blood was significantly higher than that normal tissue/blood (OR=5.46, 95%CI 3.12-9.55, P<0.0001) by random effects model with small heterogeneity. Conclusions: Thus, p16 promoter methylation may be associated with thyroid cancer risk.

A study on APR-1400 core design for heterogeneous thorium fuel (APR-1400 원전을 위한 비균질 토륨핵연료 노심설계 방안연구)

  • 배강목;김관희;김명현
    • Proceedings of the Korea Society for Energy Engineering kosee Conference
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    • 2002.05a
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    • pp.135-141
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    • 2002
  • An optimization of KTF thorium fuel assembly design was performed on the basis of the design parameter studies. Optimization goals ware to make the core have both proliferation resistance and fuel cycle economics. Four kinds of proliferation resistance indexes were used; SNS, TG, BCM, Toxicity. A new index, FEI was regarded as a limiting index for the maximization of fuel cycle economics. Optimized thorium fuel design was applied for APR-1400 reactor core. Nuclear core design procedures were examined to solve the thorium fuel reactor problems. It was shown that heterogeneous thorium fuel core option is acceptable in safety and economics aspects.

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Electrorheology of conducting polyaniline-$BaTiO_3$ composite

  • Kim Ji-Hye;Fang Fei Fei;Lee Ki-Bo;Choi Hyoung-Jin
    • Korea-Australia Rheology Journal
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    • v.18 no.2
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    • pp.103-107
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    • 2006
  • Organic-inorganic composite of polyaniline and barium titanate (PANI-$BaTiO_3$) was synthesized via an in-situ oxidation polymerization of aniline in the presence of barium titanate ($BaTiO_3$) nanoparticles dispersed in an acidic medium. Barium titanate has large electric resistance and relatively high dielectric constant which is one of the essential properties for its electrorheological (ER) applications. The microstructure and composition of the obtained PANI/$BaTiO_3$ composite were characterized by SEM, FT-IR and XRD. In addition, we also employed a rotational rheometer to investigate the rheological performance of the ER fluids based on both pure PANI particle and PANI/$BaTiO_3$ composite. It was found that the composite materials possess much higher yield stresses than the pristine PANI due to unique dielectric properties of the inorganic $BaTiO_3$ particles. Finally, we also examined dynamic yield stress by analyzing its extrapolated yield stress data as a function of electric field strengths. Using the critical electric field strengths deduced, we further found that the universal yield stress equation collapses their data onto a single curve.

Overview of Performance-Based Seismic Design of Building Structures in China

  • Li, Guo-Qiang;Xu, Yan-Bin;Sun, Fei-Fei
    • International Journal of High-Rise Buildings
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    • v.1 no.3
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    • pp.169-179
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    • 2012
  • The development history, the current situation and the future of the performance-based seismic design of building structures in China are presented in this paper. Firstly, the evolution of performance-based seismic design of building structures specified in the Chinese codes for seismic design of buildings of the edition 1974, 1978, 1989, 2001 and 2010 are introduced and compared. Secondly, in two parts, this paper details the provisions of performance-based seismic design in different Chinese codes. The first part is about the "Code for Seismic Design of Buildings" (GB50011) (edition 1989, 2001 and 2010) and "Technical Specification for Concrete Structures of Tall Building", which presents the concepts and methods of performance-based seismic design adopted in Chinese codes; The second part is about "Management Provisions for Seismic Design of Outof-codes High-rise Building Structures" and "Guidelines for Seismic Design of Out-of-codes High-rise Building Structures", which concludes the performance-based seismic design requirements for high-rise building structures over the relevant codes in China. Finally, according to those mentioned above, this paper pointed out the imperfections of current performance-based seismic design in China and proposed the possible direction for further improvement.