• Journal of Genetic Medicine
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• 제16권2호
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• pp.85-89
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• 2019

Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a rare autosomal recessive urea cycle disorder. HHH is caused by a deficiency of the mitochondrial ornithine transporter protein, which is encoded by the solute carrier family 25, member 15 (SLC25A15) gene. Recently, government supported Korean newborn screening has been expanded to include a tandem mass spectrometry (MS/MS) measurement of ornithine level. We report a case of a neonate with HHH syndrome showing a normal MS/MS measurement of ornithine level. A female newborn was admitted to neonatal intensive unit due to familial history of HHH syndrome. Her parents were consanguineous Parkistani couple. The subject's older sister was diagnosed with HHH syndrome at age of 30 months based on altered mental status and liver dysfunction. Even though the subject displayed normal ammonia and ornithine levels based on MS/MS analysis, a molecular test confirmed the diagnosis of HHH syndrome. At 1 month of age, amino acid analysis of blood and urine showed high levels of ornithine and homocitrulline. After 11 months of follow up, she showed normal growth and development, whereas affected sister showed progressive cognitive impairment despite no further hyperammonemia after protein restriction and standard therapy. Our report is in agreement with a previous Canadian study, which showed that neonatal samples from HHH syndrome patients demonstrate normal ornithine levels despite having known mutations. Considering the delayed rise of ornithine in affected patients, genetic testing, and repetitive metabolic testing is needed to prevent patient loss in high risk patients.

• 대한정형도수물리치료학회지
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• 제4권1호
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• pp.71-82
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• 1998

The purpose of this study is to analyze the phases of back pain occurring on pregnant women, and to raise the necessity of the pain management on the basis of the former analysis. The objective group is 284 pregnant women who visited department of OBGY of hospital located both in Seoul and Andong. The results are as follows; 1. 204(71.8%) pregnant women were suffering from back pain. The ratio of pain occurrance in terms of the duration of pregnancy shows that 78.3% within 3 pregnant months, 68.4% between four and six months and 72.1% over seven month. Most common ares of pain was low back area rating 60.5%. 2. The most painful postural for the suffering women was lying on the back rating 35.9% and the next painful posture was standing rating 34.4%. And the most painful movement was to maintaining continues movement(57.8%). Twisting back rates the second(17.2%). These two variables were relevant each other(p<0.05). 3. 46.7% of pregnant women were experiencing nocturnal pain. Among women experienced the pain before pregnancy, 39.9% were suffering during the pregnancy. The occurrence of nocturnal pain was related to the pain before and after the pregnancy(p<0.05). 4. 58.8% of pregnant women who experience back pain take the pain for granted as a normal proceeding of pregnancy while 3.9% recognize the symptom as an abnormal. Pain recognition in accordance with the phases does not show much difference(p<0.05). 5. It is shown that the more one delivers the number of babies, the faster back pain occurs(p<0.01). 6. 32.3% of the pain-suffering women have family member(s) having back pain. Family member(s) of the women who does not experience the pain don't have the pain either. This case reports 46.1%. Statistically, these two variables are relevant(p<0.01). 7. 43.0% of back pain experiencing women does not have any particular management plan against the pain. 20.7% is exercising as for prevention. Women who recognize the necessity of some means of therapy for their pain marked 42.9%. The majority(65.8%) of women responded exercise gymnastic work-out are most appropriate pain management. The above results show that a great number of pregnant women is experiencing back pain, however, they properly managed. This span suggests that appropriate advocacy and education for pregnant women is necessary. It is recommended that positive contribution can be made to better health of pregnant women when pain management by physical therapist is given.

• 한국발생생물학회지:발생과생식
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• 제4권1호
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• pp.87-93
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• 2000

eCG는LH, FSH및 TSH와 같이 당단백질 호르몬에 속하고, 당쇄가 많이 첨가된 $\alpha$와 $\beta$-subunits의 비공유결합으로 구성되어 있고, 말에서 보다 다른 동물에서 FSH와 LH의 이중 생리활성을 나타내는 아주 특이한 성선 자극 호르몬이다. eCG는 임신 40~130일 사이에 말의 자궁내막배의 영양막세포에서 합성ㆍ분비된다. 따라서 본 연구에서는 eCG, eLH 및 eFSH의 각각 subunits mRNA발현을 태반과 뇌하수체에서 분석하였다. mRNA의 추출은 임신 70일의 태반과 27개월된 숫컷말의 뇌하수체에서 분리하였다. 말 태반을 이용한eCG mRNA발현의 Northern blotting분석결과 $\beta$ subunit가 $\alpha$ subunit보다 아주 많이 발현되었으며, 또한 뇌하수체에서 $\alpha$-, LH $\beta$-, FSH $\beta$-subunit의 분석결과 $\alpha$ subunit는 약 0.8 kb, FSH $\beta$ subunit는 1.8 kb의 크기로 발현되었는데, 이러한 FSH $\beta$ subunit는 cloning되어진 cDNA의 크기와 일치한다. 뇌하수체 전엽에서는 $\alpha$ subunit가 LH $\beta$ subunit와 FSH $\beta$ subunit보다 현저히 많이 발현된다는 사실이 밝혀졌다. 따라서, 태반과 뇌하수체에서 발현되는 각각 subunit의 mRNA는 독립적으로 조절되어 결과적으로 발현량에 차이가 나타난다고 시사되어진다.

