• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.997-1001
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• 2013

Background: Lymphangiogenesis, assessed as lymphovascular density (LVD), is the initial step of generalized tumor lymphovascular invasion (LVI). It also involves VEGF-C as the most important protein family. Lymphangiogenesis among breast cancer cases correlations with several clinicopathological factors are important to determine prognosis and treatment strategies, but results have been controversial and require clarification. Aim: To define correlations between VEGF-C expression, LVD and LVI with several clinicopathological parameters from Indonesian breast cancer patients. Materials and Methods: Using a cross-sectional study, a total of 48 paraffin-embedded tissues of breast cancer from Dr. Sardjito General Hospital Indonesia were assessed for VEGF-C expression, LVD and LVI by immunohistochemistry. Correlations of these markers with clinicopathological parameters like patient age, tumor size, lymph node status, grade, ER/PR and Her-2 status, cell proliferation and p-53 expression were investigated by linear analysis. Correlations of VEGF-C expression and LVI with several clinicopathological parameters were analyzed with Coefficient Contingency Chi-Square test. Results: The mean of patients age was 53.0 year, pre and post-menopausal patients accounting for 56.3% and 43.8%, respectively. Some 10.4% were well, 41.7% moderate and 47.9% poorly differentiated. ER positivity was evident in 50% while PR and Her-2 positivity was found in 31.3% and 33.3%, respectively. Breast cancer cells with over-expression of p-53 was 64.6% and with high cell proliferation was 56.3%. Lymph node metastasis was noted in 63.5%, and LVI in 72.9%. Significant correlations were found between LVD and tumor size (p:0.037), grade (p:0.000), lymphnode status (p:0.036), LVI (p:0.003), as well as with p-53 and cell proliferation. There were also significant correlation of VEGF-C (p:0.011) and LVI (p:0.001) with tumor grade. Only ER status was found to have a correlation with tumor size (p:0.027). Conclusions: This study suggested that in Indonesian breast cancer patients, lymphangiogenesis is correlated with tumor size, grade, lymph node status and tumor lymphovascular invasion, the latter also being related with p-53 over expression and high cell proliferation.

• BMB Reports
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• v.43 no.3
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• pp.212-218
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• 2010

Zinc finger-containing transcription factors are the largest single family of transcriptional regulators in mammals, which play an essential role in cell differentiation, cell proliferation, apoptosis, and neoplastic transformation. Here we have cloned a novel KRAB-related zinc finger gene, ZNF424, encoding a protein of 555aa. ZNF424 gene consisted of 4 exons and 3 introns, and mapped to chromosome 19p13.3. ZNF424 gene was ubiquitously expressed in human embryo tissues by Northern blot analysis. ZNF424 is conserved across species in evolution. Using a GFP-labeled ZNF424 protein, we demonstrate that ZNF424 localizes mostly in the nucleus. Transcriptional activity assays shows ZNF424 suppresses transcriptional activity of L8G5-luciferase. Overexpression of ZNF424 in HEK-293 cells inhibited the transcriptional activity of NFAT and p21, which may be silenced by siRNA. The results suggest that ZNF424 protein may act as a transcriptional repressor that suppresses NFAT and p21 pathway to mediate cellular functions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.10
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• pp.4467-4474
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• 2011

The purpose of this study was to examine the factor of the quality of elderly women's sleep. The subjects in this study were 198 elderly women who were at the age of 60 and up. One instrument used to assess their quality of sleep was Buysse, et. al.(1989)'s Pittsburgh Sleep Quality Index(PSQI), and the other used to check their urinary incontinence was Jackson, et. al.(1996)'s Urination Symptom Inventory. The collected data were analyzed by the statistical package SPSS 18.0. The elderly women got $7.09{\pm}4.29$ in the quality of sleep of the PSQI, and 67.7 percent suffered from sleep disorders. Among the subfactors of the PSQI, their subjective quality of sleep was low, and the quality of sleep during, sleep latency was low as well. And their sleep disturbance was great. In contrast, the effectiveness of their habitual sleep was relatively good, and they didn't take medicine such as a sleep pill a lot, and their functional sleep disorder in the daytime wasn't great. There were differences in the quality of sleep according to their education, financial state, self-rated health status and family relations, and whether they worked out on a regular basis or not made a difference to that as well. No differences were found according to age, religion, occupation and having a coffee or not. There was a positive correlation between their quality of sleep in the PSQI and urinary incontinence(r=.51, p=.000). Out of the subfactors of the PSQI, the sleep disturbance factor was most closely linked to urinary incontinence(r=.465, p=.001). Finally, urinary incontinence and subjective health status were identified as the variables that exerted a statistically significant influence on the quality of sleep. Those variables made a 31% prediction of it.

