• 대한전기학회논문지:시스템및제어부문D
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• 제53권11호
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• pp.768-775
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• 2004

The SSA technique in the digital circuit test is required to be repeated the input pattern stream to n bits output nodes n times in case of using a multiplexor. Because the method adopting a parallel/serial bit convertor to remove this inefficiency has disadvantage of requiring the test time n times for a pattern, the test strategy is required, which can enhance the test productivity by reducing the test time based on simplified fault detection mechanism. Accordingly, this paper proposes a test strategy which enhances the test productivity and efficiency by appling PAS (Parallel Signature Analysis) technique to those after analyzing the structure and characteristics of the digital devices including TTL and CMOS family ICs as well as ROM and RAM. The PSA technique identifies the faults by comparing the reminder from good device with reminder from the tested device. At this time, the reminder is obtained by enforcing the data stream obtained from output pins of the tested device on the LFSR(Linear Feedback Shift Resister) representing the characteristic equation. Also, the method to obtain the optimal signature analyzer is explained by furnishing the short bit input streams to the long bit input streams to the LFSR having 8, 12, 16, 20bit input/output pins and by analyzing the occurring probability of error which is impossible to detect. Finally, the effectiveness of the proposed test strategy is verified by simulating the stuck at 1 errors or stuck at 0 errors for several devices on typical 8051 digital board.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2751-2756
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• 2015

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can specifically induce apoptosis limited to various cancer cells, so this reagent is considered a promising medicine for cancer therapy. TRAIL also exerts effects on non-apoptotic signals, relevant to processes such as metastasis, autophagy and proliferation in cancer cells. However, the mechanisms of TRAIL-regulated non-apoptotic signals are unclear. The purpose of this study was to investigate MADD/CXCR7 effects in TRAIL-mediated breast cancer cell migration. Materials and Methods: The ability of MADD/CXCR7 to regulate MVP signaling in TRAIL-mediated breast cancer cells migration was evaluated by transwell migration assay, quantitative RT-PCR, Western blotting and knock down experiments. Results: In this study, we found that treatment with TRAIL resulted in induced expression levels of MADD and CXCR7 in breast cancer cells. Knock down of MADD followed by treatment with TRAIL resulted in increased cell migration compared to either treatment alone. Similarly, through overexpression and knockdown experiments, we demonstrated that CXCR7 also positively regulated TRAIL-inhibited migration. Surprisingly, knock down of MADD lead to inhibition of TRAIL-induced CXCR7 mRNA and protein expression and overexpression of CXCR7 lead to the reduction of MADD expression, indicating that MADD is an upstream regulatory factor of TRAIL-triggered CXCR7 production and a negative feedback mechanism between MADD and CXCR7. Furthermore, we showed that CXCR7 is involved in MADD-inhibited migration in breast cancer cells. Conclusions: Our work defined a novel signaling pathway implicated in the control of breast cancer migration.

• 한국전자거래학회지
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• 제18권4호
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• pp.1-24
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• 2013

우리나라 정부부처 및 공공기관에서는 매우 많은 양의 전자기록물을 생산하고 있는데, 그 종류도 다양하다. 또한, 이질적인 전자기록물이 결합하여 하나의 전자기록물을 이루기도 하는데, 이 논문에서는 이를 복합전자기록물이라고 부른다. 복합전자기록물의 대표적인 예로는 소셜 네트워크 서비스(Social Network Service) 기록물이 있다. 현재, 우리나라 대부분의 정부부처에서는 페이스북을 이용하여 각 정부부처의 정책 공지 및 국민의견을 수렴하는 등 그 활용도와 가치가 높다. 이 외에도 많은 복합전자기록물이 우리나라 정부부처로부터 생산 및 활용되고 있는 실정이나, 이들에 대한 보존 방안이 제대로 마련되어 있지 않아 많은 정보가 유실되거나 방치되고 있다. 이 논문에서는 현재 우리나라 정부부처에서 생산 및 유통되는 복합전자기록물의 종류 및 특성을 살펴보고, 복합전자기록물 보존 관련연구를 조사 분석한 뒤 장기보존 전략을 제안한다.

• 한국경제지리학회지
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• 제15권4호
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• pp.628-641
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• 2012

이 연구에서는 네트워크와 공간의 형성과정을 사회와 기술의 변화를 나타내는 공진화(co-evolution)현상의 하이프 곡선을 이용하여 고찰해 보았다. 이를 위해 공진화 현상의 초기 네트워크의 출현과 공간적 사회화 시작, 외부와의 상호작용을 통한 기대감 최고조, 기대의 반작용, 학습단계, 안정적인 사회적 수용과 내면화 단계에 적용하여 분석하였다. 이 연구는 공간과 네트워크의 공진화(co-evolution) 작용메커니즘을 기관유형별로 시간적 변화를 통해 고찰하였다는 특징이 있다. 네트워크는 공간 정책에 의해 상호 피드백을 형성하며 진화와 분화를 반복하며 형성된다. 또한 네트워크와 공간의 상호작용단계에서 정책에 대한 기대와 실망 그리고 조정 등의 사회적 수용과정에서 나타나는 시간적 지연(delay)의 가시성을 보인다. 초기 성장거점의 발전 단계를 지나 균형발전 그리고 광역발전으로 이루어지는 공간정책이 네트워크 성장에 중요한 영향을 미치고 있다.