• 한국조리학회지
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• 제17권3호
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• pp.151-161
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• 2011

본 연구의 목적은 주부들의 비만도와 외식행동 및 식생활습관과의 관계를 알아보기 위하여 부산 경남지역 주부 249명을 대상으로 조사하였다. 이를 확인하기 위하여 SPSS통계프로그램 17.0을 활용하여 빈도분석, 요인분석, $x^2$-test, 군집분석과 One Way ANOVA분석을 실시하였다. 분석결과는 주부들의 평균키는 160.75 cm, 평균체중은 57.51 kg로 조사되었고, 주부들의 체질량지수(BMI)를 보면 정상체중이 56.6%, 과체중과 비만체중이 37.0%로 조사되었다. 한 달 외식하는 횟수는 4회 이하가 65.5%이고, 1인당 외식비는 7001원에서 11000만원사이가 34.9%로 나타났으며, 외식목적은 가족과 함께 44.2%, 외식동반자는 가족 친지가 63.8%, 선호식당은 일반대중식당이 47.8%, 외식정보는 주위사람들을 통해서가 79.1%로 조사되었다. 식생활습관요인에 따른 군집분석결과 군집1은 (중도적 식생활습관집단), 군집2는 (좋지 않는 식생활집단), 군집3은 (좋은 식생활집단)으로 명명하였고, 3개의 군집과 식생활습관요인과의 차이분석에서 (P<0.01) 유의한 결과를 나타내었다. 따라서 부산 경남지역 주부들은 37.0%가 과체중과 비만체중을 나타내어, 식생활습관의 변화가 필요한 것으로 사료된다. 또한 젊은 주부들에 비하여 나이가 많은 주부들이 건강에 좋은 식품과 규칙적인 식생활 습관을 가지고 있지만, 비만 도에서는 51세 이상에서 30세 이하보다 높게 나타난 것은 51세 이상의 주부들이 폐경기를 겪으면서 비만의 원인이 되는 것으로 사료된다.

• Journal of Preventive Medicine and Public Health
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• 제44권5호
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• pp.226-233
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• 2011

Objectives: Being overweight or obese is central to metabolic syndrome, and these characteristics constitute dominant risk factors for chronic diseases. Although behavioral factors, including eating habits and sedentary lifestyles, are considered to be determinants of obesity, the specific childhood factors that contribute to this condition have not been clearly defined. Methods: The subjects consisted of 261 children aged 7- 9 years who were recruited from an elementary school during October 2003. Information was obtained from their parents using a questionnaire focused on eating behaviors and lifestyle factors, additional data were also collected via anthropometric measurements and biochemical examinations, including blood tests. Results: A total of 48 (18.4%) of the 261 children were overweight, and 34 (70.8%) had at least one other component of metabolic syndrome. Eating behaviors emerged as significant lifestyle-related risk factors for being overweight or obese. Those who engaged in overeating more than twice per week had three times the risk of being overweight (odds ratio [OR], 3.10, 95% confidence interval [CI], 1.39 to 6.92), and those who ate rapidly had three times the risk of being overweight (OR, 3.28; 95% CI, 1.68 to 6.41). Those who had fewer family meals (fewer than 2?3/month) had a nine times higher risk of being overweight than those who had family meals more frequently (at least 1/day) (OR, 9.51; 95% CI, 1.21 to 74.82). Conclusions: This study showed that being overweight or obese during preadolescence is associated with a higher risk of metabolic syndrome and is related to unhealthy eating behaviors. Thus, weight-control strategies and healthy eating behaviors should be developed early in life to reduce the risk for metabolic syndrome.