• Journal of Korean society of Dental Hygiene
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• v.17 no.2
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• pp.181-191
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• 2017

Objectives: The objective of the study was to investigate the use of dental hygiene devices in Korean adolescents. Methods: The study subjects were 70,362 adolescents in 800 schools who completed the 2015 Korean Youth Risk Behavior Web-based survey. Dependent variables included usage of dental floss, interdental brushes and mouthwash solutions. Independent variables included demographic characteristics of the subjects, health state and behaviors, and oral health behaviors and experience of oral diseases. Results: The related factors of usage of dental hygiene devices included gender, where females showed higher usage (OR=1.10) compared to males, father and mother's level of education where usage was higher in above university graduates (OR=1.20, OR=1.14) compared to less than high school graduation, economic status where usage was higherin high and middle (OR=1.93, OR=1.26) compared to low, vigorous physical activity where usage was higher in those who responded yes (OR=1.35) compared to no, subjective weight recognition where usage was higher in normal (OR=1.07) compared to under weight, sleep time where usage was higher in enough (OR=1.12) compared to not enough, number of toothbrushing (day) where usage was higher in 2 times or over 3 times (OR=1.35, OR=1.75) compared to below 1, oral health education experience (OR=1.10), sealant experience (OR=1.17) and scaling experience (OR=1.45) where usage was higher in those who responded yes compared to no, school where usage was lower in high school (OR=0.64) compared to middle school, residential type where usage was lower in rural area (OR=0.74) compared to metropolitan area, living form where usage was lower in other (OR=0.77), compared to with family, smoking (OR=0.93), and alcohol drinking (OR=0.90) where usage was lower in those who engage in the activities compared to those who didn't, BMI where usage was lower in normal (OR=0.87) and over weight (OR=0.98) compared to under weight. Conclusions: To expand the use of dental hygiene devices in the adolescents, it is necessary to improve the continuing education program for need and motivation of dental hygiene device usage.

• Journal of Preventive Medicine and Public Health
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• v.24 no.4 s.36
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• pp.516-530
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• 1991

A case-control study was conducted to investigate the effect of low-level blood lead on the blood pressure. The plasma renin activity(PRA) was measured also to investigate one of the possible mechanisms by which lead nay play a role to influence on the blood pressure. Seventy-two hypertensive and sixty -nine control study subjects were selected from the workers who had no history of b-related lead exposure, in Ulsan city and it's vicinity, Korea. In addition to measuring blood lead levels and PRA, body mass index(BMI), hematocrit, serum sodium, potassium, creatinine, ionized calcium, and cholesterol were measured. Also, the habits of smoking, alcohol drinking and family history of hypertension were checked. The blood lead level of the hypertensive group was $19.8{\pm}5.5{\mu}g/dl$, which was significantly higher than that of the control group, $12.5{\pm}4.7{\mu}g/dl$(p<0.01). On multiple logistic regression analysis, the odds ratio of blood lead level on the occurence of high blood pressure was 1.38, also statistically significant (p<0.01). There was no significant differences between the hypertensive and the control group in the PRA or In (PRA), but there was a marginally significant linear relationship between blood lead and PRA in the hypertensive group(p<0.1). In conclusion, blood lead level which has been known to be within normal limits may be one of the possible risk factors of hypertension and PRA alteration by lead may act as one of the mechanisms.

• Korean Journal of Head & Neck Oncology
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• v.19 no.2
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• pp.148-157
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• 2003

Background and Objectives: Individual genetic susceptibilities to chemical carcinogens have been recognized as a major important host factors in human cancers. The cytochrome P450 family (CYPs) and glutathione S-transferase(GST) have been reported to be associated with risks to the smoking-related human cancers. Inactivation of tumor suppressor genes like p53 playa key role in tumor progression. The purpose of this study is to demonstrate an association between p53 overexpression and the prevalence of the genetic polymorphisms of CYP1A1 and GSTs in Korean head and neck squamous cell carcinoma (HNSCC). Materials and Methods: The polymorphisms of CYPIA1 and GSTs were analyzed by PCR and PCR-RFLP in 98 Korean head and neck squamous cell carcinoma patients. The expression of p53 was analyzed by immunohistochemistry with anti-p53 Ab (DO7). Results: Overexpression of p53 detected in 45.9% of HNSCC. The odds ratio for p53 overexpression in GSTM1(-), GSTT1(-), GSTP1(val/val) and CYP1A1(val/val) were 1.53, 1.83, 1.17 and 1.47, respectively. Among the combined genotypes, the odds ratio of the CYP1A1 val/val, GSTM1 (-), CYP1A1 val/val, GSTT1(-), and CYP1A1 val/val, GSTT1(-) were 2.0, 2.34 and 4.68, respectively. Conclusion: Based on our results, it might be suggested that p53 overexpression is slightly increased in GSTM1(-), GSTT1(-), GSTP1 val/val, CYP1A1 val/val genotypes. The further study is needed to evaluate the relationship and mechanism between the p53 overexpression and the specific CYP1A1 and GSTs genotypes.