• Nuclear Engineering and Technology
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• 제44권7호
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• pp.825-830
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• 2012

Radiation and its various industrial applications have been growing at approximately 10 percent per year for the past decade in Korea. As a result, the importance of the Education and Training (E&T) in radiation protection is of upmost importance. This paper is intended to investigate the present status of the E&T on radiation protection and safety in Korea and to draw up the improvements of the E&T courses required for building the national radiation safety infrastructure. For these purposes, the E&T data from the six major domestic organizations providing radiation protection training courses were investigated and analyzed. Each of the organizations is offering several kinds of E&T courses based on their own specific functions. These organizations have administrative facilities equipped with the latest technology for E&T in radiation protection. The E&T courses mainly cover the training courses for radiation workers, radiological emergency staff, license applicants, license holders, and regulatory staff. In 2010, a total of 58 E&T courses were carried out across six organizations. The conclusions make a number of observations highlighting challenges such as: establishing a formal feedback mechanism, introducing more practical training sessions, developing training courses tailored to the job categories and target audiences, and designing education and training courses in radiation protection that comply with current obligations as well as future requirements.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.125-125
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• 2017

The roots of Platycodon grandiflorum are commonly used for treating bronchitis, asthma, tuberculosis, diabetes, and other inflammatory diseases. Since the molecular mechanism underlying the roots of the plant is unclear. Therefore, the present study was conducted to profile proteins from liquid cultured tetraploid roots of Platycodon grandi orum fl using high throughput proteome approach. Two-dimensional gels stained with CBB, a total of 659 differentially expressed proteins were identified from the liquid medium cultured tetraploid roots of which 32 proteins spots (${\geq}1.5-fold$) were sorted for mass spectrometry analysis. Out of these 32 proteins, a total of 15 proteins were up-regulated such as Serine carboxypeptidase-like 27, Transcription factor bHLH150, 60 kDa jasmonate-induced protein, Cytosolic Fe-S cluster assembly factor NBP35, Regulatory associated protein of TOR 2 and a total of 17 proteins were down-regulated such as Protein G1-like2, Phenylalanine ammonia-lyase, Fructokinase-2, Trihelix transcription factor GT-3a, Guanine nucleotide-binding protein alpha-1 subunit. However, the frequency distribution of identified proteins was carried out within functional categories based on molecular functions, cellular components, and biological processes. Functional categorization revealed that the most of the identified proteins from the explants were mainly associated with the nucleic acid binding, oxidoreductase, transferase activity, protein binding and hydrolase activity. In addition, the proteomic feedback of tetraploid roots of P. grandiflorum may potentially be used to understand the characteristics of proteins and their functions.

• Biomolecules & Therapeutics
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• 제19권2호
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• pp.174-180
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• 2011

Experiments were carried out to determine the role of Raf-1 kinase in the development of drug resistance to paclitaxel in v-H-ras transformed NIH 3T3 fibroblasts (Ras-NIH 3T3). We established a multidrug-resistant cell line (Ras-NIH 3T3/Mdr) from Ras-NIH 3T3 cells by stepwise increases in paclitaxel. Drug sensitivity assays indicated that the $IC_{50}$ value for drug-resistant Ras-NIH 3T3/Mdr cells was more than 1 ${\mu}M$ paclitaxel, 10- or more-fold higher than for the parental Ras-NIH 3T3 cells. Western blot and RT-PCR analysis showed that the drug efflux pump a P-glycoprotein were highly expressed in Ras-NIH 3T3/Mdr cells, while not being detectable in Ras-NIH 3T3 cells. Additionally, verapamil, which appears to inhibit drug efflux by acting as a substrate for P-glycoprotein, completely reversed resistance to paclitaxel in Ras-NIH 3T3/Mdr cell line, indicating that resistance to paclitaxel is associated with overexpression of the multidrug resistance gene. Interestingly, Ras-NIH 3T3/Mdr cells have higher basal Raf-1 activity compared to Ras-NIH 3T3 cells. Unexpectedly, however, the colocalization of Raf-1 and its negative regulator Spry2 was less observed in cytoplasm of Ras-NIH 3T3/Mdr cells due to translocation of Spry2 around the nucleus in the perinuclear zone, implying that Raf-1 may be released from negative feedback inhibition by interacting with Spry2. We also showed that shRNA-mediated knockdown of Raf-1 caused a moderate increase in cell susceptibility to paclitaxel. Thus, the results presented here suggest that a Raf-1-dependent pathway plays an important role in the development of acquired drug-resistance.