• Nutrition Research and Practice
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• 제11권3호
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• pp.232-239
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• 2017

BACKGROUND/OBJECTIVES: Increased consumption of instant noodles has recently been reported to be positively associated with obesity and cardiometabolic syndrome in South Korea, which has the highest per capita instant noodle consumption worldwide. This study aimed to investigate the association between instant noodle consumption and cardiometabolic risk factors among college students in Seoul. SUBJECTS/METHODS: The study subjects consisted of 3,397 college students (1,782 male; 1,615 female) aged 18-29 years who participated in a health checkup. Information on instant noodle consumption was obtained from the participants' answers to a question about their average frequency of instant noodle intake over the 1 year period prior to the survey. RESULTS: Statistical analysis using a general linear model that adjusted for age, body mass index, gender, family income, health-related behaviors, and other dietary factors important for cardiometabolic risk, showed a positive association between the frequency of instant noodle consumption and plasma triglyceride levels, diastolic blood pressure, and fasting blood glucose levels in all subjects. Compared to the group with the lowest frequency of instant noodle intake (${\leq}1/month$), the odds ratio for hypertriglyceridemia in the group with an intake of ${\geq}3/week$ was 2.639 [95% confidence interval (CI), 1.393-5.000] for all subjects, while it was 2.149 (95% CI, 1.045-4.419) and 5.992 (95% CI, 1.859-21.824) for male and female students, respectively. In female students, diastolic blood pressure was also higher among more frequent consumers of instant noodles. CONCLUSIONS: Our results suggest that frequent consumption of instant noodles may be associated with increased cardiometabolic risk factors among apparently healthy college students aged 18-29 years.

• 여성건강간호학회지
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• 제5권2호
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• pp.222-229
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• 1999

These days, as the society has been in the trends of highly industrialized and the family has been downsized, there is remarkably increasing number of women who follow occupation. These changes have made it more difficult for the family to help post-partum mother, which had been performed in side of house. By the help of social believe that during at least 1 month after childbirth professional nursing program is indispensable for both maternity protection and physical-mental recuperation, now many post-partum care centers for post-partum mother have been in operation. Although these post-partum care center have in use for a long time, no study was performed before this study on the same subject. Data were analyzed using by SAS. The results of study are as follow : 1. The general features of the user of the post-partum care center. The predominant band of user's age is extended from 26 to 30. The users are mainly housewives and they are in higher level of incomes and educations. As for the feature of delivery methods, they performed the normal spontaneous vaginal delivery method by 58.0% and the Caesarean operation method by 42.0%. As for the sexuality for babies, 59.3% of infants are male, and 40.7% are female. The highest delivery order of users is first and admission after 1-3days delivery is highest. 2. The results for the investigation into the actual condition of the post-partum care center are as follow : About the main reason for entrance of the post-partum care center was found to be the needs for the better nursing programs for recuperation after childbirth. This demands are also supported by their husbands. The average length of stay in the post-partum care center is 17.6 days and the besides promised expense ; powdered milk, milk-suckers, disposable dippers, skin cares, body shape cares, entrophics, injections. The post-partum have private rooms for mother and infants. Over the half of average expense is 229 million won. They are paying accessory fees the post-partum care center have similar step organization : the nurses, the skin carers, the cleaners. Mostly both ways of feeding powdered milk and breast feeding are in use, and mother's milk is preserved in the night time to be given to infant by nurse in charge. 3. The results of the investigation on users' nursing demand to the post-partum care center and satisfaction are as follow : The ranking order of nursing demand of mothers who used the is that ; infant care demands, environmental demands, emotional and mental care demands, education and training demands. As much as 70% of the respondents have dissatisfaction in nursing program, The ranking order of service satisfaction of mothers who used appears to be higher following order ; satisfaction in infant care demand, satisfaction in physical nursing demand, satisfaction in emotional and mental nursing demand, satisfaction in education and training demand, satisfaction in environment nursing demand. The results of pearson correlation. between nursing demand and service satisfaction of mothers who used are found to be relative noticeable in the level of 0.05. only infant care. The 61.7% of the women who used the post-partum care center. are responding that they will reuse the same post-partum care center again.

• 한방안이비인후피부과학회지
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• 제23권3호
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• pp.122-137
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• 2010

Objective : Atopic dermatitis (AD) in children may profoundly affect the quality of life (QOL), and also cause financial burden, to the families of those suffering from this ailment. The aim of our study was to examine the quality of life and the financial burden of atopic dermatitis in children and their families to evaluate this relationship with the degree of AD. Methods : 37 infant and child atopic dermatitis patients were included and evaluated using the SCORing of Atopic Dermatitis (SCORAD) Index and Eczema Area and Severity Index (EASI). Patients and carers were asked to fill in the questionnaires about their quality of life and financial costs during the past year. Data about sleep disturbance and pruritus were also obtained. Pearson's correlation was used for statistical analysis. Results : 1. The mean score of Children's Dermatology Life Quality Index (CDLQI) was $10.52{\pm}4.82$, Infants' Dermatologic Quality of Life (IDQOL) was $8.21{\pm}3.95$. 2. The mean score of Family Dermatology Life Quality Index (FDLQI) was $13.30{\pm}5.72$, Dermatitis Family Impact (DFI) was $12.5{\pm}4.98$. 3. By analyzing the questionnaire, the monthly average cost was determined to be 730,800 won for each patient : the direct cost was 283,500 won, and the indirect cost was 447,300 won. 4. By analyzing the correlation between the severity of AD and QOL, subjective SCORAD were significantly and positively correlated with QOL(IDQOL, FDLQI, DFI, CDLQI). 5. By analyzing the correlation between the severity of AD and any economic impact, EASI were significantly and positively correlated with the direct cost. Conclusion : The above results show that the QOL of the patients and carers is significantly related to their disease severity. Atopic dermatitis patients pay an average of 730,800 won a month, and the economic impact on the patients is significantly related to their disease severity. The CDLQI, IDQOL, FDLQI and DFImay potentially be of value to help in the appropriate management of AD and can be used as an added measurement in clinical trials involving AD management.