• The Journal of the Korea Contents Association
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• v.12 no.7
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• pp.368-377
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• 2012

The comprehensive countermeasures against school violence recently announced by the government include some content on physical education classes. Physical education has long been ignored in school paradoxically in spite of the deteriorating physical strength and health of adolescents. The physical education subject undervalued in the middle of overly excessive competitions for college entrance exams finds its core goal in whole person education and officially emphasizes the development of personality aspects, which means that physical education claims important significance by providing diverse approaches to school violence prevention. This study thus set out to enhance the roles of physical education for school violence prevention. In Korean society, school violence has taken deep root due to the combined results of individual, family, school and community factors, the growth-first policy driven by compressed modern growth, and neoliberalism based on economic efficiency. School violence possesses such fixed value systems and convictions in Korean society. Education has failed to achieve some effectiveness because of the serious level of school violence, which calls for assessment of ideology having big impacts on educational environments. Given that it has been rediscovered that physical education has legitimacy of alleviating or preventing school violence through its value, an alternative to eradicate school violence should start with physical education normalization in school. Specific alternatives including the activation of sports clubs in school will be established as more fundamental practical alternatives when accompanied by the development of school violence-related programs and the operation of in-service training programs for physical education teachers.

• Korean Journal of Social Welfare
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• v.60 no.3
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• pp.177-200
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• 2008

The study is to investigate the extent to which public sector and private sector have established local governance at the community level. Also, it examines similarity and dissimilarity in the perception of unmet needs in the community service delivery system among local officials and workers in social service agencies for poor female-headed households, using survey questionnaire. It finally aims to propose more effective way of local governance between officials and workers in service agencies, and to improve living conditions for poor female headed households. Results show that first, about 70% of survey participant assess community governance and network system do not work well. Second, the more positive people evaluate their outreach efforts and the network level among community service agencies, the more they perceive that unmet needs are satisfied and recipients are well benefited. Third, the perceptions are significantly different in the extent of service delivery and the unmet needs between local officials and service workers who implement direct social service to female-headed households, after controlling for other related factors. In conclusion, suggestions are given to develope more effective service delivery system for poor female-headed households.

• Korea journal of population studies
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• v.21 no.1
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• pp.129-161
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• 1998

Change in the future household members is closely related to the change in the size and structure of the population which, in turn, is affected by factors of fertility and mortality and the household itself due to changing social values on family. This study aims to estimate the number of households and to thereby analyze the characteristics of household, using a household projection method chosen by reviewing various methods for Korea. In selecting the method of estimating households, the irregularity of the source data should be carefully taken into consideration with a society like the Korean society which is changing rapidly. The review on the proojection methods suggests the breakdown of the ages into two groups, namely 34 years old or less and 35 years old or more, for projecting the households for Korea. Thus, the Exponential Method for the former age group and the Net Transitional Method for the latter are adopted in this study. As a result, the number of households is expected to increase from 12,956 thousand in 1995 to 20,006 thousand in 2030 or by 54% during this period. The average number of members per household will decrease from 3.3 persons in 1995 to 2.5 persons in 2030. One of the main features of change in the housohold structure will be a rapid increase in the number of one person households and a decrease in the number of households with three generations or more.

• Journal of dental hygiene science
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• v.12 no.3
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• pp.217-225
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• 2012

The purpose of this study is to measure the relation of employment stress and self-esteem in some health college students and to consider a proper means for the solution. The population of the research is some randomly chosen health college students located in Seoul City during the period from May 10 to June 11 2010, and the sample of 295 students were recruited as the analysis object group. The data on general characteristics and employment stress were collected by a questionnaire survey. The collected data were analyzed with the SPSS WIN 12.0 program. The following shows the results of this study. 1. Employment stress was low in high group of satisfaction in campus life. It was statistically significant(p<0.001). 2. Mean scores of total self-esteem in study population were 3.1 and positive self-esteem level(3.76) were higher than negative ones (2.44)(p<0.001). 3. The relation between employment stress and selfesteem(r=0.132) revealed significant correlation. 4. In regression analysis, home economy, competence for a schoolwork, satisfaction in campus life, self-esteem(p<0.001) were proved as significant factors that is related to the employment stress. In other words, It is significant statistically that the lower home economy, competence for a schoolwork, satisfaction in campus life, self-esteem, the higher employment stress level. I suggest with the result of the study that for coping effectively employment stress of health college students, we will need to open an educational development considering self-esteem and an exclusive employment counsel window for better administrationwelfare service in campus, to expand industry-academic cooperation in community. Because of students are independent responsibility of employment, active effort must take precedence in order for the solution of problem by themselves. Also, we will need to create better academic environment and show more concern, consideration, love in family.