• Journal of Chest Surgery
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• 제26권2호
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• pp.75-79
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• 1993

Myocardial protection against ischemic and reperfusion injuries is still in troublesome eventhough couples of the way of myocardial protection have been applied since 1970's. One of the possibility in myocardial protection is adding Fructose-l,6-diphosphate(FDP) in cardioplegic solution. It is assumed that FDP can promote ATP production under anaerobic condition as well as inhibiting the supressing effect of lactate on phosphofructokinase. We compared the myocardial protecting effects of FDP in crystalloid cardioplegic solution (St. Thomas formula, 10$^{\circ}C$, pH = 7.4) and reperfusate using isolated rat hearts in modified Langendorf apparatus by the parameters of preischemic and post reperfusing heart rate, time to first beat, occurance of arrhythmia, time to stabilization, and the rate of left ventricular pressure developing. Group A (n = 10), containing no FDP in cardioplegic and reperfusing solutions was control. Group B (n = 5), containing FDP in cardioplegic solution, showed statistically significant superiority of postischemic left ventricular pressure development than the control group. Group C (n = 5), containing FDP in reperfusate, showed statistically significant myocardial depressing effect than the controls. Other parameters were unremarkable. The cause is uncertain, but it is assumed that the negative feedback inhibition of FDP in energy metabolism or unknown blocking effect of FDP on certain transmembrane ionic currents is present. In conclusion, 1) FDP in cardioplegic solution has beneficial effect on postischemic left ventricular preservation. 2) FDP is strong acid when is hydrolyzed, so precise acid titration is neccessary. 3) FDP in reperfusate has negative left ventricular preservation, otherwise the mechanism is still uncertain.

• Asian Journal for Public Opinion Research
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• 제5권2호
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• pp.143-174
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• 2018

A cultural exchange program widens the horizons of students. It gives them the opportunity to associate with other societies and learn their cultures at the same time. This program also serves as a training ground where students enhance their skills, acquire learnings, and gain experiences that will help them in their future careers and make them more competitive than others. Hence, the objective of this study is to come up with an output from a set of guidelines established and gathered from the different "work and travel" experiences of the participants. This study adopted the phenomenological and was conducted in places that are relatively quiet for recording, and suitable and convenient for both the researchers and participants. The researchers gathered data through in-depth interviews of samples gathered through snowball sampling. Cellphones were used to record interviews. At the end of the thematic analysis of information, the researchers came up with three major categories which included: (1) 'having the opportunity to know the industry well and improve one's capability', 'undergoing different cultural exchange experiences for better development', and 'being able to practice intercultural immersion'. Some of the researchers' recommendations would be to institute a feedback mechanism such as personal interviews, monitoring visits, etc. and use the output, a set of guidelines, that would help the future 'work and travel' participants to prepare and anticipate the program they would undergo.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2006년도 PARALLEL CFD 2006
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• pp.311-314
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• 2006

The supersonic flow around tandem cavities was investigated by three- dimensional numerical simulations using the Reynolds-Averaged Navier-Stokes(RANS) equation with the $\kappa-\omega$ thrbulence model. The flow around a cavity is characterized as unsteady flow because of the formation and dissipation of vortices due to the interaction between the freestream shear layer and cavity internal flow, the generation of shock and expansion waves, and the acoustic effect transmitted from wake flow to upstream. The upwind TVD scheme based on the flux vector split using van Leer's limiter was used as the numerical method. Numerical calculations were performed by the parallel processing with time discretizations carried out by the 4th-order Runge-Kutta method. The aspect ratio of cavities are 3 for the first cavity and 1 for the second cavity. The ratio of cavity interval to depth is 1. The ratio of cavity width to depth is 1 in the case of three dimensional flow. The Mach number and the Reynolds number were 1.5 and $4.5{\times}10^5$, respectively. The characteristics of the dominant frequency between two-dimensional and three-dimensional flows were compared, and the characteristics of the second cavity flow due to the fire cavity flow cavity flow was analyzed. Both two dimensional and three dimensional flow oscillations were in the 'shear layer mode', which is based on the feedback mechanism of Rossiter's formula. However, three dimensional flow was much less turbulent than two dimensional flow, depending on whether it could inflow and outflow laterally. The dominant frequencies of the two dimensional flow and three dimensional flows coincided with Rossiter's 2nd mode frequency. The another dominant frequency of the three dimensional flow corresponded to Rossiter's 1st mode frequency.