• 한국산림과학회지
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• 제96권6호
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• pp.705-713
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• 2007

본 연구의 목적은 임업총조사 결과의 활용이라는 관점에서 2005년 임업총조사와 임가경제조사 결과를 중심으로 우리나라 임가 구조 및 임가 소득에 대한 구조를 파악하는 데 였다. 분석결과, 2005년 현재, 우리나라의 총 임가 수는 97,108가구였으며, 이 중 전업임가는 7,925가구(8.2%), 겸업임가 88,183가구(91.8%)로서 우리나라의 임가는 대부분 겸업인가인 것으로 나타났다. 임가의 평균 가구원수는 2.7명으로 농가인구와 비슷하였다. 임가 경영주의 연령은 60대가 32,628명 (33.6%)으로 가장 많았으며, 60세 이상인 경영주가 51,505명으로 전체의 53%를 차지하고 있었다. 임가 경영주의 임업종사기간은 6개월 이상이 39,229가구(40.4%)로 가장 많았으며, 1개월 미만은 7,216가구(7.4%)인 것으로 나타났다. 산림보유 임가의 산림보유 평균 면적은 4.6ha 이였으며, 업종별로는 벌목업 임가에서 19.5ha를 보유하여 가장 많은 것으로 나타났다. 2005년 임가의 가구당 평균 소득은 27,148천원이었으며, 이 중 임업소득은 6,529천원으로 임가소득의 24.1%를 차지하였다. 그리고 임가의 임산물 판매는 500만원 이하인 임가가 51,633가구로 전체 임가의 64%를 차지하고 있었다. 임가의 임업경영비는 가구당 평균 6,566천원이었다. 한편, 임가가 존재하는 마을 수는 우리나라 전체 36,041개 마을 중 32.8%를 차지하는 11,829개 마을이었으며, 행정구역 중 경상북도의 2,979개 마을에 임가가 존재하여 가장 많았다.

• Clinical and Experimental Pediatrics
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• 제45권12호
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• pp.1540-1545
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• 2002

목 적 : 방광요관역류는 국외의 연구에 의하면 가족력이 중요하며 무증상 형제 자매에서의 방광요관역류 발생빈도가 26-51%의 높은 빈도로 보고되고 있고 역류성 신병증, 소아 고혈압, 만성 신부전으로 진행될 수 있으므로 선별검사의 중요성이 강조되어 왔는데 우리나라 소아에서도 무증상 형제 자매의 방광요관역류 빈도를 조사하여 선별검사의 근거를 제시하고자 본 연구를 시행하였다. 방 법: 인제대학교 의과대학 상계백병원에 내원하여 방광요관역류로 진단받은 환아 중 VCUG 검사에 동의한 28명의 무증상 형제 자매를 대상으로 하였고 방광요관역류 환아의 무증상 형제 자매 중 VUR로 진단받은 형제 자매는 모두 DMSA 신스캔을 시행하였다. 결 과 : VUR로 진단받은 환아는 총 28명이고 남아 14 명, 여아 14 명, 나이는 1개월에서 8년 5개월로 평균 2.7세였다. VCUG 검사에 동의한 무증상 형제 자매는 총 28명으로 남아 17명, 여아 11명, 나이는 2개월에서 7년 5개월로 평균 3.3세였다. VUR로 진단된 환아 28명 중 20례에서 신손상이 있어 전체적으로 71.4%의 신손상의 빈도를 보였다. 무증상 형제 자매 28명 중 VCUG 검사상 VUR로 진단된 형제 자매는 3명으로 10.7%의 VUR 발생빈도를 보였고 DMSA 신스캔 상 이상이 발견된 경우는 1명이였다. 결 론 : 방광요관역류 환아의 무증상 형제 자매에서 역류빈도는 10.7%로 조사되어 방광요관역류의 위험인자로서 가족력이 중요함을 제시해주고 있으며 방광요관역류의 가족선별검사의 근거를 확립하기 위해서 앞으로 더 많은 연구가 시행되어야 하겠다.